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Found 12 results

  1. Loreli:Trintellix

    Hi, I found this site after watching the you tube video. I have been very concerned about the foggy headed feeling I always have. I also can't remember things unless I write them down. I also have blunted emotions and low libido. And even though I'm taking Trintellix I still feel depressed. It does control my anxiety and my running mind. I call it ruminating. I would really like to be off this medicine but after exploring this site I realize it's not going to be easy. I'm debating on when to start my taper because I have a couple of big events coming up. I have a family wedding in May and a big family reunion in June. I don't want to be sick for them. Maybe I wont feel bad until I get to the lower doses? Or should I wait to taper later in the summer?
  2. Hello! About two months ago I have stopped taking Celexa (20mg) and Wellbutrin (150XR) and started Trintellix (5mg). For the first week, it was like a miracle. I was super clear and felt really balanced (not manic or just "better") then the itching started. If I don't take an antihistamine it is unbearable, but I really wanted this relief to continue so I figured it was a small price to pay. Unfortunately, over the last month I have developed vision and stomach issues, agitation, pain, swelling and numbness in my hands, arms, feet, major muscle spasms and a general feeling of discomfort. These symptoms come and go. Over the past 2 years I've become involved in different therapies and modalities of healing for PTSD and the myriad of issues that it causes. Because of the healing I've experienced and the support I currently have, I believe it's a good time to try tapering off the Trintellix and giving my brain a chance to reboot and see how it goes. Since I'm already on the smallest dosage, 5 mg, I was hoping to get some advice on making my own liquid dosage and how best to proceed. Thank you! Diagnosed w/ Early Childhood PTSD, Major Depressive Disorder Medicated with a variety of AD meds off and on for 42 years
  3. Touchtheclouds87 off Paxil

    I was on Paxil for 6 years. The doctor took me from 40mg to 0mg in 8 weeks. I had to get off it because I was so depressed about sexual dysfuntion. Had a psychotic episode followed by the most horrendous depression and acute anxiety. Had to go back on paxil for a year. Then switched to lithium then switched to lamotrigine. I came off paxil the second time over a 6 month period and it was OK. No major withdrawal issues. It's just like everybody says come of the meds slowly and it will be OK.
  4. So, a 5 mg pill of Trintellix weighs .155 grams on a milligram scale. I'm better with words than mathematical calculations. Can someone help me through making the calculations for a 10% reduction? My plan is not to create a liquid suspension but to crush the pills, and add the powder to a capsule, or to water and drink it. Many thanks!
  5. I joined this forum last June before I began an unsuccessful taper from Celexa, however, this is my first post. I honestly had no idea until then how horrific untethering from these substances is, and how devastating it can be long term. What I really need is some good news. Is there any good news in the midst of this real-life horror story? Right now I feel completely alone. I haven't found a medical practitioner to forge a partnership for helping me discontinue successfully--or even reach the psych NP who prescribed my meds for a change when things went really wrong. So, there is no "discussing anything with a trusted healthcare practitioner". All I have is you all. So, I'm sort of pleading with you for guidance. I am still not sleeping well. I slept fine, for years on Celexa, then weaned off and threw everything out of balance. To be fair, the year prior to my discontinuation was incredibly stressful. I abruptly ended Trintellix this week (because I ran out and can't get anymore) and am taking approximately 10mg of Prozac (approximately because I'm splitting 20mg of powder roughly in half) as of today. The Prozac instantly quelled my WD symptoms from the Trintellix within the hour, and my plan is to either formulate a liquid suspension of this drug or find a doctor who will prescribe one. I have exhaustively researched how to overcome this problem. I'm an athlete, so I've stacked as many cards in my favor with diet, lifestyle and nutrition as well as I possibly can. But I can't seem to find a way through this, or make a plan that makes sense, and I'm scared I'll never be okay.
  6. Hey everyone, I’m hopeful this site can help me figure out what to do or how to even cope. I’m a 37 year old, successful salesman, an extrovert, generally positive individual. I’ve always had anxiety as a big part of my life and also struggle with just excessive worrying. I was out on Paxil while in college around the year 2000. I was having major anxiety and depression with dealing with being gay and the 40mg of Paxil seemed to do the trick. Long story short, 17 years have passed and i had a bit of a rough year dating this year, and a doc decided to put me on trintellix because it was so much safer and better for you. He also thought it would be very easy to switch from Paxil. This was in August of this year. Id always wanted to get off of Paxil, and had only been taking 10 milligrams since around 2012. I accepted this change as an opportunity to get off the drug. I thought it worked. I noticed as my time with trintellix went on, i was incredibly tired, fatigued, and the worrying went on and on. Eventually suicidal thoughts came on and i went from 19mg trintellix, to 5mg trintellix, to off everything December first. I am not sure if i was having Paxil withdrawal or if the trintellix was affecting me. Anyways, it’s now the day after Christmas, 26 days after the last dose of trintellix, and i am riddled with anxiety. I’m not having panic attacks like I’m used to, but just a general anxiety and feeling of dread. I’m very concerned this is the new me. Could it still be the Paxil? I have had days as well where i feel really great about things as well since December first. It’s like I’m either really happy and full of optimism or full of dread and hipelessness with anxiety. I have so so much to be thankful for. I want to feel good again. Does anyone have any insight? I don’t know what else to do. The psychiatrist wants to put me on 10mg of Prozac because he feels i should be better by now. I don’t want to get back on SSRIs if i don’t have to. Sincerely, Feeling alone in Dallas
  7. Cigarettes at age 11. Alcohol periodically from age 13 to age 30. Valium episodically from age 18 to age 27. I have been on myriad anti-depressants since 1982 for major depression and generalized anxiety. Imipramine, desyrel, ativan. Off drugs from 1984 till 1995. Started Prozac 1995 till 2014 (did well from 1995 to 2011). Tried Wellbutrin, Cymbalta. Abilify and Trintellix from March 2014 till August 8, 2017 (depression free). Had to withdraw due to cervical dystonia and tremors which still persist. Terrible experience withdrawing from Abilify and Trintellix. Started Wellbutrin 150 mg. and Prozac 10 mg. for one week to help with withdrawal. Then increased Wellbutrin to 300 mg. and experienced ringing in ears; stopped the Wellbutrin and increased Prozac to 20 mg. (10 in A.M.; 10 in P.M.) Now on Prozac 20 mg. per day, occasional Propranolol for tremors (doesn't help). I've read that coming off Abilify can take up to 3 months or more, and it has been 2 months so far. I feel like I've spent (wasted) my entire adult life trying to feel better, first by self-medicating, then by psychiatric medicating. I'm 72 years old. I wonder if there is any hope for me.
  8. Hello everyone, Short history: I have a long history of On/Off misc. antidepressant use for various periods, icluding SSRIs & SNRIs and atypicals. In previous times, when I went off medication I didn't experience withdrawal but I guess that this bombardment of my brain with various chemicals left it scarred and vulnerable. My first withdrawal occured when I went off 150mg of Effexor XR (Venlafaxine). I took it for only 2 months (July-August 2015) and I experienced withdrawal over the course of 6 months (September 2015 - February 2016), in which I was pretty much disabled and all I did was wait until things will get better. Current state: After a reoccurence of severe depression, I felt desperate and went back on antidepressants. The psychiatrist suggested Vortioxetine (Brintellix/Trintellix), a "brand new" drug. I started from a dose of 5mg which I took for 1 week, then went up to 10mg which I took for 2 weeks, after that I went up to 15mg, severe itching ensued so I dropped back to 10mg. I stopped taking it after 1 week without tapering because Vortioxetine has a long half life. All in all, I took it for 4-5 weeks, and have been off it since August 2016. About a week after discontinuing, a myriad of symptoms appeared: Tight muscles in head/traps/shoulders/stomach, hot flashes, extreme irritability and agitation, impaired cognition (no concentration, focus, memory etc...), anhedonia, no motivation, akathisia, jaw pain. In general, I feel like my brain has been fried. Currently, I feel very confused and discouraged. Sometimes it seems that it's getting slightly better, sometimes I feel that no change occured and I'm still experiencing the symptoms in the same strength. I haven't tried any other medications apart from Propranolol in an effort to reduce the akathisia but it didn't help. I'm extremely hopeless, I cannot continue my life in this manner. I will meet the psychiatrist in the next week to discuss reinstatement, although I feel it will be the final nail in my brain's coffin. If anyone has any suggestions or can share his/her Vortioxetine experience I would be happy to hear. Thanks
  9. Hey everyone, I'm posting this in a relatively scared/anxious state. I've been doubting every day whether this will actually ever get better, and the thought of this lasting for the rest of my life is terrifying. So, my background: I took Trintellix 10 mg (started at 5 mg for a week, then increased) for about 2.5 months. It also has gone by the names Brintellix and vortioxetine. My psychiatrist at the time said that I didn't have to taper off, since it says in the accompanying informational booklet that there's no possibility of adverse effects when discontinuing such a low dose. So, I stopped cold turkey. I had been off of plenty of antidepressants in the past, and never experienced a real problem, and I thought I knew what to expect from the withdrawal. It was standard at first. Occasional brain zaps, vertigo, etc. I had a couple alarming incidents where for a period of 5-10 seconds, I would become completely confused/disoriented, forgetting where/who I was for those brief periods. From what I understand, those couldn't be absence seizures because I was fully aware that I was having them. They were a bit scary, but they sort of just stopped, and those haven't resurfaced since. However, about 6 weeks after I had stopped taking the drug, the real symptoms surfaced, seemingly overnight, and they've persisted to the present moment. I went to sleep one night with a lot of stress on my mind, and woke up with a sore neck (which has since gone away), as well as all of my current symptoms: disorientation/confusion, random moderate bouts of vertigo, and an inability to visually process information like I used to. I can't look at pictures or screens anymore, because my eyes get tired instantly; it's like they don't know where to look, and trying to move them is exhausting. I also can't drive, and I can't work. I feel disabled, and the only clue I've gotten is from a different psychiatrist (not the one who prescribed the medication), telling me that these symptoms sound consistent with SNRI discontinuation syndrome, even though Trintellix isn't a strict SNRI. For obvious reasons, I haven't taken any other medications since I stopped Trintellix, and I luckily wasn't on any others at the time of discontinuation. Simply put, this has ruined my life. I can't enjoy anything in this current state, because I feel so detached, and even the seemingly-easy task of sitting down and enjoying a movie has become exhausting and daunting. I haven't really felt any enjoyment or happiness since this all started about 4 weeks ago. As far as I can tell, it also hasn't gotten any better. I'm terrified at the prospect of this being permanent. I'm terrified at the prospect of this even lasting another month. Every day feels like agony for me. Out of nowhere, my life has basically been put on hold, and I'm not sure whether I'll ever be able to get back to it. Any advice or experience with similar symptoms would be much appreciated. I feel like I'm losing my mind. Thanks, and hope your journeys are going better than mine.
  10. I'm 32, I have a 6 year old, and I've decided I want to have another child finally. My GYN says, when you find out you're pregnant, just quit taking your medications. Wtf? I've been on wellbutrin xl, metoprolol, a beta blocker for heart rate associated with anxiety, and random benzos for about 5 years. I've been on and off of zoloft, which was rough. I take trazodone at night for sleep. And I've been on trintellix for a while now also, and I'm up to 20mg. Lately I've been so lethargic and having a hard time with any task, even getting dressed, brushing my teeth, much less actually cleaning up. I've also not been able to really get out of the house if I'm alone. I haven't had a xanax in over a week, so that's good, but idk what's going on. I've gained a ton of weight, constantly getting sick with something, and my skin looks terrible, and my eyes stay sunken in. I really want to come off of all my medications and rely on a more natural approach. I'm tired of feeling like a dead person walking around, and I want to feel things like I used to. I'm also running out of time to decide to quit everything and have another child. Where should I start tapering? Thanks for any advice.
  11. Hi Courageous ones. I'm happy and frightened to be here. I'm new, 56, not tech or math savvy. Dx 1986 Generalized Anxiety Disorder, Panic Disorder, Major Depressive Episodes. Prescribed Xanax for 30 years beginning 1/4 mg 3 times per day as needed and ending prescription 1 mg/ day as needed. The highest dose I ever too was 1/2 mg, three times a day but always at least 1/2 mg per day towards the end, then hit suddenly stopped working, was taken off, experienced severe PAWS for 3 weeks and psychiatrist then put me on Klonapin 1mg, twice a day which I take faithfully and have been on for 5 months now with two, unsuccessful taper attempts in the time as I was cutting to much to quickly even though it was doctor's advice. ANTIDEPRESSANTS ;( in order of being prescribed over 30 year course); Desipramine, Parnate, Prozac, Trazadone, Paxil, Celexa, Cymbalta, Remeron, currently Trintellix 15mg once a day. I'm sure their may be others I've forgotten. Since Xanax tolerence and severe PAWS in autumn of 2016, I have had to for lose on my home!E, move in with elderly parents, surrender pets, give up professional career and placed on government disability (1/3 my job pay) and having many financial woes. I would like to start to taper the Klonapin off successfully then, about a year after that, taper Trintellix antidepressant. Is this sound or is it better to taper the antidepressant first? All knowledge, experience, encouragement and tips are accepted with gratitude. Peace & Love, Mellow please
  12. ADMIN NOTE Please read this entire topic for tips about tapering vortioxetine. There are many reports on the Web about withdrawal symptoms from vortioxetine, despite their being overlooked by drug companies. Vortioxetine appears to have a withdrawal syndrome similar to almost all the antidepressants and should be tapered slowly to avoid severe or prolonged withdrawal symptoms. See Why taper by 10% of my dosage? According to https://pubchem.ncbi.nlm.nih.gov/compound/vortioxetine#section=Top According to https://www.drugs.com/pro/brintellix.html , Brintellix is available as 5mg 10mg 15mg 20mg film-coated tablets. It has a very long half-life, somewhere around 66 hours. There is no ingredient in or coating on the tablet to make it extended-release, that would be unnecessary. (In May 2016, Takeda changed the name of this drug from Brintellix to Trintellix in the US to avoid confusion with another drug.) SOLUBILITY -- MAKING YOUR OWN LIQUID The active ingredient in the tablets, vortioxetine, is slightly soluble in water. This means you or a compounding pharmacy can make a liquid suspension from vortioxetine, see How to make a liquid from tablets or capsules Brintellix is not soluble at all in water, so using a water titration you'll have a suspension not a consistent or "homeogenous" solution. It is highly soluble in a substance called DMSO, as are many psycho-neuro-active prescription medications. You can get oral or medical grade DMSO from many sources. If you want to use this and have questions about it, feel free to post them here. source: selleckchem.com Measuring a drug for tapering by 10% at a time is easier using a liquid formulation. Since vortioxetine is available in fairly low dosages, you can take part of your daily dosage as a 5mg, 10mg, or 15mg tablet and add the rest as a liquid until your dosage is less than 5mg, where you would take your entire dose as a liquid. Taking part as a tablet and part as a liquid makes it easier to switch from a tablet to a liquid. METABOLIZED BY LIVER ENZYME CYP 2D6 Vortioxetine is metabolized in the liver by several liver enzymes; however, enzyme cyp 2D6 is very important in its metabolization. Taking vortioxetine with other drugs that are metabolized in the liver, as many psychiatric drugs are, can lead to drug-drug interactions, particularly if the other drugs utilize cyp 2D6. From https://pubchem.ncbi.nlm.nih.gov/compound/vortioxetine#section=Drug-and-Medication-Information I have a friend on vortioxetine (Brintellix) so I was wondering, does anyone have any info on how tapering this drug might look like? Thanks in advance.
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