I rarely post topics like this, but I believe I've finally stumbled upon one of the potential mechanisms behind the symptoms that I've been suffering with for the past several years. It's in regards to the hypothesized glutamanergic hyperactivity related to downregulation of serotonin receptors, as hypothesized by some prominent members of this forum. At first I tended to dismiss that hypothesis as simple disregulation which would result in the brain communicating incorrectly with its various regions, but then I did a little bit more investigation and stumbled upon this:
Long Story Short: Glutamate in the correct proportions is critical for the correct functioning of the central nervous system - but when these proportions change, the effects can be disastrous. If SSRI users experience chronic downregulation of serotonin receptors, which then causes an uptick in glutamanergic processes - how can one not see the possible connection? Even short term increases in a "glutamanergic storm" in the brain can cause serious harm in healthy people - what happens when we not only have a glutamanergic storm, but also a hyperactive sympathetic nervous system, and all the downstream effects of increased levels of norepinephrine, cortisol, - changes in acetylcholine, dopamine, thyroid hormones, sex hormones, etc etc etc etc?
It's definitely not good, and anyone who escapes taking antidepressants without long term harm should honestly consider themselves as lucky as someone who manages to walk away from a plane wreck unscathed.
It's hypothesized with a remarkable amount of anecdotal evidence at this juncture that antidepressants can cause neuropathies, this is evidenced by PSSD and various long term symptoms that people who try to stop taking antidepressants experience (eye pain, burning in the head, burning and tingling in the extremities, a "wet glove" sensation along the limbs)".
Dr. Healy considers neuropathies in more detail in this video:
(START AT 29 MINUTES):