In 1987, the year that Prozac was approved for marketing, there were 1.25 million adults in the United States receiving an SSI or SSDI payment due to a mental disorder. This produced a disability rate of 543 per 100,000 people. Since that time, the number of adults on government disability due to a mental disorder has risen to more than 4.5 million in 2014, a disability rate of 1,408 per 100,000.
Thus, during the Prozac era, the disability rate has nearly tripled in the United States.
The same sharp rise in disability due to mental disorders has occurred in country after country that has adopted widespread use of psychiatric drugs. Australia, New Zealand, Canada, United Kingdom, Iceland, Denmark, Sweden and numerous other countries have reported similar sharp rises in disability due to mental disorders.
All of which raises a question, which is the focus of this paper: Do these drugs help people stay well, or, for some paradoxical reason, do they worsen long-term outcomes and thus increase the risk that a person suffering from a psychiatric disorder will end up disabled by it?
But this is not the end of this scientific story. Research into the chemical imbalance theory of mental disorders did bear fruit in one way: it helped flesh out an understanding of how the brain is changed by a psychiatric drug. And what the researchers found is that a psychiatric drug, in essence, creates the very chemical imbalance hypothesized to cause the disorder in the first place.
Prior to the antidepressant era, depression was understood to be an episodic disorder. But once antidepressants began to be commonly used, at least a few psychiatrists began to worry that the drugs were causing a “chronification” of the disease, and numerous studies have since found that depression runs a much more chronic course today than it did before the advent of the drugs. In addition, long-term studies conducted during the past 20 years have regularly found that the unmedicated patients have better outcomes. These findings have led to the worry, first expressed by Giovanni Fava in 1994, that antidepressants induce a biological change in the brain that increases a person’s biological vulnerability to depression.
In a review of this question, Rif El-Mallakh, an expert in mood disorders from the University of Louisville School of Medicine, concluded that SSRI antidepressantscould induce a chronic depressive state he called tardive dysphoria. “Continued drug treatment may induce processes that are the opposite of what the medication originally produced,” he wrote. This may “cause a worsening of the illness, continue for a period of time after discontinuation of the medicine, and may not be reversible.”
This problem of oppositional toleranceis likely a universal one with longterm use of psychiatric drugs. The drugs induce compensatory adaptations in the brain that are the opposite of theirintended effect. Long-term outcome studies of other psychiatric disorders provide additional reason to worry that this might be so. Over the long-term, benzodiazepine users are likely to experience an increase in anxiety symptoms. Long-term outcomes for bipolar patients have notably deteriorated in the last forty years. Studies of stimulants as a treatment for ADHD have failed to find that the treatment provides a long-term benefit
2000 amitryptaline, nortriptaline venlafaxine clonazepam for arm pain from keyboard use, told I had a chemical imbalance it would fix my arm was just a matter of finding the right med for me not informed of the nature of these drugs assured safe and not addictive, CT off Effexor after being told to double the dose on reporting adverse effects...later ..uncharacteristic psych panic tearful presented to doctor to get answers. Given paroxetine no questions asked 'safe and not addictive' next please.2001-2010 paroxetine (paxil) 2 failed attempts to quit, a learned helplessness set in. Feb 10 - Sept 10, 8 month clueless taper, hell. Doc said I had underlying depression .. I said that's not right' then found online support group and the truth!...overcome with inconceivable humiliation and outrage. 28 Sept 10 drug free ... daily psych and emotional torture beginning in the waking hours of the morning receding somewhat in the evening only to start up again the next day. 28 Sept 12 (24 months) Stabilizing (What an indescribable unimaginable non-functional nightmare). sleep issues start up at 3 yrs waking daily at 2am -4.30am)28 Sept 15 (5yrs drug free), cf, cmw, insomnia horrifying pssd continues, still feel Rip van Winkle-ish, cognitively doing heaps better. 28 Sept 16 after 6 yrs start working again on a casual basis.
"It is unsafe for people who suffer from something that could be treated with an ssri to consult a psychiatrist." Gotzshe 2015. [ I think Gotzsche could have easily meant to say 'to consult anyone with prescribing privileges'].
“Paroxetine is not safe, it is not effective and it meets every known definition of addictive.” McLaren, N, (2016) 'Psychiatry as bullsh*t’ p55..."Psychiatry is stuffed full of 'deep nonsense' better known as bullsh*t." McLaren 2016
"Within the first week of when you go on an antidepressant you may have a sexual dysfunction, it can go on forever, often only appearing when you go off the drug ...its extraordinarily common" Healy 2015
See my intro post #451 for the xanax back story and for a CV -GSKs. Come on guys get taperwise see a TaperMe Schedule.
For a staggeringly shocking 'prozac back story' see the truth post #523
"If I were an enemy combatant and the NZ army did this to me someone would be dragged to the Hague and jailed!" nz11