erer Posted October 6, 2015 Share Posted October 6, 2015 (edited) ADMIN NOTE Please read this entire topic for tips about tapering vortioxetine. There are many reports on the Web about withdrawal symptoms from vortioxetine, despite their being overlooked by drug companies. Vortioxetine appears to have a withdrawal syndrome similar to almost all the antidepressants and should be tapered slowly to avoid severe or prolonged withdrawal symptoms. See Why taper by 10% of my dosage? According to https://pubchem.ncbi.nlm.nih.gov/compound/vortioxetine#section=Top Quote Vortioxetine is an atypical antipsychotic and antidepressant indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and simulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin receptors and inhibits the reuptake of serotonin. More specifically, vortioxetine acts via the following biological mechanisms: as a serotonin reuptake inhibitor (SRI) through inhibition of the serotonin transporter, as a partial agonist of the 5-HT1B receptor, an agonist of 5-HT1A, and an antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors. SMSs were developed because there are many different subtypes of serotonin receptors, however, not all of these receptors appear to be involved in the antidepressant effects of SRIs. Some serotonin receptors seem to play a relatively neutral or insignificant role in the regulation of mood, but others, such as 5-HT1A autoreceptors and 5-HT7 receptors, appear to play an oppositional role in the efficacy of SRIs in treating depression. According to https://www.drugs.com/pro/brintellix.html , Brintellix is available as 5mg 10mg 15mg 20mg film-coated tablets. It has a very long half-life, somewhere around 66 hours. There is no ingredient in or coating on the tablet to make it extended-release, that would be unnecessary. (In May 2016, Takeda changed the name of this drug from Brintellix to Trintellix in the US to avoid confusion with another drug.) More biochemical detail about vortioxetine at DrugBank. Vortioxetine is metabolized in the liver by several liver enzymes; however, enzyme cyp 2D6 is very important in its metabolization. Taking vortioxetine with other drugs that are metabolized in the liver, as many psychiatric drugs are, can lead to drug-drug interactions, particularly if the other drugs utilize cyp 2D6. From https://pubchem.ncbi.nlm.nih.gov/compound/vortioxetine#section=Drug-and-Medication-Information Quote Vortioxetine has been associated with a low rate of minor serum aminotransferase elevations during treatment, but has not been linked to instances of clinically apparent acute liver injury. Check for drug-drug interactions. Reduce by splitting tablets Depending on your daily dosage, you may be able to taper by dry-cutting tablets. For example, if you are taking 20mg per day, you may request that your prescription be filled with a combination of 10mg and 5mg tablets with the intention of splitting one 5mg tablet into fourths (1.25mg per quarter tablet). This will enable you to reduce from 20mg to 18.75mg, 17.50mg, 16.25mg, 15mg, 13.75mg, 12.5mg, 10mg -- all reductions within the 10% guideline. (Your doctor will have to specify the reason, such as "take x mg in the a.m. and x mg in the p.m.", for most insurance to cover this type of prescription). At 10mg, you will want to get your prescription filled with two 5mg tablets. At this point, to maintain a reduction rate of 10%, you will need to either 1) use a digital scale to weight tablet fragments of 1mg active ingredient (mgai) or less; OR 2) convert one 5mg tablet into a liquid to measure with an oral syringe. (See below.) Use a digital scale to measure doses If you are very sensitive to dosage reductions, you may wish to weigh tablet fragments, see Using a digital scale to measure doses Taper with vortioxetine liquid Measuring a drug for tapering by 10% at a time is easier using a liquid formulation. Since vortioxetine is available in fairly low dosages, you can take part of your daily dosage as a 5mg, 10mg, or 15mg tablet and add the rest as a liquid until your dosage is less than 5mg, where you would take your entire dose as a liquid. Taking part as a tablet and part as a liquid makes it easier to switch from a tablet to a liquid. Vortioxetine liquid may be available by prescription in some countries (other than the U.S). Check with your pharmacist. Make your own vortioxetine liquid The active ingredient in the tablets, vortioxetine, is slightly soluble in water. This means you or a compounding pharmacy can make a liquid suspension from vortioxetine, see How to make a liquid from tablets or capsules A liquid will be a suspension, not a consistent or "homeogenous" solution. Vortioxetine is highly soluble in ethanol and a substance called DMSO, as are many psycho-neuro-active prescription medications. Ethanol is readily available in vodka. You can get oral or medical grade DMSO from many sources. If you have questions about this, feel free to post them in this topic. Have a compounding pharmacy make custom capsule dosages or a liquid or for tapering Compounding pharmacies can make capsules of the drug in any dosage or a liquid from the tablets. You will need a prescription written for the custom compound. The only drawback is this can be expensive. I have a friend on vortioxetine (Brintellix) so I was wondering, does anyone have any info on how tapering this drug might look like? Thanks in advance. Edited November 20, 2018 by ChessieCat updated 2,5 years of slowly tapering down Cymbalta from 60 mg. Then tried going from 8,44 mg to 1 mg in 8 days. (April 1st 2015). That's when the real hell started. Reinstated. Didn't help. I was added Ativan (2 mg 2 times a day for relentless akathisia that started with jumping Cymbalta). For years had been taking Zopitin 7,5 mg and Stilnox 10 mg for I had not been able to sleep naturally since the 1st day I started Cymbalta). Used to take Xanax occasionally. All of the above were stopped cold turkey when I was hospitalized in the beginning of May 2015. Prior to that I have been on and off the whole spectrum of different AD-s for 15 years (since I was 17). My introduction. Tapering: Olanzapine (starting point 2,1 mg): Jan 2016 /---/ April 2018 0 mg. (From 2,1 mg to 0 mg in 1y 3mo). Diazepam (starting at 5 mg) : switching to liquid May 2018; 4,6 mg (June 2018) /---/ 0 mg (Feb 2020) (From 10 to 5 - nobody knows, from 5 to 0 in 1 y 10 mo) Valdoxan (starting at 25 mg): switching to liquid (Feb 2019) /---/ 0 mg (July 2020) Link to comment Share on other sites More sharing options...
Lexy Posted October 20, 2015 Share Posted October 20, 2015 I'm on Brintellix to help get me off effexor. Brintellix has a longer half life than effexor. Even so I would still taper off at the recommended 10% rate. When I'm done with effexor I will taper the brintellix. Can I ask how your friend is doing? Started Effexor August 2012 Sept'12-150mg=extreme anxiety Oct'12 cut half-75mg severe wds Feb 2013 68.5mg. Mar'13- 65mg. Apr'13-59mg. May'13-57mg. June '13-52mg Aug'13 49.75mg. Sep'13-48.75. Nov'13-47mg Dec'13-45..5mg May 2014 42mg. Jun'14 40mg (depressive mood started). Aug'14 -40mg/ started brintellix 2.5mg Oct '14 -39 Nov'14 36.89 Dec'14 34.45 Jan 2015- 31 Feb'15 29mg. Mar'15 26.72. Apr'15 24.48. May'15 22.31mg. Jun'15 20.30mg Aug'15-18.89. Oct'15 16.96. Nov/16- 16.10. Dec/15- 15mg Jan 2016-14.22. May'16 11.45. Aug'16-9.60. Sep/16- 8.88mg. Oct/16- 8.39mg. Nov/16- 8.13. Dec/16- 7.89 Link to comment Share on other sites More sharing options...
erer Posted October 20, 2015 Author Share Posted October 20, 2015 I'm on Brintellix to help get me off effexor. Brintellix has a longer half life than effexor. Even so I would still taper off at the recommended 10% rate. When I'm done with effexor I will taper the brintellix. Can I ask how your friend is doing? She is not doing well - not feeling any effect from the medicine. How are you planning to be doing the 10% cuts for those pills? 2,5 years of slowly tapering down Cymbalta from 60 mg. Then tried going from 8,44 mg to 1 mg in 8 days. (April 1st 2015). That's when the real hell started. Reinstated. Didn't help. I was added Ativan (2 mg 2 times a day for relentless akathisia that started with jumping Cymbalta). For years had been taking Zopitin 7,5 mg and Stilnox 10 mg for I had not been able to sleep naturally since the 1st day I started Cymbalta). Used to take Xanax occasionally. All of the above were stopped cold turkey when I was hospitalized in the beginning of May 2015. Prior to that I have been on and off the whole spectrum of different AD-s for 15 years (since I was 17). My introduction. Tapering: Olanzapine (starting point 2,1 mg): Jan 2016 /---/ April 2018 0 mg. (From 2,1 mg to 0 mg in 1y 3mo). Diazepam (starting at 5 mg) : switching to liquid May 2018; 4,6 mg (June 2018) /---/ 0 mg (Feb 2020) (From 10 to 5 - nobody knows, from 5 to 0 in 1 y 10 mo) Valdoxan (starting at 25 mg): switching to liquid (Feb 2019) /---/ 0 mg (July 2020) Link to comment Share on other sites More sharing options...
Moderator Emeritus Petunia Posted October 20, 2015 Moderator Emeritus Share Posted October 20, 2015 Lexy is correct, Brintellix needs to be tapered carefully, starting with the 10% per month method. Its an instant release formula, so using the usual methods here for reducing dose should be appropriate. See: http://survivingantidepressants.org/index.php?/topic/2693-how-to-make-a-liquid-from-tablets-or-capsules/?p=27942 I'm not a doctor. My comments are not medical advise. These are my opinions based on my own experience and what I've learned. Please discuss your situation with a medical practitioner who has knowledge of tapering and withdrawal...if you are lucky enough to find one. My Introduction Thread Full Drug and Withdrawal History Brief Summary Several SSRIs for 13 years starting 1997 (for mild to moderate partly situational anxiety) Xanax PRN ~ Various other drugs over the years for side effects 2 month 'taper' off Lexapro 2010 Short acute withdrawal, followed by 2 -3 months of improvement then delayed protracted withdrawal DX ADHD followed by several years of stimulants and other drugs trying to manage increasing symptoms Failed reinstatement of Lexapro and trial of Prozac (became suicidal) May 2013 Found SA, learned about withdrawal, stopped taking drugs...healing begins. Protracted withdrawal, with a very sensitized nervous system, slowly recovering as time passes Supplements which have helped: Vitamin C, Magnesium, Taurine Bad reactions: Many supplements but mostly fish oil and Vitamin D June 2016 - Started daily juicing, mostly vegetables and lots of greens. Aug 2016 - Oct 2016 Best window ever, felt almost completely recovered Oct 2016 -Symptoms returned - bad days and less bad days. April 2018 - No windows, but significant improvement, it feels like permanent full recovery is close. VIDEO: Where did the chemical imbalance theory come from? VIDEO: How are psychiatric diagnoses made? VIDEO: Why do psychiatric drugs have withdrawal syndromes? VIDEO: Can psychiatric drugs cause long-lasting negative effects? VIDEO: Dr. Claire Weekes Link to comment Share on other sites More sharing options...
Lexy Posted January 11, 2016 Share Posted January 11, 2016 Personally I would start with 5-7% taper. You have become sensitized with all the pill switching you have gone through. I would not want you to destabilize after the all the progress you have made to get to this point. I'm on 3mg brintellix to help with effexor wds. My doctor who believes in withdrawals prescribed B to help buff out wd symptoms. I will have to taper of that when I'm done with effexor. Please keep updating your taper journey. Started Effexor August 2012 Sept'12-150mg=extreme anxiety Oct'12 cut half-75mg severe wds Feb 2013 68.5mg. Mar'13- 65mg. Apr'13-59mg. May'13-57mg. June '13-52mg Aug'13 49.75mg. Sep'13-48.75. Nov'13-47mg Dec'13-45..5mg May 2014 42mg. Jun'14 40mg (depressive mood started). Aug'14 -40mg/ started brintellix 2.5mg Oct '14 -39 Nov'14 36.89 Dec'14 34.45 Jan 2015- 31 Feb'15 29mg. Mar'15 26.72. Apr'15 24.48. May'15 22.31mg. Jun'15 20.30mg Aug'15-18.89. Oct'15 16.96. Nov/16- 16.10. Dec/15- 15mg Jan 2016-14.22. May'16 11.45. Aug'16-9.60. Sep/16- 8.88mg. Oct/16- 8.39mg. Nov/16- 8.13. Dec/16- 7.89 Link to comment Share on other sites More sharing options...
nz11 Posted January 5, 2018 Share Posted January 5, 2018 Just been reading about this trintellix as it is a new word to me and has come to my attention as new people are joining who are taking it. My goodness this drug costs $340 for thirty 5mg tablets. That's basically $11 a tablet!!!! And that's the price for cash paying customers its apparently different for insurance payers! (no doubt more). Lets say a doctor gets $100 a month prescribing kickback. Then if he has 100 patients on it then he will get ...wait for it $10,000 a month or $120,000 a year for doing nothing!!!! Question: If you were a doctor would you like to get more people on trintellix? Would you inform them that once started it may be difficult to get off the drug? Answer: What do you think! I'd be interested to know what the mg:mg dose equivalent is say with any other ad. Anyone know that? It looks like the pharma marketing department have been doing some overtime thinking up some more nonmedical and non scientific terms ...such as ' serotonin modulator and simulator. ' nz11 Thought for the day: Lets stand up, and let’s speak out , together. G Olsen We have until the 14th. Feb 2018. URGENT REQUEST Please consider submitting for the petition on Prescribed Drug Dependence and Withdrawal currently awaiting its third consideration at the Scottish Parliament. You don't even have to be from Scotland. By clicking on the link below you can read some of the previous submissions but be warned many of them are quite harrowing. http://www.parliament.scot/GettingInvolved/Petitions/PE01651 Please tell them about your problems taking and withdrawing from antidepressants and/or benzos. Send by email to petitions@parliament.scot and quote PE01651 in the subject heading. Keep to a maximum of 3 sides of A4 and you can't name for legal reasons any doctor you have consulted. Tell them if you wish to remain anonymous. We need the numbers to help convince the committee members we are not isolated cases. You have until mid February. Thank you Recovering paxil addict None of the published articles shed light on what ssri's ... actually do or what their hazards might be. Healy 2013. This is so true, with anything you get on these drugs, dependance, tapering, withdrawal symptoms, side effects, just silent. And if there is something mentioned then their is a serious disconnect between what is said and reality! "Every time I read of a multi-person shooting, I always presume that person had just started a SSRI or had just stopped." Dr Mosher. Me too! Over two decades later, the number of antidepressant prescriptions a year is slightly more than the number of people in the Western world. Most (nine out of 10) prescriptions are for patients who faced difficulties on stopping, equating to about a tenth of the population. These patients are often advised to continue treatment because their difficulties indicate they need ongoing treatment, just as a person with diabetes needs insulin. Healy 2015 I believe the ssri era will soon stand as one of the most shameful in the history of medicine. Healy 2015 Let people help people ... in a natural, kind, non-addictive (and non-big pharma) way. J Broadley 2017 Link to comment Share on other sites More sharing options...
Jony Posted January 6, 2018 Share Posted January 6, 2018 Sometimes I get really angry and wonder why these guys are not in jail ... This is the document of approval of the drug by the institute that rules the medicines in Portugal. I didn´t found out in other language, sorry. In the last paragraph of the first page we can read: Interruption of treatment: Patients treated with Brintellix may stop taking the drug suddenly without the need for a gradual dose reduction (see section 5.1). Morning Escitalopram 10 mg from 2005 to present Dec 10.17 reduced to 9 mg; reinstated 10 mg; Jan 2.18 9 mg; Fev 12.18 8 mg; Jan 30.20 5 mg; Feb 6.20 reinstated 6 mg Ethyl Loflazepate 2 mg from 2005 to present Night Mirtazapine 15 mg from 2015 to present (November reinforcement 30mg) Dec 8.17 15 mg Levomepromazine 25 mg started November 2017 8/12/2017 12.5 mg; 13/12/17 6.25 mg; 20/12/2017 3.125 mg; 23/12/2017 last 3.125 mg Clonazepam 2 mg started Nov. 2017 (occasionally) ; last week 2 mg; Dec 19.17 1 mg; Dec 21.17 1.5 mg ; Dec 22.17 2 mg; Jan 2.2018 1.9 mg; Jan 7.2018 3mg; Jan 8.18 2mg; Jan 16.18 1.8 mg; Jan 17.18 1.5 mg ; Jan 18.18 1.7 mg; Jan 19.18 1.6 mg; Fev 12.18 1.5 mg; Jan 30.20 0.5 mg Xanax XR 1 mg in subtitution of Ethyl Loflazepate 2mg (occasionally) Link to comment Share on other sites More sharing options...
manny03 Posted September 7, 2018 Share Posted September 7, 2018 On 1/6/2018 at 7:45 AM, Jony said: Sometimes I get really angry and wonder why these guys are not in jail ... This is the document of approval of the drug by the institute that rules the medicines in Portugal. I didn´t found out in other language, sorry. In the last paragraph of the first page we can read: Interruption of treatment: Patients treated with Brintellix may stop taking the drug suddenly without the need for a gradual dose reduction (see section 5.1). I was taking 5mg for two years and followed this advice. Good lord, I'm experiencing some intense withdrawals. I stopped in July 2018. Today, I'm still experiencing weakness, skin rashes/hives, shifting headaches, eye pressure, visual disturbances. I asked the local pharmacist about this, she went back and told me this exact thing. She mentioned the only way this could be happening is due to length of time I took the medication and recommend me to reinstate. Trintellix (Brintellix) 5mg - December 2015 to Mid July 2018 Vitamin C 500mgs daily January 2019 - March 30 2019 Boost my immune system through my withdrawal - Stopped Up and Up 3 Billion Probiotics - Daily for IBS. - Stopped Up and Up 30 Billion Probiotics - Daily for IBS. - Stopped June 16-26 2018: C/T to take Antiviral medication for Shingles outbreak (Due to excessive stress - SSRI Poop Out). June 27 2018: Reinstated (5mg) July 14 2018 last dose due to acute withdrawal symptoms. Link to comment Share on other sites More sharing options...
Pattycat Posted November 20, 2018 Share Posted November 20, 2018 Has anyone tapered off brintellix yet? Im on 2.5 m nightly.im interested in ways to lower my dose safely. At the moment im cutting a 5mg tablet in half. Once i cut about 5 tablets in half,and put them all in an old coffee cup in the top cupboard.(sick of cutting them.) So onward i go, taking my meds, when i started having withdrawal symptoms. I found that even my disrupting my dose, (cutting 5 or 6 tablets up at once) can have a real effect on me. So i had to return to cutting them only as i needed them,to ensure that while i may not be getting exactly 2.5 mg per day,but i was definitely getting 5 mg every 2nd day,and my nervous system settled back down. 2005-2012 250 mg pristiq.3 month taper meltdown(dr knows best) 2012-2013 40 mg prozac stopped due to extreme anxiety. 2014-present 20 mg brintellix viortioxetine. Dropped down to 10 mg 5-6 months ago. Overnight (dr knows best) now on 10 mg with bearable withdrawal hoping to ride it out, then taper. Last 2 years 2.5mg brintellix. Hoping to taper off. Link to comment Share on other sites More sharing options...
YachtRock Posted November 5, 2021 Share Posted November 5, 2021 On 1/5/2018 at 11:41 AM, nz11 said: My goodness this drug costs $340 for thirty 5mg tablets. That's basically $11 a tablet!!!! And that's the price for cash paying customers its apparently different for insurance payers! (no doubt more). I had been getting Trintellix through Kaiser Permanente and all three dosages (20mg, 10mg and 5mg) were costing me $220 per month. Apparently that was 50% of the retail cost in 2020/2021. But I was willing to paying it for something better than Effexor. The doctor at the same said that it showed significantly less sexual side effects and I can say that was absolutely true compared to Celexa, Lexapro, Cymbalta and Effexor. We are looking at a new insurance company now for 2022 and it is on their formulary so it would be $20/month. My Introduction thread 2002-2003 Celexa/Lexapro (first ride, very mild withdrawal). 2004-2012 Drug free 2013-2018 Cymbalta 60mg | 2019 Effexor 75mg - 150mg (can't recall specifics) 2020-Apr 2021 Trintellix 20mg | May-Jun 10mg | Jul-Aug 5mg (stopped Aug 12th, 2021) WD symptoms began 4-6 weeks after last dose, increased severely at the 4 month mark 2021 Oct 9th Propranolol 10mg 2x/day (10am and 7pm) tapered to 5mg. Stopped 2/1/22. Lorazepam (Ativan) 0.5-1mg as needed Started a 0.5mg Trintellix reinstatement on 12/17/21 Tapered to ~0.4mg and 0.3mg by end of May 2022 Stopped Caffeine 1/1/2022 and Nicotine on 4/1/2022. Jan 19, 2022 - Added Vitamin D3 (2000iu), Super Omega-3 (2500mg) December 2022 - Finished taper of reinstatement dose around 0.09mg Link to comment Share on other sites More sharing options...
YachtRock Posted November 5, 2021 Share Posted November 5, 2021 On 11/20/2018 at 2:53 AM, Pattycat said: Has anyone tapered off brintellix yet? Im on 2.5 m nightly.im interested in ways to lower my dose safely. My experience was NOT the safer approach. My taper was over 4 months - from 20 to 10 then 10 to 5. Had I read this site first, I would have done it differently and probably not be experiencing the WDS I am now. Your last post was 3 years ago, how are things now? Being at 2.5mg sounds like you were already on the right track! My Introduction thread 2002-2003 Celexa/Lexapro (first ride, very mild withdrawal). 2004-2012 Drug free 2013-2018 Cymbalta 60mg | 2019 Effexor 75mg - 150mg (can't recall specifics) 2020-Apr 2021 Trintellix 20mg | May-Jun 10mg | Jul-Aug 5mg (stopped Aug 12th, 2021) WD symptoms began 4-6 weeks after last dose, increased severely at the 4 month mark 2021 Oct 9th Propranolol 10mg 2x/day (10am and 7pm) tapered to 5mg. Stopped 2/1/22. Lorazepam (Ativan) 0.5-1mg as needed Started a 0.5mg Trintellix reinstatement on 12/17/21 Tapered to ~0.4mg and 0.3mg by end of May 2022 Stopped Caffeine 1/1/2022 and Nicotine on 4/1/2022. Jan 19, 2022 - Added Vitamin D3 (2000iu), Super Omega-3 (2500mg) December 2022 - Finished taper of reinstatement dose around 0.09mg Link to comment Share on other sites More sharing options...
Moderator Emeritus ChessieCat Posted December 21, 2021 Moderator Emeritus Share Posted December 21, 2021 Some information about vortioxetine: https://psychscenehub.com/psychinsights/vortioxetine-mechanism-of-action-2/ * NO LONGER ACTIVE on SA * MISSION ACCOMPLISHED: (6 year taper) 0mg Pristiq on 13th November 2021 ADs since ~1992: 25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq: 50mg 2012, 100mg beg 2013 (Serotonin Toxicity) Tapering from Oct 2015 - 13 Nov 2021 LAST DOSE 0.0025mg Post 0 updates start here My tapering program My Intro (goes to tapering graph) VIDEO: Antidepressant Withdrawal Syndrome and its Management Link to comment Share on other sites More sharing options...
Finnishgirl Posted September 22, 2022 Share Posted September 22, 2022 How do you taper below 10mg if you want to keep the reductions in 10 percent? Just shaving the pill? I have seen that with some other meds it is recommended to grind the tablets and put the doses in capsules. Why is the recommendation different with Trintellix? Citalopram for OCD 2008-2012, Drug free 2012-2015, Citalopram for anxiety 2015-2016, Drug free 2016-2017 (pregnancy), Sertralin for OCD 10/2017-04/2019. Tried fast tapering in 2019 for second pregnancy, failed (depression started), reinstated, med did not work anymore. Used Ativan then for 4 moths an tapered down in a few weeks with no problem. Built tolerance and interdose wothdrawal early on Ativan even with 3/day dosing. Since that, depression meds have had no effect. Until Jun/2021: escitalopram 20mg (monotherapy), Jun/2021-Jul/2021: escitalopram 20mg + bupropion 150mg Jul/2021-Jul/2021: escitalopram 10mg + clomipramine 10-75mg (tried to switch escitalopram to clomipramine but too bad side effects), Jul/2021-Aug/2021: bupropion 150mg (reinstated in hospital) + escitalopram 15mg, Aug/2021-Sept/27/2021: bupropion 300mg (upped dose) + escitalopram 15mg Sept/27/2021-Sept/17/2021: Bupropion 150mg (lowered dose) + Trintellix 5-10mg (switched escitalopram to Trintellix) Sept/17/2021-Dec/8/2021: Trintellix 20mg (dosage doubled after stopping Wellbutrin since Wellbutrin doubles Trintellix's blood concentration with doses 150-300mg) Dec/8/2021 : Trintellix 18mg, August 2022: crash at 5,8 mg Trintellix, hospitalized September 2022: Trintellix 20mg, Ativan 1mgx3, mirtazapine 7,5mg, October 2022: Stupid rapid taper attempt of Trintellix 20mg -> 10mg -> 7,5 mg. Back up to 15mg 10/16/2022. Trintellix: 12/12/2022 13,94 mg (-7%); 1/9/2023 13,0mg (-7%) Link to comment Share on other sites More sharing options...
Moderator Emeritus ChessieCat Posted September 22, 2022 Moderator Emeritus Share Posted September 22, 2022 3 minutes ago, Finnishgirl said: How do you taper below 10mg if you want to keep the reductions in 10 percent? Just shaving the pill? I have seen that with some other meds it is recommended to grind the tablets and put the doses in capsules. Why is the recommendation different with Trintellix? There is information in Post #1 explaining the various ways to get non standard doses. You can make your own liquid using tablets and the information is provided there. * NO LONGER ACTIVE on SA * MISSION ACCOMPLISHED: (6 year taper) 0mg Pristiq on 13th November 2021 ADs since ~1992: 25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq: 50mg 2012, 100mg beg 2013 (Serotonin Toxicity) Tapering from Oct 2015 - 13 Nov 2021 LAST DOSE 0.0025mg Post 0 updates start here My tapering program My Intro (goes to tapering graph) VIDEO: Antidepressant Withdrawal Syndrome and its Management Link to comment Share on other sites More sharing options...
Moderator Emeritus ChessieCat Posted September 22, 2022 Moderator Emeritus Share Posted September 22, 2022 5 minutes ago, Finnishgirl said: How do you taper below 10mg if you want to keep the reductions in 10 percent? Just shaving the pill? I have seen that with some other meds it is recommended to grind the tablets and put the doses in capsules. Why is the recommendation different with Trintellix? Please read the following topic which provides suggestions about changing from tablet to liquid: cross-over-changing-form-eg-tablet-to-liquid-of-drug-or-changing-brand-of-same-drug * NO LONGER ACTIVE on SA * MISSION ACCOMPLISHED: (6 year taper) 0mg Pristiq on 13th November 2021 ADs since ~1992: 25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq: 50mg 2012, 100mg beg 2013 (Serotonin Toxicity) Tapering from Oct 2015 - 13 Nov 2021 LAST DOSE 0.0025mg Post 0 updates start here My tapering program My Intro (goes to tapering graph) VIDEO: Antidepressant Withdrawal Syndrome and its Management Link to comment Share on other sites More sharing options...
Finnishgirl Posted September 22, 2022 Share Posted September 22, 2022 Okay, thank you!! Citalopram for OCD 2008-2012, Drug free 2012-2015, Citalopram for anxiety 2015-2016, Drug free 2016-2017 (pregnancy), Sertralin for OCD 10/2017-04/2019. Tried fast tapering in 2019 for second pregnancy, failed (depression started), reinstated, med did not work anymore. Used Ativan then for 4 moths an tapered down in a few weeks with no problem. Built tolerance and interdose wothdrawal early on Ativan even with 3/day dosing. Since that, depression meds have had no effect. Until Jun/2021: escitalopram 20mg (monotherapy), Jun/2021-Jul/2021: escitalopram 20mg + bupropion 150mg Jul/2021-Jul/2021: escitalopram 10mg + clomipramine 10-75mg (tried to switch escitalopram to clomipramine but too bad side effects), Jul/2021-Aug/2021: bupropion 150mg (reinstated in hospital) + escitalopram 15mg, Aug/2021-Sept/27/2021: bupropion 300mg (upped dose) + escitalopram 15mg Sept/27/2021-Sept/17/2021: Bupropion 150mg (lowered dose) + Trintellix 5-10mg (switched escitalopram to Trintellix) Sept/17/2021-Dec/8/2021: Trintellix 20mg (dosage doubled after stopping Wellbutrin since Wellbutrin doubles Trintellix's blood concentration with doses 150-300mg) Dec/8/2021 : Trintellix 18mg, August 2022: crash at 5,8 mg Trintellix, hospitalized September 2022: Trintellix 20mg, Ativan 1mgx3, mirtazapine 7,5mg, October 2022: Stupid rapid taper attempt of Trintellix 20mg -> 10mg -> 7,5 mg. Back up to 15mg 10/16/2022. Trintellix: 12/12/2022 13,94 mg (-7%); 1/9/2023 13,0mg (-7%) Link to comment Share on other sites More sharing options...
Finnishgirl Posted September 22, 2022 Share Posted September 22, 2022 So does that mean that by mixing with ethanol, the liquid is homogenous but by mixing with water it is heterogenous suspension? (I am not native) Citalopram for OCD 2008-2012, Drug free 2012-2015, Citalopram for anxiety 2015-2016, Drug free 2016-2017 (pregnancy), Sertralin for OCD 10/2017-04/2019. Tried fast tapering in 2019 for second pregnancy, failed (depression started), reinstated, med did not work anymore. Used Ativan then for 4 moths an tapered down in a few weeks with no problem. Built tolerance and interdose wothdrawal early on Ativan even with 3/day dosing. Since that, depression meds have had no effect. Until Jun/2021: escitalopram 20mg (monotherapy), Jun/2021-Jul/2021: escitalopram 20mg + bupropion 150mg Jul/2021-Jul/2021: escitalopram 10mg + clomipramine 10-75mg (tried to switch escitalopram to clomipramine but too bad side effects), Jul/2021-Aug/2021: bupropion 150mg (reinstated in hospital) + escitalopram 15mg, Aug/2021-Sept/27/2021: bupropion 300mg (upped dose) + escitalopram 15mg Sept/27/2021-Sept/17/2021: Bupropion 150mg (lowered dose) + Trintellix 5-10mg (switched escitalopram to Trintellix) Sept/17/2021-Dec/8/2021: Trintellix 20mg (dosage doubled after stopping Wellbutrin since Wellbutrin doubles Trintellix's blood concentration with doses 150-300mg) Dec/8/2021 : Trintellix 18mg, August 2022: crash at 5,8 mg Trintellix, hospitalized September 2022: Trintellix 20mg, Ativan 1mgx3, mirtazapine 7,5mg, October 2022: Stupid rapid taper attempt of Trintellix 20mg -> 10mg -> 7,5 mg. Back up to 15mg 10/16/2022. Trintellix: 12/12/2022 13,94 mg (-7%); 1/9/2023 13,0mg (-7%) Link to comment Share on other sites More sharing options...
Finnishgirl Posted September 22, 2022 Share Posted September 22, 2022 I mean, if it is heterogenous, then measuring the right amount is impossible. Citalopram for OCD 2008-2012, Drug free 2012-2015, Citalopram for anxiety 2015-2016, Drug free 2016-2017 (pregnancy), Sertralin for OCD 10/2017-04/2019. Tried fast tapering in 2019 for second pregnancy, failed (depression started), reinstated, med did not work anymore. Used Ativan then for 4 moths an tapered down in a few weeks with no problem. Built tolerance and interdose wothdrawal early on Ativan even with 3/day dosing. Since that, depression meds have had no effect. Until Jun/2021: escitalopram 20mg (monotherapy), Jun/2021-Jul/2021: escitalopram 20mg + bupropion 150mg Jul/2021-Jul/2021: escitalopram 10mg + clomipramine 10-75mg (tried to switch escitalopram to clomipramine but too bad side effects), Jul/2021-Aug/2021: bupropion 150mg (reinstated in hospital) + escitalopram 15mg, Aug/2021-Sept/27/2021: bupropion 300mg (upped dose) + escitalopram 15mg Sept/27/2021-Sept/17/2021: Bupropion 150mg (lowered dose) + Trintellix 5-10mg (switched escitalopram to Trintellix) Sept/17/2021-Dec/8/2021: Trintellix 20mg (dosage doubled after stopping Wellbutrin since Wellbutrin doubles Trintellix's blood concentration with doses 150-300mg) Dec/8/2021 : Trintellix 18mg, August 2022: crash at 5,8 mg Trintellix, hospitalized September 2022: Trintellix 20mg, Ativan 1mgx3, mirtazapine 7,5mg, October 2022: Stupid rapid taper attempt of Trintellix 20mg -> 10mg -> 7,5 mg. Back up to 15mg 10/16/2022. Trintellix: 12/12/2022 13,94 mg (-7%); 1/9/2023 13,0mg (-7%) Link to comment Share on other sites More sharing options...
Moderator Emeritus ChessieCat Posted September 22, 2022 Moderator Emeritus Share Posted September 22, 2022 On 5/11/2022 at 5:53 AM, brassmonkey said: Suspension: Some materials that do not dissolve can be suspended in a liquid. Finally ground powder can be mixed in and left to “float” in the liquid. With thin liquids, like water, the powder can settle out quite quickly. They require constant mixing to keep the powder suspended. In thicker liquids the powders can stay suspended for much longer periods of time. Generally compound pharmacies will use a suspension liquid, eg Ora Plus. There is information about this in (Main topic Link) how-to-make-a-liquid-from-tablets-or-capsules There is a discussion about what other things you could try to make a suspension starting from this post: (Link to specific post) how-to-make-a-liquid-from-tablets-or-capsules On 5/11/2022 at 5:53 AM, brassmonkey said: Alcohol is common in most communities. There are, however, several different types of alcohol that get talked about online when discussing dissolving medications. Only one of them is suitable for human consumption. That is ethanol or ethyl alcohol. Any other type of alcohol, rubbing, isopropyl, methanol, or denatured, to name a few CAN NOT BE USED as they are poisonous. When online discussions refer to alcohol, they are talking about laboratory grade ethanol, unless they specify differently. Laboratory grade alcohol is not the stuff you buy in stores, in fact the average person will have trouble getting ahold of it. For our purposes 90proof vodka is what I will be basing the calculations on. Preparations made using a combination of alcohol and water tend to work quite nicely. But because of the intoxicating effects of alcohol and problems alcohol can cause with a taper, it is a good idea to use just enough alcohol to dissolve the medication and round out the volume with water. * NO LONGER ACTIVE on SA * MISSION ACCOMPLISHED: (6 year taper) 0mg Pristiq on 13th November 2021 ADs since ~1992: 25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq: 50mg 2012, 100mg beg 2013 (Serotonin Toxicity) Tapering from Oct 2015 - 13 Nov 2021 LAST DOSE 0.0025mg Post 0 updates start here My tapering program My Intro (goes to tapering graph) VIDEO: Antidepressant Withdrawal Syndrome and its Management Link to comment Share on other sites More sharing options...
Finnishgirl Posted September 22, 2022 Share Posted September 22, 2022 I already read those materials. I was just wondering how accurate the suspension liquid method really is if the particles are not evenly spread in the liquid. Do you know how homogenously spread the active ingredient tends to be in the tablets? One option presented above was just to measure the dose on a diamond scale (basically dry cutting). I already have a scale so would you recommend a self-made liquid or scale? Maybe dry cutting for now but changing to liquid in very small doses? Citalopram for OCD 2008-2012, Drug free 2012-2015, Citalopram for anxiety 2015-2016, Drug free 2016-2017 (pregnancy), Sertralin for OCD 10/2017-04/2019. Tried fast tapering in 2019 for second pregnancy, failed (depression started), reinstated, med did not work anymore. Used Ativan then for 4 moths an tapered down in a few weeks with no problem. Built tolerance and interdose wothdrawal early on Ativan even with 3/day dosing. Since that, depression meds have had no effect. Until Jun/2021: escitalopram 20mg (monotherapy), Jun/2021-Jul/2021: escitalopram 20mg + bupropion 150mg Jul/2021-Jul/2021: escitalopram 10mg + clomipramine 10-75mg (tried to switch escitalopram to clomipramine but too bad side effects), Jul/2021-Aug/2021: bupropion 150mg (reinstated in hospital) + escitalopram 15mg, Aug/2021-Sept/27/2021: bupropion 300mg (upped dose) + escitalopram 15mg Sept/27/2021-Sept/17/2021: Bupropion 150mg (lowered dose) + Trintellix 5-10mg (switched escitalopram to Trintellix) Sept/17/2021-Dec/8/2021: Trintellix 20mg (dosage doubled after stopping Wellbutrin since Wellbutrin doubles Trintellix's blood concentration with doses 150-300mg) Dec/8/2021 : Trintellix 18mg, August 2022: crash at 5,8 mg Trintellix, hospitalized September 2022: Trintellix 20mg, Ativan 1mgx3, mirtazapine 7,5mg, October 2022: Stupid rapid taper attempt of Trintellix 20mg -> 10mg -> 7,5 mg. Back up to 15mg 10/16/2022. Trintellix: 12/12/2022 13,94 mg (-7%); 1/9/2023 13,0mg (-7%) Link to comment Share on other sites More sharing options...
YachtRock Posted September 22, 2022 Share Posted September 22, 2022 7 hours ago, Finnishgirl said: How do you taper below 10mg if you want to keep the reductions in 10 percent? Just shaving the pill? I have seen that with some other meds it is recommended to grind the tablets and put the doses in capsules. Why is the recommendation different with Trintellix? I have been crushing Trintellix 5mg pills for 10 months. It works just fine. Where are you seeing a different suggestion? My Introduction thread 2002-2003 Celexa/Lexapro (first ride, very mild withdrawal). 2004-2012 Drug free 2013-2018 Cymbalta 60mg | 2019 Effexor 75mg - 150mg (can't recall specifics) 2020-Apr 2021 Trintellix 20mg | May-Jun 10mg | Jul-Aug 5mg (stopped Aug 12th, 2021) WD symptoms began 4-6 weeks after last dose, increased severely at the 4 month mark 2021 Oct 9th Propranolol 10mg 2x/day (10am and 7pm) tapered to 5mg. Stopped 2/1/22. Lorazepam (Ativan) 0.5-1mg as needed Started a 0.5mg Trintellix reinstatement on 12/17/21 Tapered to ~0.4mg and 0.3mg by end of May 2022 Stopped Caffeine 1/1/2022 and Nicotine on 4/1/2022. Jan 19, 2022 - Added Vitamin D3 (2000iu), Super Omega-3 (2500mg) December 2022 - Finished taper of reinstatement dose around 0.09mg Link to comment Share on other sites More sharing options...
Finnishgirl Posted September 23, 2022 Share Posted September 23, 2022 19 hours ago, YachtRock said: I have been crushing Trintellix 5mg pills for 10 months. It works just fine. Where are you seeing a different suggestion? There is no such suggestion in this thread. Are you able to crush the coating as well or do you only use the insides of the tablet? Citalopram for OCD 2008-2012, Drug free 2012-2015, Citalopram for anxiety 2015-2016, Drug free 2016-2017 (pregnancy), Sertralin for OCD 10/2017-04/2019. Tried fast tapering in 2019 for second pregnancy, failed (depression started), reinstated, med did not work anymore. Used Ativan then for 4 moths an tapered down in a few weeks with no problem. Built tolerance and interdose wothdrawal early on Ativan even with 3/day dosing. Since that, depression meds have had no effect. Until Jun/2021: escitalopram 20mg (monotherapy), Jun/2021-Jul/2021: escitalopram 20mg + bupropion 150mg Jul/2021-Jul/2021: escitalopram 10mg + clomipramine 10-75mg (tried to switch escitalopram to clomipramine but too bad side effects), Jul/2021-Aug/2021: bupropion 150mg (reinstated in hospital) + escitalopram 15mg, Aug/2021-Sept/27/2021: bupropion 300mg (upped dose) + escitalopram 15mg Sept/27/2021-Sept/17/2021: Bupropion 150mg (lowered dose) + Trintellix 5-10mg (switched escitalopram to Trintellix) Sept/17/2021-Dec/8/2021: Trintellix 20mg (dosage doubled after stopping Wellbutrin since Wellbutrin doubles Trintellix's blood concentration with doses 150-300mg) Dec/8/2021 : Trintellix 18mg, August 2022: crash at 5,8 mg Trintellix, hospitalized September 2022: Trintellix 20mg, Ativan 1mgx3, mirtazapine 7,5mg, October 2022: Stupid rapid taper attempt of Trintellix 20mg -> 10mg -> 7,5 mg. Back up to 15mg 10/16/2022. Trintellix: 12/12/2022 13,94 mg (-7%); 1/9/2023 13,0mg (-7%) Link to comment Share on other sites More sharing options...
YachtRock Posted September 23, 2022 Share Posted September 23, 2022 5 hours ago, Finnishgirl said: There is no such suggestion in this thread. Are you able to crush the coating as well or do you only use the insides of the tablet? I crush the coating (entire pill, two at a time) but the coating remains in a "flaky" form no matter how "fine" I try to set the grinder. I try to include some shell fragment in each pill if possible, but I don't freak out about it. I suspect the shell has no medicine in it at all. This is my pill crusher which I would rate a 3/5: https://www.amazon.com/gp/product/B07D3X37L8 If I were to do it again I might remove all the shell coating fragments prior to calculating the target pill weight and prior to filling, as removing the coating would increase drug content I would think and stretch it out more. But at this point I have already dropped over 5 months from 0.015g (15mg) total pill weight containing ~0.5mg of Trintellix, now to 5 or 6mg of powder containing roughly 0.2mg? You can't strictly follow 10% reductions when you are in single digit milligram counts. @FinnishgirlI am sorry I can not pinpoint where I was directed to this approach but I don't think I read anything saying I couldn't crush Trintellix. My Introduction thread 2002-2003 Celexa/Lexapro (first ride, very mild withdrawal). 2004-2012 Drug free 2013-2018 Cymbalta 60mg | 2019 Effexor 75mg - 150mg (can't recall specifics) 2020-Apr 2021 Trintellix 20mg | May-Jun 10mg | Jul-Aug 5mg (stopped Aug 12th, 2021) WD symptoms began 4-6 weeks after last dose, increased severely at the 4 month mark 2021 Oct 9th Propranolol 10mg 2x/day (10am and 7pm) tapered to 5mg. Stopped 2/1/22. Lorazepam (Ativan) 0.5-1mg as needed Started a 0.5mg Trintellix reinstatement on 12/17/21 Tapered to ~0.4mg and 0.3mg by end of May 2022 Stopped Caffeine 1/1/2022 and Nicotine on 4/1/2022. Jan 19, 2022 - Added Vitamin D3 (2000iu), Super Omega-3 (2500mg) December 2022 - Finished taper of reinstatement dose around 0.09mg Link to comment Share on other sites More sharing options...
fontana Posted July 30, 2023 Share Posted July 30, 2023 How do you go down from 1.25mg (1/4 of 5 mg pill). It is already so small, a close to accurate cut is also difficult. Crush the 1.25mg with a spoon then mix with water ? Then use a measuring cup to go down further slowly. Ugh! 2004: Prozac 6months 2013: Prozac 5months+ 2022: 2 months Alprazolam, 2 months Escitalopram 5/10mg (I remember tinnitus started during this time). Cold turkey Escitalopram due to Akathisia (Doctor advised-"wash out" he said). 2023: Jan-May: On and off use, then tapered and come off Alprazolam. March-May: 2 months Fluoxetine 5mg/10mg, terrible anxiety side effects and some mild Akathisia. Needed some small pieces of Alprazolam. May-July: currently tapering low dose Vortioxetine 5mg (trying to taper because of side effects -nausea, being on a boat feeling, constipation, sexual dysfunction, tinnitus, etc). (10mg cause me mild Akathisia so I was brought down to 5mg). I am hoping I would be better off without these antidepressants as I was able to come off short-term use of Flouxetine years ago and got better. Tapered from Vortioxetine 5mg to 2.5mg (9 days) to 1.25mg now. Link to comment Share on other sites More sharing options...
fontana Posted September 8, 2023 Share Posted September 8, 2023 From crumbs of Vortioxetine, I jump off around August 17. The past few days, I wake up really earlier than usual. Is this withdrawal? From https://www.therecoveryvillage.com/ site: "How Long Does Brintellix (Vortioxetine) Stay In Your System? Because Brintellix has a relatively short half-life of 57 to 66 hours, it is likely the medication will be completely removed from your body within 16 days." Wow 16 days. It seems to be on point. So no more of this in my body, and now I am going trough withdrawal? 2004: Prozac 6months 2013: Prozac 5months+ 2022: 2 months Alprazolam, 2 months Escitalopram 5/10mg (I remember tinnitus started during this time). Cold turkey Escitalopram due to Akathisia (Doctor advised-"wash out" he said). 2023: Jan-May: On and off use, then tapered and come off Alprazolam. March-May: 2 months Fluoxetine 5mg/10mg, terrible anxiety side effects and some mild Akathisia. Needed some small pieces of Alprazolam. May-July: currently tapering low dose Vortioxetine 5mg (trying to taper because of side effects -nausea, being on a boat feeling, constipation, sexual dysfunction, tinnitus, etc). (10mg cause me mild Akathisia so I was brought down to 5mg). I am hoping I would be better off without these antidepressants as I was able to come off short-term use of Flouxetine years ago and got better. Tapered from Vortioxetine 5mg to 2.5mg (9 days) to 1.25mg now. Link to comment Share on other sites More sharing options...
fontana Posted September 23, 2023 Share Posted September 23, 2023 I can only find a weighing scale that can measure up to 1mg. How do I go lower? 2004: Prozac 6months 2013: Prozac 5months+ 2022: 2 months Alprazolam, 2 months Escitalopram 5/10mg (I remember tinnitus started during this time). Cold turkey Escitalopram due to Akathisia (Doctor advised-"wash out" he said). 2023: Jan-May: On and off use, then tapered and come off Alprazolam. March-May: 2 months Fluoxetine 5mg/10mg, terrible anxiety side effects and some mild Akathisia. Needed some small pieces of Alprazolam. May-July: currently tapering low dose Vortioxetine 5mg (trying to taper because of side effects -nausea, being on a boat feeling, constipation, sexual dysfunction, tinnitus, etc). (10mg cause me mild Akathisia so I was brought down to 5mg). I am hoping I would be better off without these antidepressants as I was able to come off short-term use of Flouxetine years ago and got better. Tapered from Vortioxetine 5mg to 2.5mg (9 days) to 1.25mg now. Link to comment Share on other sites More sharing options...
meehai Posted December 5, 2023 Share Posted December 5, 2023 How exactly do you make a liquid solution with vortioxetine? As far as I read, it's just partially soluble in water. > Vortioxetine hydrobromide is slightly soluble in water; at ambient temperature solubility is equivalent to approximately 1.3 mg base/mL, pH being 5.5 in the saturated solution. https://www.tga.gov.au/sites/default/files/auspar-vortioxetine-hydrobromide-140708-pi.docx#:~:text=Vortioxetine hydrobromide is slightly soluble,5.5 in the saturated solution. 1.3 mg base/mL means*? Also, if it is about ethanol solutions: 30183.pdf (caymanchem.com) Solubility at 5mg/ml in ethanol, so it's not gonna be 1mg per 1 ml ratio*? I'm not very sure how to interpret those but, happy to hear what you think Feb 21 50mg Zoloft - 1mg Rispridone - 200mg Depakine; Mar 21 CT; Aug 21 5mg Olanzapine, 50mg Zoloft, 1 mg Ativan*; Mar 22 Zoloft some days*; Aug 22 Paroxetine 10mg; Jan 23 CT; Mar 23 25mg Zoloft; Apr 23 Tianeptine & Trazadone; Jun 23 Mirtazapine; Jul 23 Trintellix 10mg; Aug 23 5mg trintellix, 300mg gabapentine. Dec 23: 4.5 mg trintellix liquid, 300mg gabapentine; 13 Dec 23: 5mg trintellix, 300mg gabap; 17 Jan 24: ↘️ 4.5 mg Trintellix, 300 mg gaba, 17 Feb ↘️ 4.05 mg Trintellix, 300mg gabap, 17 Mar ↘️ 3.65 mg Trintellix, 300mg gabap Link to comment Share on other sites More sharing options...
Moderator brassmonkey Posted December 5, 2023 Moderator Share Posted December 5, 2023 The word base is confusing the issue. It is soluble at a rate of 1.3mg active ingredient per 1mL of water. Multiply the strength of a whole tablet by 1.3 and use that number for the volume of water you use. This will give a 1:1 solution. Things will work better using ethanol. Use the strength of the tablet as the volume of ethanol and you will get a 1:1 solution. This is providing that you can tolerate a small amount of alcohol. 20 years on Paxil starting at 20mg and working up to 40mg. Sept 2011 started 10% every 6 weeks taper (2.5% every week for 4 weeks then hold for 2 additional weeks), currently at 7.9mg. Oct 2011 CTed 15oz vodka a night, to only drinking 2 beers most nights, totally sober Feb 2013. Since I wrote this I have continued to decrease my dose by 10% every 6 weeks (2.5% every week for 4 weeks and then hold for an additional 2 weeks). I added in an extra 6 week hold when I hit 10mg to let things settle out even more. When I hit 3mgpw it became hard to split the drop into 4 parts so I switched to dropping 1mgpw (pill weight) every week for 3 weeks and then holding for another 3 weeks. The 3 + 3 schedule turned out to be too harsh so I cut back to dropping 1mgpw every 4 weeks which is working better. Final Dose 0.016mg. Current dose 0.000mg 04-15-2017 "It's also important not to become angry, no matter how difficult life is, because you can loose all hope if you can't laugh at yourself and at life in general." Stephen Hawking Link to comment Share on other sites More sharing options...
meehai Posted December 5, 2023 Share Posted December 5, 2023 Thanks for answering! So for example, for a 5mg tablet, you would get 5*1.3 = 6.5 ml of water to get a ratio of 1:1, but what does that mean? Wouldn't that mean that each 1.3 ml of water has 1mg of active substance? So the ratio is just switched? 1mg/1.3ml Sorry I'm just confused and I'm trying to make sense of those. Feb 21 50mg Zoloft - 1mg Rispridone - 200mg Depakine; Mar 21 CT; Aug 21 5mg Olanzapine, 50mg Zoloft, 1 mg Ativan*; Mar 22 Zoloft some days*; Aug 22 Paroxetine 10mg; Jan 23 CT; Mar 23 25mg Zoloft; Apr 23 Tianeptine & Trazadone; Jun 23 Mirtazapine; Jul 23 Trintellix 10mg; Aug 23 5mg trintellix, 300mg gabapentine. Dec 23: 4.5 mg trintellix liquid, 300mg gabapentine; 13 Dec 23: 5mg trintellix, 300mg gabap; 17 Jan 24: ↘️ 4.5 mg Trintellix, 300 mg gaba, 17 Feb ↘️ 4.05 mg Trintellix, 300mg gabap, 17 Mar ↘️ 3.65 mg Trintellix, 300mg gabap Link to comment Share on other sites More sharing options...
Greenowala Posted January 12 Share Posted January 12 HI guys! I'm looking for a reinstated dosage recommendation for my specific situation. The withdrawal is pretty uncomfortable. Its been a full 10 days completely discontinued. Thank you!! 2017-2018 - Ciprelex (highest dosage) 2018 - 2023 - Trintellix (Vortioxetine) - 20mg 11/25/2023 - 15mg 12/09/2023 - 10mg 12/23/2023 - 5mg 12/30/2023 - 5mg every other day 01/03/2024 - 0mg - discontinued 01/12/2023 - 2.5mg reinstated daily dosage Link to comment Share on other sites More sharing options...
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