Seriphos is the supplement I used. I agree, don't bother with a mail-order cortisol test. (I have issues with the Mood Cure because they pretend to balance neurotransmitters. I've actually phoned them to give them a hard time about this.)
My notes on Seriphos from 2007-2009:
8/26/07 I just went to see [an integrative doctor] who believes phosphatidylserine can counteract cortisol. He recommends a product called Seriphos, manufactured by T.E. Neesby, to take for phosphatidylserine. One capsule of Seriphos contains about 50mg calcium, 50mg of our old friend magnesium, 180mg phosphorus, and 50mg L-Serine.
Your metabolism combines the phosphorus with the L-serine, supposedly a better way to get phosphatidylserine into your system. Take one or two capsules before bedtime.
I tried this last night and I found it definitely works in about a half-hour. I took one capsule before bedtime and one capsule when I woke up around 3 a.m.
The best price I could find on T.E. Neesby Seriphos is $23.57 for 100 capsules at www.vitaminshoppe.com. (I'm not sure if Interplexus Seriphos is the same. I'm checking on this. It's a little less expensive, $17.22 for 100 capsules at www.vitaminlife.com.)
According to the naturopath-like Pacific Health Center: http://pacifichealth.../updates/32.asp "...In cases of hyper functioning adrenals, a specific supplement called phosphoralated serine (brand name [Neesby] "Seriphos") may be helpful. This helps the hypothalamus and pituitary glands to reduce their ACTH hormone output, which is the cause of the adrenals pumping out excessive cortisol. If you're "wired" at bedtime, and thus have difficulty getting to sleep, this may help...."
8/27/07 I verified that Interplexus and Neesby Seriphos is the same. [10/10/13 note: This may not be true. On the chronic fatigue syndrome forums) people seem to like the Neesby product better.]
8/30/07 So far, I am getting excellent results from [Neesby] Seriphos. It is helping me sleep and, when I wake up in the middle of the night, helping me get back to sleep.
9/16/07 Effects from Seriphos seemed to taper off. I talked to my doctor and he said I can take 2 capsules at once for sleep.
My doc is now recommending I take lecithin to augment the phosphatidylserine derived from the supplement Seriphos. Lecithin contains phosphatidylcholine and phosphatidylinositol, which convert to phosphatidylserine. He recommended taking NOW brand.
I put a tablespoon in my cereal in the morning and in my whey protein in the evening. It doesn't have much taste, maybe a little buttery. It's relatively inexpensive. I've only been taking it for about a week but it does seem to be calming.
1/22/08 [a new doctor, Dr. P] advised me to temporarily reduce Seriphos (phosphatidylserine), folate (metafolin), and DHEA as these can be stimulating.
10/18/09 I saw Dr. P early this week.... He recommended phosphatidylserine to help cortisol regulation, at first once a day with breakfast, then also with lunch. I have T.E. Neesby Seriphos left over from from a naturopathic recommendation a couple years back. I'm not sure what happened after that.
I still have the (now expired) Neesby Seriphos in the refrigerator, so I guess I didn't take it. (As I recall, I phoned the Neesby people and they said the product was very stable.) I might try it again.
[10/10/13 note: See http://survivinganti...hos/#entry64381
I just talked to the T. E. Neesby manufacturer, Pinnacle. Interplexus and Neesby both manufactured a product called Seriphos. Many people preferred the Neesby product. The two companies had a trademark dispute. A similar Neesby phosphatidylserine product is now available, called Cortiphos. It contains more phosphorylated serine than Neesby Seriphos did -- it is stronger. (Neesby/Pinnacle had initially produced Enerphos to replace Seriphos, but those who were using Neesby Seriphos found it unsatifactory. Neesby/Pinnacle reformulated the product into Cortiphos.)]
Edited by Altostrata, 19 February 2015 - 06:29 PM.