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  1. Hi, I'm a Spanish member who developed neuropathic pain in both legs during 2 months of successive trials with 3 ADs (2 weeks desvenlafaxine, 2 weeks amitriptyline, 4 weeks imipramine), during last December and January mostly. The pain subsided mildly but not totally after stopping them and now the pain is usually a 6 and a 7.5 during waves, I really don't have actual windows. I do take mirtazapine 15 mg and tolerate it well since 2 years ago, when it was prescribed to deal with very severe IBS pain. But the combination with the aforementioned ADs shattered my nervous system, my IBS pain (which was a 5) disappeared and was replaced by this torture in my legs. It's now 4 months off the ADs that destroyed me, I am desperate for other people's experiences since I don't think I'm any better after all this time... PS: I have an extreme food intolerance with the IBS, I've been practically disabled for the last 3 years (30 now) and unable to eat anything appart from white meat, white fish and rice. Recent electromiogram is negative for neuropathy, lumbar RM shows Schmorl's hernia with edema in L5, but Drs don't think that's the cause of the burning pains. This is my history with meds: I began with extreme IBS pain, and my first year tried all kinds of natural approaches and diets. I ended up eating 3-4 things and still with crippling pain. Then... Dec 2018 to Sep 2019: Mirtazapine 15 (pain reduced from 7-8 to a 5) Sep 2019 to Oct 2019: Mirtazapine 15 + Olanzapine 2.5 Nov 2019 (2 weeks): Mirtazapine 15 + Duloxetine 30 (gave me extreme nausea after 12 days, but it was working for the pain) Dec 2019 (2 weeks): Mirtazapine 15 + Desvenlafaxine 50 (5/10 IBS pain disappears and 7/10 neuropathic pain appears in both legs) Dec 2019 to January 2020 (2 weeks): Mirtazapine 15 + Amitriptyline 20 (burning gets worse) January 2020 to Feb 2020 (4 weeks): Mirtazapine 15 + Imipramine 25 (burning gets much worse, I'm ready to quit after 2 weeks, but Dr claims the pain will subside if I keep taking it, after 4 weeks the pain is brutal, I stop imipramine on the 10th of Feb and keep just the mirtazapine, pain gets a bit better) March 2020 to April 2020 (1 month): I stop mirtazapine to see if it's causing the burning pain, with inconclusive findings. After a month WD kicks in, can't sleep and the pain is way worse, I reintroduce and symptoms calm down after 3-4 weeks. I still take the mirtazapine 15 and haven't done more changes.
  2. I was on Prozac and amitryptyline for 25 years the last three of those Xanax was apart for Fibromyalgia. A year and a half ago I was in such bad shape , thought I was dying. Mainly from Xanax interdose withdrawals. I started taper of Xanax but I checked myself into a rehab drug detox center as my doctor at the time wanted to add more drugs etc. the center stopped Xanax and Prozac cold turkey . They put me in neurontin to prevent seizure. Needless to say I was in worse shape. Horrific withdrawals. And sensory overload . A few months later I stopped amitryptyline. But couldn't cope. So I was put in lexapro. I was on that the whole time through withdrawals, paws, discontinuation syndrome. Due to side effects if lexapro I tapered off lexapro last February . Which was another horrific withdrawal. It's been 5 months now without any drug and I'm a mess. My brain is toast. I can't even type correctly half the time . I feel so physically sick, depressed, anxious etc. I can't do anything , can't read a book, which I always did, I am physically wasted. Can't do much of anything. I've lost friends , family, my life! I am a shell of who I used to be. Each day I wake up in panic, can't breath etc. will I ever get better, will I ever be normal or sane again, drs say I have to go back on the drugs. I fight it every day. But I'm so alone and afraid . The damage these drugs have done to me is horrific and no one, I mean no one helps me or understands. I feel crazy. I am so afraid of the future and just how much damage has been done to my brain and body physically and emotionally. I am 64. I'm not young any more. Will this horrific nightmare end?
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