Jump to content

If you find useful information here, your gift would help keep this site going. Our staff is entirely volunteer.

Photo
* * * * * 1 votes

Tips for tapering off Wellbutrin, IR, SR, XR, XL (bupropion)


  • Please log in to reply
95 replies to this topic

#37 findingme

findingme

    Member

  • Members
  • PipPip
  • 39 posts
  • LocationCT

Posted 20 November 2013 - 04:43 PM

I am feeling fairly even ...not "jazzed" , not high, not low... If I feel any "lean" toward sadness, I go outside in the sun or exercise on my treadmill... that helps me stay grounded... overall the taper is going very well...

Since approximately 1992

have been on and off Paxil , Prozac(had a horrible reaction), Lorazepam , Celexa, Lexapro, Risperdal ( which was supposed to "kick start" the Lexapro) , and Wellbutrin...

By 2013, I was only on Wellbutrin and generic Lexapro ( 20mg)

I weaned successfully off the Wellbutrin, but by the time I was down to 10mg Lexapro, I suffered panic attacks on bridges, and creeping depression ,

July 2014, reinstated 20 mg generic Lexapro


#38 Altostrata

Altostrata

    Administrator

  • Administrators
  • PipPipPipPipPipPip
  • 24,005 posts
  • LocationSan Francisco, CA

Posted 21 November 2013 - 04:54 PM

I would hold for another week and then make your next decrease of 18.75mg. I wouldn't make decreases any faster than every 2 weeks.
This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

#39 LightEmergesFromDarkness

LightEmergesFromDarkness

    Member

  • Members
  • PipPip
  • 13 posts
  • LocationUSA

Posted 13 December 2013 - 12:38 PM

just want to add to the conversation here. i had been taking Wellbutrin XL (the generic) at a lower dose of 75 mgs, once per day from 2007 up until 2012. before that i used to take it at 300 mgs once per day as prescribed until the side effects became too bothersome for me. anyways just want to say that i have been reading a variety of articles and books that all seem to agree that Wellbutrin can sometimes be used off-label to treat ADHD? and is considered to be a psycho-stimulant? i have a concern with this because my pdoc had been giving me Wellbutrin for yrs on end and never told me that it had stimulant properties to it! i always wondered why Wellbutrin had a false-positive for amphetimines on drug tests! the reason that i did a rapid taper of my Wellbutrin was because in the fall of 2012, i noticed myself starting to become hypo-manic-like. i immediately told my pdoc about this and he did not seem that worried. that was a major red-flag to me because my dx is bipolar NOS. he did want to updose my Depakote, which i was not okay with for fear that it would aggravate my hypothyroidism even further. my line of thinking was why not just get rid of the offending agent, which is the antidepressant. 



#40 Altostrata

Altostrata

    Administrator

  • Administrators
  • PipPipPipPipPipPip
  • 24,005 posts
  • LocationSan Francisco, CA

Posted 13 December 2013 - 03:33 PM

Chemically, Wellbutrin is related to amphetamine.

 

It is very well-known to be stimulating. Common side effects are nervousness, agitation, and sleeplessness.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

#41 max750

max750

    Getting started

  • Members
  • Pip
  • 1 posts
  • LocationCroatia

Posted 14 January 2014 - 09:02 AM

I'm currently taking Wellbutrin XR 150 mg every morning. I would cut the pills and taper off slowly, but the problem is that in Croatia where I live, only the XR version of Wellbutrin is available and I am not able to switch to other versions.

 

You said that even the XR pills can be cut, but then they turn to immediate release version. Since that is the case, what would you recommend me? How would you cut the pill and how many times a day would you take it? I repeat that only Wellbutrin XR 150 mg is available to me.

 

If anyone has a suggestion, PLEASE HELP!!!! Because, when I tried to stop drinking Wellbutrin 150 mg I felt terrible.



#42 Meimeiquest

Meimeiquest

    Platinum star

  • Members
  • PipPipPipPipPip
  • 2,879 posts
  • LocationSpring Hill, TN

Posted 14 January 2014 - 09:41 AM

Google-glancing, it looks like the generic, buproprion, is available as SR (sustained release). It would normally be dosed twice a day, and can be cut, and I assume, be crushed and suspended in liquid. I have done everything physically possible to the XL...hopeless.
1st round Prozac 1989/90, clear depression symptoms. 2nd round Prozac started 1999 when admitted to dr. I was tired. Prozac pooped out, switch to Cymbalta 3/2006. Diagnosed with bipolar disorder due to mania 6/2006--then I was taken abruptly off Cymbalta and didn't know I had SSRI withdrawal. Lots of meds for my intractable "bipolar" symptoms.
Zyprexa started about 9/06, mostly 5mg. Tapered 4/12 through12/29/12
Wellbutrin. XL 300 mg started 1/07, tapered 1/18/13 through 7/8/13
Oxazepam mostly continuously since 6/06, 30mg since 12/12, tapered 1.17.14 through 8.26.15
11/06 Lithium 600mg twice daily, 2.2.14 400mg TID DIY liquid, 2.12.14 1150mg, 3.2.14 1100mg, 3.18.14 1075mg, 4/14 updose to 1100mg, 6.1.14 900 mg capsules 7.8.14 810mg, 8.17.14 725mg, 8.24.24 700mg...10.22.14 487.5mg, 3.9.15 475mg, 4.1.15 462.5mg 4.21.15 450mg 8.11.15 375mg, 11.28.15 362.5mg, back to 375mg four days later, 3.4.16 updose to 475 (too much going on to risk trouble)
9/4/13 Toprol-XL 25mg daily for sudden hypertension, tapered 11.12.13 through 5.3.14, last 10 days or so switched to atenolol
7.4.14 Started Walsh Protocol
56 years old

#43 Altostrata

Altostrata

    Administrator

  • Administrators
  • PipPipPipPipPipPip
  • 24,005 posts
  • LocationSan Francisco, CA

Posted 14 January 2014 - 09:44 AM

See the first post in this topic.

 

You can cut up Wellbutrin XR; it reverts to regular Wellbutrin, which is taken twice a day.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

#44 findingme

findingme

    Member

  • Members
  • PipPip
  • 39 posts
  • LocationCT

Posted 08 February 2014 - 04:52 AM

Hi Everyone,

Has anyone else had trouble with weight gain when tapering off Wellbutrin?....

I started tapering off my 150 XL/day  about 4 mos ago...

I am now down to 1/6th of a 75mg immediate release ,,, so about 12.5mg...

My mood has been good, but I am noticing a definite weight gain...

I am still on 20 mg/day of Lexapro ... and won't begin that taper til I'm totally free of the Wellbutrin...

In the meantime , if anyone has any ideas, I'm

forever thnakful for this site,

Findingme 


Since approximately 1992

have been on and off Paxil , Prozac(had a horrible reaction), Lorazepam , Celexa, Lexapro, Risperdal ( which was supposed to "kick start" the Lexapro) , and Wellbutrin...

By 2013, I was only on Wellbutrin and generic Lexapro ( 20mg)

I weaned successfully off the Wellbutrin, but by the time I was down to 10mg Lexapro, I suffered panic attacks on bridges, and creeping depression ,

July 2014, reinstated 20 mg generic Lexapro


#45 Altostrata

Altostrata

    Administrator

  • Administrators
  • PipPipPipPipPipPip
  • 24,005 posts
  • LocationSan Francisco, CA

Posted 08 February 2014 - 12:07 PM

A side effect of Wellbutrin is appetite suppression -- it is chemically related to amphetamine. Coming off Wellbutrin could cause a rebound in appetite.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

#46 greenwell3977

greenwell3977

    Member

  • Members
  • PipPip
  • 34 posts
  • LocationUnited States

Posted 15 February 2014 - 12:06 PM

Hello. I am currently taking 100 mg of Bupropion SR in the morning and about 70 mg at night. For my next taper, should I cut the morning pill or afternoon pill? I prefer cutting the afternoon pill again so I can sleep better but this may cause an imbalance where I'm taking a higher dosage in the beginning of the day vs the end of the day. How important is it that the two SR doses are relatively equally in mgs? If an imbalance is okay, how big can this imbalance be for the SR? Thanks!

Serzone (Nefadazone) and Wellbutrin (Buoproprin) for over ten years
Nefazadone Starting Point 150 mg
12/2 135 mg, 12/16 130 mg, 12/21 125 mg, 12/24 120 mg, 1/5 110 mg, 1/26 100 mg, 2/9 90 mg, 3/1 80 mg, 3/22 70 mg, 4/12 60 mg
5/3 50 mg, 5/15 55 mg, 8/15 70 mg, 10/15 90 mg, 11/1/12 100 mg, 10/1/13 90 mg, 10/15/13 85 mg, 10/20/13 90 mg, 3/29/15 16 mg

Buproprin Starting Point 300 mg

5/1/13 270, 5/15/13 240, 6/1/13 230, 6/15/13 200, 7/1/13 185, 7/20/13 170, 8/20/13 185, 3/29/15 170

 

 


#47 Altostrata

Altostrata

    Administrator

  • Administrators
  • PipPipPipPipPipPip
  • 24,005 posts
  • LocationSan Francisco, CA

Posted 15 February 2014 - 12:10 PM

By how much are you going to reduce?
This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

#48 greenwell3977

greenwell3977

    Member

  • Members
  • PipPip
  • 34 posts
  • LocationUnited States

Posted 15 February 2014 - 12:49 PM

About 20mg, which would be close to 10% of the total.


Serzone (Nefadazone) and Wellbutrin (Buoproprin) for over ten years
Nefazadone Starting Point 150 mg
12/2 135 mg, 12/16 130 mg, 12/21 125 mg, 12/24 120 mg, 1/5 110 mg, 1/26 100 mg, 2/9 90 mg, 3/1 80 mg, 3/22 70 mg, 4/12 60 mg
5/3 50 mg, 5/15 55 mg, 8/15 70 mg, 10/15 90 mg, 11/1/12 100 mg, 10/1/13 90 mg, 10/15/13 85 mg, 10/20/13 90 mg, 3/29/15 16 mg

Buproprin Starting Point 300 mg

5/1/13 270, 5/15/13 240, 6/1/13 230, 6/15/13 200, 7/1/13 185, 7/20/13 170, 8/20/13 185, 3/29/15 170

 

 


#49 Altostrata

Altostrata

    Administrator

  • Administrators
  • PipPipPipPipPipPip
  • 24,005 posts
  • LocationSan Francisco, CA

Posted 15 February 2014 - 03:37 PM

If your sleep has been destabilized by past reductions, you may wish to taper by a smaller amount.

 

Since immediate-release buproprion has such a short half-life, it's taken twice a day or more. If you take the major portion in the early part of the day, you run the risk of having withdrawal symptoms later or at night.

 

However, it makes sense to take a smaller amount in the evening to reduce the stimulating effect when you're trying to sleep.

 

Everyone's different, so you might be able to get by with 100mg in the morning and 60mg in the evening. Next time around, you might want to make the reduction in the daytime dose.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

#50 Rhiannon

Rhiannon

    Platinum star

  • Moderators
  • 3,783 posts
  • LocationPacific Northwest US

Posted 12 August 2014 - 12:48 PM

Bumping for a friend.

 

Also, can the immediate release tablets be made into a liquid for tapering? Do they dissolve okay?

 

Also, how have people done with taking a larger amount earlier in the day and less later in the day, in order to reduce stimulation before sleep time?


Started on Prozac and Xanax in 1992 for PTSD after an assault. One drug led to more, the usual story. Got sicker and sicker, but believed I needed the drugs for my "underlying disease" as I was told. Long and tragic story...lost everything. Life savings, home, physical and mental health, relationships, friendships, ability to work, everything.

 

Now tapering, ironically (but not surprisingly) healthier and more functional than I ever was during the years on the "meds," even with withdrawal (usually fairly mild at this slow pace).

 

Started multidrug taper in Feb 2010.  Doing a very slow microtaper, down to low doses now and feeling SO much better, getting my old personality and my brain back! Able to work full time, have a full social life, and cope with stress better than ever. Not perfect, but much better. After 23 lost years. Big Pharma has a lot to answer for. And "medicine for profit" is just not a great idea.

 

Feb 15 2010:  300 mg Neurontin  200 Lamictal   10 Celexa      0.65 Xanax   and 5 mg Ambien 

Feb 14 2011:   86 mg Neurontin   144 Lamictal,    5.5 Celexa   0.42 Xanax      1.9 mg Valium

Feb 16 2012:   10 mg Neurontin   115 Lamictal     3.7 Celexa   0.285 Xanax     2.0 Valium

Feb 22 2013:   86 Lamictal    2.05 Celexa       0.23 Xanax      1.8 Valium

Feb 10 2014:   62 Lamictal    1.1 Celexa         0.135 Xanax    1.8 Valium

Feb 10 2015:   50 Lamictal      0.875 Celexa    0.11 Xanax      1.5 Valium

Feb 15 2016:   47.5 Lamictal   0.75 Celexa      0.0875 Xanax    1.42 Valium    

Now:                43                    0.625                 0.0775            1.3

 

I'm not a doctor. Any advice I give is just my civilian opinion.


#51 Meimeiquest

Meimeiquest

    Platinum star

  • Members
  • PipPipPipPipPip
  • 2,879 posts
  • LocationSpring Hill, TN

Posted 12 August 2014 - 03:17 PM

Anything but XL can be made into a solution. It seemed they dissolved with some white coloring from filler left in the water. Yes, uneven dosing for sleep reasons can and has been done.
1st round Prozac 1989/90, clear depression symptoms. 2nd round Prozac started 1999 when admitted to dr. I was tired. Prozac pooped out, switch to Cymbalta 3/2006. Diagnosed with bipolar disorder due to mania 6/2006--then I was taken abruptly off Cymbalta and didn't know I had SSRI withdrawal. Lots of meds for my intractable "bipolar" symptoms.
Zyprexa started about 9/06, mostly 5mg. Tapered 4/12 through12/29/12
Wellbutrin. XL 300 mg started 1/07, tapered 1/18/13 through 7/8/13
Oxazepam mostly continuously since 6/06, 30mg since 12/12, tapered 1.17.14 through 8.26.15
11/06 Lithium 600mg twice daily, 2.2.14 400mg TID DIY liquid, 2.12.14 1150mg, 3.2.14 1100mg, 3.18.14 1075mg, 4/14 updose to 1100mg, 6.1.14 900 mg capsules 7.8.14 810mg, 8.17.14 725mg, 8.24.24 700mg...10.22.14 487.5mg, 3.9.15 475mg, 4.1.15 462.5mg 4.21.15 450mg 8.11.15 375mg, 11.28.15 362.5mg, back to 375mg four days later, 3.4.16 updose to 475 (too much going on to risk trouble)
9/4/13 Toprol-XL 25mg daily for sudden hypertension, tapered 11.12.13 through 5.3.14, last 10 days or so switched to atenolol
7.4.14 Started Walsh Protocol
56 years old

#52 mlrp

mlrp

    Silver star

  • Members
  • PipPipPip
  • 250 posts
  • LocationWashington DC

Posted 13 August 2014 - 05:12 AM

I've been successfully dissolving my 75 mg. tablets in 75 ml. of water prior to portioning out for dosing. The tablet takes about 30 min to dissolve, and the resulting liquid is cloudy white. Tastes pretty bad - very bitter. I chase my dose with water or juice.

 

It takes some getting used to, but the process is much easier than I had anticipated. Wish I had dosed this way (for accuracy) from the start of my w/d.


04/2013 diagnoses: severe insomnia, major depressive disorder, anxiety disorder, agoraphobia. PTSD (my diagnosis)

Original scripts: 30 mg mirtazapine (Remeron) (1x day), 75 mg Bupropion HCL (Wellbutrin) (2x day), and 0.5 lorazepam (1x day or as needed)

05/05/14: Onset of acute Wellbutrin withdrawal symptoms after haphazard "taper" of 6-8 wks.

05/10/14: Joined this site.

05/11/14: Reinstated approx. 25 mg Wellbutrin (1x day)

05/14/14: Switched to 12.5 mg Wellbutrin (2x day)

06/28/14: Changed lorazepam dosing to .25 mg 2x a day - seems to be reducing anxiety flare-ups

07/28/14: Dosing Wellbutrin in a (home made) solution form 12.5 mg (2x day) 08/15/14: Remeron 28 25.2 22.7 20.5 18.5 16.7 15.1 13.6 mg (home made) solution

05/16/15: Have been dosing lorazepam at .5 mg in the morning, .25 mg in the afternoon, and .25 mg at bedtime. Anxiety has increased somewhat, possibly due to tolerance.

 

 

 


#53 Altostrata

Altostrata

    Administrator

  • Administrators
  • PipPipPipPipPipPip
  • 24,005 posts
  • LocationSan Francisco, CA

Posted 16 August 2014 - 02:43 PM

Where's the Like button!


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

#54 Rhiannon

Rhiannon

    Platinum star

  • Moderators
  • 3,783 posts
  • LocationPacific Northwest US

Posted 16 August 2014 - 06:44 PM

I know, right? Thanks you guys!


Started on Prozac and Xanax in 1992 for PTSD after an assault. One drug led to more, the usual story. Got sicker and sicker, but believed I needed the drugs for my "underlying disease" as I was told. Long and tragic story...lost everything. Life savings, home, physical and mental health, relationships, friendships, ability to work, everything.

 

Now tapering, ironically (but not surprisingly) healthier and more functional than I ever was during the years on the "meds," even with withdrawal (usually fairly mild at this slow pace).

 

Started multidrug taper in Feb 2010.  Doing a very slow microtaper, down to low doses now and feeling SO much better, getting my old personality and my brain back! Able to work full time, have a full social life, and cope with stress better than ever. Not perfect, but much better. After 23 lost years. Big Pharma has a lot to answer for. And "medicine for profit" is just not a great idea.

 

Feb 15 2010:  300 mg Neurontin  200 Lamictal   10 Celexa      0.65 Xanax   and 5 mg Ambien 

Feb 14 2011:   86 mg Neurontin   144 Lamictal,    5.5 Celexa   0.42 Xanax      1.9 mg Valium

Feb 16 2012:   10 mg Neurontin   115 Lamictal     3.7 Celexa   0.285 Xanax     2.0 Valium

Feb 22 2013:   86 Lamictal    2.05 Celexa       0.23 Xanax      1.8 Valium

Feb 10 2014:   62 Lamictal    1.1 Celexa         0.135 Xanax    1.8 Valium

Feb 10 2015:   50 Lamictal      0.875 Celexa    0.11 Xanax      1.5 Valium

Feb 15 2016:   47.5 Lamictal   0.75 Celexa      0.0875 Xanax    1.42 Valium    

Now:                43                    0.625                 0.0775            1.3

 

I'm not a doctor. Any advice I give is just my civilian opinion.


#55 Rhiannon

Rhiannon

    Platinum star

  • Moderators
  • 3,783 posts
  • LocationPacific Northwest US

Posted 04 September 2014 - 10:02 AM

How gradually should I taper buproprion?
There is little information about tapering off Wellbutrin, probably because it is assumed not much of a taper is needed.

As with all other psychiatric medications, do not skip doses to taper. If you're susceptible to withdrawal symptoms, this is an excellent way to trigger them.

Personally, I found a 50mg taper per week to be sufficiently gradual. If you wish to be more cautious, you may wish to taper at 25mg every two weeks, cutting up 100mg immediate-release or sustained-release tablets into quarters (see below).

If you get withdrawal symptoms when tapering by 25mg-50mg every 2 weeks, reduce the amount of your dosage decrease and extend the tapering interval to 4 weeks.

I tapered off 50mg at a time, probably for a week at each level, or even faster, because I had adverse effects (blood pressure spikes). (I found this is a small decrease for bupropion. I found ramping up on it a lot harder.)
 

 

Alto, I am concerned about this advice. I know it went well for you, and apparently it has for some people, but I've seen several people now who have done poorly with these fast tapers off Wellbutrin. Most recently Addax dropped about 80% of her dose in two months and she's having some nasty withdrawal symptoms. I myself never tapered Wellbutrin in a systematic fashion but I did 50% cuts many times and got sick every time. And I'm working with a friend now who finds Wellbutrin every bit as challenging to taper as any SSRI.

 

Since we have no actual data on Wellbutrin withdrawal, only our collection of anecdotal experiences, and not really all that many of those where Wellbutrin is concerned, it's really hard to predict how any given individual is going to do.

 

Given our overall harm reduction philosophy here, I think it might be advisable to give more conservative advice. Perhaps we could suggest that people start with a 10% cut and hold for 4 weeks, the usual thing, and if they have absolutely no problem they can then ramp it up to bigger cuts and/or shorter holds, ramping up incrementally to their optimal taper speed, with the usual "listen to your body, we're all different" advice.

 

(This would be assuming there's no pressing medical need to get off faster, as usual with all of them.)


Started on Prozac and Xanax in 1992 for PTSD after an assault. One drug led to more, the usual story. Got sicker and sicker, but believed I needed the drugs for my "underlying disease" as I was told. Long and tragic story...lost everything. Life savings, home, physical and mental health, relationships, friendships, ability to work, everything.

 

Now tapering, ironically (but not surprisingly) healthier and more functional than I ever was during the years on the "meds," even with withdrawal (usually fairly mild at this slow pace).

 

Started multidrug taper in Feb 2010.  Doing a very slow microtaper, down to low doses now and feeling SO much better, getting my old personality and my brain back! Able to work full time, have a full social life, and cope with stress better than ever. Not perfect, but much better. After 23 lost years. Big Pharma has a lot to answer for. And "medicine for profit" is just not a great idea.

 

Feb 15 2010:  300 mg Neurontin  200 Lamictal   10 Celexa      0.65 Xanax   and 5 mg Ambien 

Feb 14 2011:   86 mg Neurontin   144 Lamictal,    5.5 Celexa   0.42 Xanax      1.9 mg Valium

Feb 16 2012:   10 mg Neurontin   115 Lamictal     3.7 Celexa   0.285 Xanax     2.0 Valium

Feb 22 2013:   86 Lamictal    2.05 Celexa       0.23 Xanax      1.8 Valium

Feb 10 2014:   62 Lamictal    1.1 Celexa         0.135 Xanax    1.8 Valium

Feb 10 2015:   50 Lamictal      0.875 Celexa    0.11 Xanax      1.5 Valium

Feb 15 2016:   47.5 Lamictal   0.75 Celexa      0.0875 Xanax    1.42 Valium    

Now:                43                    0.625                 0.0775            1.3

 

I'm not a doctor. Any advice I give is just my civilian opinion.


#56 Altostrata

Altostrata

    Administrator

  • Administrators
  • PipPipPipPipPipPip
  • 24,005 posts
  • LocationSan Francisco, CA

Posted 04 September 2014 - 03:00 PM

Rhi, I agree it's a tricky subject. I've revised post #1.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

#57 areyouthere

areyouthere

    Silver star

  • Members
  • PipPipPip
  • 943 posts
  • Locationmidwest

Posted 06 September 2014 - 05:59 AM

I would like to concur that Wellbutrin may not be as easy to taper from than other SSRIs. I tapered by 50 % in a month and would not recommend it.

 

RU


Fall 1995 xanax, zoloft. switched to Serzone
1996- spring 2003serzone/ xanax/ lightbox.
b]Fall 2003- Fall 2004? Lexapro 10 mg. Light box /4 mg. xanax.[/b]
2004 - Fall of 2009 10 mg Lex, 150 mg Wellbutrin XL % 4 mg xanax
November 2009- Sept. 2011 10 mg lex., 300 Well. XL, 4 mg Xanax [/b
Sept.2012- July 2012 20 mg Lex 300 Well. XL, 4 mg Xanax
My mantra " go slow & with the flow "
3/2/13.. Began equal dosing 5 Xs /day xanax, while simultaneously incorporating a 2.5 % drop ( from 3.5 mg/day to 3.4 mg/day)

4/6/13 dropped from 300 mg. Wellbutrin XL to 150 mg. Difficult but DONE! Down to 3.3 mg xanax/ day / 6/10/13 3 mg xanax/day; 7/15/2013 2.88mg xanax/day.
10/ 1/2013...... 2.5 mg xanax… ( switched to tablets again) WOO HOO!!!!!! Holding here… cont. with Lexapro.
1/ 2/2014.. tapered to 18mg ( by weight) of a 26 mg ( by weight) pill of 20 mg tab. lexapro. goal is 13mg (by weight OR 10 mg by ingredient content) and STOPPED. Feeling very down with unbalanced, unpredictable WD symptoms.
1/2/2014- ??? Taking a brain-healing break from tapering anything after actively tapering something for 1.5 years. So… daily doses as of 2/2/2014: 18 mg by weight Lex, 150 mg Well. XL, 2.5 mg xanax, down from 26 mg by weight Lex., 300 mg well. XL, 4 mg xanax in August, 2012. I'll take it. :) 5/8/14 started equivalent dose liquid./ tabs. 5/13/14 1.5 % cut.

#58 Altostrata

Altostrata

    Administrator

  • Administrators
  • PipPipPipPipPipPip
  • 24,005 posts
  • LocationSan Francisco, CA

Posted 06 September 2014 - 03:01 PM

No, I believe Wellbutrin is easier to taper than the other antidepressants but, as with Prozac, some people still need to go slowly. Since we can't predict who can do a faster taper, it's prudent to start with a small reduction.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

#59 HikingAlong

HikingAlong

    Getting started

  • Members
  • Pip
  • 7 posts
  • LocationOregon

Posted 07 September 2014 - 08:24 PM

Tapering Wellbutrin might be easy for some, but it's been the most difficult AD for me to taper from, by far. And I don't think it's fair to call it a weak antidepressant, just different.

 

A month ago, I switched over from XL to immediate release in preparation for tapering, and have had headaches, sleeplessness, sleepiness, tremors, crying jags, hopelessness, deja vu, and worst of all, suicidality for the first time in years. Ah, death wish, I did not miss you.

 

My symptoms this week are just dizziness, confusion and fog. Or are they the same thing?

 

HA


1984 Elavil, then Zoloft, followed by wellbutrin, elavil, other ADs

1995 wellbutrin. Light therapy in winter.

2000-2002 Tapered wellbutrin very very slowly

2003-2008 No ADs, no therapy. Felt good, vital, motivated.

2008-July 2014 citalopram, escitalipram, zoloft, 300 mg wellbutrin, XL

August 2014      300 mg wellbutrin, immediate    1200 mg neurontin     200 mg tramadol

Sept 13, 2014    275mg                                        1200                          200

April 15, 2015    175 mg                                       1050                          200
June 15, 2015    150 mg                                       900                           200
April 18, 2017     112 mg                                       600                            150

Treating depression with FeelBright Light visor, green smoothies, green tea powder, fish oil, TDCS


#60 Meimeiquest

Meimeiquest

    Platinum star

  • Members
  • PipPipPipPipPip
  • 2,879 posts
  • LocationSpring Hill, TN

Posted 08 September 2014 - 04:27 PM

Tapering Wellbutrin might be easy for some, but it's been the most difficult AD for me to taper from, by far. And I don't think it's fair to call it a weak antidepressant, just different.
 
A month ago, I switched over from XL to immediate release in preparation for tapering, and have had headaches, sleeplessness, sleepiness, tremors, crying jags, hopelessness, deja vu, and worst of all, suicidality for the first time in years. Ah, death wish, I did not miss you.
 
My symptoms this week are just dizziness, confusion and fog. Or are they the same thing?
 
HA


Hi HA,

Are you dividing up your dose? Immediate release usually needs to be taken in three doses/day. Otherwise you will be sick from overdose part of the day and in withdrawal the rest of the day. I personally recommend using extended release (different from XL) as long as you can. It can be divided without losing its small extended-release properties. It is typically dosed twice a day. These doses need to be completed early enough in the day to allow you to sleep at night. I think I used 4 pm as a cutoff time.
1st round Prozac 1989/90, clear depression symptoms. 2nd round Prozac started 1999 when admitted to dr. I was tired. Prozac pooped out, switch to Cymbalta 3/2006. Diagnosed with bipolar disorder due to mania 6/2006--then I was taken abruptly off Cymbalta and didn't know I had SSRI withdrawal. Lots of meds for my intractable "bipolar" symptoms.
Zyprexa started about 9/06, mostly 5mg. Tapered 4/12 through12/29/12
Wellbutrin. XL 300 mg started 1/07, tapered 1/18/13 through 7/8/13
Oxazepam mostly continuously since 6/06, 30mg since 12/12, tapered 1.17.14 through 8.26.15
11/06 Lithium 600mg twice daily, 2.2.14 400mg TID DIY liquid, 2.12.14 1150mg, 3.2.14 1100mg, 3.18.14 1075mg, 4/14 updose to 1100mg, 6.1.14 900 mg capsules 7.8.14 810mg, 8.17.14 725mg, 8.24.24 700mg...10.22.14 487.5mg, 3.9.15 475mg, 4.1.15 462.5mg 4.21.15 450mg 8.11.15 375mg, 11.28.15 362.5mg, back to 375mg four days later, 3.4.16 updose to 475 (too much going on to risk trouble)
9/4/13 Toprol-XL 25mg daily for sudden hypertension, tapered 11.12.13 through 5.3.14, last 10 days or so switched to atenolol
7.4.14 Started Walsh Protocol
56 years old

#61 HikingAlong

HikingAlong

    Getting started

  • Members
  • Pip
  • 7 posts
  • LocationOregon

Posted 11 September 2014 - 09:06 PM

Thanks for the advice. I'm taking it 4 x a day, with 330 as my cutoff. Still not sleeping well, but sleeping. I see you tapered from 300 to nothing in six months? I'm wondering what's best for my brain. It took me around 1 1/2 years last time I tapered off Wellbutrin.

HA


1984 Elavil, then Zoloft, followed by wellbutrin, elavil, other ADs

1995 wellbutrin. Light therapy in winter.

2000-2002 Tapered wellbutrin very very slowly

2003-2008 No ADs, no therapy. Felt good, vital, motivated.

2008-July 2014 citalopram, escitalipram, zoloft, 300 mg wellbutrin, XL

August 2014      300 mg wellbutrin, immediate    1200 mg neurontin     200 mg tramadol

Sept 13, 2014    275mg                                        1200                          200

April 15, 2015    175 mg                                       1050                          200
June 15, 2015    150 mg                                       900                           200
April 18, 2017     112 mg                                       600                            150

Treating depression with FeelBright Light visor, green smoothies, green tea powder, fish oil, TDCS


#62 Meimeiquest

Meimeiquest

    Platinum star

  • Members
  • PipPipPipPipPip
  • 2,879 posts
  • LocationSpring Hill, TN

Posted 12 September 2014 - 08:28 AM

My situation was odd. When I went off Zyprexa I was bats*** crazy, as Amy would say. So about two weeks after I stopped it, I dropped Welllbutrin from 300 to 200mg. And until I got to low doses, I would drop because I was overstimulated, then be in WD from dropping. Rinse and repeat. Alto really saved my bacon, obviously no one else understood what was happening....I absolutely can not tolerate drugs that increase dopamine and/or norepinephrine. So that made for a fast taper. But really, I came out of it okay, it was right for me. But not right for most people. I am doing my current drugs much slower. So do what you are doing....make a change, stabilize, make another change. I don't think you can plan it out, but the more we go off and on, the slower we have to make changes to stay stable. I felt a huge difference going off the XL, I don't think that is a reason for concern.
1st round Prozac 1989/90, clear depression symptoms. 2nd round Prozac started 1999 when admitted to dr. I was tired. Prozac pooped out, switch to Cymbalta 3/2006. Diagnosed with bipolar disorder due to mania 6/2006--then I was taken abruptly off Cymbalta and didn't know I had SSRI withdrawal. Lots of meds for my intractable "bipolar" symptoms.
Zyprexa started about 9/06, mostly 5mg. Tapered 4/12 through12/29/12
Wellbutrin. XL 300 mg started 1/07, tapered 1/18/13 through 7/8/13
Oxazepam mostly continuously since 6/06, 30mg since 12/12, tapered 1.17.14 through 8.26.15
11/06 Lithium 600mg twice daily, 2.2.14 400mg TID DIY liquid, 2.12.14 1150mg, 3.2.14 1100mg, 3.18.14 1075mg, 4/14 updose to 1100mg, 6.1.14 900 mg capsules 7.8.14 810mg, 8.17.14 725mg, 8.24.24 700mg...10.22.14 487.5mg, 3.9.15 475mg, 4.1.15 462.5mg 4.21.15 450mg 8.11.15 375mg, 11.28.15 362.5mg, back to 375mg four days later, 3.4.16 updose to 475 (too much going on to risk trouble)
9/4/13 Toprol-XL 25mg daily for sudden hypertension, tapered 11.12.13 through 5.3.14, last 10 days or so switched to atenolol
7.4.14 Started Walsh Protocol
56 years old

#63 Sabina

Sabina

    Getting started

  • Members
  • Pip
  • 1 posts
  • LocationSan Diego

Posted 25 September 2014 - 10:40 AM

Due to an insurance change, there was a delay in renewing my Wellbutrin 300 XL prescription.  I've taken that dose daily for 5 years, as well as 75 mg Lamictal.  I have been off them cold turkey for eight days.

 

I started wellbutrin at the suggestion of my brother who takes it for fatigue (I've felt tired my whole life).  The lamictal was added a couple weeks later after an episode of uncontrolled crying.   I did feel an improvement in my energy level.

 

However, I am finding it harder to afford this medication, and am tired of the 'how long have you been bipolar' discussions with any medical professional to whom I disclose the prescription.  

 

Reading this forum, it seems tapering would have been the wise option.  I tried to discuss going off the meds with the (new) psychiatrist, but he was busy taking phone calls and using his computer and didn't want to do anything except refill the existing script.

 

So... should I resume taking it? At what dose? Or continue the cold turkey method?  

 

My main symptoms are sleepiness, irritability and brain fog.  Will those improve? 

 

Thanks for any input.

 

 

 

 



#64 mlrp

mlrp

    Silver star

  • Members
  • PipPipPip
  • 250 posts
  • LocationWashington DC

Posted 25 September 2014 - 12:13 PM

Sabina,

 

I suggest starting a thread for yourself in the Introductions and Updates forum and include as complete a drug history as you can (in your signature, preferably). A moderator can then weigh in on suggestions for you to consider. All I can say is, I ended up on this website in bad shape after what I thought (and was told by my pdoc) was a very conservative taper off of Wellbutrin. I crashed something like five weeks after the last dose. Knowing what I know now, I would never consider CT'ing my meds, and that is me with little time on psych drugs (compared to many here).

 

You will likely be advised to reinstate. But start a thread in Intros and wait for a mod to reply.

 

Best of luck to you!


04/2013 diagnoses: severe insomnia, major depressive disorder, anxiety disorder, agoraphobia. PTSD (my diagnosis)

Original scripts: 30 mg mirtazapine (Remeron) (1x day), 75 mg Bupropion HCL (Wellbutrin) (2x day), and 0.5 lorazepam (1x day or as needed)

05/05/14: Onset of acute Wellbutrin withdrawal symptoms after haphazard "taper" of 6-8 wks.

05/10/14: Joined this site.

05/11/14: Reinstated approx. 25 mg Wellbutrin (1x day)

05/14/14: Switched to 12.5 mg Wellbutrin (2x day)

06/28/14: Changed lorazepam dosing to .25 mg 2x a day - seems to be reducing anxiety flare-ups

07/28/14: Dosing Wellbutrin in a (home made) solution form 12.5 mg (2x day) 08/15/14: Remeron 28 25.2 22.7 20.5 18.5 16.7 15.1 13.6 mg (home made) solution

05/16/15: Have been dosing lorazepam at .5 mg in the morning, .25 mg in the afternoon, and .25 mg at bedtime. Anxiety has increased somewhat, possibly due to tolerance.

 

 

 


#65 Mjau

Mjau

    Silver star

  • Members
  • PipPipPip
  • 125 posts
  • LocationScandinavia

Posted 10 October 2014 - 02:37 AM

I'm currently taking Wellbutrin XR 150 mg every morning. I would cut the pills and taper off slowly, but the problem is that in Croatia where I live, only the XR version of Wellbutrin is available and I am not able to switch to other versions.

 

You said that even the XR pills can be cut, but then they turn to immediate release version. Since that is the case, what would you recommend me? How would you cut the pill and how many times a day would you take it? I repeat that only Wellbutrin XR 150 mg is available to me.

 

If anyone has a suggestion, PLEASE HELP!!!! Because, when I tried to stop drinking Wellbutrin 150 mg I felt terrible.

Hi Max and everybody else! This is my first post - and first of all - thank you for a great forum! :)

 

I'm in exactly the same situation as you Max. Have you succeeded with tapering?

I'm on Voxra 150 mg wich should be the same as Wellbutrin XR or XL. Does anyone know the difference between XR and XL, btw?

Was initially on Voxra 300 mg, switched to 150 mg in march this year, was very tired but now better (maybe thanks to an increased dose of Sertraline...who knows). Anyway, I will cut the pill in halfs and quarters, 75 mg in the morning and 37,5 mg later during the day. Hopefully this will work!


1997-1999 Citalopram 20 mg

1999-2014 Sertraline 50 mg

2012 Sertraline very quick taper due to side effects. Switched to Wellbutrin 150 mg-300 mg. Reinstated Sertraline 25 mg-50 mg.

2013 Exhaustion. Wellbutrin 150 mg. Sertraline 75 mg-100 mg.

Sept 2014 Found this site. Started tapering. Sertraline 87,5 mg + Wellbutrin 150 mg 

Aug 2015 No more Wellbutrin!! Sertraline 50 mg

2016 Sertraline 35 mg (January) - 33 mg (March 21st) - 32,5 mg (July 11) - 32 mg (July 27)

2017 March 28,2 mg and holding

 


#66 mammaP

mammaP

    Platinum star

  • Moderators
  • 4,079 posts
  • LocationEurope

Posted 10 October 2014 - 12:26 PM

Hi Mjau, welcome to SA,   XL and XR are extended release and taken once a day. SR is taken twice a day.

Cutting the pills makes them rapid release and should be split in to 3 or 4 doses per day.

 

It would be great if you could start a topic for yourself in the Introductions forum and we 

can get to know you.  You will get lots of support there.  :)


Edited by Altostrata, 10 October 2014 - 12:55 PM.
corrected forum

**I am not a medical professional, if in doubt please consult a doctor with withdrawal knowledge.

 

See how to create a signature here http://survivingantidepressants.org/index.php?/topic/12364-please-put-your-withdrawal-history-in-your-signature/

 

Many drugs for many years, prescribed diazepam first 1973, took occasionally. 3 or 4 tricyclics  for short periods.

1993 had a breakdown leading to 10 years of drug experiments with all classes of psych drugs.

2002  effexor. 

Tapered by counting beads from March 2012 to March 2013, ending with 5 beads.

Withdrawal April 2013 . Reinstated 5 beads reduced to 4 beads May 2013

Restarted taper  Nov 2013  

OFF EFFEXOR Feb 2015    :D 

 

Also tapered atenolol and omeprazole Dec 2013 - May 2014

 

Tapering tramadol, Feb 2015 100mg , March 2015 50mg -hold- Feb2016 46mg  March 8 2016 45 April 44mg  May 11  43mg June 14 42mg

Taking fish oil, magnesium, pro biotic.

 

My story http://survivinganti...king-in/page-33

 

Lesson learned, slow down taper at lower doses. Taper no more than 10% of CURRENT dose if possible

 

Following every sunset is a brand new day


#67 bekoshun

bekoshun

    Getting started

  • Members
  • Pip
  • 2 posts
  • LocationTustin, CA

Posted 27 October 2014 - 03:48 PM

Hi, I'm new to this site!  I'm currently taking Welbutrin SR 100mg once a day (as my dr prescribed).  I already have a year's worth of prescription for this so I'm not looking to get a different dosage.  So, if I cut the 100mg SR in half, and cut one of the 50mg pieces in half to make two 25mg pieces, it is OK to take the half (50mg) and one 25mg at the same time?  I realize this is a 25% decrease, as opposed to 10%, but I don't feel comfortable dissolving them in liquid.   :unsure:


Started Wellbutrin XL300mg in 2008 for Post Partum Depression, this was too high, made me dizzy, had horrible nightmares.

Lowered down to Wellbutrin XL150mg soon after.

Over the passed few years, I have been tapering by taking Wellbutrin SR 100mg (once a day) only one day a week and Wellbutrin XL 150mg the other 6 days of the week.  After a couple months, I would take the Wellbutrin SR 100mg (once a day) Wednesdays and Saturdays and Wellbutrin 150mg the other 5 days of the week.  Following this pattern, then I did weekends and Wednesdays, and continued to taper down until I was on 100mg of Wellbutrin SR 7 days a week.  After each taper I felt very anxious, sometimes felt like I was getting sick, nauseous, cold sweats at night, hot flashes, and trouble sleeping.  After about a month of withdrawal symptoms, I would even out and feel fine.  That's when I knew it was time for the next taper.  

I'm currently at 100mg Wellbutrin SR 7 days a week and getting ready to taper again, but not sure how to go about it.  Skipping days didn't work well for me so I am considering cutting the pills.

To help with withdrawal symptoms - Vitamin D, choline, magnesium, and B vitamins.  Yoga helps as well.  Cutting out white sugar, processed foods and grains makes a big difference too!

 


#68 Meimeiquest

Meimeiquest

    Platinum star

  • Members
  • PipPipPipPipPip
  • 2,879 posts
  • LocationSpring Hill, TN

Posted 27 October 2014 - 04:01 PM

Yes, but once you cut the tablet, the sustained release mechanism is diminished. It might work better to take the largest dose in the a.m. and the smaller dose in the early afternoon.

I never tried this with Wellbutrin, but with another drug...crush it up and divide it as evenly as you can into 10 empty capsules, take 9 for a 10 percent reduction. Or divide half a tablet into five capsules. You'll be a pharmacist by the time you're done :)

The SR tablets don't dissolve anyway, only the immediate release.
1st round Prozac 1989/90, clear depression symptoms. 2nd round Prozac started 1999 when admitted to dr. I was tired. Prozac pooped out, switch to Cymbalta 3/2006. Diagnosed with bipolar disorder due to mania 6/2006--then I was taken abruptly off Cymbalta and didn't know I had SSRI withdrawal. Lots of meds for my intractable "bipolar" symptoms.
Zyprexa started about 9/06, mostly 5mg. Tapered 4/12 through12/29/12
Wellbutrin. XL 300 mg started 1/07, tapered 1/18/13 through 7/8/13
Oxazepam mostly continuously since 6/06, 30mg since 12/12, tapered 1.17.14 through 8.26.15
11/06 Lithium 600mg twice daily, 2.2.14 400mg TID DIY liquid, 2.12.14 1150mg, 3.2.14 1100mg, 3.18.14 1075mg, 4/14 updose to 1100mg, 6.1.14 900 mg capsules 7.8.14 810mg, 8.17.14 725mg, 8.24.24 700mg...10.22.14 487.5mg, 3.9.15 475mg, 4.1.15 462.5mg 4.21.15 450mg 8.11.15 375mg, 11.28.15 362.5mg, back to 375mg four days later, 3.4.16 updose to 475 (too much going on to risk trouble)
9/4/13 Toprol-XL 25mg daily for sudden hypertension, tapered 11.12.13 through 5.3.14, last 10 days or so switched to atenolol
7.4.14 Started Walsh Protocol
56 years old

#69 bekoshun

bekoshun

    Getting started

  • Members
  • Pip
  • 2 posts
  • LocationTustin, CA

Posted 28 October 2014 - 09:51 AM

Hi Meimei, thanks for your response!  From what I've read on this site, the SR retains it's time-release when cut.  I just hope 25% isn't too big of a taper....


Started Wellbutrin XL300mg in 2008 for Post Partum Depression, this was too high, made me dizzy, had horrible nightmares.

Lowered down to Wellbutrin XL150mg soon after.

Over the passed few years, I have been tapering by taking Wellbutrin SR 100mg (once a day) only one day a week and Wellbutrin XL 150mg the other 6 days of the week.  After a couple months, I would take the Wellbutrin SR 100mg (once a day) Wednesdays and Saturdays and Wellbutrin 150mg the other 5 days of the week.  Following this pattern, then I did weekends and Wednesdays, and continued to taper down until I was on 100mg of Wellbutrin SR 7 days a week.  After each taper I felt very anxious, sometimes felt like I was getting sick, nauseous, cold sweats at night, hot flashes, and trouble sleeping.  After about a month of withdrawal symptoms, I would even out and feel fine.  That's when I knew it was time for the next taper.  

I'm currently at 100mg Wellbutrin SR 7 days a week and getting ready to taper again, but not sure how to go about it.  Skipping days didn't work well for me so I am considering cutting the pills.

To help with withdrawal symptoms - Vitamin D, choline, magnesium, and B vitamins.  Yoga helps as well.  Cutting out white sugar, processed foods and grains makes a big difference too!

 


#70 Altostrata

Altostrata

    Administrator

  • Administrators
  • PipPipPipPipPipPip
  • 24,005 posts
  • LocationSan Francisco, CA

Posted 28 October 2014 - 10:31 AM

Please read the first post in this topic http://survivinganti...roprion/?p=7534

 

Wellbutrin SR retains its time-release quality when cut up.

 

Immediate-release bupropion is a very inexpensive generic. You may wish to combine liquid made from it with Wellbutrin SR for more gradual tapering.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

#71 Meimeiquest

Meimeiquest

    Platinum star

  • Members
  • PipPipPipPipPip
  • 2,879 posts
  • LocationSpring Hill, TN

Posted 28 October 2014 - 10:37 AM

Hi Meimei, thanks for your response!  From what I've read on this site, the SR retains it's time-release when cut.  I just hope 25% isn't too big of a taper....


It does, but you will find it peters out. My dr. at the time ( never wrong, lol) is the one who said it is partially retained. Was just my experience. It is normally dosed twice daily in the typical psychiatric world.
1st round Prozac 1989/90, clear depression symptoms. 2nd round Prozac started 1999 when admitted to dr. I was tired. Prozac pooped out, switch to Cymbalta 3/2006. Diagnosed with bipolar disorder due to mania 6/2006--then I was taken abruptly off Cymbalta and didn't know I had SSRI withdrawal. Lots of meds for my intractable "bipolar" symptoms.
Zyprexa started about 9/06, mostly 5mg. Tapered 4/12 through12/29/12
Wellbutrin. XL 300 mg started 1/07, tapered 1/18/13 through 7/8/13
Oxazepam mostly continuously since 6/06, 30mg since 12/12, tapered 1.17.14 through 8.26.15
11/06 Lithium 600mg twice daily, 2.2.14 400mg TID DIY liquid, 2.12.14 1150mg, 3.2.14 1100mg, 3.18.14 1075mg, 4/14 updose to 1100mg, 6.1.14 900 mg capsules 7.8.14 810mg, 8.17.14 725mg, 8.24.24 700mg...10.22.14 487.5mg, 3.9.15 475mg, 4.1.15 462.5mg 4.21.15 450mg 8.11.15 375mg, 11.28.15 362.5mg, back to 375mg four days later, 3.4.16 updose to 475 (too much going on to risk trouble)
9/4/13 Toprol-XL 25mg daily for sudden hypertension, tapered 11.12.13 through 5.3.14, last 10 days or so switched to atenolol
7.4.14 Started Walsh Protocol
56 years old

#72 Addax

Addax

    Silver star

  • Members
  • PipPipPip
  • 561 posts
  • LocationWest Coast

Posted 05 December 2014 - 08:22 AM

After a very bad withdrawal experience I have done a great amount of reflection on my taper as well as reading and asking questions about Wellbutrin when combined with prozac. I wanted to add a note of caution here if tapering Wellbutrin while taking an SSRI.

Here is my understanding of what occurs:
It appears that when used in conjunction with an SSRI Wellbutrin will cause an increase in the plasma level of the SSRI. The basic story is Wellbutrin competes with the SSRI to be metabolized. This causes the SSRI to be metabolized more slowly, essentially causing a "back-up" and increasing the amount of SSRI in your system. It's like increasing the amount of prozac you are taking without actually taking a higher dose. This competition to be metabolized also keeps the SSRI in your system longer, or in other words, extends the half-life.

What does this mean? As I understand it it means that when you taper Wellbutrin you are inadvertently tapering your SSRI, even if you haven't decreased the actual amount of the SSRI you are taking. This means the unintentional taper of your SSRI is probably much steeper than what would be a 10% decrease. In some cases Wellbutrin appears to cause large increases in the SSRI level.

I and my new pdoc believe this is what happened to me. My large and quick drops in my Wellbutrin dose effected major drops in my blood plasma level of prozac even though I wasn't actively tapering my prozac dose at the time. This is likely to be why my withdrawal symptoms were so delayed, sudden, and extreme.

Because the relationship between the drop in Wellbutrin dose and drop in the plasma level of the SSRI can be significant but does not appear to be linear I suggest you proceed with your Wellbutrin taper with extreme caution. Be very conservative even if you feel fine while decreasing your Wellbutrin.
1988-2012: Prozac @ 60mg to treat an eating disorder. Several unsuccessful attempts to discontinue.Fall 2012: Failed attempt to discontinue then -> 40mg Prozac and added 150mg Wellbutrin.Late summer 2013:Began slower Prozac taper.Spring 2014:Got to 10mg Prozac, 75mg of Wellbutrin -April 2014: 9mg Prozac & 37.5mg Wellbutrin 2x/day -> 9mg Prozac & 25 mg Wellbutrin 2x/day->9mg Prozac 1x/day & ~8mg Wellbutrin 2x/day -> 8.1mg Prozac, 0 WellbutrinSept '14: 8.1mg Prozac -> crashed hardOct '14: 10mg ProzacNov '14: 20mg -> 30mgDec '14: 30mg, Feb 10: 27mg. Mar 7: 25mg Mar 21, 2015: 20mg. May 21, 2016: 20mg and holding strong.

My experience: http://rxisk.org/ant...a-prozac-story/