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Flockhart Cytochrome P450 Drug Interaction Table


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#1 Altostrata

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Posted 17 November 2011 - 02:25 PM

Psychiatric drugs are often metabolized by liver enzymes. Multiple drugs may utilize the same enzyme, causing drug interactions, or normal variability in these enzymes may affect ability to metabolize specific drugs.

This go-to reference indicates potential drug interactions resulting from competition for, or effects on the human cytochrome P450 system, a way to identify the liver enzymes.

Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). http://medicine.iupu...dis/table.aspx. Accessed 17 Nov 2011.

Full text pdf available at http://medicine.iupu...clinpharm/ddis/

An online interactive table is here.
This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

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#2 Altostrata

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Posted 15 May 2015 - 11:57 AM

Another good source of P450 cytochrome information for specific drugs is http://www.drugbank.ca/.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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#3 westcoast

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Posted 17 May 2015 - 12:55 PM

What an amazing amount of data. Might explain a lot. Venlafaxine/Effexor interactions could fill a phone book. Seroquel/quetiapine too. Bupropion/Wellbutrin not so much. (Alto's second post, above.)

2009: Cancer hospital said I had adjustment disorder because I thought they were doing it wrong. Their headshrinker prescribed Effexor, and my life set on a new course. I didn't know what was ahead, like a passenger on Disneyland's Matterhorn, smiling and waving as it climbs...clink, clink, clink.

2010: Post surgical accidental Effexor discontinuation by nurses, masked by intravenous Dilaudid. (The car is balanced at the top of the track.) I get home, pop a Vicodin, and ...

Whooosh...down, down, down, down, down...goes the trajectory of my life, up goes my mood and tendency to think everything is a good idea.
2012: After the bipolar jig was up, now a walking bag of unrelated symptoms, I went crazy on Daytrana (the Ritalin skin patch by Noven), because ADHD was a perfect fit for a bag of unrelated symptoms. I was prescribed Effexor for the nervousness of it, and things got neurological. An EEG showed enough activity to warrant an epilepsy diagnosis rather than non-epileptic ("psychogenic") seizures.

:o 2013-2014: Quit everything and got worse. I probably went through DAWS: dopamine agonist withdrawal syndrome. I drank to not feel, but I felt a lot: dread, fear, regret, grief: an utter sense of total loss of everything worth breathing about, for almost two years.

I was not suicidal but I wanted to be dead, at least dead to the experience of my own brain and body.

2015: I  began to recover after adding virgin coconut oil and organic grass-fed fed butter to a cup of instant coffee in the morning.

I did it hoping for mental acuity and better memory. After ten days of that, I was much better, mood-wise. Approximately neutral.

And, I experienced drowsiness. I could sleep. Not exactly happy, I did 30 days on Wellbutrin, because it had done me no harm in the past. 

I don't have the DAWS mood or state of mind. It never feel like doing anything if it means standing up.

In fact, I don't especially like moving. I'm a brain with a beanbag body.   :unsure: