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  2. Altostrata

    Audo Effexor Reinstatement Fail?

    Why did you try to switch to a later dose of Effexor? My guess is that 1) You may be getting rebound symptoms in the morning from the Klonopin; or 2) You're not taking enough Effexor to provide coverage through the night and you're getting breakthrough withdrawal symptoms. The fix is different depending on symptom pattern. I need this info:
  3. Int J Risk Saf Med. 2018 May 9. doi: 10.3233/JRS-180018. [Epub ahead of print] SSRI and SNRI withdrawal symptoms reported on an internet forum. Stockmann T1, Odegbaro D2, Timimi S3, Moncrieff J4. Abstract at https://www.ncbi.nlm.nih.gov/pubmed/29758951 Full text requested. BACKGROUND: Antidepressant withdrawal symptoms are well-recognised, but their potential duration remains uncertain. OBJECTIVE: We aimed to describe the characteristics of withdrawal associated with two popular classes of antidepressants, including duration. METHODS: We analysed the content of a sample of posts on an antidepressant withdrawal website. We compared the characteristics of withdrawal associated with SSRIs and SNRIs, including time of onset, duration and nature of symptoms. RESULTS: 110 posts about SSRI withdrawal, and 63 concerning SNRI withdrawal, were analysed. The mean duration of withdrawal symptoms was significantly longer with SSRIs than SNRIs: 90.5 weeks (standard deviation, SD, 150.0) and 50.8 weeks (SD 76.0) respectively; p = 0.043). Neurological symptoms, such as 'brain zaps,' were more common among SNRI users (p = 0.023). Psychosexual/genitourinary symptoms may be more common among SSRI users (p = 0.054). LIMITATIONS: The website aims to help people with antidepressant withdrawal, and is therefore likely to attract people who have difficulties. Length of prior use of antidepressants was long, with a mean of 252.2 weeks (SD 250.8). CONCLUSIONS: People accessing antidepressant withdrawal websites report experiencing protracted withdrawal symptoms. There are some differences in the characteristics of withdrawal associated with different classes of antidepressants. KEYWORDS: Antidepressant; SNRI; SSRI; antidepressant withdrawal; online report
  4. Thoughtfultoo

    Very Thankful for These Boards; by Thoughtfultoo

    I could not agree with you more. And yes, the hyperaroused amygdala and hippocampus are subdued. The process takes time and effort and is in its infancy, but clinical trials are being done. Personally, since incorporating these modalities I'm starting to sleep more then three hours a night; everything spiked once I went off of Effexor and I was exhausted. Very hopeful now!
  5. Altostrata

    Tammylovesdogs Prozac & Wellbutrin

    What times of day do the headaches and anger and rage occur? When do you take your drugs? Please keep daily notes on paper about your symptoms, when you take your drugs, and their dosages. Some of your symptoms do sound like they''re withdrawal from tapering too fast. If I were you, I'd hold for a while. Many people do better with fish oil and magnesium supplements, see http://survivingantidepressants.org/index.php?/topic/36-king-of-supplements-omega-3-fatty-acids-fish-oil/ http://survivingantidepressants.org/topic/15483-magnesium-natures-calcium-channel-blocker/ A lot of people find them helpful. Try a little bit of one at a time to see how it affects you. Magnesium citrate can help with tight muscles and constipation. ^ Third request. You might have to do this on a computer.
  6. Today
  7. Yes, it is well known that antidepressants disturb sleep architecture. Doctors who are clueless will routinely prescribe benzodiazepines with antidepressants to counter this effect.
  8. Whenever you come across medical terminology that alarms you, be sure to thoroughly Google it and find out what it means from a reliable source. Universities or textbooks are good. Very often, it's not what you think it is, and if you post it here, you might unnecessarily frighten people. Here is Wikipedia's very incomplete description of irreversible antagonist We all know of people taking aspirin and omeprazole. They do not suffer permanent nerve or enzyme damage. Here is a more complete description from a pharmacology textbook: In other words, it is "irreversible" because another drug can't act on the receptors it affects. You have to wait for the "irreversible antagonist" to wear off. It does not cause permanent damage of any kind, the body gradually removes it and metabolizes it. For example, monoamine oxidase inhibitors (MAOIs) are an irreversible antagonist type of antidepressant. Doctors are cautioned to wait after a "wash out" period before starting a different antidepressant, because while the MAOI is being metabolized, it still occupies serotonin receptors and adding another serotonergic can cause serotonin toxicity. There is no question that the MAOI eventually wears off -- as do all "irreversible" antagonists. I found this out by Googling, and you can, too. Please do this so you can post good, valuable information on this site. Someone's poorly informed suppositions from another forum site do not belong in our Journals and Scientific Sources section.
  9. They seemingly improve. I actually attempted to switch to an afternoon/evening dose, but the delay not only gave me new withdrawal symptoms, but I think it destabilized me for a couple of days. It's not conclusive yet, but that's my fear and possibly a recent trend...
  10. Risilox, your nervous system is still very, very sensitive from going on and off all those drugs. Anything, even an herb, that is neuroactive might upset it. Have your symptoms changed at all since March 19? How is your sleep? How have the muscle twitches changed?
  11. powerback

    PapayaShake: Tapering Cymbalta

    HI PS sorry to hear your in so much pain .it doesn't help you but I'm having a bad day myself .I get you about the kids issue ,i don't know how you approach this because its stressful to even think about it ,I'm in a similar boat . SA Is a great tool and help but keep trying to find hope for yourself ,I read an article In madinamerica.com yesterday that gave me hope and determination . The fact your posting and reaching out means there's something still inside your soul its just tangled up in this dam mess .I had to stop listening to a podcast there because I'm exhausted and my wanting to be well is over taking my common sense so ile try find something less taxing on my brain . Nutrition and the mechanics of the body ,I recommend keep learning everything you can about your body and what works for it .# its taken this mess for me to seek spirituality . Keep at it and you are not alone . Peace.
  12. Altostrata

    PapayaShake: Tapering Cymbalta

    Hello, PapayaShake. Long time no see. What happened in your Cymbalta taper? Please update your signature. When you say you're feeling awful, what do you mean? Is it the absence of feeling?
  13. Sounds like you're taking care of yourself in a very reasonable way. It also sounds like your body does not like risperidone and you had an adverse reaction to it. The legacy of symptoms will very gradually go away. I hope you will see improvement in a month but as you've read, recovery can take a lot longer and be very frustrating. Some people are very sensitive to not having enough sleep. You may be one of these people. Please also be sure you go to bed and get up at regular hours, the nervous system likes stability and this will help it heal. Please let us know how you're doing.
  14. Let's see how it goes for a bit, Hazel. PS For further reference, breakthrough symptoms from 7.5mg Paxil indicates you are a fast metabolizer via the liver enzyme known as P450 cyp2D6.
  15. Please let us know how you're doing. If the symptoms get worse, you'll probably want to reinstate ASAP.
  16. You're welcome. Please don't taper the psychiatric drugs until the amiloride issue is settled.
  17. Altostrata

    Audo Effexor Reinstatement Fail?

    How do your symptoms change in the hours after you take Effexor? Did the Klonopin work better for a while and then not so well?
  18. PapayaShake

    PapayaShake: Tapering Cymbalta

    This days I've been feeling awful. Ironically I think, how can I feel awful if Im feeling nothing? I just want to give up, I want to end it all I don't know if this is the right place to say it but it's my reality. Its so hard to get up, so hard to do everyday tasks. I say to people around me that I am not right and they just tell me to not think about it. I think I have said it so many times that it has just become normal to hear me say it, and nobody thinks it is dangerous anymore, just the same old song. But everyday I feel like is harder and harder. Its hard to make choices, to keep trying, to set goals when you have nothing inside. And my girlfriend is now bringing the " having kids" topic. I can't t decide if I want to have children If I can't even stand myself. Just waking up seems like a big task, I can't imagine myself having children to care for. Actually I can't imagine myself doing anything. How can someone be so empty and so dead inside. I don't want anything. And I can't see the light at the end of the tunel. I am so lost I don't have words to describe the horror I'm living. I cannot se any hope Sorry I'm posting this I really don't know how what to do.
  19. You can try 0.5mg, that might be enough. People react badly to doses that are too high, don't overdo it. Please let us know how you're doing.
  20. yes i took 1mg given by doc then 1mg tablet by parents next day at home.The third time i took only half tablet because it started feeling strange.Then i left taking them and after 4 days of withdrawal the doc told i need to be shifted to psych-ward because of non-compliance,then i left home.(Guess i had it coming) No i didn't had any antipsychotic drug history just some melatonin history for anxiety sleep disorder 2 years back.(I had failed in two of my college exams) I really want to thank you all for i reached another doc 1 week back and he gave me nexiton plus tablets which he said will counter risperidone effects.I was almost going to take them but reading this website i came to know no such meds exist! I am almost 50%-60% recovered now i feel it might have to do with your site helped me so much in these manners- 1-i didnt over exert myself in working and just did enough i knew my body could tolerate in a day. 2-did some exercise daily even though i felt heavily down on doing so. 3-restrained myself from taking more respiridone or even nexiton plus but i still kept some for emergency if need be as told by the site guidelines to properly taper. 4-ate normal healthy food i knew my body could digest even though i couldn't feel my stomach at all in withdrawal period. 5-I got to know about a cousin who is taking antidepressants since last 8-9years because a doctor misdiagnosed him too and he was still believing his counter antidepressants are whats keeping him working(his life is still hell though)and expected me to do same as him.So i referred him to this website and advised him to taper off very slowly to improve his quality of life and also to solve the root cause which led him to taking these evil meds.(He had failed in his college exams 9 years back) 6-I also bought the magnesium supplement as advised and i actually felt it soothing my nerves and rejuvenating them. 7-I practically feel your site guidance might as well make me 100% normal within 1 more month as opposed to risperdalhater who had to endure 14months.Thanks for saving my life again!
  21. What could there possibly be online that would bother anyone? 🙂. Thanks for the articles. Interesting hypothesis about EMDR treatment—so it takes the hyperarousal out of the amygdala and hippocampus allowing the brain to process it. Fascinating if true. Quite the portrait of the pharmaceutical industry. Lack of oversight around prescribers has always bothered me. I believe people have good intentions, but when you set up a system where a lot of money can be made with no accountability you are just asking for trouble.
  22. SOOO glad to know you are slowly improving Hazel! Thinking about you!!!
  23. Rosetta

    DMV64: Reinstate Saphris?

    Yes, I know. I hope it's getting better. - R
  24. Bandboy

    Bandboy: Introduction

    Thx again, Shep. I was unaware of the dysphasia associated with the benzo and z-drugs. At the moment I am feeling better. I had a nice and comfortable dinner last night with my sister and brother-in-law. For the the moment I am going to continue with the Latuda taper. I am a couple of weeks or so before I'm tentatively scheduled to reduce the Latuda from 27.5 to 25mg, so I will wait to make any further decisions until I see how that reduction feels. From the information you have given me it appears the Adderall should be tapered next (better for my heart) but that will be a long way off and I am not looking forward to splitting the Lunesta; they have a hard coating that looks like it may impede my pill cutter. The withdrawal insomnia has decreased--getting to sleep 2:00-2:30am instead of 4:30. Not great but better. I was was surprised at the overlap of interactions among my drugs, especially those involving heart medication, all of which are quite common. Neither my internist nor psychiatrist addressed these issues, though my p dr was also concerned with my weight gain (145-165 in a short time). One symptom I neglected to mention is my memory. I play in a band as a hobby and over the last 2-3 years I have found it too difficult to remember many songs, especially those with several chord changes. I chalked it up to age (62) but I wonder if these meds are exacerbating this. Thank you for all of your time and help. I hope to have the chance to return the favor to you or others. I will keep posting my progress or lack thereof. Bandboy
  25. Hello and welcome to SA. I am so happy you found us before tapering — that bodes really well for your taper. It sounds like you are in a good place to do so, and have a great attitude about it. How long have you been taking Amitriptyline? Please let us know your dosage history and any other meds, by creating a signature as described here: http://survivingantidepressants.org/topic/12364-please-put-your-withdrawal-history-in-your-signature/ There is a ton of information and support on this site. : ) Probably the most important right now are: http://survivingantidepressants.org/topic/1008-before-you-begin-tapering-what-you-need-to-know/ We usually see best results with tapers at a rate of 10% per month or less: http://survivingantidepressants.org/topic/1024-why-taper-by-10-of-my-dosage/ One of our moderators has devised an even gentler plan (very popular and effective) that we lovingly call the Brassmonkey Slide: http://survivingantidepressants.org/topic/17671-the-brassmonkey-slide-method-of-micro-tapering/?tab=comments#comment-347786 Again, welcome!
  26. Rosetta

    ☼ Happy2Heal: Hope I'm doing this right

    As always, you keep refilling my hope, H2H! Thank you!!! - Rosetta
  27. Thank you so much for your response Altostrata. For the last month: 6-8am: Effexor XR 20mg 8pm: Klonopin 0.25mg. Additional 0.25mg btwn 10pm-12am if necessary for sleep. The 3 weeks prior: 6-8am: Zoloft 25mg 45-days prior to that: Zoloft 25mg while tapering Effexor Symptoms are generally worst first thing in the morning before my dose and breakfast, and as I'm trying to fall asleep. Symptoms include buzzing hands, an extreme nervous/restlessness/agitation in my abdomen, and burning in my gut. And extreme insomnia that the Klonopin has helped. I have also noticed that if I have even 1 drink, or do the lightest exercise, my body goes into overdrive for hours and makes everything so much worse worse. I'm just so sensitive. All new from 2-weeks post-Effexor and since reinstatement. Since reinstating the Klonopin, I'm able to fall asleep usually around midnight and wake up to symptoms around 4-5am. In one month I have seen no evidence of stabilizing on the reinstated Effexor and starting to worry I'm needing progressively higher doses of Klonopin for sleep. It's ironic that I survived the horrific med cocktail and withdrawal (see original post) -- with the suicidal ideation, panic attacks, extreme agitation and/or akathisia, deep depression and horrifying anxiety -- without personal undoing. However, it's this, with the general absence of most mental side effects (aside from situational despair), and the insomnia, that has me most scared and at risk of losing my job. Looking back, I obviously tapered off of Effexor too fast (45-days), and then again with the Zoloft (corrected: 5-days). At the time I just didn't know better. The questions remain: Do I try to stick it out for another month, getting some sleep but risking more severe benzo dependence and withdrawal? Do I reinstate to the original 37.5mg of Effexor? Do I reinstate a small dose of Zoloft? Do I just get off of benzos and deal with the insomnia the best I can? I've already prepared myself for losing my job and fortunately I have a support system if that happens. If I have to go through hell for the next year or two so I can be better for the following 5, 10, 20 years, I'll do that. I'll do whatever I need to do to be there for my wife and 1.5 yr old son, I just don't know what this is. Any advice would be appreciated more than you know. Thank you.
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