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Tips for tapering off trazodone (Desyrel)


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#1 Altostrata

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Posted 19 July 2012 - 06:40 PM

Aka Oleptro, Beneficat, Deprax, Desirel, Molipaxin, Thombran, Trazorel, Trialodine, Trittico, and Mesyrel

Trazodone (trazodone hydrochloride) is a nasty drug often added to antidepressants and other "activating" drugs to aid sleep.

It's nasty because it has an evil active metabolite, meta-Chlorophenylpiperazine (mCPP), and a huge number of interactions with other drugs that can make you feel very sick.

First, carefully read the below to see if you have any adverse effects from trazodone.

Trazodone's evil byproduct, mCPP
Trazodone's active metabolite, mCPP, does the opposite of aiding sleep -- it's very, very activating, often in an unpleasant way.

Wikipedia on mCPP http://en.wikipedia....henylpiperazine


Meta-chlorophenylpiperazine is a major metabolite of the psychotropic drug trazodone, and may be responsible for some of its side-effects, such as headaches and migraines induced many hours after initial consumption.

Half-lives:
trazodone (3-6 hrs) ---> mCPP (2-6 hrs) ---> other metabolites

per Wikipedia http://en.wikipedia.org/wiki/Trazodone

The mean blood elimination half-life is biphasic: the first phase's half-life is 3–6 hours, and the following phase's half-life is 5–9 hours. The drug is extensively metabolized with 3 or 4 major metabolites having been identified in the human body, particularly mCPP,[39] which may contribute to the side effect profile of trazodone.

....mCPP, a non-selective serotonin receptor agonist and serotonin releasing agent, is an active metabolite of trazodone and has been suggested to possibly play a role in its therapeutic benefits.[31][32][33] However, scientific research has not supported this hypothesis, and mCPP may actually antagonize trazodone's efficacy as well as produce additional side effects....

 

mCPP is used to induce anxiety for study in the laboratory, e.g. http://www.ncbi.nlm....pubmed/20828578

For some people, mCPP produces not only anxiety but headaches and a hallucinatory effect. So while trazodone may help you sleep at night, mCPP might make you feel sick, anxious, and out of control during the day.
 
http://www.ncbi.nlm....pubmed/19384678

World J Biol Psychiatry. 2009;10(4 Pt 2):682-5. doi: 10.1080/15622970902836022.
Trazodone generates m-CPP: in 2008 risks from m-CPP might outweigh benefits of trazodone.
Kast RE.

Source
Department of Psychiatry, University of Vermont, Burlington, VT 05401, USA. rekast at email.com

Abstract
Since deleterious effects of m-CPP, the primary catabolic metabolite of trazodone, were last reviewed 2 years ago, research data continue to accrue showing that clinically significant levels of m-CPP (a) are generated in patients using trazodone for sleep and ( B) are present 24 h a day and © have potentially serious ill effects. This commentary argues that the documented potential for harm and multiple risks of m-CPP outweigh potential benefits of trazodone, given the development and marketing of many safer alternatives since trazodone's introduction in the 1980s.

 

Traffic jams with antidepressants in the liver
While trazodone is metabolized by liver enzyme P450 cyp 3A4 http://www.ncbi.nlm..../pubmed/9616194

mCPP requires enzyme cyp 2D6 to leave your body Example: http://www.ncbi.nlm..../pubmed/9836023

Liver enzyme enzyme cyp 2D6 also is necessary for metabolization of most antidepressants, such as Prozac and Paxil, and all tricyclic antidepressants.
 

If two or more drugs try to use cyp 2D6 in the liver, a "traffic jam" occurs and one or both of the drugs backs up, causing adverse reactions and possibly liver damage.

 

Additionally, about 10% of the population are cyp 2D6 "poor metabolizers" and particularly prone to this type of adverse reaction.

When trazodone is taken with another drug utilizing liver enzyme CYP2D6, the "traffic jam" in the liver can cause increased levels of mCPP, the other drug, or both in the blood stream, increasing the incidence of adverse events.

Special problems with Abilify (aripiprazole)
Abilify conflicts with trazodone via two liver pathways, cyp 3A4 and cyp 2D6. See https://www.pharmgkb...bel/PA166104839

 

This can cause 1) delay of trazodone metabolism via cyp 3A4 and a backup of trazodone, increasing side effects or 2) delay of mCPP metabolism via cyp 2D6 and a backup of mCPP, or 3) both.

 

Huge number of drug interactions with trazodone
Major drug interactions with trazodone http://www.drugs.com.../trazodone.html
include:

5-HTP (5-hydroxytryptophan)
amitriptyline
BuSpar (buspirone)
Celexa (citalopram)
Cymbalta (duloxetine)
doxepin
Lexapro (escitalopram)
lithium
Luvox (fluvoxamine)
mirtazapine
Nardil (phenelzine)
nefazodone
nortriptyline
Prozac (fluoxetine)
Savella (milnacipran)
Wellbutrin (bupropion)
Zoloft (sertraline)
and on for 138 drugs, and that's just the major interactions.

Danger of serotonin syndrome
Trazodone and mCPP are serotonergics. Taking trazodone with antidepressants can cause serotonin overload or serotonin syndrome.

At the extreme, serotonin syndrome is a life-threatening condition. But even an increased serotonin level of serotonin in the bloodstream can be dangerous.

Unnecessary polypharmacy
If your doctor has given you a benzo to help with adverse effects caused by trazodone, mCPP, or drug interactions, you are taking two medications to counter the adverse effects of another drug: Trazodone to counter insomnia from the antidepressant and a benzo to counter the effects of trazodone.

Should I go off trazodone first?
If you are having any of the above adverse effects of trazodone, you might consider reducing trazodone first.

BUT -- if you're taking trazodone because your antidepressant keeps you awake, what should you do?

You might reduce the antidepressant first, part way. If it's interacting with trazodone, this may enable the trazodone and mCPP to be metabolized faster, and reduce the adverse effects of trazodone.

To see if reducing your antidepressant (or other medication) will help reduce adverse effects of trazodone, look here to see if your antidepressant is a substrate or inhibitor of cyp 3A4 or cyp 2D6, the liver enzymes needed to metabolize trazodone and mCPP.

Trazodone tablet dosages
Official FDA information (with NDC codes for ordering): http://www.drugs.com.../trazodone.html
 

Trazodone HCl is supplied for oral administration in 50 mg, 100 mg and 150 mg tablets.

....
Peak plasma levels occur approximately one hour after dosing when Trazodone hydrochloride is taken on an empty stomach or two hours after dosing when taken with food.

 

Reduce trazodone by 10% per month to start
The 10% rule holds for trazodone, just like other antidepressants: Reduce by 10% per month, calculated on the last dosage. (The amount of the reduction gets progressively smaller.)

See Why taper by 10% of my dosage?

Cutting up tablets to taper
If you're taking more than 50mg trazodone, you might ask your doctor or pharmacy to fill your prescription with 50mg tablets (i.e. instead of 30 100mg tablets, 60 50mg tablets per month).

Then you can cut a piece from a 50mg tablet to reduce your dosage by 10%.

Weighing your tablets with a digital scale will enable accurate dosage.

Get trazodone oral solution from the pharmacy
In the UK, trazodone is available in liquid form, each 5ml containing 50mg trazodone.

Use an oral syringe for dosing.

Order a liquid from a compounding pharmacy
Compounding pharmacies can make a liquid from medications that do not have special extended-release coatings or Cymbalta.

Your doctor will have to write a prescription specifying how the drug is to be compounded.

Use an oral syringe for dosing.

Dissolving trazodone in water to make a liquid
According to the US National Library of Medicine http://dailymed.nlm....398a#nlm34089-3
 

It is a white to off-white crystalline powder which is sparingly soluble in chloroform and in water.

On the other hand, according to this Material Safety Data Sheet (pdf) from ScienceLab, it may be "partially soluble in cold water."

Our member Rhi has made suspensions from drugs that are technically insoluble in water, see http://survivinganti...dpost__p__45161

I haven't personally done this and I don't know of anyone who has, so if you do it, please post your experience in this topic.

Also see How to make a liquid from tablets or capsules

Use an oral syringe for dosing.

 

Using a combination of tablets or capsules and liquid

Rather than switch directly to an all-liquid dose, you may wish to take part of your dose in liquid and part in lower-dose tablets or capsules, gradually converting to all liquid as you get to lower dosages. This can be very convenient and reduce any problems switching from one form of the drug to another.

 

If your doctor prescribes liquid and tablets or capsules at the same time, most likely he or she will have to indicate "divided doses" in the prescriptions to get the drugs covered by insurance.


Edited by Altostrata, 10 June 2015 - 11:31 AM.
updated

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

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#2 primrose

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Posted 31 January 2013 - 03:33 PM

Hi Alto After seeing my doctor today and discussing some problems with her regarding trazodone, we both decided that it would be best for me to take 75mgs every 6 hours instead of the 100mgs every 8 hours, because 100mgs started to make me feel zombied and didn't seem to last until my next dose was due. As we know, tablets don't come in 75mgs only 150, 100 and 50, and my doctor said she was unable to prescribe me a liquid version because of the cost, and the liquids were only reserved for people with feeding tubes or otherwise unable to take a tablet. My intention was to make 100mg : 100ml solution and draw off 25mgs leaving me with 75mgs each dose time. When I went back to my jar of trazodone solution, however, it looked uneven, as if something had not dissolved. The water was cloudy and there seemed a deposit on the bottom. Whilst doing a google search to see how to get around this problem, I came up with this link which says trazodone is insoluble. http://www.sigmaaldr...ed-kingdom.html I went and spoke to a pharmacist at our local chemists, and she advised me not to try to get 75mg trazodone from a 100mg capsule as capsules were not designed to be tampered with, and there was a high chance I would not be giving my self the correct dose, because of the uneven distribution of the trazodone in the liquid. She never said anything about solubility or insolubility. She was really helpful and phoned my surgery and got a doctor to issue me with 150mg pills, as I can split them into 75mg pieces. It seems opinions on trazodones solubility is divided, as I read another post from a trazodone user who also said it did not dissolve, but they were not scientifically qualified.

pregan taper 600mg down to 240mg, daily cuts since xmas

valium, just over 75mg, tapering 0.1 a day, will keep this more udated, cos amounts going down

i have borderline personality, chronic ptsd, and suspected adhd and substance misuse as a symptom, which i am addressing with help of medical staff, drugs agencies & mh sta


#3 Altostrata

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Posted 31 January 2013 - 06:02 PM

primrose, if you want to take 75mg trazodone, splitting a 150mg tablet seems as good a way as any. Apparently trazodone is "sparingly soluble" in water, meaning not so much. The FDA info I had from drugs.com was incorrect. I've corrected post #1.
This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

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#4 primrose

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Posted 01 February 2013 - 03:25 AM

Hi Alto and thanks. What does sparingly soluble mean please?

pregan taper 600mg down to 240mg, daily cuts since xmas

valium, just over 75mg, tapering 0.1 a day, will keep this more udated, cos amounts going down

i have borderline personality, chronic ptsd, and suspected adhd and substance misuse as a symptom, which i am addressing with help of medical staff, drugs agencies & mh sta


#5 Altostrata

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Posted 01 February 2013 - 10:11 AM

Slightly soluble.
This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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#6 flower

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Posted 02 February 2013 - 02:21 AM

Doc told me the other day Traz comes in a powder. Don't know what that would be measured with but I'll find out next visit..
C/T Celexa and Trazadone on Jan.29th 2014
Prescribed 1mg of Klonopin every 6 hours on Jan.29th
Began tapering Klonopin April 18th..stretching time between doses...at first one hour for 2 weeks then a half hour for app.10 days then another half hour 10days later.
Presently at .25 three times a day..6 2 and 10pm. Trying to stabilize.
Also still taking gabapentin 300mgs 2xs a day..

#7 primrose

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Posted 02 February 2013 - 04:56 AM

Hi Alto and flower, that would be useful to know. Luckily, my 150mg tablets were ready to pick up yesterday, so I am now on two of them a day (chopping them up to make 75mgs 4 x a day) This link seems to suggest that light degrades trazodone and to keep in a light sensitive container http://dailymed.nlm....fo.cfm?id=33648 It's relevant for me because I have my pills split in half so the powder is exposed.

pregan taper 600mg down to 240mg, daily cuts since xmas

valium, just over 75mg, tapering 0.1 a day, will keep this more udated, cos amounts going down

i have borderline personality, chronic ptsd, and suspected adhd and substance misuse as a symptom, which i am addressing with help of medical staff, drugs agencies & mh sta


#8 flower

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Posted 02 February 2013 - 07:58 AM

Hi Alto and flower, that would be useful to know.

Luckily, my 150mg tablets were ready to pick up yesterday, so I am now on two of them a day (chopping them up to make 75mgs 4 x a day)

This link seems to suggest that light degrades trazodone and to keep in a light sensitive container http://dailymed.nlm....fo.cfm?id=33648
It's relevant for me because I have my pills split in half so the powder is exposed.

that's good to know, are you preparing to taper?
C/T Celexa and Trazadone on Jan.29th 2014
Prescribed 1mg of Klonopin every 6 hours on Jan.29th
Began tapering Klonopin April 18th..stretching time between doses...at first one hour for 2 weeks then a half hour for app.10 days then another half hour 10days later.
Presently at .25 three times a day..6 2 and 10pm. Trying to stabilize.
Also still taking gabapentin 300mgs 2xs a day..

#9 primrose

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Posted 03 February 2013 - 08:11 AM


Hi Alto and flower, that would be useful to know.

Luckily, my 150mg tablets were ready to pick up yesterday, so I am now on two of them a day (chopping them up to make 75mgs 4 x a day)

This link seems to suggest that light degrades trazodone and to keep in a light sensitive container http://dailymed.nlm....fo.cfm?id=33648
It's relevant for me because I have my pills split in half so the powder is exposed.

that's good to know, are you preparing to taper?

Not yet Flower

I was tapering my valium and held the taper due to symptoms. When things got better, I cut 112.5mg off my seroquel last week, so am holding things again at the moment.
I will then taper my valium again.

Not looking forward to the traz taper. Beleiving it to be water soluble, I thought there would not be a problem, but discovered that it is not fully water soluble.

pregan taper 600mg down to 240mg, daily cuts since xmas

valium, just over 75mg, tapering 0.1 a day, will keep this more udated, cos amounts going down

i have borderline personality, chronic ptsd, and suspected adhd and substance misuse as a symptom, which i am addressing with help of medical staff, drugs agencies & mh sta


#10 Altostrata

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Posted 03 February 2013 - 10:44 AM

As near as I can tell, trazodone powder is available only for experimental purposes. If you find you can get it by prescription, please let us know.

From Children’s Hospitals and Clinics of Minnesota http://www.childrens.../med/018920.pdf

Trazodone comes in pill form. It can also be
made into liquid by your pharmacist.

Give it at regular times, to keep a steady
level in the bloodstream. It may take 1-4
weeks for effects to be seen.

If using the liquid form, shake well right
before using. ....

For children who cannot swallow pills:

• Crush it between 2 spoons or crush it
inside a plastic bag or in folded paper.

• Mix the powder with a very small
amount (about 1 teaspoon) of soft food,
such as applesauce, chocolate syrup, ice
cream, jelly, or yogurt. Make sure your
child takes all of the mixture.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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#11 primrose

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Posted 03 February 2013 - 01:17 PM

*Woops* I made a mistake above I cut from 112.5mg seroquel to 100mgs, sorry for the confusion.

pregan taper 600mg down to 240mg, daily cuts since xmas

valium, just over 75mg, tapering 0.1 a day, will keep this more udated, cos amounts going down

i have borderline personality, chronic ptsd, and suspected adhd and substance misuse as a symptom, which i am addressing with help of medical staff, drugs agencies & mh sta


#12 Altostrata

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Posted 27 February 2013 - 10:23 AM

About solubility or insolubility, Rhi has made many, many homemade liquids:

I'm kind of out of it right now and need to go to bed, but I just wanted to toss in my usual bit on the subject of making preparations for liquid tapering, which is: I personally don't worry about solubility.

None of the meds I'm tapering are actually soluble in water. But the pills dissolve into small enough particles that I can stir them up and keep them suspended in water while I measure them out, and that seems to work for me. I stir well before I measure, I stir a little while pipetting them up; I dissolve the pills in glass and pipette out of glass so that I can see visually how evenly everything is suspended, and that's good enough for me.

I use water as a medium because I like it that I can easily see for myself how evenly the little particles are suspended or if they seem to be settling out. Also because it's handy and cheap and I don't have to carry it with me if I travel.

Mostly I would just say, I don't think it really matters if the medication is soluble in whatever vehicle you're using, as long as it can be evenly distributed. What really matters is that it be evenly distributed and that your method be repeatable and consistent.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

#13 primrose

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Posted 27 February 2013 - 11:51 AM

That is encouraging thankyou.

pregan taper 600mg down to 240mg, daily cuts since xmas

valium, just over 75mg, tapering 0.1 a day, will keep this more udated, cos amounts going down

i have borderline personality, chronic ptsd, and suspected adhd and substance misuse as a symptom, which i am addressing with help of medical staff, drugs agencies & mh sta


#14 sassy

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Posted 08 April 2013 - 10:20 PM

I am on trazodone 50 mg and want to come off can somebody suggest the best way to taper each time i try i hit total sleeplessness

#15 flower

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Posted 09 April 2013 - 03:00 AM

If you figure this out Sassy let me know..I too take 75mgs.. How long have you taken it? I will watch your progress.
C/T Celexa and Trazadone on Jan.29th 2014
Prescribed 1mg of Klonopin every 6 hours on Jan.29th
Began tapering Klonopin April 18th..stretching time between doses...at first one hour for 2 weeks then a half hour for app.10 days then another half hour 10days later.
Presently at .25 three times a day..6 2 and 10pm. Trying to stabilize.
Also still taking gabapentin 300mgs 2xs a day..

#16 GiaK

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Posted 09 April 2013 - 05:58 AM

the general rule... 10% of current dose tapers...every 2 to 4 weeks... I've seen work just fine... also it seems, in general, that most people have less problems with trazadone causing other symptoms besides insomnia...so just going really slow and easy, allowing the body to adapt to the change, seems to work quite well.

Beyond Meds: http://beyondmeds.com/

I withdrew from a cocktail of 6 psychiatric drugs that included every class of psych drug.

I took a bit over 6 years to do it. Finished on Feb 9 2010. I'm still recovering from iatrogenesis.


#17 GiaK

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Posted 09 April 2013 - 06:00 AM

you can read about the general rule here: http://survivinganti...0-of-my-dosage/

Beyond Meds: http://beyondmeds.com/

I withdrew from a cocktail of 6 psychiatric drugs that included every class of psych drug.

I took a bit over 6 years to do it. Finished on Feb 9 2010. I'm still recovering from iatrogenesis.


#18 anna7887

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Posted 25 September 2013 - 07:06 PM

I apologize if this was addressed in a previous post but I can't seem to find it.

 

I was thinking of using a mg scale to measure my Trazadone reductions but not sure if it makes sense: are medications assigned a mg based on the weight of the pill or the amount of active medication? In other words, can I use a pill cutter to weigh 20mg traz, etc.

 

Thank you!

 

Anna


-1/10-Rxed 50mg Zoloft & .5mg Klonopin daily after a death in the family

- 2/2012 Successfully micro tapered off .5mg of Klonopin after being on daily for 2 years. Started 100mg of Trazadone for sleep slowly tapered to 25mg w/ out issues.

- 2/2012-7/213- Symptom free not an ounce of anxiety or depression. 

- July 2013- Stopped trazadone for 5 days and immediately reinstated. 3 weeks started having severe withdrawal episodes that mimicked benzo w/d. Took 4 rescue doses of klonopin within 2 months (less that .125 mg) since w/d felt so bad ( Ear clogging, derealzation, intolerance to caffeine, feeling of impending doom, night terror, suicidal like thoughts, or scared I'll become suicidal etc.)

- Oct 2013- Quickly tapered off 25mg of trazadone. Trazadone free. 

- July 2015- present Became very ill with lyme like symptoms. Ongoing issues ( deep muscle aches, throat infections, chronic fatigue, depression etc.). Hoping to start a taper off zoloft in the near future as I'm approaching 6 years. 


#19 Petunia

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Posted 25 September 2013 - 09:17 PM

Hi Anna,

 

Here is the information about using a scale for measuring medication:

 

http://survivinganti...ses/#entry13379

 

scroll down to post #8 for an answer to your question.

 

 


I'm not a doctor.  My comments are not medical advise. These are my opinions based on my own experience and what I've learned. Please discuss your situation with a medical practitioner who has knowledge of tapering and withdrawal...if you are lucky enough to find one.

 

My Introduction Thread

 

Full Drug and Withdrawal History

 

Brief Summary

Several SSRIs for 13 years starting 1997 (for mild to moderate partly situational anxiety)

Xanax PRN

Various other drugs over the years for side effects

2 month 'taper' off Lexapro 2010

Short acute withdrawal, followed by 2 -3 months of improvement then delayed protracted withdrawal

DX ADHD followed by several years of stimulants and other drugs trying to manage increasing symptoms

Failed reinstatement of Lexapro and trial of Prozac (became suicidal)

May 2013 Found SA, learned about withdrawal, stopped taking drugs...healing begins.

Protracted withdrawal, with a very sensitized nervous system, slowly recovering as time passes animal25.gif

 

Supplements which seem to help:  High doses of Vitamin C, Magnesium, Garlic and Ginger.  Taurine, Vit D3, L-Theanine and Inositol. I'm one of the rare people who react badly to fish oil.

 

June 2016 - Started daily juicing, mostly vegetables and lots of greens.

 

VIDEO: Where did the chemical imbalance theory come from?



VIDEO: How are psychiatric diagnoses made?



VIDEO: Why do psychiatric drugs have withdrawal syndromes?



VIDEO: Can psychiatric drugs cause long-lasting negative effects?

VIDEO: Dr. Claire Weekes

 

 

 


#20 mammaP

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Posted 07 December 2013 - 01:06 PM

Bumping to the front page for newbies. 


**I am not a medical professional, if in doubt please consult a doctor with withdrawal knowledge.

 

See how to create a signature here http://survivingantidepressants.org/index.php?/topic/12364-please-put-your-withdrawal-history-in-your-signature/

 

Many drugs for many years, prescribed diazepam first 1973, took occasionally. 3 or 4 tricyclics  for short periods.

1993 had a breakdown leading to 10 years of drug experiments with all classes of psych drugs.

2002  effexor. 

Tapered by counting beads from March 2012 to March 2013, ending with 5 beads.

Withdrawal April 2013 . Reinstated 5 beads reduced to 4 beads May 2013

Restarted taper  Nov 2013  

OFF EFFEXOR Feb 2015    :D 

 

Also tapered atenolol and omeprazole Dec 2013 - May 2014

 

Tapering tramadol, Feb 2015 100mg , March 2015 50mg -hold- Feb2016 46mg  March 8 2016 45 April 44mg  May 11  43mg June 14 42mg

Taking fish oil, magnesium, pro biotic.

 

My story http://survivinganti...king-in/page-33

 

Lesson learned, slow down taper at lower doses. Taper no more than 10% of CURRENT dose if possible

 

Following every sunset is a brand new day


#21 lanah

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Posted 22 April 2015 - 02:21 AM

I updosed last night to 50 mgs and will stay there for a few months, not going to make the same mistake twice (made a 20% cut and had horrible withdrawal sx) 
But I would like to read other people's experiences and get as much information as possible.


Several ssri's, antipsychotics, opiads and benzo's since 2003.

Flurazepam: rapid taper after 6 weeks usage in beginning of march 2015

Trazodone: rapid taper from 50ms to 0mgs end of july 2015

Current medication:12 mgs seroquel (from 25mgs)


#22 Amygdala

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Posted 24 April 2015 - 05:16 PM

I had no problem cutting from 150 mg --> 50 --> 25 but I made the mistake of going from 25 to 0. The withdrawal took a couple of days to hit but was quite pronounced when it did come. Tremors, confusion, akathisia, ataxia and lots of aches and pains. I went back to 25 mg but it did not help so I tried going back to 50 mg and the relief was almost immediate, I could not believe the difference.

 

So I started over a couple of months later and I am back down to 25 mg where I will hold for at least 2 months before making about a 10% reduction this time. I made the mistaken assumption that Trazodone would be easier to stop than my other meds, maybe the initial cuts were far easier but CT from 25 mg was just as bad as other things I have stopped.

 

BTW I also had a severe psychotic reaction within a couple of hours of taking 50 mg of Trazodone after cutting Zopiclone by 50% based on my doctor's recommendation.


Cymbalta - 90 mg
Risperidone - 5 mg
Ativan - 3-5 mg (3mg tablets, 2 mg sub-lingual)
* Zopiclone - 7.5 mg (down from 15 mg)
* Trazodone - 25 mg (down from150 mg)
Tegretol - 900 mg
Baclofen - 30 mg
Inderal - 40 mg

My Introduction Page


#23 blackhawks89

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Posted 01 May 2015 - 01:02 PM

Hi,

I was put on trazodone 3 weeks ago 50mg. I tried to cut a quarter off to taper and felt horrible the next day. I  had to go back to 50mg. I'm going to get a pill cutter and just take a little off. I don't want to be on something that causes so much pain when you don't take it.


I have been on Lexapro for 10 years. I have tried almost every other antidepressant but always went back to Lexapro.

In 2014 I started to taper off 20mg Lexapro using the liquid form because I wanted to get off to get pregnant. 

About a month ago I got down to 6mg and crashed. I went back up to 8mg. A ton of stressors happened in my life and I had a breakdown. I was then hospitalized and put on 15mg Lexapro.

I tried going down on lexapro to 14mg but went straight into withdrawal

Dr added wellbutrin 75mg.

Took for one day and felt HORRIBLE.

Now Im stuck..afraid to go down on medicine or switch to another one.

 


#24 Wondering

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Posted 12 May 2015 - 10:30 AM

I get the 10% taper, but specifically what would be the tapering amounts for tapering off 300mg of Trazodone. I can't figure out the math and the other posts were about 50 or 150 Trazodone. Thanks for any specific advice or maybe there is someone on this forum that helps people with their tapers?
Trazodone 150-300 nightly
Ambien CR. 3-5 times a week
Taking Klonopin crossing over to Valium started 6-25-15

#25 Amygdala

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Posted 23 May 2015 - 01:26 AM

300-->270-->243-->218.7-->196.8-->177.2-->159.4-->143.5-->129.1-->116.2-->104.6-->94.2-->84.7-->76.3-->68.6-->61.8-->55.6-->50-->45-->

 

40.5-->36.4-->32.8-->29.5-->26.5-->23.9-->21.5-->19.3-->17.4-->15.7-->14.1-->13.0-->11.7-->10.5-->9.5-->8.5-->7.7-->6.9-->6.2-->5.6-->5-->

 

4.5-->4.1-->3.7-->3.3-->3-->2.7-->2.4-->2.2-->2-->1.8-->1.6-->1.5-->1.3-->1.2-->1.1-->1

 

Numbers are less accurate the smaller they get but this should still be a good guideline.


Cymbalta - 90 mg
Risperidone - 5 mg
Ativan - 3-5 mg (3mg tablets, 2 mg sub-lingual)
* Zopiclone - 7.5 mg (down from 15 mg)
* Trazodone - 25 mg (down from150 mg)
Tegretol - 900 mg
Baclofen - 30 mg
Inderal - 40 mg

My Introduction Page


#26 lanah

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Posted 23 May 2015 - 02:14 AM

If you get really pronounced symptoms, do you need to updose or wait it out? I'm confused about this. 


Several ssri's, antipsychotics, opiads and benzo's since 2003.

Flurazepam: rapid taper after 6 weeks usage in beginning of march 2015

Trazodone: rapid taper from 50ms to 0mgs end of july 2015

Current medication:12 mgs seroquel (from 25mgs)


#27 Altostrata

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Posted 24 May 2015 - 03:22 PM

Thank you, Amygdala.

 

lanah, if you get really pronounced withdrawal symptoms, you are tapering too fast. If you have been reducing by more than 10% for a while, thus risking withdrawal symptoms, you may need to updose.

 

If you have just made a 10% decrease and experience really pronounced withdrawal symptoms for the first time, you might try waiting it out and make a smaller decrease the next time. There's no way to predict if waiting it out will work. It's up to you if you want to go back to the previous dose at which you were stable.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

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#28 marie123

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Posted 17 October 2015 - 02:03 PM

I had no problem cutting from 150 mg --> 50 --> 25 but I made the mistake of going from 25 to 0. The withdrawal took a couple of days to hit but was quite pronounced when it did come. Tremors, confusion, akathisia, ataxia and lots of aches and pains. I went back to 25 mg but it did not help so I tried going back to 50 mg and the relief was almost immediate, I could not believe the difference.

 

So I started over a couple of months later and I am back down to 25 mg where I will hold for at least 2 months before making about a 10% reduction this time. I made the mistaken assumption that Trazodone would be easier to stop than my other meds, maybe the initial cuts were far easier but CT from 25 mg was just as bad as other things I have stopped.

 

BTW I also had a severe psychotic reaction within a couple of hours of taking 50 mg of Trazodone after cutting Zopiclone by 50% based on my doctor's recommendation.

Hi Amygdala.  I also have been tapering Trazadone. I am down to 33 mg from 75 mg and have been dry cutting. Did you ever taper off from the 25 mg Trazadone? I would like to know your experience, so I know how fast I can go. I am losing patience with this taper.  Thank you.


10/13--10/14 Ambien   Done                                                                                  

3/14  7.5 Remeron  still taking this.                              

2/14         75 Trazodone   -    Tapered by dry cutting all the way down.

2/22/15    69 Traz

3/13/15    63 Traz

4/12/15    56 Traz

5/14/15    50 Traz

6/3/15      47 Traz

7/3/15      45 Traz

9/10/15    37 Traz

10/10/15  33 Traz, 10/24/15 30 mg 11/5/15 25 mg 11/20 12.5 mg 12/9/15 9 mg 12/22 6 mg 1/1/16 4 mg JUMPED.4/2/16 Rein 1 mg, 6/7/16 updose 2mg

8/13/16    1.1 Traz tapered from 2 mg, 10/26/16 1 mg Traz .92 mg CURRENT DOSE


#29 Altostrata

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Posted 17 October 2015 - 02:23 PM

You might send Amygdala a personal message with that question.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

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#30 Cabinhope

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Posted 16 November 2016 - 02:52 PM

Why do I feel sooooo profoundly different on liquid Trazodone vs tablet? I've been gradually switching over to liquid and two nights ago increased the ratio of liquid to tablet so that now I'm on mostly liquid. Today was rough. And looking back I think the liquid has made me feel different from the beginning. When I switched two nights ago I did not change the dose. It's really unpleasant for me and I'm thinking of going back to tablet only.
Symptoms are extremely spaced out, like I'm on another planet, can't concentrate or focus, like I'm in a dream land.
Thoughts?
1995-2013, Paxil 20mg, Tegretol 200mg
Fall 2013....quick Paxil taper up to Lexapro 100mg, quick taper off Lexapro back onto Paxil 20mg, hospitalized
Spring 2014....Paxil 40mg, Depakote ?mg, Klonopin .5mg, Trazodone 50mg, added Mirena IUD May
Summer 2014...IUD removed, Depakote stopped abruptly, Trileptal added ?mg, Remeron added 15mg, Klonopin stopped
Fall 2014...Nuvaring started, Paxil reduced quickly again to 10mg from 40mg, Pristiq 100mg added, Lamictal started
Finally, nothing could stop the crying until Lithium 600mg added November, Klonopin re-added, Nuvaring stopped
Currently on: Paxil 20mg, Pristiq 100mg, Trazodone 50mg, Klonopin .5mg, Lamictal 125mg, Lithium 600mg, Remeron 7.5mg
April 2016, 125mg Lamictal dropped to 100mg
June 2016, down to 25 trazodone from 50 over 2 weeks, too quick
July 2016, back up to 37.5 Trazodone
November 2016, 32 Trazodone, switching to all liquid

#31 ChessieCat

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Posted 17 November 2016 - 07:39 PM

Cabinhope your question was answered in another topic.  Please see the response.


Reminder to self:      P A T I E N C E       I want to go faster    but I won't

 

Antidepressants:  25 years - 1 unknown, Prozac (caused muscle weakness), Zoloft; Cipramil CTed (very sick for 2.5 wks soon after)

Pristiq:  50mg mid 2012, 100mg beg 2014 (mild Serotonin Toxicity)     Current:  Pristiq 24mg (from 19 May 2017)

 

Tapering history & graph

My website - includes my brief history + links to videos & information on the web

 

Podcasts:    Let's Talk Withdrawal

 

PLEASE NOTE:  I am not a medical professional.


#32 Magnolis

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Posted 07 March 2017 - 07:22 AM

Does Trazadone ( a non-Ssri) have the same risks of causing The protracted withdrawal syndrome caused by SSRI's, when it is discontinued at a slow taper?



#33 Altostrata

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Posted 07 March 2017 - 07:20 PM

We have people here who have had problems going off trazodone and took quite a while to recover. It's difficult to tell if the risk of withdrawal syndrome is the same as the SSRIs, trazodone isn't prescribed as often.


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#34 Rob66

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Posted 15 May 2017 - 06:58 PM

My GP handed me a prescription for Trazadone a year ago for sleep issues. I used to work swing shift and had many sleep issues. He knew I was already on Zoloft but handed them out to me anyway. He said "It probably will even help with your depression"....Ugh!! Of course at that time I didn't know any better and used them on a as needed basis. So basically popping a 20mg pill once or twice a week when my bad sleep periods would hit. I used them like sleeping pills because I didn't know any better. I quit using them months ago but never tapered, just CT'd. I haven't experienced anything negative after quitting. That may be due to the short sporadic time I was using them. I know better now. The complete ignorance that some doctors have is very disturbing to me. It's hard for me to have trust in doctors anymore.

My brief story and why I'm here:

http://survivinganti...ser/9543-rob66/

5/8/17:  Started my taper.  100>90mg Zoloft.

1995 to 5/8/17:  100mg Zoloft/day.  Working well but suspecting some signs of Tolerance this past year.

4/5/17:  Started Testosterone Replacement Therapy via T pellet insertion.  Diagnosed with Secondary Hypogonadism.

Supplements:  1000mg fish oil with K2, 10,000iu Vit D3, 400mg Magnesium, Probiotic, Whey Protein.

Aug 2014 to present:  Quit smoking.  Presently Nicotine free.

Aug 2014 to present:  Quit drinking alcohol except on rare occasions.

Diet:  I try my best to follow a Paleo diet.  Heavy focus on Healthy fats, Protein, and Vegetables.  I stay away from carbs, processed foods and any added sugars.  


#35 Altostrata

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Posted 15 May 2017 - 09:40 PM

Yes, sporadic use may not cause the neurological adaptation that leads to withdrawal syndrome.

 

The combination of trazodone with an SSRI like Zoloft is common but often leads to drug-drug conflicts, see https://www.drugs.co...-2057-1348.html


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

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