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N-acetylcysteine (NAC)


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#1 Phil

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Posted 03 July 2011 - 06:12 AM

Has anyone tried this during withdrawal? Does it help any symptoms? I've read about it on the other forum but have never got round to trying it, mostly because I'm scared of potentially feeling worse (I feel bad enough as it is). I have some in my cupboard. I wonder if it would help sleep or to reduce rumination, as I've read it is used for OCD. If it would help reduce some of my negative thoughts I'd be glad to try it.
Off Lexapro since 3rd November 2011.

#2 serotonin

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Posted 03 July 2011 - 08:59 AM

I never heard of it but can u tell us what it does?

#3 Phil

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Posted 03 July 2011 - 10:28 AM

From the wiki on it:

"Psychiatry

Acetylcysteine has been shown to reduce the symptoms of both schizophrenia[21] and bipolar disorder[22] in two placebo controlled trials conducted at Melbourne University. It is thought to act via modulation of NMDA glutamate receptors or by increasing glutathione. Replicatory trials in bipolar disorder, schizophrenia and depression are underway."


I think it's supposed to help from its actions on glutamate, as supposedly glutamate is involved in withdrawal syndrome (see this post: http://survivinganti...rawal-syndrome/)
Off Lexapro since 3rd November 2011.

#4 Altostrata

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Posted 03 July 2011 - 05:07 PM

N-Acetylcysteine aka acetylcysteine or NAC may help subdue the hyperactivity of the glutamate system that causes the withdrawal symptoms of insomnia, pseudo-anxiety, and pseudo-depression, excessive cortisol production and the awful sensations of autonomic dumping; also, the symptoms of OCD triggered in some of us by withdrawal.

I started looking at it to treat the eye inflammation I had in 2008 http://bastyrcenter....ntent/view/776/
NAC helps break down mucus, which might help me. It also contributes to the production of glutathione, the master anti-oxidant (although this is self-limiting).

I found there's a study going on at Yale by Christopher J Pittenger, MD, Ph.D. N-Acetylcysteine Augmentation in Treatment-Refractory Obsessive-Compulsive Disorder http://clinicaltrial...0539513?order=2
"...Existing medications for obsessive-compulsive disorder affect the neurotransmitters serotonin or dopamine; but increasing evidence suggests that functional disruptions of a different neurotransmitter, glutamate, may contribute to some cases of OCD. We are therefore interested in using medications that target glutamate as novel treatment options for those OCD patients who do not benefit from established treatments. One such medication is the drug N-Acetylcysteine, whose glutamatergic antagonistic properties may be effective in reducing the glutamatergic hyperactivity that is thought to contribute to the pathophysiology of OCD and MDD...." Citations for two papers by Dr. Pittenger are attached to the study proposal.

Edited by Altostrata, 12 February 2014 - 09:43 AM.
fixed text

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

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#5 Altostrata

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Posted 03 July 2011 - 05:09 PM

Also in 2008, I talked to a knowledgeable doctor about NAC. Dosage is an issue, and here's why (as he explained it): The glutamatergic and GABA systems are complementary. When they are in tune, everything works well. Glutamate is one of those things, like cortisol, where too little is bad and too much is bad but just right is just right. The system needs glutamic acid to produce the calming inhibitory neurotransmitter GABA and GABA regulates glutamate production.

If GABA is reduced, the glutamatergic system gets out of hand. If glutamate is too high, GABA is overwhelmed; if glutamate is reduced too much, inadequate GABA is produced. Any which way, you get symptoms of anxiety and agitation.

The right glutamategic-correcting dosage of NAC might even vary from person to person. This doctor knew exactly how NAC acted on the glutamate system and said its mode of action was different from lamotrigine and it might be complementary to Lamictal. My guess is it could be used to taper people off lamotrigine. It might also help benzo withdrawal, since an imbalance similar to antidepressant withdrawal is in place: too much glutamate. In benzo withdrawal, it is due to downregulation of GABA; in antidepressant withdrawal, downregulation of serotonin.

Edited by Altostrata, 12 February 2014 - 09:45 AM.
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#6 Altostrata

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Posted 03 July 2011 - 05:25 PM

NAC appears to have a number of therapeutic effects; one of them to break up excessive mucus. When used for eyelid inflammation, the dosage is 100mg three times a day. (And this is the normal NAC, with a half-life of 1.5 hours.) What is does is change the composition of eye lubrication so it doesn't tend to form an irritating crust. This indicates to me the lower dosage is sufficient for systemic effects -- it gets all the way into tear production.

It looks like the most common dosages available are 500mg-600mg tabs or caps.

This is what my experience with NAC was in September 2008: I chose to try the Jarrow sustained release dosage; the tablets are 600mg. The Jarrow tabs are in two layers. I wrote Jarrow and found the wider layer, 400mg of the 600mg tablet, is the sustained-release NAC. Cutting up the tablet does not affect the sustained-release part.

I cut the 600mg tab into quarters; the layers separated. I took 1/4, approximately 150mg, on an empty stomach with fruit juice. My experience was mixed. Being hypersensitive, I believe I can fairly accurately tell what something does. At first, I felt energized and calm, so pretty good there. I had lunch. Later in the day, the sustained-release part kicked in, majorly upset my stomach, and increased anxiety. The unpleasant part lasted for many hours. I could barely eat dinner. I had as close to an anxiety attack as I've had in 8 months.

Fortunately, I was able to sleep some anyway and the next day I feel okay. All together, I felt the effects for 12 hours. This makes sense because the sustained-release part is supposed to increase NAC half-life in the small intestine from 1.5 hours to 4 hours. Adding the normal-release component, this sums up to a half-life of maybe 5.5 hours and more than 10 hours to be out of the bloodstream completely. (I have no doubt that the Jarrow product is sustained-release -- I had effects from their NAC-Sustain for 12 hours.)

My interpretation of what happened fits the glutamate-GABA model. When the sustained-release part kicked in, the dosage of NAC was too much for me and lowered my glutamate too much. This left the GABA system with not enough glutamic acid to work with, raising anxiety. (And the stomach distress didn't help, either.)

I conclude that NAC probably does lower glutamate production, which is a good thing for people suffering from anxiety, but it is quite powerful. Figuring out dosage could be challenging. If you are suffering from anxiety, start with a very small dose of the normal-release NAC in the morning, which will limit unpleasant effects, if any, to a few hours. To try this again, I'd just take a quarter of the 200mg normal-release layer.

My hypothesis is that minimal dosages of NAC may be enough to temper the glutamatergic system and reduce anxiety. Large sustained-release doses may not be necessary for this purpose. This is another one of those things where more is not better.

----------------------
I've been giving NAC (n-acetyl cysteine) a try for about a week, and so far the results are promising. Dosage is tricky. I cut up the Jarrow tablets and have been taking 50mg of the regular-release NAC in mid-morning on an empty stomach. Even when I feel really crummy, I find it makes me feel calm and happy for a few hours (half-life is 1.5 hours). (I am not having rushes of anxiety any more, but I often feel lousy from too little sleep.)

Yesterday I took 50mg at 11 a.m. and again at 4 p.m. and it seemed to work both times. But, toward evening, I started to feel a little buzzy, so it might have been too much. Fortunately, it did not seem to interfere with sleep; I slept a little better last night. I am thinking this might be a good thing to take when I wake up at 2 a.m. It might help me get back to sleep. (Also, it seems to have helped my eye inflammation.)

----------------------
My experience with NAC as so far been good. The thing is, I can only take 50mg at a time because, taken on an empty stomach, 100mg seems to cause upset, even when it's extended-release. While I've had okay results with NAC during the day, it's not going to work for me when I wake up -- I get an upset stomach even when I take 50mg in the middle of the night. For me, it needs some food around it to cushion it.

Talked to the knowledgeable doctor about NAC at night and he said something really interesting. Seems that when the body is doing its repair work during deep sleep, it works best in an environment without additional antioxidants as they interfere with the repairs. He said NAC in the early part of the night would be fine.

Remember the paradoxical character of the alerting reaction: if you go after it too aggressively, you will set it off. Starting with very low doses and slowly titrating up is the way to go.

Edited by Altostrata, 12 February 2014 - 09:48 AM.
fixed text

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

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#7 Altostrata

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Posted 03 July 2011 - 05:27 PM

The following is a little chewy but seems to explain the calming effects of NAC (H2S is hydrogen sulfide): "...The H2S produced from cysteine functions as a neuromodulator and smooth muscle relaxant...."

Nutr Rev. 2004 Sep;62(9):348-53.

New roles for cysteine and transsulfuration enzymes: production of H2S, a neuromodulator and smooth muscle relaxant.

Dominy JE, Stipanuk MH.

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.

Abstract at http://www.ncbi.nlm....Pubmed_RVDocSum

The enzymes of the transsulfuration pathway also have the capacity to catalyze the desulfhydration of cysteine. Recent studies demonstrate a role of the transsulfuration enzymes, cystathionine gamma-lyase and cystathionine beta-synthase, in catalyzing the desulfhydration of cysteine in brain and smooth muscle. The H2S produced from cysteine functions as a neuromodulator and smooth muscle relaxant. In glutamatergic neurons, the production of H2S by cystathionine beta-synthase enhances N-methyl-D-aspartate (NMDA) receptor-mediated currents. In smooth muscle cells, H2S produced by cystathionine gamma-lyase enhances the outward flux of potassium by opening potassium channels, leading to hyperpolarization of membrane potential and smooth muscle relaxation.
This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

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#8 peggy

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Posted 29 July 2012 - 11:41 PM

I am bumping this for any updates? I am interested in maybe trying this for anxiety and ruminating anxious thoughts.... to have in my tool box
Started Effexor in 1998 or 1999 - can't remember which!
On 150mg most of the time.
Reduced off easily first time - but got depressed (not too much anxiety) 6 months later
Back on effexor for another 9 months.
Reduced off again with no immediate w/d - got depressed again 3 or 4 months later.
Back on effexor - this time for 3 years
Reduced off over a month - 6 weeks later terrible anxiety - back on.
Rinse and repeat 4 more times.
Jan - July 2012 75mg down to 37.5mg;, 8/3/12 - 35mg. 8/25/12 - 32mg. 9/11- 28mg, 10/2 - 25mg, 10/29 - 22mg, 11/19 - 19.8mg; 12/11 - 17m,
1/1- 15.5mg; 1/22 -14mg, 2/7 14.9mg, 2/18 - 17.8mg

#9 GiaK

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Posted 30 July 2012 - 04:20 AM

just to share...I've taken NAC off and on for several years now...I don't FEEL anything but I have felt it may help foundational well-being... I now take long breaks between periods of taking it because I talked to a interesting and knowledgable psychiatrist who said it messes really badly with mucous production which has all sorts of broad implications but bottom line she didn't know how serious that might be and so caution is warranted... the times I take it now is when I take tylenol which grossly depletes ones body of glutathione...so if and when I take tylenol I will take NAC for a few days to hopefully get my glutathione back on track... sorry, I don't have documentation for these statements...you'll have to use google if you need that!!
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I withdrew from a cocktail of 6 psychiatric drugs that included every class of psych drug.

I took a bit over 6 years to do it. Finished on Feb 9 2010. I'm still recovering from iatrogenesis.

#10 peggy

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Posted 30 July 2012 - 12:48 PM

Thanks Gia! Any one else?
Started Effexor in 1998 or 1999 - can't remember which!
On 150mg most of the time.
Reduced off easily first time - but got depressed (not too much anxiety) 6 months later
Back on effexor for another 9 months.
Reduced off again with no immediate w/d - got depressed again 3 or 4 months later.
Back on effexor - this time for 3 years
Reduced off over a month - 6 weeks later terrible anxiety - back on.
Rinse and repeat 4 more times.
Jan - July 2012 75mg down to 37.5mg;, 8/3/12 - 35mg. 8/25/12 - 32mg. 9/11- 28mg, 10/2 - 25mg, 10/29 - 22mg, 11/19 - 19.8mg; 12/11 - 17m,
1/1- 15.5mg; 1/22 -14mg, 2/7 14.9mg, 2/18 - 17.8mg

#11 spectio

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Posted 01 August 2012 - 03:15 PM

Hi, Peggy: this supplement was one of many I took when I was withdrawing from remeron. I had no knowledge of any paradoxical effects for these supplements since I was under the care of my integrative doctor and he prescribed according to the supplement company. I did finally quit it because it was making my already volatile anxiety even worse, a lot worse. I did notice after I quit it that it contains a sulfa component. I was always wondering about the color of the material. It definitely is orange. Long story short, I've had a sulfa allergy my whole life. I wasn't sure that was the reason for the reaction I had to it. I had reactions to just about any supplement that was offered to me. That could be the reason why I am still very miserable nearly a year after remeron withdrawal. My brain may be reeling from a compound exposure to all these supplements plus 12 years of remeron. Be very careful. It sounds like alto had some pretty thoughtful experience with it.
I started withdrawing off remeron in August of 2009, with the help of a holistic physician.The reason for the withdrawal was a year or two of off and on nausea, deterioration in my thinking, and more depression. It took me a full year to work from 135 mg down to 45mg. At that point, more drops were causing more depression. Unfortuately, the nervousness that I was also feeling for the last year continued with the 45 mg. Thirty one days ago, I stopped the remeron. I am still feeling the nervousness every day and the last week, I am feeling what I think is depression but not sure. In bed in the morning, I'm already dreading another day feeling this way. I am intensely unsure of myself and find it very hard to do anything. I was a practicing veterinarian for 29 years until I found I could not practice anymore. First of all I couldn't think, or remember, and I had absolutely no confidence in anything I did. These were things I did with relative ease for twenty+ years. So, this feeling of no confidence has been during the time I was on the AD(the last 2 years) and today. I take no other medication other than my blood pressure meds. I tried supplements with my holistic dr. but they seemed to make the intense nervousness even more intense. Anyway, I truly feel stuck.

#12 Rhi

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Posted 02 August 2012 - 09:11 PM

I've been taking NAC for a few years to support glutathione production, because of chemical sensitivities. I take a supplement that provides 200 mg at a time. I usually take it with lunch before I go to work, and at work I'm usually bombarded with stimuli so not really tuned in to my subtle intrapersonal reactions and sensations. I've never noticed any obvious effect from the NAC. That doesn't mean it's not doing anything, though. The supplement I use has 200 mg of NAC along with a few other things.

Started on Prozac and Xanax in 1992 for PTSD after an assault. One drug led to more, due to side effects and attempted withdrawal. Got sicker and sicker, but believed I needed the drugs for my "underlying disease" as I was told. Long and tragic story...lost everything.

Now tapering, healthier and more functional than I ever was during the years on the "meds" and getting gradually better all the time. On an extremely slow multidrug taper, as below.

 

Started multidrug taper in Feb 2010.  March 2010 added 2 mg Valium in (failed) attempt to cross over from Xanax.

 

Feb 15 2010:  300 mg Neurontin  200 Lamictal   10 Celexa      0.65 Xanax   and 5 mg Ambien 

Feb 14 2011:   86 mg Neurontin   144 Lamictal,    5.5 Celexa   0.42 Xanax      1.9 mg Valium

Feb 16 2012:   10 mg Neurontin   115 Lamictal     3.7 Celexa   0.285 Xanax     2.0 Valium

Feb 22 2013:   86 Lamictal    2.05 Celexa    0.23 Xanax     1.8 Valium

Feb 10 2014:   62 Lamictal    1.1 Celexa      0.135 Xanax   1.8 Valium

 


#13 Rhi

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Posted 02 August 2012 - 10:01 PM

"In glutamatergic neurons, the production of H2S by cystathionine beta-synthase enhances N-methyl-D-aspartate (NMDA) receptor-mediated currents. " Wouldn't that be stimulating? It's so tricky trying to tweak body chemistry. I'm tempted to just quit all supplements altogether. But not yet, because I see that NAC is water soluble, which means Fun With Liquids for Rhiannon! So I mixed up some 600 mg capsules that have been sitting in my closet since I tried them and decided 600 mg was too strong. Now I have a 6 mg/mL solution of NAC and I can play with that and see what effect if any it has on my anxiety and stimulation. Heh heh heh...mad scientist...love my pipettes...

Started on Prozac and Xanax in 1992 for PTSD after an assault. One drug led to more, due to side effects and attempted withdrawal. Got sicker and sicker, but believed I needed the drugs for my "underlying disease" as I was told. Long and tragic story...lost everything.

Now tapering, healthier and more functional than I ever was during the years on the "meds" and getting gradually better all the time. On an extremely slow multidrug taper, as below.

 

Started multidrug taper in Feb 2010.  March 2010 added 2 mg Valium in (failed) attempt to cross over from Xanax.

 

Feb 15 2010:  300 mg Neurontin  200 Lamictal   10 Celexa      0.65 Xanax   and 5 mg Ambien 

Feb 14 2011:   86 mg Neurontin   144 Lamictal,    5.5 Celexa   0.42 Xanax      1.9 mg Valium

Feb 16 2012:   10 mg Neurontin   115 Lamictal     3.7 Celexa   0.285 Xanax     2.0 Valium

Feb 22 2013:   86 Lamictal    2.05 Celexa    0.23 Xanax     1.8 Valium

Feb 10 2014:   62 Lamictal    1.1 Celexa      0.135 Xanax   1.8 Valium

 


#14 Nadia

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Posted 07 August 2012 - 04:45 PM

How weird!! This is the second supplement (the other being l-arginine) that is up for discussion in Symptoms and self-care and which I am coincidentally taking for another reason entirely (fertile cervical mucus to try to get pregnant). (So what GiaK says about mucus production really makes sense! Boy, does it work.) I'm mention here again that I first started taking FertileCM (containing both NAC and l-arginine, but it doesn't disclose the amounts of each) in March/April, and I had a definite period of improvement. I had attributed it to the panax ginseng I was also taking. I'm taking FertileCM AND ginseng both now, though, and am doing awful (then again, maybe I'd be worse if I wasn't taking them!). Like Rhi, I'm tempted to quit all supplements also. I actually did for the the three weeks I was on vacation, and I was the best I've ever been for the first couple of weeks. Next to zero anxiety, zero depression, and incredible sleep. I still tired easily and was really exhausted all the time, but it was so great to be able to sleep naps and sleep in... on a few days I slept 8 to 9 hours straight without waking up! Maybe it's a good idea to quit supplements once in a while? Or perhaps removal of all stress for a while overrides just about anything else!

'94-'08 On/off ADs. Mostly Zoloft & Wellbutrin, but also Prozac, Celexa, Effexor, etc.
6/08 quit Z & W after tapering, awful anxiety 3 mos. later, reinstated.
11/10 CTed. Severe anxiety 3 mos. later & @ 8 mos. much worse (set off by metronidazole). Anxiety, depression, anhedonia, DP, DR, dizziness, severe insomnia, high serum AM cortisol, flu-like feelings, muscle discomfort.
9/11-9/12 Waves and windows of recovery.
10/12 Awful relapse, DP/DR. Hydrocortisone?
11/12 Improved fairly quickly even though relapse was one of worst waves ever.

1/13 Best I've ever felt.

3/13 A bit of a relapse... then faster and shorter waves and windows.

4/14 Have to watch out for triggers, but feel completely normal about 80% of the time.


#15 peggy

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Posted 09 March 2013 - 09:59 PM

i took the NAC faithfully for a few months - i was taking 1000mg in the morning. Can't say i noticed anything either way - good or bad, but i have just decided to recommence. I will break the tablets up to start so i don't start with 1000mg outright. My psych doc recommended i take it - she had me on 1000mg daily for a month then up to 2000mg daily. I don't seem to be overly sensitive to medications - with the exception of reducing effexor :lol:
Started Effexor in 1998 or 1999 - can't remember which!
On 150mg most of the time.
Reduced off easily first time - but got depressed (not too much anxiety) 6 months later
Back on effexor for another 9 months.
Reduced off again with no immediate w/d - got depressed again 3 or 4 months later.
Back on effexor - this time for 3 years
Reduced off over a month - 6 weeks later terrible anxiety - back on.
Rinse and repeat 4 more times.
Jan - July 2012 75mg down to 37.5mg;, 8/3/12 - 35mg. 8/25/12 - 32mg. 9/11- 28mg, 10/2 - 25mg, 10/29 - 22mg, 11/19 - 19.8mg; 12/11 - 17m,
1/1- 15.5mg; 1/22 -14mg, 2/7 14.9mg, 2/18 - 17.8mg

#16 Finn

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Posted 03 April 2013 - 11:22 AM

I started taking it because I read that it has anti-oxidant benefits that help damage caused by stress and that it is a precursor to an amino acid that fights depression. I haven't started my taper yet, but since taking NAC, I seem to have more energy and motivation, which is symptom relief I never got from an antidepressant. I also take lots of omega-3. What do others think? Have you had any other success with supplements?

Stopped Prozac from 3mg, Mar 3  2014

Stopped Effexor Dec 10th; Started 10mg Prozac

Reinstated Effexor 15mg on Nov. 18th, 2013

Stopped from 21mg on Oct. 22nd, 2013
Effexor 112.5mg, since Dec. 8, 2012
Stopped Zoloft cold turkey ( from 50mg), Nov. 2012
Zoloft 100mg, Sept.- Nov. 2012

Other medications/supplements: 2x500mg metformin (pcos), 1,200mg NAC, 1,800mg Omega-3, vitamin E and vitamin C


#17 compsports

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Posted 03 April 2013 - 11:40 AM

I started taking it because I read that it has anti-oxidant benefits that help damage caused by stress and that it is a precursor to an amino acid that fights depression. I haven't started my taper yet, but since taking NAC, I seem to have more energy and motivation, which is symptom relief I never got from an antidepressant. I also take lots of omega-3.

What do others think? Have you had any other success with supplements?


Hi Finn,

I am glad NAC is working for you.

I have thought about taking it because it is supposed to be helpful in fighting the affects of sleep apnea. But because I have had reactions to so called harmless supplements, I am very reluctant to take it.

I have had the best luck with fish oil, cal/mag, cod liver/butter oil.

CS
Drug cocktail 1995 - 2006
Tapered off of Adderall, Wellbutrin XL, Remeron, and Doxepin for nearly 4 years
Drug free since June 10, 2010

#18 Barbarannamated

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Posted 03 April 2013 - 11:56 AM

In case anyone else is also unfamiliar with NAC, posting link to brief article by Emily Deans, MD, in Psychology Today: http://m.psychologyt...lems-i-have-nac Tangentially, I found this statement very disturbing: "As a specialist I am required by medical convention to stick to the brain and keep my little nose out of other parts of the body... but NAC has some interesting properties in the noggin as well." Therein lies the problem with medicine.

Pristiq tapered over 8 months ending Spring 2011 after 18 years of polydrugging that began w/Zoloft for fatigue/general malaise (not mood). 
CURRENT: 1mg Klonopin qhs (SSRI bruxism), 75mg trazodone qhs, various hormones

Litigation for 11 years for Work-related injury, settled 2004. Involuntary medical retirement in 2001 (age 39). 
2012 - brain MRI showing diffuse, chronic cerebrovascular damage/demyelination possibly vasculitis/cerebritis. Dx w/autoimmune polyendocrine failure.

2013 - Dx w/CNS Sjogren's Lupus (FANA antibodies first appeared in 1997 but missed by doc). 


#19 compsports

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Posted 03 April 2013 - 12:01 PM

In case anyone else is also unfamiliar with NAC, posting link to brief article by Emily Deans, MD, in Psychology Today:
http://m.psychologyt...lems-i-have-nac

Tangentially, I found this statement very disturbing:

"As a specialist I am required by medical convention to stick to the brain and keep my little nose out of other parts of the body... but NAC has some interesting properties in the noggin as well."

Therein lies the problem with medicine.


That is funny, they are allowed to prescribe drugs off label when there is no evidence they work but they are not allowed to mention supplements that might be helpful. Yup, medicine has a problem.

CS
Drug cocktail 1995 - 2006
Tapered off of Adderall, Wellbutrin XL, Remeron, and Doxepin for nearly 4 years
Drug free since June 10, 2010

#20 Barbarannamated

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Posted 03 April 2013 - 12:20 PM


In case anyone else is also unfamiliar with NAC, posting link to brief article by Emily Deans, MD, in Psychology Today:
http://m.psychologyt...lems-i-have-nac

Tangentially, I found this statement very disturbing:

"As a specialist I am required by medical convention to stick to the brain and keep my little nose out of other parts of the body... but NAC has some interesting properties in the noggin as well."

Therein lies the problem with medicine.


That is funny, they are allowed to prescribe drugs off label when there is no evidence they work but they are not allowed to mention supplements that might be helpful. Yup, medicine has a problem.


Nor *allowed* by medical convention to address how drugs they use (for given specialty / body part) effect the rest of the body...is how I read it. How many times we've been dismissed because doctors think psychotropic drugs don't effect anything below the neck..? When did the brain cease to control the body??

Ok, off my soapbox!

Pristiq tapered over 8 months ending Spring 2011 after 18 years of polydrugging that began w/Zoloft for fatigue/general malaise (not mood). 
CURRENT: 1mg Klonopin qhs (SSRI bruxism), 75mg trazodone qhs, various hormones

Litigation for 11 years for Work-related injury, settled 2004. Involuntary medical retirement in 2001 (age 39). 
2012 - brain MRI showing diffuse, chronic cerebrovascular damage/demyelination possibly vasculitis/cerebritis. Dx w/autoimmune polyendocrine failure.

2013 - Dx w/CNS Sjogren's Lupus (FANA antibodies first appeared in 1997 but missed by doc). 


#21 Finn

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Posted 03 April 2013 - 01:04 PM

Yeah, seriously. Cuz you know, the body is made of distinct parts, not one holistic, integrated system. :lol: Here's another link: http://www.livestron...and-depression/

Stopped Prozac from 3mg, Mar 3  2014

Stopped Effexor Dec 10th; Started 10mg Prozac

Reinstated Effexor 15mg on Nov. 18th, 2013

Stopped from 21mg on Oct. 22nd, 2013
Effexor 112.5mg, since Dec. 8, 2012
Stopped Zoloft cold turkey ( from 50mg), Nov. 2012
Zoloft 100mg, Sept.- Nov. 2012

Other medications/supplements: 2x500mg metformin (pcos), 1,200mg NAC, 1,800mg Omega-3, vitamin E and vitamin C


#22 Jemima

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Posted 03 April 2013 - 06:05 PM

It's probably best to avoid supplements when tapering off of antidepressants, especially stimulating ones. The only ones that seem to be almost universally helpful are high quality fish oil and magnesium, and a few people here have found that even the fish oil is too stimulating. Right now your mind and body are numbed to some extent from Effexor, but once you begin tapering it will likely be a different story. People who taper off of antidepressants generally find that many things that had never bothered them before will be over-stimulating during withdrawal.

Psychotropic drug history: Pristiq 50 mg. time-released (mid-September 2010 through February 2011), Remeron (mid-September 2010 through January 2011), Lexapro 10 mg. (mid-February 2011 through mid-December 2011), Lorazepam (Ativan) 1 mg. as needed mid-September 2010 through early March 2012

"Never attribute to malice that which is adequately explained by stupidity." -Hanlon's Razor


Introduction: http://survivinganti...oducing-jemima/

Please note that I am not a medical professional and my advice is based on personal experience, reading, and anecdotal information posted by other sufferers.


#23 compsports

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Posted 04 April 2013 - 01:30 AM



In case anyone else is also unfamiliar with NAC, posting link to brief article by Emily Deans, MD, in Psychology Today:
http://m.psychologyt...lems-i-have-nac

Tangentially, I found this statement very disturbing:

"As a specialist I am required by medical convention to stick to the brain and keep my little nose out of other parts of the body... but NAC has some interesting properties in the noggin as well."

Therein lies the problem with medicine.


That is funny, they are allowed to prescribe drugs off label when there is no evidence they work but they are not allowed to mention supplements that might be helpful. Yup, medicine has a problem.


Nor *allowed* by medical convention to address how drugs they use (for given specialty / body part) effect the rest of the body...is how I read it. How many times we've been dismissed because doctors think psychotropic drugs don't effect anything below the neck..? When did the brain cease to control the body??

Ok, off my soapbox!


Nah, don't leave :lol:

Great point as ironically we keep hearing the propaganda that you can't separate the brain from the rest of the body. But yet, when it suits the purpose of psychiatry, it is ok to do that.

CS
Drug cocktail 1995 - 2006
Tapered off of Adderall, Wellbutrin XL, Remeron, and Doxepin for nearly 4 years
Drug free since June 10, 2010

#24 Barbarannamated

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Posted 04 April 2013 - 09:07 AM

Thanks for your posts. I'm in an exceptionally bad mind space right now and felt guilty all night for shanghaiing the NAC topic.

Pristiq tapered over 8 months ending Spring 2011 after 18 years of polydrugging that began w/Zoloft for fatigue/general malaise (not mood). 
CURRENT: 1mg Klonopin qhs (SSRI bruxism), 75mg trazodone qhs, various hormones

Litigation for 11 years for Work-related injury, settled 2004. Involuntary medical retirement in 2001 (age 39). 
2012 - brain MRI showing diffuse, chronic cerebrovascular damage/demyelination possibly vasculitis/cerebritis. Dx w/autoimmune polyendocrine failure.

2013 - Dx w/CNS Sjogren's Lupus (FANA antibodies first appeared in 1997 but missed by doc). 


#25 compsports

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Posted 04 April 2013 - 09:22 AM

Thanks for your posts. I'm in an exceptionally bad mind space right now and felt guilty all night for shanghaiing the NAC topic.


I am sorry to hear that Barb and hope things improve.

CS
Drug cocktail 1995 - 2006
Tapered off of Adderall, Wellbutrin XL, Remeron, and Doxepin for nearly 4 years
Drug free since June 10, 2010

#26 Finn

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Posted 04 April 2013 - 09:46 AM

Thanks for your posts. I'm in an exceptionally bad mind space right now and felt guilty all night for shanghaiing the NAC topic.


Hugs to you. I hope you feel better soon. We're here to listen and not judge.

Stopped Prozac from 3mg, Mar 3  2014

Stopped Effexor Dec 10th; Started 10mg Prozac

Reinstated Effexor 15mg on Nov. 18th, 2013

Stopped from 21mg on Oct. 22nd, 2013
Effexor 112.5mg, since Dec. 8, 2012
Stopped Zoloft cold turkey ( from 50mg), Nov. 2012
Zoloft 100mg, Sept.- Nov. 2012

Other medications/supplements: 2x500mg metformin (pcos), 1,200mg NAC, 1,800mg Omega-3, vitamin E and vitamin C


#27 Finn

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Posted 06 April 2013 - 09:04 AM

Thanks for integrating my posts with the other information on the supplement. I found the dosing information very helpful. I was actually taking 3 of the 600mg pills daily, which I now understand might be way too much. But in the research studies, they were using around 2000mg, which is approximately 3 x 600mg. Long story short, I am very agitated! I will cut down to one a day, though, especially as I start tapering and trying to stabilize what I put into my body.

Stopped Prozac from 3mg, Mar 3  2014

Stopped Effexor Dec 10th; Started 10mg Prozac

Reinstated Effexor 15mg on Nov. 18th, 2013

Stopped from 21mg on Oct. 22nd, 2013
Effexor 112.5mg, since Dec. 8, 2012
Stopped Zoloft cold turkey ( from 50mg), Nov. 2012
Zoloft 100mg, Sept.- Nov. 2012

Other medications/supplements: 2x500mg metformin (pcos), 1,200mg NAC, 1,800mg Omega-3, vitamin E and vitamin C


#28 Altostrata

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Posted 06 April 2013 - 11:20 AM

I don't know how they managed to get 2000mg NAC into those people in the study. It sure didn't agree with me.
This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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#29 Finn

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Posted 07 April 2013 - 07:43 AM

It must just be an individual difference thing. Some people can stomach more without stomach upset. For the study, they probably eliminated all the people who couldn't handle the dose. Personally, it never bugged my stomach at all, even when I took two 600mg pills at once.

Stopped Prozac from 3mg, Mar 3  2014

Stopped Effexor Dec 10th; Started 10mg Prozac

Reinstated Effexor 15mg on Nov. 18th, 2013

Stopped from 21mg on Oct. 22nd, 2013
Effexor 112.5mg, since Dec. 8, 2012
Stopped Zoloft cold turkey ( from 50mg), Nov. 2012
Zoloft 100mg, Sept.- Nov. 2012

Other medications/supplements: 2x500mg metformin (pcos), 1,200mg NAC, 1,800mg Omega-3, vitamin E and vitamin C


#30 Altostrata

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Posted 08 April 2013 - 11:50 AM

I believe it can be helpful if you can tolerate it.
This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.