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New meta-analysis


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#1 Cipramillion

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Posted 13 February 2017 - 08:16 AM

New meta-analysis 2017:

 

https://www.ncbi.nlm...pubmed/28178949

 

CONCLUSIONS:

SSRIs might have statistically significant effects on depressive symptoms, but all trials were at high risk of bias and the clinical significance seems questionable. SSRIs significantly increase the risk of both serious and non-serious adverse events. The potential small beneficial effects seem to be outweighed by harmful effects.


<p>Sept 2015: 5 mg Cipralex for 3 weeks. Lots of side effects. Reduced to 2.5 mg for 2 weeks. Experiencing withdrawal and side effects still after dose reduction. Quit after almost 4 weeks on 2.5 mg because of adverse effects. Experiencing withdrawal symptoms still. Reinstating 1mg after 3 weeks. Reduced to 0.50 after 2 days due to sensitive reaction (dysautonomia) and trip to ER. January 2016: After 14 months of tapering from 0.5 mg im now down to 0.08mg. Planing on one more drop before 4-8 weeks healing, then jump to zero. 14.03.17: Lexapro free!


#2 btdt

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Posted 17 February 2017 - 12:51 PM

" An eight-step procedure was followed to assess if thresholds for statistical and clinical significance were crossed. Primary outcomes were reduction of depressive symptoms, remission, and adverse events. Secondary outcomes were suicides, suicide attempts, suicide ideation, and quality of life."

 

 

and around we go. 


WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivinganti...ng-myself-btdt/

There is a crack in everything ..That's how the light gets in :)


#3 rapunzel2

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Posted 18 February 2017 - 10:20 AM

this is awesome!


in 2002- cipramil for half a year, ended it uneventfully. in 2006 - citalopram for half a year, ended in horrific state, ditched the drugs CT. 2006-2008 not feeling well but drug free. in 2008 prozac 20mg + quetiapine 25mg. 2009 tried to stop, ended up in hole after couple of months, started zoloft. 2009-2011 zoloft 50mg. went to 25mg in 2011 summer, it resulted in half a year horrible suffering. reinstated, changed drugs, nothing happened. by 2012 beginning suddenly felt great and CT meds. after 4 months came suddenly most horrible human suffering that's possible. started tapering slowly, GFCF diet and Hardy Nutritionals vitamins in 2013 summer. 

current medications: 1) fluoxetine and quetiapine since Aug 2012; 2) Daily Essential Nutrients by Hardy Nutritionals 10 capsules / since May 2013 + omega3; 3) Gluten-free-casein-free diet since june 2013; 4) free form amino acid complex 3 capsules 5) milk thistle 6) niacin 1500mg

25. april'13 fluoxetine 40mg -> 36mg (10%); 25. may'13 fluoxetine 36mg -> 32mg (1 month inbetween, 11%); 4. july'13 fluoxetine 32mg-> 28mg (5,5 weeks, 13%); 27. july'13 quetiapine 50 -> 45mg (10%); 15. aug'13 fluoxetine 28mg -> 24mg (6 weeks, 14%); 29. sept'13 quetiapine 45 -> 40mg (1,5 months, 11%); 14. oct'13 quetiapine 40mg -> 35mg (2 weeks, 13%); 16. oct'13 quetiapine 35mg -> 40mg; 17. oct'13 fluoxetine 24mg -> 22 mg (8%); 4. feb’14 fluoxetine 22mg -> 21mg (3,5 months hold inbetween, 5% cut); 21. feb'14 fluoxetine 21mg -> 20,5mg (2,5 weeks, 2,4% cut); 27 feb'14 fluoxetine 20,5mg -> 20mg (1 week, 2,4% cut); 30 mar'14 fluoxetine 20mg -> 19,5mg (4,5 weeks, 2,4% cut); 17 may'14 quetiapine 40mg -> 31mg (22% cut); 31 may'14 fluoxetine 19,5mg -> 17,56mg (9,9%); 13 july'14 quetiapine 31mg -> 25mg (19% cut); 19 july'14 quetiapine 25mg -> 18, 75mg (25% cut, 6 days); 28. july'14 quetiapine 18,75mg -> 22mg (-15%); 9. aug'14 fluoxetine 17,52mg -> 17,12mg (2,3% cut, 10 weeks, over 2 months); 19. aug'14 back to 17,52mg due to bad withdrawal symptoms; 20. oct'14 fluoxetine 17,52 -> 17,2mg (1,8% cut); 28. nov'14 fluoxetine 17,2 -> 15,6 (9,8%); 9. feb’15 fluoxetine 15,6 -> 14,4 (7,7%); 3. may’15 quetiapine 22mg -> 19mg (-14%); 27. may’15 fluoxetine 14,4mg -> 12,6mg (-12,5%, 1,8mg); 2. july’15 fluoxetine 12,6mg -> 10,6mg (15,9%, 2mg); 26. oct'15 fluoxetine 10,6mg - 9mg (15%, 1,6mg); 18. jan'16 quetiapine 18mg -> 15mg (17%); 16. mar'16 fluoxetine 9mg -> 7,4mg (18%); 22.may'16 fluoxetine 7,4mg -> 6mg (19%); 19.sept'16 quetiapine 12,5 -> 11,25 (10%); 26. sept'16 quetiapine 11,25 -> 10,25 (9%), 3 oct'16 quetiapine 10,25 -> 9,25 (10%); 10 oc'16 quetiapine 9,25-> 8,25mg (11%), 14 nov'16 quetiapine 8,25 -> 7,25 (12%); 9 Jan'17 fluoxetine 6mg -> 5,8mg (3%): 18 jan fluoxetine 5,8mg -> 5,6mg (3%); 6 feb fluoxetine 5,6mg -> 5,4mg (4%); 19 feb fluoxetine 5,4mg -> 5,2mg (4%); 5 mar fluox 5,2 -> 5,0 (4%).