faultandfracture Posted December 26, 2015 Share Posted December 26, 2015 If the theory of up-regulated serotonin receptor sites is true as an explanation for depression, this could be a compensatory measure taken by the brain as a result of anxiety, acute stress responses, environmental factors, and even other medications. Seems to me that only non-pharmacological interventions would have any real long-term therapeutic value. Ie. cognitive behavioral therapy, altered thinking process, etc. Any thoughts? Vaulted on to 20mg Lexapro in 2004. Consistently on until 2009, roughly. Stopped, cold turkey. <----naïve, didn't know any better. Experienced irritability, dysphoria, and - you guessed it - depression. Went off and on, on and off for a while. Experimented with Wellbutrin and Zoloft. On 10mg fluoxetine hcl for the last 2 years. I believe my erratic medication behavior has compounded my depression 10 fold, and has made it very hard to live without AD's. Have gone 2 years without them before, and had to return. It's that bad. Link to comment Share on other sites More sharing options...
Moderator Emeritus KarenB Posted December 27, 2015 Moderator Emeritus Share Posted December 27, 2015 The serotonin theory has been completely debunked. See http://survivingantidepressants.org/index.php?/topic/4291-again-chemical-imbalance-is-a-myth-stop-the-lies-please/ for further info. 2010 Fluoxetine 20mg. 2011 Escitalopram 20mg. 2013 Tapered badly and destabilised CNS. Effexor 150mg. 2015 Begin using info at SurvivingAntidepressants. Cut 10% - bad w/d 2 months, held 1 month. Micro-tapering: four weekly 0.4% cuts, hold 4 weeks (struggling with symptoms). 8 month hold. 2017 Micro-tapering: four weekly 1% cuts, hold 4 weeks (symptoms almost non-existent). 2020 Still micro-tapering. Just over 2/3 of the way off effexor. Minimal symptoms, - and sleeping well. Supplements: Fish oil, vitamin C, iron, oat-straw tea, nettle tea. 2023 December - Now on 5 micro-beads Effexor. Minimal symptoms but much more time needed between drops. Symptoms begin to increase. 2024 April - Updosed to 6 microbeads - immediate increase in symptoms for 4 days. Decreased to 5 microbeads. 'The possibility of renewal exists so long as life exists.' Dr Gabor Mate. Link to comment Share on other sites More sharing options...
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