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van Praag, 2014 Exercise, Energy Intake, Glucose Homeostasis, and the Brain


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#1 Sertralinsomnia

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Posted 05 March 2017 - 12:47 PM

Hello,

I just found this study made on rats only unfortunattely not humans. But since some people in this forums report that exercise benefits on relieving ssri widhdrawal symptoms. Upon looking to this study, i found that exercise could contribute to homeostasis of the brain. It seems to help upregulate the serotonin autoreceptors wish are downregulated on SSR chronic use.

 

http://www.jneurosci.../15139.full.pdf

 

Exercise, Energy Intake, Glucose Homeostasis, and the Brain

 

Relevant parts:

 

Additionally, wheel running facilitates the recovery of stress-evoked disruptions in diurnal rhythms of physiology and sleep architecture (Fleshner et al., 2013; R.S. Thompsonand M.F., unpublished observations), improves corticosterone response habituation (Sasse et al., 2008), and elicits plasticity in serotonergic, noradrenergic, and dopaminergic stress-responsive brain circuitry

 

Regular, moderate physical activity (6 weeks wheel running) produces adaptations in the circuit that include upregulation of 5HT1A inhibitory autoreceptors on DRN cell bodies and a downregulation in 5HT2C receptors in DRN projection sites, amygdala (AMG) and dorsal striatum (DS). Together, these changes constrain the 5HT response to uncontrollable stress and prevent neural sensitization and the expression of learned helplessness behaviors.


Started zoloft 25 mg on October 2009. Started tapering May 2016 to june 2016, last week at 12,5 mg and quit

Crashed 23 january 2017, severe headache and panic (never had this panic all my life) next morning.Tried to reinstate with prozac 5 mg a day on 25 January 2016, bad choice, got arrhytmias and stopped. Started propranolol 40 mg as needed on january
23 - 28 Feb 2017 Tried zoloft reinstatement at 1mg didnt work, more akathisia and head pressure.

1 April 2017 Started Pregabalin 3 x 25 / day to help widhdrawal of zoloft - akathisia and head pressure are now gone. Tried Seroquel 12.5 mg for sleep and quit - because having twitches. Now on mirtazapine 7.5mg and it is helping Insomnia a lot better, sleeping but awaking many times

 


#2 catnapt

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Posted 07 March 2017 - 04:29 PM

there are studies that have shown that exercise is better at treating depression than all of the anti depressants

 

and there's a lot of new research being done in neuroplasticity; exercise keeps coming up as one of the most beneficial things to do, along with learning a new skill, language, etc (challenging your brain) eating well (esp avoiding processed foods) and meditating, all help the brain to heal from injuries (strokes, concussions, etc)

 

to my mind, psych meds cause brain injury, so I am trying to learn as much as I can about healing from a brain injury.

 

I have these books on order, as well:

Bouncing Back: Rewiring your brain for maximum resilience and wellbeing by Linda Graham

 

Hardwiring Happiness: The new brain science of contentment, calm and confidence by Rick Hanson

Buddha's Brain by Rick Hanson


1974-2002 many psych meds, all types; longest used drugs include lithium, seroquel, SSRI's zoloft & celexa; many CT's off drugs

2002-2015 on varying doses of lexapro, as  high as 40 mgs, but usually 20mgs

June 2015: tapered too fast to 2.5mgs, then to 2.5mgs every other day Dec 2015:  found SA forum; holding at 2.5mgs 

Early May 2016: jumped off at 2.5mgs, not smart- crashed in late Sept.

Oct 26 2016  reinstated liquid lexapro 0.05ml/day at night, dose +/- til settling on 0.15BID (0.3/day)= windows and waves

Jan 8, 2017 too quick switch to single dose in the morning, 0.3mgs (bad mistake, led to a crash)

Jan 12 added low dose zyprexa for SI, took infrequently as rescue med, last dose Feb.15

Jan 26 lexapro 0.27mg Feb 25 lexapro updose back to 0.3mg due to unrelenting severe insomnia

March 1 insomnia worse, back down to 0.29 for one day, then 0.27, then 0.25- improving!! March 17 0.24  April 7 0.21

March 7 added low dose lamictal, adjusting dose based on response (currently ~18mgs)

Supplements: Magnesium taurate 250mg, chromium, pro-biotic, biotin, glycine 2grams PM, 1 gram AM 


#3 catnapt

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Posted 07 March 2017 - 04:31 PM

you might be interested in these videos by one of my favorite Drs:

http://nutritionfact...for-depression/

 

http://nutritionfact...gs-really-work/

 

http://nutritionfact...pressant-drugs/

 

one quote: "Putting all the best studies together, the evidence indicates that exercise, at least, has a moderate antidepressant effect, and at best, exercise has a large effect on reductions in depression symptoms and could be categorized as a very useful and powerful intervention. Unfortunately, while studies support the use of exercise as a treatment for depression, exercise is rarely prescribed as a treatment for this common and debilitating problem."

 

 

Dr Michael Gregor is one of the many drs speaking out against the big pharma, the FDA, and the many problems and conflicts of interest in our  Health, or rather, illness, system

 

This is one of my favorite videos-

 

http://nutritionfact...auses-of-death/


1974-2002 many psych meds, all types; longest used drugs include lithium, seroquel, SSRI's zoloft & celexa; many CT's off drugs

2002-2015 on varying doses of lexapro, as  high as 40 mgs, but usually 20mgs

June 2015: tapered too fast to 2.5mgs, then to 2.5mgs every other day Dec 2015:  found SA forum; holding at 2.5mgs 

Early May 2016: jumped off at 2.5mgs, not smart- crashed in late Sept.

Oct 26 2016  reinstated liquid lexapro 0.05ml/day at night, dose +/- til settling on 0.15BID (0.3/day)= windows and waves

Jan 8, 2017 too quick switch to single dose in the morning, 0.3mgs (bad mistake, led to a crash)

Jan 12 added low dose zyprexa for SI, took infrequently as rescue med, last dose Feb.15

Jan 26 lexapro 0.27mg Feb 25 lexapro updose back to 0.3mg due to unrelenting severe insomnia

March 1 insomnia worse, back down to 0.29 for one day, then 0.27, then 0.25- improving!! March 17 0.24  April 7 0.21

March 7 added low dose lamictal, adjusting dose based on response (currently ~18mgs)

Supplements: Magnesium taurate 250mg, chromium, pro-biotic, biotin, glycine 2grams PM, 1 gram AM 


#4 Altostrata

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Posted 07 March 2017 - 07:14 PM

Exercise helps your body run better and regulate its internal activity.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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#5 catnapt

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Posted 08 March 2017 - 06:31 AM

Exercise helps your body run better and regulate its internal activity.

 

I think I read somewhere that it also helps to regulate your temperature, so I am forcing myself to get out and walk, even when I don't feel like it.

I have had such a hard time with being too hot and then too cold!

I think I had this issue even before WD, although not as pronounced.
Having been over medicated for years, I'd become quite the couch potato. :(


1974-2002 many psych meds, all types; longest used drugs include lithium, seroquel, SSRI's zoloft & celexa; many CT's off drugs

2002-2015 on varying doses of lexapro, as  high as 40 mgs, but usually 20mgs

June 2015: tapered too fast to 2.5mgs, then to 2.5mgs every other day Dec 2015:  found SA forum; holding at 2.5mgs 

Early May 2016: jumped off at 2.5mgs, not smart- crashed in late Sept.

Oct 26 2016  reinstated liquid lexapro 0.05ml/day at night, dose +/- til settling on 0.15BID (0.3/day)= windows and waves

Jan 8, 2017 too quick switch to single dose in the morning, 0.3mgs (bad mistake, led to a crash)

Jan 12 added low dose zyprexa for SI, took infrequently as rescue med, last dose Feb.15

Jan 26 lexapro 0.27mg Feb 25 lexapro updose back to 0.3mg due to unrelenting severe insomnia

March 1 insomnia worse, back down to 0.29 for one day, then 0.27, then 0.25- improving!! March 17 0.24  April 7 0.21

March 7 added low dose lamictal, adjusting dose based on response (currently ~18mgs)

Supplements: Magnesium taurate 250mg, chromium, pro-biotic, biotin, glycine 2grams PM, 1 gram AM 


#6 Sertralinsomnia

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Posted 10 March 2017 - 05:15 AM

Did your walks helpef wiyh your insomnia?

Started zoloft 25 mg on October 2009. Started tapering May 2016 to june 2016, last week at 12,5 mg and quit

Crashed 23 january 2017, severe headache and panic (never had this panic all my life) next morning.Tried to reinstate with prozac 5 mg a day on 25 January 2016, bad choice, got arrhytmias and stopped. Started propranolol 40 mg as needed on january
23 - 28 Feb 2017 Tried zoloft reinstatement at 1mg didnt work, more akathisia and head pressure.

1 April 2017 Started Pregabalin 3 x 25 / day to help widhdrawal of zoloft - akathisia and head pressure are now gone. Tried Seroquel 12.5 mg for sleep and quit - because having twitches. Now on mirtazapine 7.5mg and it is helping Insomnia a lot better, sleeping but awaking many times

 


#7 powerback

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Posted 11 March 2017 - 02:57 AM

Hi all.I believe exercise is an absolute must ,the last few months I am experiencing very serious depression and yesterday I had probably the most profound depressive episode I think I've had so far .

My self critic was horrendous, nearly an audible sound of the usual negative horrible criticism.[psychiatrist  once told me I had the strongest self critic he came across ].

PLEASE believe u can exercise ,I look forward to it ,it does so much for us.I totally understand some days we are too tired .   

I put my favourite music on and I'm lost to the world while my muscles are being relieved of the stress that builds up them.

Take care, the forest and hills are calling me ,I'm off for my ramble  .


21​/06/2012 citrol10mg for stress, constant urination ,diazepam 2mg 26/07/2012 .12/07/2012 citroll 20mg,

​24/09/2013 Lexapro 20mg.didnt take them for a week during this year felt extremely strange ,had no idea down to drugs at the time .

​20/10/2014 venlafaxine xl 75mg.09/01/2015 venlafaxine xl 37.5. questioned doctor about drop in dose ,I was told no problem.

​13/04/2015 venlafaxine xl 150mg NEVER TOOK THEM getting wise?.20/04/2015 venlafaxine xl 75mg.19/08/2015 Xanax 250mcg [agitated]

​10/06/2015 venlafaxine 37.5mg.02/03/2016 five beads out for taper only lasted till 06/06/2016 extreme irritability and anxiety. 

​11/11/2016 Xanax 250mcg took them for few days ,fairly distressing time [working nearly impossible].11/11/2016 I was given a prescription for  Zyprexa 2.5mg AND DECIDED  NOT TO GET IT FROM CHEMIST.[my doctor gave them a great sales pitch ,talking about other patients that have benefited ,in witch it just annoyed me ]


#8 Lakelander82

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Posted 12 March 2017 - 06:15 AM

I've always been athletic, I'd think nothing of running 6 miles or doing high intensity sprints but during this withdrawal craic I've had to moderate my activity and make sure not to overdo it. Exercise is touted as the the single most beneficial activity to optimum brain health, even before nutrition, supplements and meditation. I believe it has it's place in the treatment of Anxiety, Depression etc but it's not a silver bullet or magical panacea in the treatment of these conditions.
May 2007 - October 2007 Citalopram 20 mg od. 1st Antidepressant ever taken. No problem with fast taper and no withdrawal effects. No antidepressants for over 5 years.

January 2013 started Citalopram 20mg.
March 2014 Switched to Sertraline 50 mg od.
23rd June 2016 started taper 45mg
23rd July 2016 40.5 mg of Sertraline
23rd August 36.45 mg of Sertraline
27th September 34.65 mg
24th October 32.90 mg
28th November 31.26 mg
4th January 32mg
25th Feb 31 mg 22nd March 30mg 14th April 29mg