Aka Lustral, Serlift, Sertawin, Zosert, etc.
Sertraline is an SSRI with a half-life of about 26 hours. It is metabolized mainly by the liver enzyme P450 CYP2B6, plus CYP 2D6 (substrate, inhibitor), CYP 3A4 (substrate, inhibitor), and CYP 2C9 (substrate). It has an active metabolite, norsertraline, with a half-life of 62 to 104 hours, which may extend its effects.
The best method for a very gradual, precise taper would be using Zoloft liquid.
Reduce by 10% per month to start
The 10% rule holds for Zoloft, just like other psychiatric drugs: Reduce by 10% per month, calculated on the last dosage. (The amount of the reduction gets progressively smaller.)
See Why taper by 10% of my dosage?
Cutting up tablets
According to FDA information at http://www.drugs.com/pro/zoloft.html, Zoloft comes in scored tablets of 25, 50 and 100 mg dosages.
The scoring on the tablets indicates they can be split. Cut them up with a pill cutter, available at any drug store.
Precisely weighing tablet pieces or crushed tablets with an electronic digital scale
You may wish to precisely measure your dosage with an electronic scale that measures milligrams. These are available for under $30 US. See http://survivinganti...-measure-doses/
Use Zoloft liquid concentrate to taper
Zoloft oral concentrate is available in a multidose 60 mL bottle. Each mL of solution contains sertraline hydrochloride equivalent to 20 mg of sertraline. The solution contains the following inactive ingredients: glycerin, alcohol (12%), menthol, butylated hydroxytoluene (BHT).
Sertraline concentrate must be diluted before use. Immediately before taking it, use the provided dropper to remove the amount of concentrate your doctor has told you to take. Mix the concentrate with 4 ounces (1/2 cup [120 milliliters]) of water, ginger ale, lemon or lime soda, lemonade, or orange juice. Do not mix the concentrate with any liquids other than the ones listed. Drink immediately.
US order code for Zoloft 20mg/ml Concentrate Solution NDC 000494940
Unlike other oral liquid antidepressant preparations, Zoloft liquid should be mixed with water because if it is taken directly from the bottle, it is likely to cause a burning sensation in the mouth.
As it is in a 20mg per mL concentration, this means using an oral syringe to measure out the proper amount. If you wish to take 50mg, you would take 2.5mL from the bottle, drop it in a small glass of water, etc., and drink it all.
If you are taking 50mg and wish to reduce by 10% (5mg), you would take 2.25mL (45mg) from the bottle, drop it in a small glass of water, etc., and drink it all.
Personally, I would use water rather than fruit juice or soda so I can see what's left in the glass. I might even drink the mixture, fill the glass again, swirl it a bit, and drink that to make sure to get all the Zoloft out of the glass.
Make your own liquid
Many people make their own Zoloft liquid out of tablets and water. See How to make a liquid from tablets or capsules
Use a combination of tablets and liquid
Rather than switch directly to an all-liquid dose, you may wish to take part of your dose in liquid and part in tablets, gradually converting to all-liquid as you get to lower dosages. This can be very convenient and reduce any problems switching from one form of the drug to another.
For example, if you are taking 100mg Zoloft and wish to reduce by 10%, you could get a prescription for 50mg tablets and the liquid, then take one 50mg tablet and 40mg Zoloft in liquid form to total a daily dose of 90mg. Most likely, the doctor who writes the prescriptions will have to indicate "divided doses" to get the drugs covered by insurance.
Have a compounding pharmacy make up capsules of smaller dosages
A compounding pharmacy will accurately weigh small doses and put them into capsules for you. See http://survivinganti..._3001#entry3001
Edited by Altostrata, 10 June 2015 - 10:16 AM.