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lionboy

Painkillers in withdrawal: Aspirin, ibuprofen, paracetamol, acetaminophen, naproxen, codeine

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lionboy

Has any one else turned to pain killers whilst in withdrawal ?

I have found paracetamol very helpfull in combating the tremor / akathesia / tension side of withdrawal.

However when taken regulally for a long period of time that actually make you feel really anxious and depressed.

Once you stop taking taking them the anxiety / depression they cause ceases within 48h in my experience.

If you scour the internet you will fing details of several experiments with rats and paracetamol that seem to suggest short term use of paracetamol increases seretonin in the brain and prolonged use suppresses the production of seretonin in the brain.

This seems to fit with my experience.

I would not suggest anyone else abuses pain killers in this way but sometimes any relief is welcome no matter what.

I have also experimented with codeine and dyhydroceine.

Both, in my experience, help greatly with the symptoms of A.D withdrawal, however both are highly addictive and are opiates, as is heroin !!

I have a long history of recreation drug abuse, including over the counter opiates and the negatives of these far outway any positives !!

After taking a theraputic dose of dyhydrocodeine recently I found myself with crippling anxiety the next day. This lasted a number of weeks !!

 

has anyone else had any similar experiences ?

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Altostrata

I've always found aspirin to be soothing. I take a baby aspirin every night.

 

The anti-inflammatory agents do seem to have a calming effect. They reduce cortisol release.

 

(Paracetamol is also known as acetaminophen. Taken in moderation, acetaminophen and aspirin are fairly safe, but high doses over a long time can cause liver damage, particularly if taken with alcohol.)

 

It makes sense to me that, given our hypersensitive nervous systems, a stronger painkiller, like codeine, will set off a paradoxical reaction, increasing neuro-anxiety etc.

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alexjuice

Hey Lion,

 

To your question, I haven't had any experience with acetaminophen in w/d. I have had experience with pain killers though this was limited and different from what you've shared, but I'll share it. I took a narcotic pain killer, hydrocodone I think, early in withdrawal. I had an overwhelmingly euphoric reaction.

 

I had taken opiates -- Oxycontin, Vicodin, morphine -- for recreational purposes in the past, while on psychiatric medication, and did not experience a strong response. So I never became a regular abuser of these types of drugs.

 

The one time in withdrawal that I took the hydrocodone, the effects were powerful. I suppose it provided some relief from sleeplessness, but, as one with a history of substance abuse, the powerof the effect scared me. I felt intoxicated and my judgment failed me. I don't like BIG reactions and I don't like feeling 'high'. I am very hypersensitive to medication, so maybe that's why the hydrocodone affected me so greatly.

 

If you have a history of opiate abuse, then you are aware of the risks of that stuff.

 

I also took a large dose of ibuprofin several times to combat inflammation and pain. The inflammation was from an injury exacerbated by my w/d. The extent of my inflammation baffled my doctors -- of course, they don't believe in long term withdrawal so my recent d/c got no consideration. Anyway, I don't recall this having a noticeable effect on my withdrawal symptoms, though the inflammation was likely a w/d symptom itself so I guess it helped with that.

 

As for the acetaminophen, I have no idea. I've not tried it or heard it used in this way.

 

Many do subscribe to the notion that providing some stability may help the brain sort itself out. In this case, 'abusing' acetaminophen for a stretch until it's efficacy fades, then going into further despair (possibly then re-starting the cycle) doesn't sound like a good idea. At least I think that's what the steady-state folks would say. (I generally think the steady-staters make sense -- in w/d not cosmology :) )

 

I don't know. And sometimes symptoms are so intense in the moment that short term urges for relief moot out other considerations.

 

I guess, as you may have figured out, I don't know. I would just advise caution especially in the area of the opiates since you know these are high risk for you.

 

Finally, what country are you in? We have no over-the-counter opiate pain killers in the US, so far as I know. These medications are rendered prescription-only by the schedules established in the Controlled Substances Act.

 

Alex.i

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angie007

Hi Lionboy,

 

Thank you for starting this thread, as i have been prescribed dihydrocodeine for back pain by my doctor,which he diagnosed as muscular/ ligament problems,

i personally believe it to be paxil wd induced, as never had any injury or back problems before tapering.

 

I decided against using this, something told me not to, and now i know i was right not to.

But i do use daily paracetemol for the pain, and have noticed a ramp up in anxiety symptoms, which i did not relate to the paracetemol

use, until i read this post. So thanks again, im sure many will be grateful to you for sharing your experience with these popular

pain relief meds. I intend to leave the paracetemol off now and see if the anxiety symptoms abates !!!!

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Nikki

[Tylenol Aleve Ibuprofen] I have come to realization that these three affect me. I made a small drop in dose last night 1/5th Celexa and took 1000mgs. tylenol for back pain. I woke with really bad anxiety and a feeling I can't explain. I get this feeling from these drugs. I feel it in my head, stomach and an overall drugged type of feeling. And I have just realized that they exacerbate morning anxiety. I take them for back pain. Alleve works the best. Anyone else? I am going to back up in dose again. Stay at the 1/5th drop I was doing and not push the envelope for a while. Anxiety was very bad this morning. Really brings me down. It's the same mental chatter or story. "God please help, what am I doing with my life, please help me to move in the right direction, is this the right path" and so on and so on. Full of self-doubt and fear. How do I get this to stop? I know I am the only one who can change it, but I don't know how. Hugs

Edited by Altostrata
parenthetical info

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poodlebell

Hi Nikki

 

I was told by a pharmacist that the most powerful drug will push the other drug out of the body. With me it was seroxat on 10mg and I took paracetamol, which I think is Tylenol, so he said that the amount of seroxat was small and so the paracetamol pushed that out of the body, liver if I remember right, and I was getting w/d from the seroxat cos of this.

 

Bit muddly hope you can understand it.

 

poodlebell

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poodlebell

Hi Nikki

 

forget to add that I came off benzos slowly and had back pain everytime I dropped it. Seroxat I came off c/t and I had the worst back pain ever at first and now get it from time to time and dont have a reason for it.

 

poodlebell

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Nikki

Poodlebell I read an article years ago about SSRI's and Restless Leg Syndrome and I totally believe it. It seems to be a symptom while on an SSRI and a WD symptom too.

 

I do have two herniated disks which bring on Sciatica, but in my heart I believe ssri's are in the mix somewhow stiring the pot.

 

In the last year or so, since I went on Celexa I have noticed more sciatica, and how the meds I mentioned make me feel lousy and seem to add to anxiety. They do work for pain, I am just never going to take them again at night. And if I absolutely have to take it, I am going to use a small amount.

 

Maybe it wasn't the drop in dose. Maybe it really was the reaction or interaction.

 

I just read a post by Strawberry....and told her who I am (Celeste. So there are three of us from seroxatmad :D

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Nikki

I forgot that I should not take Ibuprofen with AD's.  My back was bothering me.

 

Always the same thing.....very vivid dreams, and morning anxiety but the intense type where I can feel strong heart palpitations.

 

Is tylenol better or is there something else?

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SigmundFreud

lionboy i experimented with paracetamol for emotional pain after i read it in some article that it could help. it dies help me some of the time but not always. i love the sedation i get from it and relief from emotional pain. i havent tried it for tension/restlessness though like you did. 

 

i only use it as needed. i start with 1/4 of 500mg and titrate to as high as 750mg until it works. with low and infrequent doses i you are probably fine. 

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Ellen042

I've occasionally used hydrocodone or oxycodone for post-surgical pain while still on AD's.  Never anything illegal!  If you read my signature, you'll see that I'm terribly physically ill in combination with trying to get off AD's.  Lyme disease and dysautonimia cause excruciating full body pain, and the skull surgeries for the chiari malformation of course require hospitalization and post-surgical IV drips for pain (usually Fentanyl).  I've founf NO effect of the pain killers on my emotional struggles of AD withdrawal- for better or for worse.

 

The one exception I can think of I haven't even tried yet, because I can't get a doctor to prescribe what I need.  The number one reason I'm still stuck on trazodone (an AD) is because of the terrible never-ending migraines it produces when withdrawing.  If I could get a thirty day supply of Immitrex each month while withdrawing from trazodone, I think I could get off the stuff.  As it is, I only get a few days worth each month for my menstrual migraines. 

 

I think you're asking about pain killers easing the emotional withdrawal symptoms though, and not the pain.  In my extensive experience with opiate pain killers, I can't say they've helped or harmed me emotionally one bit.  That's just my tuppence worth, and everyone is different.

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Altostrata

I've found taking a 81mg aspirin can help relax me and get me back to sleep when I wake up in the middle of the night.

 

Anyone else have experience with the common analgesics for withdrawal symptoms?

 

(Note: Aspirin can be irritating to the stomach, used enteric coated aspirin and take with food. I take it with a fish oil capsule.)

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GiaK

tylenol does that for me sometimes...it's gone south on me too and made me trip, but if I don't over use it it's good...

 

Ibuprofen raises my histamine...I don't touch it anymore. 

 

haven't tried aspirin in a long while...I suspect it would be helpful like the tylenol...

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Petunia

I only ever take aspirin for pain now, one 300mg pill, which compared with what Alto takes is a high dose, but compared to what I used to need for pain its low.

 

It will take the edge off a bad headache or other body pain and I have noticed a calming effect from it, but I don't take it unless I need it for pain.

 

Yesterday I started researching histamine intolerance and remember seeing aspirin on a high histamine list, but so far, it has worked ok for me for occasional use.

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acetyl

I have no idea if they'll help, but would taking paracetamol or codeine to try and manage the bad migraines be safe?

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Altostrata

Please use search to find discussions about those drugs.

 

Codeine is OTC??

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Petunia

You can get codeine OTC in Australia in a combination product.

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btdt

I looked it up and found this serious drug interaction you are not to take these codeine with chlorpromazine 

 

chlorpromazine oral and promethazine-phenyleph-codeine oral

chlorpromazine oral and promethazine-phenyleph-codeine oral both increase causing a dangerous abnormal heart rhythm.

Patient Drug Interactions Source: RxList
© 2014 RxList, Inc.

I wish you peace. 

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HalfPerson

From what I know given my experience with Fluoroquinolones, the NSAID/fluoride combo can be a bomb to the blood-brain barrier. Not good!

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fj929

2 weeks ago i became very very ill. Now those of you who have followed my posts know I became very ill after trying Cerebrolysin back in November. I thought I was slowly improving until 2 weeks ago when i got smashed with the worse symptoms. I did 2 things prior to the symptoms coming on.

 

1. was in the sun for a good few hours. Never had any bad reactions to the sun prior.

 

2. Took an ibuprofen for a headache the night before. I have taken Ibuprofen before and never had a reaction. 

 

Although i have done both of these with no previous reactions I have not had  significant sun expose or taken an Ibuprofen since taking the Cerebrolysin.

 

Could it be one of these? Anyone have bad reactions to either?

 

 

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InvisibleUnless

i am not qualified to state the relative statistical likelihoods of either of those impacting your situation, but sunlight (the less potentially problematic element) has an influence on stuff like serotonin production, and ibuprofen can dramatically impact your system, also including serotonin production.  ibuprofen and similar drugs can mess with your gut, which can tie into withdrawal symptoms pretty heavily.

 

i would not, without further information, immediately conclude that either one of those things has worsened your situation, but i would not be surprised at all if it was the ibuprofen, and your reaction to various substances, especially substances that 'normal'/healthy people can have bad reactions to, can change from week to week while you are in withdrawal and your body is still dealing with damage or resetting how some things operate.  since you stated you hadnt taken it since the latest drug-complication incident, i think it is a contender.

 

sunlight is not to be ignored as a potential trigger, but less people experience issues with it than drugs i would say.  if the ibuprofen compromised your healing gut, or the sunlight caused reactions due to your bodys state that it was not prepared to deal with or was not even properly reporting at the time (i have a lot of overheating/temperature misreporting/nerve response issues, for example), they could separately or collectively account for things.

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fj929

i am not qualified to state the relative statistical likelihoods of either of those impacting your situation, but sunlight (the less potentially problematic element) has an influence on stuff like serotonin production, and ibuprofen can dramatically impact your system, also including serotonin production.  ibuprofen and similar drugs can mess with your gut, which can tie into withdrawal symptoms pretty heavily.

 

i would not, without further information, immediately conclude that either one of those things has worsened your situation, but i would not be surprised at all if it was the ibuprofen, and your reaction to various substances, especially substances that 'normal'/healthy people can have bad reactions to, can change from week to week while you are in withdrawal and your body is still dealing with damage or resetting how some things operate.  since you stated you hadnt taken it since the latest drug-complication incident, i think it is a contender.

 

sunlight is not to be ignored as a potential trigger, but less people experience issues with it than drugs i would say.  if the ibuprofen compromised your healing gut, or the sunlight caused reactions due to your bodys state that it was not prepared to deal with or was not even properly reporting at the time (i have a lot of overheating/temperature misreporting/nerve response issues, for example), they could separately or collectively account for things.

 

 

Can you point me to any studies\articles that can speak to Ibuprofen's ability to impact serotonin production?

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cymbaltawithdrawal5600

There are several threads on ibuprofen already. A search will bring them up and you can get a lot of collected wisdom there (especially if it all gets put in one place....)

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fj929

There are several threads on ibuprofen already. A search will bring them up and you can get a lot of collected wisdom there (especially if it all gets put in one place....)

Thanks Cymbalta

 

I did some searches previously but didn't find anything specific to intolerance or any studies related to it's interaction with Serotonin. 

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InvisibleUnless

it might not be explicitly spelled out in many conversations because it involves an amalgam of data, and is not about mere intolerance.  firstly, the gut has its own serotonin system of sorts and has shown to be involved in many disorders previously considered confined to the brain or other parts of the body in terms of causation or even symptoms.  this includes things grouped under the 'mental illness' umbrella as well as many degenerative or acute neurological disorders.  you can find news articles like this that get into it a bit.  the second important piece of information is how ibuprofen can alter the environment of your gut---changes in mucus levels, acidity, and various conditions of preference for the native flora and fauna that help you coordinate your everyday activities.  lots of stuff on the internet about that, as well.  (theres also warnings about dangerous complications with SSRIs or other psych meds like lithium, but i dont know how many of those are relevant to the serotonin situation or the decimation of friendly gut species, and my brain is a bit too fried to be doing much reading on it right now.)

 

i dont have any academic sources on hand for sharing, but maybe my mentioning the connection will allow you to better contextualize the already available materials.

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Annie3

I am having a tooth extraction on my molar done and I am wondering if anyone has any ideas on how to deal with pain. My last trial with Advil sent anxiety surges through my body, now I am scared to try anything. I was thinking maybe going to emerg after for another dental freezing for any pain. Any other suggestions on natural pain relief for this?

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Annie3

Thank you Petunia, I am now just using ice packs that seem to be keeping the pain at a tolerable level.

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Beetlebabe

So I was wondering about taking other meds. I hurt my back yesterday and I'm having muscle spasms. I have to get out of bed because I take care of my 85 year old MIL who has onset Alzheimer's. Is it ok to take anti inflammatories, like ibuprofen?

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mammaP

Everyone is different BB, some can tolerate ibuprofen or paracetamol (tylenol) but others can't. Ice packs are good, I get the stick on ones from the pharmacy, like a stick on patch. I use the heat ones too but for injury the cool ones are best.  If you try the painkillers just try a tiny baby dose to start and see if there are any reactions. I can now tolerate a half of the 6 year olds dose of paracetamol and the same of ibuprofen together, but only very occasionally or they make my stomach really bad and cause more trouble than it's worth!  Others are fine with them. 

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Iamfine

Hello all, I hope the day is leaving you all with happy spirits. My taper is coming along just dandy. However, I just got a tooth extracted, and my mouth is killing me. The dentist wrote me a scrip for hydrocodone and before I pop one of these things I thought I would ask you all' opinion. Will this med derail my taper and foul up this window I've been in? Thanks in advance

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brassmonkey

Hi Iamfine--  I just had a root channel a few weeks ago and used some and didn't have a problem.  I did notice that it affected my sleep a bit for a day or two but that went away when I stopped taking it.  If your worried maybe try taking a half tab and see how it goes. With any luck the pain shouldn't last more than a few days, so you shouldn't have to take to many.  Joy of joys I get to go in for a deep cleaning/ scaling tomorrow.  Last time I couldn't feel my face for a day afterwards, then I felt it too much for a week.  Hope you are feeling better soon.

 

((((((((((((((((((((((HUGS))))))))))))))))))))

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Iamfine

Thanks brass, I hate dentists. I had braces when I was a kid and that experience made me loathe them as an adult. I just didn't want to derail a so far pretty successful taper by taking pain meds for something that will pass on its own. This dentist is like my old nurse practitioner, I told him I didn't want anything but he actually talked me into it. I guess I didn't have to get it filled though, now the bottle is sitting on my bar and my aching mouth is telling me to take just one...

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brassmonkey

Might try some Tylenol to take the edge off while things settle naturally.  Save the big guns incase it gets unbearable.

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Iamfine

I went ahead and took one, the scrip was just for 12 pills that shouldn't be a problem I don't think. I know my gums feel better at least :)

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