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How to make a liquid from tablets or capsules


Rhiannon

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  • Moderator Emeritus
1 hour ago, Deean said:

2. 

 

Stir the liquid gently before you extract the extra amount.  You also need to decide if you are going to rinse the container and drink it or not worry about any residue.  Again do the same thing each time.

 

It is normal for there to be some residue.  There are fillers that do not dissolve.

* NO LONGER ACTIVE on SA *

MISSION ACCOMPLISHED:  (6 year taper)      0mg Pristiq  on 13th November 2021

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering from Oct 2015 - 13 Nov 2021   LAST DOSE 0.0025mg

Post 0 updates start here    My tapering program     My Intro (goes to tapering graph)

 VIDEO:   Antidepressant Withdrawal Syndrome and its Management

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  • Moderator Emeritus
1 hour ago, Deean said:

I guess I have a 3rd question...

 

It doesn't matter which way you do it so long as you are able to measure a consistent amount of water every time you make up your liquid.

 

I also suggest to members to use the same tools, the same area of the bench/table to measure (not many surfaces are perfectly level) and to use the same process every time for that reduction cycle.

* NO LONGER ACTIVE on SA *

MISSION ACCOMPLISHED:  (6 year taper)      0mg Pristiq  on 13th November 2021

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering from Oct 2015 - 13 Nov 2021   LAST DOSE 0.0025mg

Post 0 updates start here    My tapering program     My Intro (goes to tapering graph)

 VIDEO:   Antidepressant Withdrawal Syndrome and its Management

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8 hours ago, ChessieCat said:

 

It doesn't matter which way you do it so long as you are able to measure a consistent amount of water every time you make up your liquid.

 

I also suggest to members to use the same tools, the same area of the bench/table to measure (not many surfaces are perfectly level) and to use the same process every time for that reduction cycle.

Alright, with sleepy- eyes I say thank you Chessiecat for all your responses and guidance...going to give this a go. 

Fill ya in later.

Does the solution need to be kept in the fridge for the 2 hours it will sit for before consuming?  Or is on the counter okay?! 🤔 

 

2001- 2010 Wellbutrin 

2016 - Present, Dessicated Thyroid 30mg

2010 - 2018 Venlafaxine XR 

2014 - 2017 - several taper attempts of Venlafaxine XR 

2017 - Methylphenidate ER (stopped taking right away, as side-effects too intense) 

2017- Vyvanse 

2017 - Lamotrigine 

2018- Escitilopram - direct switch-out from Venlafaxine XR to Escitilopram

2021 - Escitilopram August 20mg slow taper down to 2022 July 10mg

2022 - Vyvanse 20mg 2022 October 1st starting taper - 10% of 20mg for 28 days with 28 day hold

Supplements - Magnesium, D, B6 Complex, Pro-Bio BB-536, Omega Oil, MenoSmart,  MegaSporeBiotic

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10 hours ago, Deean said:

Hi again brassmonkey,

 

Well tomorrow is supposed to be my first day to start tapering.

I did a practice run-through today and have 2 questions that I feel are important to ask.

1.  If I am doing a 10-1 ratio, can I not take the smaller amount of mL's of mixed solution out of the container, and then just drink the rest that is left?

For example.  If I have 200 mL's of solution and I need to take  150mL's to get my proper dose (just random numbers here)...can I not take out 50mL's and dump that...then drink the rest?  Does it matter if I consume the filler ingredients at the bottom of the container?

Asking because it seems more practical to do that, rather than syringe out 150mL's leaving 50 mL's at the end.

Is there a specific reason that we shouldn't have the filler contents?

 

2.  So after letting my "practise run" solution sit for a couple of hours, there is quite a bit of sediment at the bottom.  How do I know that the medication actually is dissolved?   I guess I am asking for "unseen" proof...but, I am a little hesitant as this is my first time.

 

I guess I have a 3rd question...

Does it matter if I pour the distilled water from its original bottle into a measuring cup and then into the glass container I am using to dissolve my medication?  (rather than pulling it out with a syringe and putting it into the container).

 

I would love to start tomorrow, so will check back early morn to see if you've had a chance to respond....however, as this is a last-minute post, I realise I may have to be patient, and start the taper when all the ducks are lined-up.  

 

Thanks brassmonkey,

 

Deean

 

  

Have also asked Chessiecat this - for the 2 hours I am to let my solution sit before consuming, is it better to keep it in the fridge? Sometimes the ambient temperature in our kitchen/living room is different day-to-day.

 

If you say it IS alright to leave out of fridge, should it be protected from the light? Say by putting it in a cupboard?

Thanks

2001- 2010 Wellbutrin 

2016 - Present, Dessicated Thyroid 30mg

2010 - 2018 Venlafaxine XR 

2014 - 2017 - several taper attempts of Venlafaxine XR 

2017 - Methylphenidate ER (stopped taking right away, as side-effects too intense) 

2017- Vyvanse 

2017 - Lamotrigine 

2018- Escitilopram - direct switch-out from Venlafaxine XR to Escitilopram

2021 - Escitilopram August 20mg slow taper down to 2022 July 10mg

2022 - Vyvanse 20mg 2022 October 1st starting taper - 10% of 20mg for 28 days with 28 day hold

Supplements - Magnesium, D, B6 Complex, Pro-Bio BB-536, Omega Oil, MenoSmart,  MegaSporeBiotic

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1 hour ago, Deean said:

Alright, with sleepy- eyes I say thank you Chessiecat for all your responses and guidance...going to give this a go. 

Fill ya in later.

Does the solution need to be kept in the fridge for the 2 hours it will sit for before consuming?  Or is on the counter okay?! 🤔 

 

Hi again..I had new questions pop up and I just posted them to brassmonkey..it is a little more detailed than my last question to you.  

Here's what I asked:

 

"for the 2 hours I am to let my solution sit before consuming, is it better to keep it in the fridge?

Sometimes the ambient temperature in our kitchen/living room is different day-to-day.

 

If you say it IS alright to leave out of the fridge, should it be protected from the light? Say by putting it in a cupboard?

 

Thanks

2001- 2010 Wellbutrin 

2016 - Present, Dessicated Thyroid 30mg

2010 - 2018 Venlafaxine XR 

2014 - 2017 - several taper attempts of Venlafaxine XR 

2017 - Methylphenidate ER (stopped taking right away, as side-effects too intense) 

2017- Vyvanse 

2017 - Lamotrigine 

2018- Escitilopram - direct switch-out from Venlafaxine XR to Escitilopram

2021 - Escitilopram August 20mg slow taper down to 2022 July 10mg

2022 - Vyvanse 20mg 2022 October 1st starting taper - 10% of 20mg for 28 days with 28 day hold

Supplements - Magnesium, D, B6 Complex, Pro-Bio BB-536, Omega Oil, MenoSmart,  MegaSporeBiotic

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  • Moderator

It's better to let it sit at room temperature, as long as the room is not hot. (70F/21C)

Yes, protect it from sunlight.

20 years on Paxil starting at 20mg and working up to 40mg. Sept 2011 started 10% every 6 weeks taper (2.5% every week for 4 weeks then hold for 2 additional weeks), currently at 7.9mg. Oct 2011 CTed 15oz vodka a night, to only drinking 2 beers most nights, totally sober Feb 2013.

Since I wrote this I have continued to decrease my dose by 10% every 6 weeks (2.5% every week for 4 weeks and then hold for an additional 2 weeks). I added in an extra 6 week hold when I hit 10mg to let things settle out even more. When I hit 3mgpw it became hard to split the drop into 4 parts so I switched to dropping 1mgpw (pill weight) every week for 3 weeks and then holding for another 3 weeks.  The 3 + 3 schedule turned out to be too harsh so I cut back to dropping 1mgpw every 4 weeks which is working better.

Final Dose 0.016mg.     Current dose 0.000mg 04-15-2017

 

"It's also important not to become angry, no matter how difficult life is, because you can loose all hope if you can't laugh at yourself and at life in general."  Stephen Hawking

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5 hours ago, brassmonkey said:

It's better to let it sit at room temperature, as long as the room is not hot. (70F/21C)

Yes, protect it from sunlight.

Okay, 10-4 on those, thank you!

So the 2nd stir before consuming, is that to get any AI that may have settled down to the bottom above the filler sediment?

2001- 2010 Wellbutrin 

2016 - Present, Dessicated Thyroid 30mg

2010 - 2018 Venlafaxine XR 

2014 - 2017 - several taper attempts of Venlafaxine XR 

2017 - Methylphenidate ER (stopped taking right away, as side-effects too intense) 

2017- Vyvanse 

2017 - Lamotrigine 

2018- Escitilopram - direct switch-out from Venlafaxine XR to Escitilopram

2021 - Escitilopram August 20mg slow taper down to 2022 July 10mg

2022 - Vyvanse 20mg 2022 October 1st starting taper - 10% of 20mg for 28 days with 28 day hold

Supplements - Magnesium, D, B6 Complex, Pro-Bio BB-536, Omega Oil, MenoSmart,  MegaSporeBiotic

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  • Moderator Emeritus
35 minutes ago, Deean said:

So the 2nd stir before consuming, is that to get any AI that may have settled down to the bottom above the filler sediment?

 

It's just to try to distribute everything as evenly as possible.  Remember that we do the best we can.  Even tablets which are compounded by compounding pharmacists cannot be guaranteed exactly the dose.  We just try to get as close as possible with what we have available to us.

* NO LONGER ACTIVE on SA *

MISSION ACCOMPLISHED:  (6 year taper)      0mg Pristiq  on 13th November 2021

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering from Oct 2015 - 13 Nov 2021   LAST DOSE 0.0025mg

Post 0 updates start here    My tapering program     My Intro (goes to tapering graph)

 VIDEO:   Antidepressant Withdrawal Syndrome and its Management

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4 hours ago, ChessieCat said:

 

It's just to try to distribute everything as evenly as possible.  Remember that we do the best we can.  Even tablets which are compounded by compounding pharmacists cannot be guaranteed exactly the dose.  We just try to get as close as possible with what we have available to us.

Got it.

Alright, thank you Chessiecat. 

I will try and let go a little and just do what I can.

Here's to day 2 💪

2001- 2010 Wellbutrin 

2016 - Present, Dessicated Thyroid 30mg

2010 - 2018 Venlafaxine XR 

2014 - 2017 - several taper attempts of Venlafaxine XR 

2017 - Methylphenidate ER (stopped taking right away, as side-effects too intense) 

2017- Vyvanse 

2017 - Lamotrigine 

2018- Escitilopram - direct switch-out from Venlafaxine XR to Escitilopram

2021 - Escitilopram August 20mg slow taper down to 2022 July 10mg

2022 - Vyvanse 20mg 2022 October 1st starting taper - 10% of 20mg for 28 days with 28 day hold

Supplements - Magnesium, D, B6 Complex, Pro-Bio BB-536, Omega Oil, MenoSmart,  MegaSporeBiotic

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  • 2 months later...

@Rhiannon  can you help me ? thank you very much

 2023.01.27 1,6 mg 2023.01.29 1,5 mg 2023.02.27 1,35 mg 2023.03.30 1,2 mg 2023.04.18 1,1 mg 04,26 1,05 mg 2023.01.26 1,05 mg 2023.02.27 .27 .20. .21 0,8 mg 2023.07.14 0,65 mg 2023.08.20 0,45 mg 2023.09.20 0,25 mg 2023.11.14 000000000!!!!!

 

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Johni,

I took your questions to your Introduction topic here

Late 2023- gone to emeritus status, inactive, don't @ me, I can check who I've posted on, and I'm not really here like I used to be......thanks.

Started with psycho meds/psychiatric care circa 1988.  In retrospect, and on contemplation, situational overwhelm.

Rounding up to 30 years of medications(30 medication trials, poly-pharmacy maximum was 3 at one time).

5/28/2015-off Adderal salts 2.5mg. (I had been on that since hospital 10/2014)

12/2015---just holding, holding, holding, with trileptal/oxcarb at 75 mg. 1/2 tab at hs.  My last psycho med ever!  Tapered @ 10% every 4 weeks, sometimes 2 weeks to

2016 Dec 16 medication free!!

Longer signature post here, with current supplements.

Herb and alcohol free since 5/15/2016.  And.....I quit smoking 11/2021. Lapsed.  Redo of quit smoking 9/28/2022.  Can you say Hallelujah?(took me long enough)💜

None of my posts are intended as medical advice.  Please discuss any decisions about your medical care with a knowledgeable medical provider.  My success story:  Blue skies ahead, clear sailing

 

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  • 1 month later...
On 11/29/2011 at 12:40 PM, Rhiannon said:

-------------------------------------------------------------------------------------

ORIGINAL TOPIC:  Making a Celexa Solution Yourself

-------------------------------------------------------------------------------------

 

Just wanted to add that I've changed my method, it's even simpler now.

 

I just dissolve the tablet in 20 mL of water directly. It does take some time to dissolve. Then I stir it up well and pipette out my dose for the day. Since I'm taking 10 mg in 20 mL, my dose is, right now, 8 mL of water, for 4 mg of Celexa. It seems to be working.

 

You could do the same thing with a syringe.

 

Really, a pipette is just a bigger syringe; a tube with lines to mark quantity, designed for sucking up and then dispensing measured amounts of liquids. Since it's bigger and actually designed for the purpose, a pipette does allow more precise measurements. But it's really the same procedure.

 

 

Thanks so much for your time. On drugs.com I read paroxetine is soluble at .00853mg/ml so 8.53mg/litre. Would this mean the drug would be evenly disolved throughout the water at this point? I noticed that you don't take into account the volume displacement that occurs when adding the drug to water. Is this because it is relatively so small it has no impact? I am very concerned about making sure the doses are consistent. When I start tapering, I want to be as symptom free as possible. I am just working on stabilizing and definitely don't want to go backwards. I've also read paroxetine isn't fully soluble so trying to do my due diligence. Thanks again.

20 yr+ Paroxetine/ Dec2018-May 2022 20 mg/ May 2022 30mg/2022.07.28-2022.08.24 30mg to 0mg/ August 24-29 2022 10mg Prozac/2022.11.28-2022.12.04- 5mg Paroxetine/December 5&6 10mg Paroxetine/ December 8&9 2022 10mg Prozac/ 2022.12.07 to 2023.07.01 5mg Paroxetine

TAPER 23.07.02-58mgpw/4.9mgai/ 23.07.21-4.8 mg/23.07.28-4.73 mg/23.08.04-4.65 mg/21.09.23-4.58 mg/27.10.23-4.56 mg/5.12.23-4.54 mg/2.1.24-4.52 mg/9.1.24-4.51 mg/17.1.24-4.49 mg/26.1.24-4.47 mg/6.2.24-4.46 mg/19.2.24-4.44mg

8am-probiotics/9am-paroxetine, 200mg magnesium bisglycinate/ 1000mg Vitamin D/75mg DGL/ noon-2 x 1000 mg algae oil (500mg DHA/10mg EPA/620mg Omega 3)/5pm-75 mg DGL/200mg calcium citrate/8pm-.25 mg melatonin

I am not a medical professional just your peer. The suggestions I give are based on personal experience and/or the well documented experience of others.

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On 3/21/2022 at 7:42 PM, ChessieCat said:

 

Yes 10mL water + 10mL Ora Plus = 20mL liquid.  20mg tablet in 20mL liquid will give a 1:1 ratio or as you say 1mL liquid = 1 mg dose

Thanks so much for your time. On drugs.com I read paroxetine is soluble at .00853mg/ml so 8.53mg/litre. Would this mean the drug would be evenly disolved throughout the water at this point? I've also read paroxetine isn't fully soluble so don't know what is correct. I noticed that you don't take into account the volume displacement that occurs when adding the drug to water. Is this because it is relatively so small it has no impact? I am very concerned about making sure the doses are consistent. When I start tapering, I want to be as symptom free as possible. I am just working on stabilizing and definitely don't want to go backwards. Also, does the drug lose potency when refrigerated? Thanks again.

20 yr+ Paroxetine/ Dec2018-May 2022 20 mg/ May 2022 30mg/2022.07.28-2022.08.24 30mg to 0mg/ August 24-29 2022 10mg Prozac/2022.11.28-2022.12.04- 5mg Paroxetine/December 5&6 10mg Paroxetine/ December 8&9 2022 10mg Prozac/ 2022.12.07 to 2023.07.01 5mg Paroxetine

TAPER 23.07.02-58mgpw/4.9mgai/ 23.07.21-4.8 mg/23.07.28-4.73 mg/23.08.04-4.65 mg/21.09.23-4.58 mg/27.10.23-4.56 mg/5.12.23-4.54 mg/2.1.24-4.52 mg/9.1.24-4.51 mg/17.1.24-4.49 mg/26.1.24-4.47 mg/6.2.24-4.46 mg/19.2.24-4.44mg

8am-probiotics/9am-paroxetine, 200mg magnesium bisglycinate/ 1000mg Vitamin D/75mg DGL/ noon-2 x 1000 mg algae oil (500mg DHA/10mg EPA/620mg Omega 3)/5pm-75 mg DGL/200mg calcium citrate/8pm-.25 mg melatonin

I am not a medical professional just your peer. The suggestions I give are based on personal experience and/or the well documented experience of others.

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Hello,

 

I'm not an expert, not a doctor, consult your doctor or pharmacist, etc. etc. 

 

Altostrata asked me to type up what I do to make a suspension(solution means something is fully absorbed and the liquid is clear, suspension means you can see particles, in my lay understanding).  I thought it was confusing at first, but turned out to be no big deal, at least for me with Bupropion.   Here's my simple method.  

 

I got a 100ml Graduated Cylinder for $9 off Amazon, a 60ml oral syringe for $7.50/10, and 20ml oral syringe for $7.50/4.   I used a canning jar as a sealed container because it was handy, but a jar with a smaller opening might work better.  

 

To make the solution, I fill up the cylinder with tap to above 75ml, because the pill I'm taking is 75mg.  1:1 water to mg of meds.  I've used distilled water, maybe it's better but I don't store anything over 24 hours so I don't bother and haven't noticed a difference so far.  The 20ml syringe is smaller than the opening of the graduated cylinder so I pop that in there and use it to fine tune the water level to exactly 75ml.   

 

Then I pour that water into the jar, throw in a 75ml tablet, seal it up and put it in the fridge overnight, and by morning it's dissolved.  If I were in a hurry I'd just swish the pill around till it dissolved, or maybe break it up but it only takes a couple minutes anyway.   

 

When it's time to take the meds in the morning, I take the jar out of the fridge and swirl it around to get the sediment off the bottom.  I use whatever oral syringe is more convenient and remove the correct amount of suspension, then just drink what's left.  I refill it a little and swirl that around just in case to make sure I'm getting all the active ingredient and drink that, but it's probably not necessary.   The wide mouth jars are easy to spill, so I'll get something smaller eventually.   Maybe I'll use the oral syringe to administrate the dose, just not my 1st choice.  

 

I'm mathematically challenged and forgetful, so for me it's easiest just to do 1:1 water to MG, 75mg pill to 75ml of water and dose like that.  I can administer a dose and make a new one in just a few minutes, so I don't worry about preserving the suspension for days or anything, I make a new one daily.  Simple works better for me.  

I am not a doctor and do not offer any medical advice, only my own experience.  Consult your physician.

2011-2015 tapered off 300MG of Effexor.  Back in the Paxil Progress days.  No rebound.   

2005-2021:  450 mg Bupropion XL Daily

2021 Buporopion May 450mg/June 400mg/July 375mg/Aug 10th 360mg/

2021 Dec - 150mg IR, 3x day = 450mg Bup, Heritage manufacturer-yellow color pill. 

2022 May 3 - 3 x 150mg IR Bup, Avet brand(pharmacist said they merged with Heritage-orange color) -migraines

REINSTATED-BACK TO MY LAST STABLE DOSE/TIME RELEASE

2022 June 5 - switched back to 3 x 150mg XL one time per day= 450 mg total Bup-Apotex brand

CURRENT TAPER 2022 Aug 31 - 450MG to 412MG IR Bup//Sep. 28, 2022: 412mg to 375mg//Oct 26, 2022: 375mg to 365 mg//Nov 21, 2022: 365mg to 327mg//Dec 27, 2022: 327 mg to 290 mg//Dec 31, 2022:  290mg to 262mg//Jan 28, 2023:  262mg to 190mg//Feb. 19, 2023:  190mg to 140mg//Mar. 18, '23:  140mg to 100mg//

 

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1 hour ago, j1290 said:

Hello,

 

I'm not an expert, not a doctor, consult your doctor or pharmacist, etc. etc. 

 

Altostrata asked me to type up what I do to make a suspension(solution means something is fully absorbed and the liquid is clear, suspension means you can see particles, in my lay understanding).  I thought it was confusing at first, but turned out to be no big deal, at least for me with Bupropion.   Here's my simple method.  

 

I got a 100ml Graduated Cylinder for $9 off Amazon, a 60ml oral syringe for $7.50/10, and 20ml oral syringe for $7.50/4.   I used a canning jar as a sealed container because it was handy, but a jar with a smaller opening might work better.  

 

To make the solution, I fill up the cylinder with tap to above 75ml, because the pill I'm taking is 75mg.  1:1 water to mg of meds.  I've used distilled water, maybe it's better but I don't store anything over 24 hours so I don't bother and haven't noticed a difference so far.  The 20ml syringe is smaller than the opening of the graduated cylinder so I pop that in there and use it to fine tune the water level to exactly 75ml.   

 

Then I pour that water into the jar, throw in a 75ml tablet, seal it up and put it in the fridge overnight, and by morning it's dissolved.  If I were in a hurry I'd just swish the pill around till it dissolved, or maybe break it up but it only takes a couple minutes anyway.   

 

When it's time to take the meds in the morning, I take the jar out of the fridge and swirl it around to get the sediment off the bottom.  I use whatever oral syringe is more convenient and remove the correct amount of suspension, then just drink what's left.  I refill it a little and swirl that around just in case to make sure I'm getting all the active ingredient and drink that, but it's probably not necessary.   The wide mouth jars are easy to spill, so I'll get something smaller eventually.   Maybe I'll use the oral syringe to administrate the dose, just not my 1st choice.  

 

I'm mathematically challenged and forgetful, so for me it's easiest just to do 1:1 water to MG, 75mg pill to 75ml of water and dose like that.  I can administer a dose and make a new one in just a few minutes, so I don't worry about preserving the suspension for days or anything, I make a new one daily.  Simple works better for me.  

Thanks for laying it out simply for me. Appreciate it. 👍

20 yr+ Paroxetine/ Dec2018-May 2022 20 mg/ May 2022 30mg/2022.07.28-2022.08.24 30mg to 0mg/ August 24-29 2022 10mg Prozac/2022.11.28-2022.12.04- 5mg Paroxetine/December 5&6 10mg Paroxetine/ December 8&9 2022 10mg Prozac/ 2022.12.07 to 2023.07.01 5mg Paroxetine

TAPER 23.07.02-58mgpw/4.9mgai/ 23.07.21-4.8 mg/23.07.28-4.73 mg/23.08.04-4.65 mg/21.09.23-4.58 mg/27.10.23-4.56 mg/5.12.23-4.54 mg/2.1.24-4.52 mg/9.1.24-4.51 mg/17.1.24-4.49 mg/26.1.24-4.47 mg/6.2.24-4.46 mg/19.2.24-4.44mg

8am-probiotics/9am-paroxetine, 200mg magnesium bisglycinate/ 1000mg Vitamin D/75mg DGL/ noon-2 x 1000 mg algae oil (500mg DHA/10mg EPA/620mg Omega 3)/5pm-75 mg DGL/200mg calcium citrate/8pm-.25 mg melatonin

I am not a medical professional just your peer. The suggestions I give are based on personal experience and/or the well documented experience of others.

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12 minutes ago, LostInCanada said:

Thanks for laying it out simply for me. Appreciate it. 👍

Sure, I was just posting for anybody who might find it useful.  Your questions are very interesting but way beyond my ability to answer.  I'm still on a relatively high dose of bupropion, so accuracy has been good enough for now.  

 

When I tapered Effexor, as I got lower it became very important to be precise, so I hear you about wanting to be as accurate as possible.  Good luck and congrats on getting down to 5 mg!

I am not a doctor and do not offer any medical advice, only my own experience.  Consult your physician.

2011-2015 tapered off 300MG of Effexor.  Back in the Paxil Progress days.  No rebound.   

2005-2021:  450 mg Bupropion XL Daily

2021 Buporopion May 450mg/June 400mg/July 375mg/Aug 10th 360mg/

2021 Dec - 150mg IR, 3x day = 450mg Bup, Heritage manufacturer-yellow color pill. 

2022 May 3 - 3 x 150mg IR Bup, Avet brand(pharmacist said they merged with Heritage-orange color) -migraines

REINSTATED-BACK TO MY LAST STABLE DOSE/TIME RELEASE

2022 June 5 - switched back to 3 x 150mg XL one time per day= 450 mg total Bup-Apotex brand

CURRENT TAPER 2022 Aug 31 - 450MG to 412MG IR Bup//Sep. 28, 2022: 412mg to 375mg//Oct 26, 2022: 375mg to 365 mg//Nov 21, 2022: 365mg to 327mg//Dec 27, 2022: 327 mg to 290 mg//Dec 31, 2022:  290mg to 262mg//Jan 28, 2023:  262mg to 190mg//Feb. 19, 2023:  190mg to 140mg//Mar. 18, '23:  140mg to 100mg//

 

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20 hours ago, LostInCanada said:
20 hours ago, LostInCanada said:

Thanks so much for your time. On drugs.com I read paroxetine is soluble at .00853mg/ml so 8.53mg/litre. Would this mean the drug would be evenly disolved throughout the water at this point? I've also read paroxetine isn't fully soluble so don't know what is correct. I noticed that you don't take into account the volume displacement that occurs when adding the drug to water. Is this because it is relatively so small it has no impact? I am very concerned about making sure the doses are consistent. When I start tapering, I want to be as symptom free as possible. I am just working on stabilizing and definitely don't want to go backwards. Also, does the drug lose potency when refrigerated? Thanks again.

 

 

@CloudyToday

20 yr+ Paroxetine/ Dec2018-May 2022 20 mg/ May 2022 30mg/2022.07.28-2022.08.24 30mg to 0mg/ August 24-29 2022 10mg Prozac/2022.11.28-2022.12.04- 5mg Paroxetine/December 5&6 10mg Paroxetine/ December 8&9 2022 10mg Prozac/ 2022.12.07 to 2023.07.01 5mg Paroxetine

TAPER 23.07.02-58mgpw/4.9mgai/ 23.07.21-4.8 mg/23.07.28-4.73 mg/23.08.04-4.65 mg/21.09.23-4.58 mg/27.10.23-4.56 mg/5.12.23-4.54 mg/2.1.24-4.52 mg/9.1.24-4.51 mg/17.1.24-4.49 mg/26.1.24-4.47 mg/6.2.24-4.46 mg/19.2.24-4.44mg

8am-probiotics/9am-paroxetine, 200mg magnesium bisglycinate/ 1000mg Vitamin D/75mg DGL/ noon-2 x 1000 mg algae oil (500mg DHA/10mg EPA/620mg Omega 3)/5pm-75 mg DGL/200mg calcium citrate/8pm-.25 mg melatonin

I am not a medical professional just your peer. The suggestions I give are based on personal experience and/or the well documented experience of others.

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  • 1 month later...
  • Mentor

I have found a very easy way to deal with making a liquid from a powdered tablet.  I couldn’t get my head around the method that most use here so a friend came up with this. It relies on having scales to weigh the right amount of powder first.  Then you always add the same amount of water (either 20 or 25ml depending if it’s for 3 or 4 days) regardless of reducing the dose of meds (at least while I’m on current doses, once I get very low the method may change a bit.  I’m on 3mg at the moment and have just changed to making a liquid.)

 

Method

 

I already have a spreadsheet of my BrassMonkey slide doses.

 

On Mondays I weigh 4 days worth of powder that I ground up myself and I will make 3 days worth of liquid. 

I measure 20ml of water using a 5ml syringe that a friend picked up at his local chemist.

I tip the powder into the 20ml of water and give it a good, gentle stir.

While the water is still swirling I draw up 5ml of water and dispense into a mini jam jar.

I repeat 2 more times (stirring is key to ensure even distribution of the powder across the water)

I keep the jars in the fridge
I dispose of the remaining liquid (I believe it is important to have more liquid than you need to account for losing it on the way and also so that there is enough liquid to keep the mixture swirling around for the final extract.) I am very suspicious of dregs where the particles settle so make sure when I draw up liquid I draw from the middle of the suspension (not at the bottom). 
This gives me 3 doses to use Mon - Wed 

 

On Thursdays I repeat but because this will do 4 days (thurs - sun) I use 25ml of water and weigh 5 days worth of powder.

 

The general opinion on SA is that homemade liquids last no longer than 4 days and it’s better to be safe than sorry. 

 

This is *really* easy to do and will work for quite some time as I’m weighing 3-4 days worth of powder at a time which means I’m weighing quite a large amount and the scales are accurate at these high amounts. At some point it will be necessary to change my method and when I get there I can share how I do that

 

am not a medical professional. I provide information and make suggestions based on my own experience and SA guidelines. I am unable to respond to private messages. 

Mirtazepine 15mg Nov 2018 -April 2019  April - Sept 2019 Mirtazepine down to around 6mg - skipping days to taper

October 2019 - Dec 2019 unwell from failed taper including jumping about in doses 

15 December 2019 to 13 June 2021 15mg Mirtazepine 

14 June 2021 started brass monkey Slide.  
2021: 23 August 12.3mg, 28 October 11.1mg, 6 Dec 10mg

2022: 12 Feb 8.5, 25 Oct 4.5mg

2023: 16 Jan 3.6mg, 28 Sept 1.8mg

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  • 2 weeks later...

Hi all!

 

A question about the absorption rate when switching to liquid.

Lets say one get effect after 10-15 minutes after taking a dry tablet of a medicine (olanzapine). And in a liquid solution it would take 30 - 60 seconds, for effect, and will hit harder as well. Is this fine and is it a normal reaction? Is it a reason to not to taper with liquid? 

 

Thanks

Medicine: Olanzapine 2017-06: 10mg

2017-08 @10mg. Taper 25% every 3 weeks .2017-11:  2.5mg (1 tablet) Staying put. Completely stabilized.

2018-09:  2.5mg 2018-09 Taper 25% every 2 weeks

2018-11 0.625 milligrams. PA´s started so held on for 3 months. 2019-02 Taper 33% every 3 weeks.

2019-04 Too much tapering. Back to 0.625 milligrams

2019- 06 Taper slower this time: 10% every 2 weeks

2019-09 0.15625 milligrams 

2020-03: Too much taper. Back to 0.625 milligrams 2020: 04 Too destabilized, back to 0.83 milligrams

2021-03 Too destabilized still, back to 1100 milligrams 2021-07 Holding

2022-11-03 Full dose reinstated at 2.5mg. Holding

Supplements: Mag/cal/zink citrate. Omega 3. Vit D 5000 ui/day

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  • Mentor
4 hours ago, Svie said:

Hi all!

 

A question about the absorption rate when switching to liquid.

Lets say one get effect after 10-15 minutes after taking a dry tablet of a medicine (olanzapine). And in a liquid solution it would take 30 - 60 seconds, for effect, and will hit harder as well. Is this fine and is it a normal reaction? Is it a reason to not to taper with liquid? 

 

Thanks

I think this is a reason to do a slow cross over.  I did not get any ill effects from crossing to a liquid and I actually just did it in one go. I was very stable and have been for a very long while now. The hairy part for me was actually getting to grips with making a liquid up! It took a cycle or two but now the felt confident ☺️
 

Quote

Our general recommendation for a crossover, whether from new brand to old brand generic or tablet to liquid is:

 

3/4 old, 1/4 new for 3 to 7 days 

1/2 old, 1/2 new for 3 to 7 days

1/4 old, 3/4 new for 3 to 7 days

all new thereafter

 

Stay at the same dose during the crossover period.

 

am not a medical professional. I provide information and make suggestions based on my own experience and SA guidelines. I am unable to respond to private messages. 

Mirtazepine 15mg Nov 2018 -April 2019  April - Sept 2019 Mirtazepine down to around 6mg - skipping days to taper

October 2019 - Dec 2019 unwell from failed taper including jumping about in doses 

15 December 2019 to 13 June 2021 15mg Mirtazepine 

14 June 2021 started brass monkey Slide.  
2021: 23 August 12.3mg, 28 October 11.1mg, 6 Dec 10mg

2022: 12 Feb 8.5, 25 Oct 4.5mg

2023: 16 Jan 3.6mg, 28 Sept 1.8mg

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1 hour ago, Faure said:

I think this is a reason to do a slow cross over.  I did not get any ill effects from crossing to a liquid and I actually just did it in one go. I was very stable and have been for a very long while now. The hairy part for me was actually getting to grips with making a liquid up! It took a cycle or two but now the felt confident ☺️
 

 

Thanks. A concern is that it might confuse the body doing 1 part of each since they get absorbed differently. But i hope that´s not an issue however

 

Great that it worked for you!

Medicine: Olanzapine 2017-06: 10mg

2017-08 @10mg. Taper 25% every 3 weeks .2017-11:  2.5mg (1 tablet) Staying put. Completely stabilized.

2018-09:  2.5mg 2018-09 Taper 25% every 2 weeks

2018-11 0.625 milligrams. PA´s started so held on for 3 months. 2019-02 Taper 33% every 3 weeks.

2019-04 Too much tapering. Back to 0.625 milligrams

2019- 06 Taper slower this time: 10% every 2 weeks

2019-09 0.15625 milligrams 

2020-03: Too much taper. Back to 0.625 milligrams 2020: 04 Too destabilized, back to 0.83 milligrams

2021-03 Too destabilized still, back to 1100 milligrams 2021-07 Holding

2022-11-03 Full dose reinstated at 2.5mg. Holding

Supplements: Mag/cal/zink citrate. Omega 3. Vit D 5000 ui/day

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@Svie Altostrata said from another post on

April 24

I suggest taking the solid part a hour earlier, then the liquid part with food.

20 yr+ Paroxetine/ Dec2018-May 2022 20 mg/ May 2022 30mg/2022.07.28-2022.08.24 30mg to 0mg/ August 24-29 2022 10mg Prozac/2022.11.28-2022.12.04- 5mg Paroxetine/December 5&6 10mg Paroxetine/ December 8&9 2022 10mg Prozac/ 2022.12.07 to 2023.07.01 5mg Paroxetine

TAPER 23.07.02-58mgpw/4.9mgai/ 23.07.21-4.8 mg/23.07.28-4.73 mg/23.08.04-4.65 mg/21.09.23-4.58 mg/27.10.23-4.56 mg/5.12.23-4.54 mg/2.1.24-4.52 mg/9.1.24-4.51 mg/17.1.24-4.49 mg/26.1.24-4.47 mg/6.2.24-4.46 mg/19.2.24-4.44mg

8am-probiotics/9am-paroxetine, 200mg magnesium bisglycinate/ 1000mg Vitamin D/75mg DGL/ noon-2 x 1000 mg algae oil (500mg DHA/10mg EPA/620mg Omega 3)/5pm-75 mg DGL/200mg calcium citrate/8pm-.25 mg melatonin

I am not a medical professional just your peer. The suggestions I give are based on personal experience and/or the well documented experience of others.

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18 hours ago, LostInCanada said:

@Svie Altostrata said from another post on

April 24

I suggest taking the solid part a hour earlier, then the liquid part with food.

Thanks, i understand. So this is generally recommended then? Do you want to link to that post please?

 

Edit. Doing this wouldn´t work for me unfortunately, it would create withdrawals since i feel the slightest change right the moment when the medicine takes effect

Medicine: Olanzapine 2017-06: 10mg

2017-08 @10mg. Taper 25% every 3 weeks .2017-11:  2.5mg (1 tablet) Staying put. Completely stabilized.

2018-09:  2.5mg 2018-09 Taper 25% every 2 weeks

2018-11 0.625 milligrams. PA´s started so held on for 3 months. 2019-02 Taper 33% every 3 weeks.

2019-04 Too much tapering. Back to 0.625 milligrams

2019- 06 Taper slower this time: 10% every 2 weeks

2019-09 0.15625 milligrams 

2020-03: Too much taper. Back to 0.625 milligrams 2020: 04 Too destabilized, back to 0.83 milligrams

2021-03 Too destabilized still, back to 1100 milligrams 2021-07 Holding

2022-11-03 Full dose reinstated at 2.5mg. Holding

Supplements: Mag/cal/zink citrate. Omega 3. Vit D 5000 ui/day

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20 yr+ Paroxetine/ Dec2018-May 2022 20 mg/ May 2022 30mg/2022.07.28-2022.08.24 30mg to 0mg/ August 24-29 2022 10mg Prozac/2022.11.28-2022.12.04- 5mg Paroxetine/December 5&6 10mg Paroxetine/ December 8&9 2022 10mg Prozac/ 2022.12.07 to 2023.07.01 5mg Paroxetine

TAPER 23.07.02-58mgpw/4.9mgai/ 23.07.21-4.8 mg/23.07.28-4.73 mg/23.08.04-4.65 mg/21.09.23-4.58 mg/27.10.23-4.56 mg/5.12.23-4.54 mg/2.1.24-4.52 mg/9.1.24-4.51 mg/17.1.24-4.49 mg/26.1.24-4.47 mg/6.2.24-4.46 mg/19.2.24-4.44mg

8am-probiotics/9am-paroxetine, 200mg magnesium bisglycinate/ 1000mg Vitamin D/75mg DGL/ noon-2 x 1000 mg algae oil (500mg DHA/10mg EPA/620mg Omega 3)/5pm-75 mg DGL/200mg calcium citrate/8pm-.25 mg melatonin

I am not a medical professional just your peer. The suggestions I give are based on personal experience and/or the well documented experience of others.

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  • 1 month later...

How to make liquid for rivitrol as it just all sinks in a millisecond before can draw out water I powder it too? 

Zopiclone; Xanax 1mg; mogodon Dec 2021 to April 2022. Added Mirtrazapine for two weeks with 25 mcg Amitryptiline right after Mirtrazapine - stopped.  Then Sertraline 25 mg March 2022 for two weeks - still on Xanax and Zopiclone. Hospitalized and put on Effexor xr ven April 2022. Started 37.5 mg increased to 187.5 mg by June, dropped to 150 mg after 3 days. Given Trazadone 100 mg April 2022 at night with Phenergen and 1mg Clonazapam. Added 0.5 mg Clonazapam daytime, but caused drowsiness - dropped 0.5 mg daytime. On Clonazapam, Trazadone and Phenergen 25 mg from April to July 2022. April to current trying to wean Effexor ven xr July 2022 to current down to .25 Clonazapam from 1mg.

Replaced Phenergen with melatonin in July.

July to Aug 2022 Effexor xr down to 112.5 mg - in Sept dropped to 75 mg and reinstated to 112.5 mg. Feb 2023 reduced from 112.5 mg Effexor xr 10 101.5 mg.

At end of Jan 2023 given 5 mg liquid Prozac to add to Effexor - stopped Prozac after 4 days. Still on 100 mg Trazadone and 0.25 mg Clonazapam 

Eltroxin for thyroid since 2006 - taken in the AM.

Ruthie3's intro thread: Ruthie3: Intro

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20 years on Paxil starting at 20mg and working up to 40mg. Sept 2011 started 10% every 6 weeks taper (2.5% every week for 4 weeks then hold for 2 additional weeks), currently at 7.9mg. Oct 2011 CTed 15oz vodka a night, to only drinking 2 beers most nights, totally sober Feb 2013.

Since I wrote this I have continued to decrease my dose by 10% every 6 weeks (2.5% every week for 4 weeks and then hold for an additional 2 weeks). I added in an extra 6 week hold when I hit 10mg to let things settle out even more. When I hit 3mgpw it became hard to split the drop into 4 parts so I switched to dropping 1mgpw (pill weight) every week for 3 weeks and then holding for another 3 weeks.  The 3 + 3 schedule turned out to be too harsh so I cut back to dropping 1mgpw every 4 weeks which is working better.

Final Dose 0.016mg.     Current dose 0.000mg 04-15-2017

 

"It's also important not to become angry, no matter how difficult life is, because you can loose all hope if you can't laugh at yourself and at life in general."  Stephen Hawking

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  • 4 weeks later...

Can I ask you veterans a question? I’ve just changed from my tablet Paxil to adding water with it only a few months ago I’m wondering if you can get slight withdrawals from doing this and I put my oaxil

tablet with water in the fridge the night before I take it, is that correct or should I just leave it out on the bench. 

1995 started Paxil 20mg slowly increasing to 50mg until 2014

-2014 I decided to tapper myself not knowing how too and crashed , DR added 50mg Seraquel

-2015 tried tapering again and crashed

 

Started Tapering Both drugs at the same time 6% per month doing daily micro-taper 

Guided by Mark Horowitz

24/09/23  14.47mg Seroquel.  16.19mg Paxil 

27/11/23.  12.13mg. Seroquel.   13.85mg Paxil

 

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  • 4 months later...

I am a bit confused as to what is on here. So can lamotrigine be dissolved in water? One part said yes on here another part said no. I need the most practical method. I will have to use 100mg tablets. My current dose is 100 mg morning and 100 mg night. I want to try 5 percent or maybe 10 percent. 


Started my medicine journey June of 2013. Obessions that were tied to fears. Basically OCD in many forms. I don’t have an accurate drug history between 2013 and 2018 but some meds I remember are viibryd, prozac, clomipramine, klonopin, quetiapine, etc.
 

Gabapentin  300mg Oct. 11, 2018 to Dec. 11, 2018; Aripiprazole 5mg Oct. 11, 2018 to Oct. 24, 2018 then upped to 10mg Oct. 24, 2018 to Nov. 24, 2018. Lamotrigine 25mg Oct. 24, 2018 to to Nov. 8, 2018. On Feb. 27, 2021 went up to 100mg. On March 24, 2021 went up too 200mg to present. Bupropion HCI 75mg Oct. 25, 2018 for one month only. Venlafaxine HCI ER 24HR 75mg Feb. 27, 2021. On June 4, 2021 went down to 37.5mg and continued until Feb. 24, 2022 on that same dose. Stopped the ven Feb. 24, 2022. 
Fluvoxamine 150mg May 4, 2021. Went up to 200mg on March 16, 2022. Went down to 175mg Sept. 12, 2022 to present.

Hydroxyzine 25mg filled three a total of three times sporadically between November 2021 and March 16, 2022. 
Currently take B-Complex, Vitamin DK, Fish Oil, and Magnesium. 
and current meds are lamotrigine 100mg at morning and 100mg at night; and fluvoxamine 175mg only at night

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