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What is withdrawal syndrome?


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#37 torvikk

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Posted 24 May 2016 - 12:55 PM

How do you discern withdrawal-depression from primary (returning) depression? I'm in 3rd week zero and have the horrible lethargy/fatigue and I know it well from my depression history. I fear it will not go away because it is the condition I started taking the med for - in which case it would be better to start taking the med again right away.


(I don't remember what I used to take before 2005. It was a few years.)

2005-venlafaxine 150 mg - for major depressive disorder

2015-venlafaxine down to 75mg

end of march - stopped venlafaxine altogether after 1 month of tapering.

beginning of march - crossfade from Vfx into brintellix 15 mg. Stopped after 1 month (Decided to stop ADs)

same time - started taking 0,625 lorazepam daily, taken at different times of the day, when most needed.

 

june 9th - reinstated 2x12,5mg/day. No change after 2 days. Some relief after 4 days. After 6 days it gets worse again. June 14th - increased to 2x25 mg/d. June 19th - Feeling all the withdrawal symptoms again.


#38 scallywag

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Posted 24 May 2016 - 01:46 PM

Welcome torvikk.

 

Many psychotropic drugs cause withdrawal; the symptoms of withdrawal are very similar to original conditions. Have you read this thread from the beginning? First post by Altostrata

 

Please start a thread in the Introductions and Updates Forum.  People are more likely to see and your question there.

 

Some questions for you to answer in your first post in your Introduction thread:

 

What drugs did you take?  How much?  When was your last one?

Did you just stop taking it or did you gradually reduce to zero? 

If you gradually reduced, how long did you take to get to zero?

 

You can write that information in your post and in a signature.  Please create a signature. When it appears below every post you make, it will help others to understand and help you.   Instructions on Making a Signature .


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.
1997-1999 Effexor; 2002-2005 Effexor XR 37.5 mg linear taper, dropping same #beads/week with bad results
Cymbalta (brand name), 60 mg 2012 - 2015; 20 mg to 7 mg in 2016, exact doses and dates in this post;
2017: 6.3 (58 beads) Feb. 1; 5.6 mg (52) Feb. 22; 5.4 mg (50) Mar. 15; 5.1 mg (47) Mar. 25; 4.9 mg (45) Apr. 5; 4.5 mg (42) Apr. 14; 3.5 mg (32) Apr. 26;
Current dose: 2.6 mg (24) 2017-May-17
+ Supplements: fish oil (1500 mg EPA/500 mg DHA), Vitamins: D3, K2, C; Minerals: Mg, Se, Cr, I, V
scallywag's Introduction
Online spreadsheet for dose taper calculations and nz11's THE WORKS spreadsheet


#39 reachingforthestars

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Posted 23 September 2016 - 01:21 AM

I read about neurogenesis and looks like there are only few areas in the brain that can grow new neuron. 

 

"Neurogenesis does not occur everywhere in the brain but is evident in the hippocampus and olfactory bulb and perhaps in the cerebral cortex. New neurons are born not from mature nerve cells but rather develop from neural stem cells that remain in our brains throughout life. "

 

I have speculated that maybe there are two types of damage(or probably more). I feel that at first my WD symptoms were due to neurotransmitter deficiency since my body and brain had to adapt different serotonin levels with SSRI and then without SSRI. 

I feel that my receptors weren't desensitized at that point since I was so full of emotions.

But when I updosed and had bad reaction to it I lost those emotions and I think that due to updosing my receptors also became desensitized. So now I have both altered levels of neurotransmitters due to SSRI and desensitized receptors due to updosing.

 

I have tried to find studies about desensitized receptors becoming sensitized again but haven't find any... 

 

Sorry my clumsy English I hope you can comprehend what I'm trying to say...


Citalopram 40mg from 2003-2015

Jan 2015 started tapering first dropped to 35mgFeb 30mg, March 25mgApril 20mg, May 17,5mg, June 15mgJuly 12,5mg, Aug 12,5mg,

Sep 0mg for 5 days because of stomac flu and after I raised to 7,5mg. All the symptoms of acute WD shaking, diarrhea, vomiting, barely could walk ect. Still didn't realize that it wasn't only stomac flu but I was also going through WD.

Oct 2,5mg and crashed again badly and quickly raised to 4mg. It was then when I knew my symptoms were due to WD.

Then in November after a month holding on 4mg raised to 5mg due to muscle weakness and had a VERY BAD reaction to reinstatement: akathisia(lasted for one or two weeks), insomnia, anhedonia... Drop quicly back to 4mg, Dec 3mg

Jan 2016 2,6mg( in the middle of Jan after I had been on 2,6mg for a week I tried to updose to 2,8mg and immediately had bad reaction to it: akathisia for a day, andehonia got worse. The next day dropped back to 2,6mg), Feb 2,4mg( a new symptom PGAD lasted 24/7 for 2 months after that on and off), March 2,4mg, April 2,3mg, May 2,2mg, June 2,1mg, July 2,0mg( Pgad almost nonexisting, sleeping pretty good, still some anhedonia but there has been a lot of gradual progress), Aug 1,97mg-1,89mg, Sep 1,88mg-1,49mg, Oct 1,48mg- 1,70mg,

Nov 0,65mg- current dose 0,5mg

 


#40 scallywag

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Posted 22 October 2016 - 08:32 AM

frustratedgirl: I've moved your post to a new Introduction topic. Here is the link: frustratedgirl: escitalopram.

 

Please ask questions, record symptoms, and post updates there. It's best to keep all that kind of information in one place.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.
1997-1999 Effexor; 2002-2005 Effexor XR 37.5 mg linear taper, dropping same #beads/week with bad results
Cymbalta (brand name), 60 mg 2012 - 2015; 20 mg to 7 mg in 2016, exact doses and dates in this post;
2017: 6.3 (58 beads) Feb. 1; 5.6 mg (52) Feb. 22; 5.4 mg (50) Mar. 15; 5.1 mg (47) Mar. 25; 4.9 mg (45) Apr. 5; 4.5 mg (42) Apr. 14; 3.5 mg (32) Apr. 26;
Current dose: 2.6 mg (24) 2017-May-17
+ Supplements: fish oil (1500 mg EPA/500 mg DHA), Vitamins: D3, K2, C; Minerals: Mg, Se, Cr, I, V
scallywag's Introduction
Online spreadsheet for dose taper calculations and nz11's THE WORKS spreadsheet


#41 OCDee

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Posted 22 October 2016 - 12:58 PM

I waned to pose a question as to the length of time it took for aome people to show sihns and symptoms of discontinuation ot withdrawal symptoms. I was completwly symtpom free for about a year and have trouble guaging whether or not the symtpoms I am having, particularly insomnia are from discontinuation or not. I began having anxiety and depression about 11 months after discontinuation and insommia almost 14 months after discontinuation. I figure taking to this thread and asking others what they went through may help me find answers.

#42 Lawyerliz

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Posted 29 December 2016 - 09:27 AM

Interesting. My stress was Trump winning the election. Was doing pretty ok, but that knocked me for a loop And he's going to be around for 4 years (at least). My PA says a lot of her clients were affected this way! Not under my control of course.

#43 Jayjohnny

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Posted 07 January 2017 - 07:57 PM

Interesting. My stress was Trump winning the election. Was doing pretty ok, but that knocked me for a loop And he's going to be around for 4 years (at least). My PA says a lot of her clients were affected this way! Not under my control of course.

Hate to break it to you but 4 years will more than likely be 8 for you!
2005: Began switching from one ssri to the next. Very little tapering time was instructed by my psychiatrist. Tried just about every drug on the market. Some two or three times. Nothing reallly helped my moderate depression and anxiety. They only made things worse most of the time!!
2014: Began experiencing severe symptoms while still taking Zoloft, oddly enough. Was forced to quit drugs altogether.
2017: A new year begins having experienced substantial improvement. Still not sure if my symptoms were severe protracted withdrawal or a severe reaction to a med, or possibly a combination of each.

#44 Bluebird2009

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Posted 28 April 2017 - 11:52 PM

I truly believe there are things that we can do to help ourselves be more at ease when we are in some stages of withdrawal. I am a firm believer in meditation and/or deep relaxation as I have found it to be helpful in almost all stages of withdrawal and it was indeed the first thing I ever noticed to make an almost unnoticeable change in my suffering. The more I did it the more noticeable the change was it was in no way a miracle but small moves towards healing need to be honored and sought if we are going to survive this wd syndrome and get to a more stable place. Yes it can be that bad and I do not want to harp on that.... but we need things to see us through this. Deep relaxation was one of those things for me... the book " The Power of Now" helped me greatly with my perspective at one point so much so you will see my recommending it all over the internet to help people survive withdrawal. How much we heal is an unanswered question how much we suffer can be helped by some things we choose sometimes...not always. An important fact as surviving this is the most important thing at the end of the day.sadly not everybody makes it out.. if we are going to survive we need to have tools to help us.
Understanding what is going on is part of the tool box in my opinion this area is still lacking but some head way has been made.

I want any new person who comes to this thread to be hopeful but not foolish... it will be challenging to get through this. Some things that will help are understanding and some tools to try. Please heed the warning of those who came before you... we/they learned by doing and have no reason to tell you any lies if we say to start supplement low it is because we suffered from not doing so... if we say taper has to be better than cold turkey it is because we have done cold turkey... let our mistakes help you to not make the same ones.. to lessen your suffering and increase your odds of a more complete recovery. The only motive we have to be here is to help other people not have to go through the pain we have lived... well that is my reason... I think it is the same for others and support.

We are all learning from each other lets try to be as kind as we call everybody hurts.

Tools to help you:
http://survivinganti...-and-self-care/

Journals to learn from:
http://survivinganti...ntific-sources/
peace

Have you recovered??
Prozac for 18years with break in 1999 for pregnancy. Started to feel unwell with numerous problems 2015 and think I was in a tolerance to drug. Started to come off May 2016 and by June 2016 wasn't able to tolerate any medications at all. Was on Lansoprazole as and when need from 2001 but haven't had to take and wldnt have been able to take since June 2016

GP gave sertraline 25mg 6/04/17 loss of appetite, gut pain and then following morning whole body shaking and vomiting. Stopped tablet.

#45 Lilu

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Posted 02 May 2017 - 07:47 AM

Antidepressant Discontinuation syndrome guide to clinicians from David McAuley, Pharm.D

This gives me some hope that there are professionals out there trying to educate clinicians about antidepressants and withdrawal. Unfortunately, he also mentions the magical 2 weeks number of withdrawal and recommends a 25% taper rate. But otherwise this is quite comprehensive.

http://www.globalrph...on_syndrome.htm


2005-2008 Effexor xr; 1/2008 Tapered 3 months, then quit.
7/2008-2009 Reinstated Effexor xr due to crying spells.
2009-3/2013 Switched to Pristiq 50 mg then 100 mg
3/2013 Switched to Lexapro 10mg. Cut down to 5 mg. CT for 2 weeks then reinstated for 6 weeks
8/2013-8/2014 Tapering Lexapro
11/2014 -8/2015: Developed severe insomnia, resumed using Ambien & Klonopin
12/2014-6/2015 Tried Ativan, Lunesta, Sonata, Trazadone, Seroquel, Rameron, Klonopin, Gabapentin
7/2015-1/2016 Reinstated Lexapro 2 mg (mild improvement, but crying spells still present)

9/2015-5/2016 Baclofen 30 mg (muscle relaxant for myoclonus) 

1/2016-5/2017 Lexapro 5 mg (worked well for 1.5 yrs, then depression relapsed.)

5/20/2017 - Now: Lexapro 10 mg 

Intro page: http://survivinganti...rsened-by-meds/