Jump to content

If you find useful information here, your gift would help keep this site going. Our staff is entirely volunteer.

Photo
- - - - -

Primary sources for data, records, papers


  • Please log in to reply
9 replies to this topic

#1 Altostrata

Altostrata

    Administrator

  • Administrators
  • PipPipPipPipPipPip
  • 24,005 posts
  • LocationSan Francisco, CA

Posted 01 May 2011 - 07:50 AM

PubMed, a site sponsored by the U.S. National Library of Medicine National Institutes of Health (NIH), is a centralized collection of scientific papers published in recognized journals from all over the world.

The search tool is easy to use. For example, enter "venlafaxine withdrawal syndrome" and you will get more than 80 results:

http://www.ncbi.nlm....drawal syndrome

(Venlafaxine is the pharmacological name for Effexor; use the pharmacological terms rather than brand names for better results.)

The results are mostly abstracts or summaries of the journal articles. In some cases, free full text is attached, or you might find free full text on other sites by Googling. If you really want an article, you usually can buy it from the journal publisher for $15-$25.

The abstracts and articles are written in scientific language and may be difficult to interpret. Do not jump to conclusions upon reading an abstract -- often you need to read the entire article, with a medical journal handy, to understand what the authors are really saying.

Even then, many studies of psychiatric drugs are funded by pharmaceutical companies and may be more positive about drug effectiveness and adverse effects than warranted by the data or by related studies.

Usually, you have to read several related studies to get a more complete picture.

Despite the pro-drug propaganda that tends to be embedded in these studies, antidepressant adverse effects and withdrawal syndrome have been documented for 30 years.

If you find interesting studies in PubMed, please start a topic and post links at least to the abstracts in this forum.

Edited by Altostrata, 29 June 2012 - 09:03 AM.
fixed link

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

#2 Brandon

Brandon

    Member

  • Members
  • PipPip
  • 21 posts
  • LocationRichmond, Virginia

Posted 01 May 2011 - 09:28 AM

Surviving- That is a good resource. Thanks for sharing... I do worry about the influence of big pharma with those studies and the potential and often prevalent underlying pro-drug sentiment. There is ambiguity and such to be found in the literature which as you stated can sometimes be hard to interpret. Often times there are conflicting statements as well. I will definitely use the site as a reference point... and try to read into what they are saying as best as I can... My brain is still in a fuzzy, hard to concentrate/comprehend point at this time however.

#3 Altostrata

Altostrata

    Administrator

  • Administrators
  • PipPipPipPipPipPip
  • 24,005 posts
  • LocationSan Francisco, CA

Posted 01 May 2011 - 10:08 AM

You don't have to be fair. Just use the studies that support your point -- that's what researchers do.

And don't forget product inserts with black-box warnings about prescribing for children. They are available from the pharma companies. For example, Effexor XR package insert labeling.pfizer.com/showlabeling.aspx?id=100
This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

#4 Altostrata

Altostrata

    Administrator

  • Administrators
  • PipPipPipPipPipPip
  • 24,005 posts
  • LocationSan Francisco, CA

Posted 22 May 2011 - 08:00 AM

US Food and Drug Administration

Information about the US Food and Drug Administration's Adverse Event Reporting System (AERS)
http://www.fda.gov/D...cts/default.htm .

AERS statistics available at
http://www.fda.gov/D...s/ucm070093.htm

Index to Drug-Specific Information
http://www.fda.gov/D...ucm111085.htm#P

FDA adverse events database

The FDA collects adverse events reports, such as antidepressant withdrawal syndrome, but has no way to mine them. (I believe you can request a raw download, but you need to put the info in a very large database to derive reports from it. I don't know how to request the raw data.)

A private company has made some basic reports from the FDA database available for free:

AdverseEvents.com: Retrieve statistics about adverse events from psychiatric drugs

PubMed
http://www.ncbi.nlm.nih.gov/pubmed/

US Clinical Trials registry
http://www.clinicaltrials.gov

Drugs@FDA
http://www.accessdat...der/drugsatfda/

NIH RePORTER
http://projectreport...ov/reporter.cfm

Dollars for Docs on Propublica http://projects.prop...org/docdollars/

Edited by Altostrata, 08 December 2011 - 07:03 PM.
updated

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

#5 erer

erer

    Silver star

  • Members
  • PipPipPip
  • 210 posts
  • LocationEstonia

Posted 13 February 2016 - 03:03 AM

Researcher illegally shares millions of science papers free online to spread knowledge

http://www.scienceal...open-up-science

 

http://sci-hub.io/


  • 2,5 years of slowly tapering down Cymbalta from 60 mg. Then tried going from 8,44 mg to 1 mg in 8 days. (April 1st 2015). That's when the real hell started. Reinstated. Didn't help. I was added Ativan (2 mg 2 times a day for relentless akathisia that started with jumping Cymbalta). For years had been taking Zopitin 7,5 mg and Stilnox 10 mg for I had not been able to sleep naturally since the 1st day I started Cymbalta). Used to take Xanax occasionally.
  • All of the above were stopped cold turkey when I was hospitalized in the beginning of May 2015.
  • Prior to that I have been on and off the whole spectrum of different AD-s for 14 years (since I was 17).

My introduction.

 

Currently (evenings): 25 mg Valdoxan (agomelatine), 5 mg Diazepam, Olanzapine (1,25 since hospital, then doctors orders mid june 2015 up to 2,5 mg. Tried cutting down to 1,875 mg July 26 (crashed on the 6th day, then managed the symptoms until it got even worse on the 17th day) Updosed Olanzapine to 2,1 mg and started diluting it and taking by a syringe on August 14th 2015.

 

  • Tapering: Olanzapine (starting point 2,1 mg): 12/02/16 - 2 mg; 23/03/16 - 1,8 mg /---/ 22/08/16 - 1,4 mg

 

Supplements: Omega 3, D3, C, probiotics, agnus castus (helps with PMS), magnesium oil topically.


#6 btdt

btdt

    Fingers of titanium

  • Members
  • PipPipPipPipPipPip
  • 7,153 posts
  • LocationCanada

Posted 14 February 2016 - 05:31 PM

I can't sort out how to use it... can't find a thing but I am not the smartest person here and not in top form... have you been able to make any use of it?


WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivinganti...ng-myself-btdt/

There is a crack in everything ..That's how the light gets in :)


#7 InvisibleUnless

InvisibleUnless

    Silver star

  • Members
  • PipPipPip
  • 338 posts
  • LocationCalifornia, USA

Posted 13 March 2016 - 01:49 PM

you have to put in the extant link, DOI, or other concrete reference to what you are trying to access.  sometimes it will only pull up the publicly shared abstract, like on pubmed articles with nothing further available, but sometimes you can access the full-page texts, pdfs, or other materials that normally throw up the "you must have a subscription!" dialogue.

 

i dont know what it does, or how widely applicable it is.  i would have to read more about it and experiment.  make sure you are allowing the scripts/cookies/whatnot that it requires to run (but dont trust those scripts/cookies/etc blindly!).


from 2005-2012, i spent 7 years taking 17 different psychotropic medications covering several classes.  i would be taking 3-7 medications at a time, and 6 out of the 17 medications listed below were maxed or overmaxed in clinical dosage before i moved on to trying the next unhelpful cocktail.
 
antidepressants (SSRIs, SNRIs, NDRIs, tetracyclics): zoloft, wellbutrin, effexor, lexapro, prozac, cymbalta, remeron
antipsychotics (atypical): abilify, zyprexa, risperdal, geodon
sleep aids (benzos, off-label antidepressants & antipsychotics, hypnotics): seroquel, temazepam, trazodone, ambien
anxiolytics: buspar
anticonvulsants: topamax
 
i tapered off all psychotropics from late 2011 through early 2013, one by one.  for all 5 years since quitting, ive been cycling through severe, disabling withdrawal symptoms spanning the gamut of the serious, less serious, and rather worrisome side effects of these assorted medications.  previous cross-tapering and medication or dosage changes had also caused undiagnosed withdrawal symptoms.
 
brainpan addlepation


#8 btdt

btdt

    Fingers of titanium

  • Members
  • PipPipPipPipPipPip
  • 7,153 posts
  • LocationCanada

Posted 13 March 2016 - 06:01 PM

thanks IU I don't know cookies.. I eat them... I don't know scripts that for a movie right?  See I have no business even using a computer as I have no clue how they work.... but thank you for your efforts I will leave it alone. 


WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivinganti...ng-myself-btdt/

There is a crack in everything ..That's how the light gets in :)


#9 InvisibleUnless

InvisibleUnless

    Silver star

  • Members
  • PipPipPip
  • 338 posts
  • LocationCalifornia, USA

Posted 14 March 2016 - 02:51 PM

haha, just internet browser muckery.  if you need any studies mined, PM me links/DOIs and i can see what comes up.


from 2005-2012, i spent 7 years taking 17 different psychotropic medications covering several classes.  i would be taking 3-7 medications at a time, and 6 out of the 17 medications listed below were maxed or overmaxed in clinical dosage before i moved on to trying the next unhelpful cocktail.
 
antidepressants (SSRIs, SNRIs, NDRIs, tetracyclics): zoloft, wellbutrin, effexor, lexapro, prozac, cymbalta, remeron
antipsychotics (atypical): abilify, zyprexa, risperdal, geodon
sleep aids (benzos, off-label antidepressants & antipsychotics, hypnotics): seroquel, temazepam, trazodone, ambien
anxiolytics: buspar
anticonvulsants: topamax
 
i tapered off all psychotropics from late 2011 through early 2013, one by one.  for all 5 years since quitting, ive been cycling through severe, disabling withdrawal symptoms spanning the gamut of the serious, less serious, and rather worrisome side effects of these assorted medications.  previous cross-tapering and medication or dosage changes had also caused undiagnosed withdrawal symptoms.
 
brainpan addlepation


#10 btdt

btdt

    Fingers of titanium

  • Members
  • PipPipPipPipPipPip
  • 7,153 posts
  • LocationCanada

Posted 16 March 2016 - 10:25 AM

haha, just internet browser muckery.  if you need any studies mined, PM me links/DOIs and i can see what comes up.

oh my even thinker into the weeds....

 

Data mining is a process used by companies to turn raw data into useful information. By using software to look for patterns in large batches of data, businesses can learn more about their customers and develop more effective marketing strategies as well as increase sales and decrease costs.

 

I know pharma does it with doctors and us to sell us more drugs... 

 

how could we use this to our benefit... what the heck is a DIO ok stop being lazy

digital object identifier (DOI) is a unique alphanumeric string assigned by a registration agency (the International DOI Foundation) to identify content and provide a persistent link to its location on the Internet. The publisher assigns a DOI when your article is published and made available electronically.

 

A message given to a Web browser by a Web server. The browser stores the message in a text file. The message is then sent back to the server each time the browser requests a page from the server. Also see session cookie and persistent cookie.....guess I am the browser right

 

script...

In computer programming, a script is a program or sequence of instructions that is interpreted or carried out by another program rather than by the computer 

 

You challenge me to learn but it is not getting in just standing at the door knocking and knocking... I don't know if it is drug damage or stupidity... 

Guess I am a bit closer to some form of understanding....

long ago when I thought I was going to heal fast I thought I would return to school and study computers and chemistry... 

 

Now I just want to get thru life without too much grief... funny what long term suffering can do to a persons plans. I truly make no plans as who knows how I will feel that day. 

Thanks for the help IU


WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivinganti...ng-myself-btdt/

There is a crack in everything ..That's how the light gets in :)