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Lee, 2016 Is increased antidepressant exposure a contributory factor to the obesity pandemic?

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#1 btdt


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Posted 20 June 2016 - 05:22 AM



Citation: Translational Psychiatry (2016) 6, e759; doi:10.1038/tp.2016.25
Published online 15 March 2016

Is increased antidepressant exposure a contributory factor to the obesity pandemic?

S H Lee1, G Paz-Filho1, C Mastronardi1, J Licinio2 and M-L Wong2


In United States of America, over the past two decades, the rate of antidepressant use has increased nearly 400%, where antidepressant drugs were the third most prescribed class of drugs for persons aged 18-44 years in 2005–2008.25 In 2010, it was reported that 52.3 daily doses were prescribed for every 1000 inhabitants in European countries.26 In Australia, 34 million prescriptions were issued for mental health-related diseases in 2013–2014, and 67% (23 million) of those were for antidepressants.27 In 2012–2013, mental health-related prescriptions cost the Australian Government over $788 million.27 With a rapid rise of individuals taking antidepressants, numerous studies have investigated the effects of different classes of antidepressants on body weight. Despite the concomitant occurrence of the frequent use of antidepressants and the high incidence of obesity in Western societies, the pathways and mechanisms by which antidepressants can induced weight gain remain unclear.

In this review, we examine the pathophysiology of MDD and obesity, and their complex interactions. More specifically, we discuss the role of antidepressant use in weight gain, and the role of interactions with environmental factors, such as stress.


In addition to the clinical studies described above, case studies have reported extreme weight gain in patients with SSRI treatment.9798 In the study conducted by Bouwer et al., treatment with citalopram led to weight gain and carbohydrate craving in eight out of eighteen patients. In a 4-week period, one female patient gained 8kg, whereas in a 5-week period one male patient gained 9kg.98 In another case study, a 33-year-old schizophrenic female patient was treated with fluoxetine (40mg per day) for a 9-month period following antipsychotic treatment with risperidone (6mg per day) and clorazepate (15mg per day).97 The patient was discontinued from fluoxetine because she underwent excessive weight gain (52kg) accompanied with carbohydrate craving.97Therefore, some individuals may be more sensitive to weight gain induced by SSRIs than others.9798



Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 


There is a crack in everything ..That's how the light gets in :)

#2 nz11


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Posted 24 June 2016 - 01:11 PM

Good question.

2000 amitryptaline, nortriptaline venlafaxine clonazepam for  arm pain from keyboard use, told I had a chemical imbalance it would fix my arm was just a matter of finding the right med for me not informed of the nature of these drugs assured safe and not addictive, CT off Effexor after being told to double the dose on reporting adverse effects...later ..uncharacteristic psych panic tearful presented to doctor to get answers. Given paroxetine no questions asked 'safe and not addictive' next please.2001-2010 paroxetine (paxil) 2 failed attempts to quit, a learned helplessness set in. Feb 10 - Sept 10,  8 month clueless taper, hell. Doc said I had underlying depression .. I said that's not right' then found online support group and the truth!...overcome with inconceivable humiliation and outrage. 28 Sept 10 drug free ...  daily psych and emotional torture beginning in the waking hours of the morning receding somewhat in the evening only to start up again the next day. 28 Sept 12 (24 months) Stabilizing  (What an indescribable unimaginable non-functional nightmare). sleep issues start up at 3 yrs  waking daily at 2am -4.30am), April 2016 return to sport for the first time since drug free, Sept 16 return to work on casual basis.  28 Sept 16 (6yrs drug free), still cant sleep with any regularity, pssd continues no sign of improvement, still feel Rip van Winkle-ish, brain fog still improving, psoriasis concerns.


"It is unsafe for people who suffer from something that could be treated with an ssri to consult a psychiatrist." Gotzshe 2015. [ I think Gotzsche could have easily meant to say 'to consult anyone with prescribing privileges']. "Going to a psychiatrist is one of the most dangerous actions a person can take." Breggin


“Paroxetine is not safe, it is not effective and it meets every known definition of addictive.” McLaren, N, (2016) 'Psychiatry as bullsh*t’ p55..."Psychiatry is stuffed full of 'deep nonsense' better known as bullsh*t." McLaren 2016


"Within the first week of when you go on an antidepressant you may have a sexual dysfunction, it can go on forever, often only appearing when you go off the drug ...its extraordinarily common" Healy 2015


See  my intro post #451 for the xanax back story and for a CV -GSKs.  Come on guys get taperwise see a TaperMe Schedule

 For a staggeringly shocking 'prozac back story' see the truth post #523


"If I were an enemy combatant and the NZ army did this to me someone would be dragged to the Hague and jailed!"  nz11

#3 Marsha


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Posted 24 June 2016 - 03:32 PM

I was a healthy fit and trim woman before antidepressants. I am ashamed to describe what I look like now 20 years later. My husband lost 30 lbs on the max dose of celexa. Pure unadulterated poison these drugs.
I try to take each day at a time, but some days hit me all at once. Will update my signature when I am ready.