escitalopramsucks Posted May 25, 2016 Share Posted May 25, 2016 I did. You have a private message there... I´m waiting for response PROBLEM. PSSD Symptons:- 1 Not arousal, not libido: the sensation of "I could live without sex" - 2 I can get orgasms but they are much weaker. -3 I have noticed that my breast don´t get swollen before menstruation (This has improved) -4 Lack of vaginal discharge (this has improved)- 5 Barely absence of vaginal odourInduced by In Escitalopram 1 year and two monthsBegining:10 mg per day -Jun 2013 to May 2013-Reduce to 10 gr every two days - Jun 2013 to Aug 2013 Eventually quit on September 2013. Slight Improvements. Window: 3 days on August 2015 WHY STARTING WITH IT?Great general anxiety that Esc. cured . Novemb 2015 anxiety hasd returnedNatural suplements or herbs you are having?: 1500 mg oil fish omega 3 daily since 28/1/2014. December 15. 0,5-1 gr lorazepam per day. "if you come up with any good ideas, please let me know" Link to comment Share on other sites More sharing options...
btdt Posted May 25, 2016 Share Posted May 25, 2016 I am also waiting on a response here not at the other site...when you have time. peace WARNING THIS WILL BE LONG Had a car accident in 85 Codeine was the pain med when I was release from hosp continuous use till 89 Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above. One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking. As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/ There is a crack in everything ..That's how the light gets in Link to comment Share on other sites More sharing options...
AppleOfSodom Posted May 27, 2016 Share Posted May 27, 2016 New study: "Persistent sexual dysfunction after early exposure to SSRIs: Systematic review of animal studies"https://www.researchgate.net/publication/301830365_Persistent_sexual_dysfunction_after_early_exposure_to_SSRIs_Systematic_review_of_animal_studies September 2011 - 75 mg Effexor, 15 mg MirtazapineSeptember 2012 - CT. Developed PSSD (mostly erectile dysfunction and diminished enjoyment of sex).January 2016 - Symptoms persist, no improvements. In fact, things seem worse now than they were in the first year. Link to comment Share on other sites More sharing options...
Gh0st Posted May 28, 2016 Share Posted May 28, 2016 The following form I wrote hopes to address Contributing/Treatment Factors to PSSD (Age, Gender, Time on Drug, Time off Drug, What Has Worked For You). It will be incredibly valuable information to have. I'll analyze it and turn it into something resembling an academic paper.>> http://goo.gl/forms/DfGT8Ihpyn1zEx5x2 <<The sad fact is that we can't really get a fair sample for this. If we could get everyone with PSSD to answer, we'd have a better idea. But I'm assuming some ages and patient types are less likely to have trickled onto this forum. Regardless, I'm going to give it a go. I'll be collecting data and eventually be writing it into a paper. I URGE EVERYONE TO SPEND 5 MINUTES FILLING THIS OUT. IT WILL BE INCREDIBLY VALUABLE! PLEASE SHARE ON ANY PSSD PLATFORM THAT YOU KNOW OF! The data is more helpful if more people do this. Escitalopram 5mg 4 days Sept 14' Adderal 1mg (Very Rarely Taken) (Not since Fall '14) Trazodone 50mg: 1 week in Sept '14. Few days Dec 14'. 3 days Jan '16. Experience with: St. John's Wort, Turmeric, Zinc, Inositol, Ginkgo "I don't want to believe. I want to know" - Carl Sagan Admin on www.pssdforum.com "Ghost"-----Moderator for PSSD subreddit "GhostPSSD" (reddit.com/r/PSSD) My Intro: http://survivingantidepressants.org/index.php?/topic/9564-gh0sts-escitalopram-wd/ My PSSD Theory: reddit.com/r/PSSD/comments/46b4w1/ghost_pssd_article/ Link to comment Share on other sites More sharing options...
Area1255 Posted May 30, 2016 Share Posted May 30, 2016 I am also waiting on a response here not at the other site...when you have time. peace Sorry friend, ventured away from here a little bit. Had some distractions going on. New study: "Persistent sexual dysfunction after early exposure to SSRIs: Systematic review of animal studies" https://www.researchgate.net/publication/301830365_Persistent_sexual_dysfunction_after_early_exposure_to_SSRIs_Systematic_review_of_animal_studies Yeah, doesn't give much information there though. You have to upgrade or log in to a clinician's account. The rest of it isn't really all that new, most of it I've put in my article and has to do with gonadotropin downregulation and a diminished oxytocin response. Past AD Experiences : (Fluvoxamine 3 years, D/C'd @ age 15). “Light thinks it travels faster than anything but it is wrong. No matter how fast light travels, it finds the darkness has always got there first, and is waiting for it” ~Terry Pratchett~ WITHDRAWAL REGIMEN/STORY Originally for OCD, the luvox took about 6 months to taper off. Withdrawal supplements; lemon balm, Vitamin B3, black water/fulvic acid, high-protein diet to restore neurotransmitters, aniracetam to counter memory issues, deprenyl for persisting anhedonia. Regimen still maintained til this day. Lemon balm, generally as capsules, however, as I suffer chronic Insomnia, I often use essential oil or as aromatherapy before bed , in combination with magnesium and lysine on bad nights. Link to comment Share on other sites More sharing options...
escitalopramsucks Posted June 24, 2016 Share Posted June 24, 2016 31/05/2016 I visited a top endocrinologist... she diagnosed hypothiroidism. I'm currently taking levotyroxine. Vitamins b6 and iron and my mood is better. I'm not so so depressed and anxious.She is gonna check again my hormones and help with pssd.I recommend you to find a good endoc.Thanks 24/06/2016 The endocrinologist, according to my last blood data has put me in an hormonal treatment as she has found "The analysis shows that it is not yet compensated thyroid deficiency . To have a libido you need about 1 TSH. There are other gaps , small , but added : magnesium deficiency , ferritin and hormone DHEA. Moreover, high estrogen is shown. This is the medication: -DHEA 25 mg -LEVOTIROXINA 25 -PROGESTERONE Apart from: -Iron, B6 vitamin, and magnesium I´m a bit concern about having hormons but this lady is known to have the feet on the fround and she has helped hundreds of people. Since I started the treatment with levotiroxine, B6 and iron, my mensatruation and ovulation are correct again. (Beloved escitalopram shorted my mensatruation lenght of 30 days to 21 and discontinued my ovulations every month, so I hope this will continua improving. One of the things I have noticed better is the sensations and orgasms that are more intense specially near the mensatruation days and my depression is still here but not as horible as on Christmas time when I was 24/7 having suicidal thoughts. Libido and interest in men are still 0. Some other big achievements are related to sleep: I sleep better, more hours and my dreams are starting to be more complex and frequent. Have some femine PSSD sufferer try hormonal treatment to exchange experiences? Thanks!! PROBLEM. PSSD Symptons:- 1 Not arousal, not libido: the sensation of "I could live without sex" - 2 I can get orgasms but they are much weaker. -3 I have noticed that my breast don´t get swollen before menstruation (This has improved) -4 Lack of vaginal discharge (this has improved)- 5 Barely absence of vaginal odourInduced by In Escitalopram 1 year and two monthsBegining:10 mg per day -Jun 2013 to May 2013-Reduce to 10 gr every two days - Jun 2013 to Aug 2013 Eventually quit on September 2013. Slight Improvements. Window: 3 days on August 2015 WHY STARTING WITH IT?Great general anxiety that Esc. cured . Novemb 2015 anxiety hasd returnedNatural suplements or herbs you are having?: 1500 mg oil fish omega 3 daily since 28/1/2014. December 15. 0,5-1 gr lorazepam per day. "if you come up with any good ideas, please let me know" Link to comment Share on other sites More sharing options...
Area1255 Posted July 8, 2016 Share Posted July 8, 2016 31/05/2016 I visited a top endocrinologist... she diagnosed hypothiroidism. I'm currently taking levotyroxine. Vitamins b6 and iron and my mood is better. I'm not so so depressed and anxious. She is gonna check again my hormones and help with pssd. I recommend you to find a good endoc. Thanks 24/06/2016 The endocrinologist, according to my last blood data has put me in an hormonal treatment as she has found "The analysis shows that it is not yet compensated thyroid deficiency . To have a libido you need about 1 TSH. There are other gaps , small , but added : magnesium deficiency , ferritin and hormone DHEA. Moreover, high estrogen is shown. This is the medication: -DHEA 25 mg -LEVOTIROXINA 25 -PROGESTERONE Apart from: -Iron, B6 vitamin, and magnesium I´m a bit concern about having hormons but this lady is known to have the feet on the fround and she has helped hundreds of people. Since I started the treatment with levotiroxine, B6 and iron, my mensatruation and ovulation are correct again. (Beloved escitalopram shorted my mensatruation lenght of 30 days to 21 and discontinued my ovulations every month, so I hope this will continua improving. One of the things I have noticed better is the sensations and orgasms that are more intense specially near the mensatruation days and my depression is still here but not as horible as on Christmas time when I was 24/7 having suicidal thoughts. Libido and interest in men are still 0. Some other big achievements are related to sleep: I sleep better, more hours and my dreams are starting to be more complex and frequent. Have some femine PSSD sufferer try hormonal treatment to exchange experiences? Thanks!! Well as a Woman the high estrogen issue is definitely shedding light there on the symptoms you are experiencing. I would definitely listen to your Docs suggestions there and take care of the magnesium deficiency - also consider adding in Zinc at about 15-20 mg, at night or morning, depending on what feels better for you. What's your diet like? Past AD Experiences : (Fluvoxamine 3 years, D/C'd @ age 15). “Light thinks it travels faster than anything but it is wrong. No matter how fast light travels, it finds the darkness has always got there first, and is waiting for it” ~Terry Pratchett~ WITHDRAWAL REGIMEN/STORY Originally for OCD, the luvox took about 6 months to taper off. Withdrawal supplements; lemon balm, Vitamin B3, black water/fulvic acid, high-protein diet to restore neurotransmitters, aniracetam to counter memory issues, deprenyl for persisting anhedonia. Regimen still maintained til this day. Lemon balm, generally as capsules, however, as I suffer chronic Insomnia, I often use essential oil or as aromatherapy before bed , in combination with magnesium and lysine on bad nights. Link to comment Share on other sites More sharing options...
Area1255 Posted July 12, 2016 Share Posted July 12, 2016 Here's something interesting. Brain Res. 2000 Jul 28;872(1-2):64-70. Activation of hypothalamic insulin by serotonin is the primary event of the insulin-serotonin interaction involved in the control of feeding. Orosco M1, Rouch C, Gerozissis K. Author information AbstractIn previous experiments, we reported a close parallelism in the responses of both serotonin (5-HT) and insulin in the hypothalamic PVN-VMH region of freely-moving rats during feeding. Thus, hypothalamic 5-HT and insulin may participate, independently or in interaction, in the control of carbohydrate and fat ingestion. The precedence of the activation of one or the other substance remained to be investigated. In adult male Wistar rats, (a) dexfenfluramine was administered to the PVN-VMH region by reverse microdialysis (80 microM for 10 min) while local insulin was assessed; ( insulin was locally infused (400 mU for 10 min) through the tip of the dialysis probe while 5-HT was measured. Dexfenfluramine immediately increased 5-HT release, and also extracellular insulin levels (+102%). This activation of insulin by serotonin is actually a central effect since neither insulinemia nor glycemia were affected. Conversely, insulin enhanced 5-HT release (+81%), but only 45 min after the beginning of its infusion. Noradrenaline, dopamine and metabolites were slightly or not at all modified by insulin. These data demonstrate that an interaction does exist between insulin and 5-HT in the VMH-PVN area. Because of the delay of 5-HT response to insulin, an activation of the serotonergic system would be the causal event acting immediately on insulin, and not the contrary. Whatever the exact mechanism of this interaction, it seems to be a link in a larger cascade of events involving numerous neurotransmitters and peptides leading to the regulation of feeding. Past AD Experiences : (Fluvoxamine 3 years, D/C'd @ age 15). “Light thinks it travels faster than anything but it is wrong. No matter how fast light travels, it finds the darkness has always got there first, and is waiting for it” ~Terry Pratchett~ WITHDRAWAL REGIMEN/STORY Originally for OCD, the luvox took about 6 months to taper off. Withdrawal supplements; lemon balm, Vitamin B3, black water/fulvic acid, high-protein diet to restore neurotransmitters, aniracetam to counter memory issues, deprenyl for persisting anhedonia. Regimen still maintained til this day. Lemon balm, generally as capsules, however, as I suffer chronic Insomnia, I often use essential oil or as aromatherapy before bed , in combination with magnesium and lysine on bad nights. Link to comment Share on other sites More sharing options...
Area1255 Posted July 17, 2016 Share Posted July 17, 2016 https://raypeatforum.com/community/threads/vitamin-b6-is-a-dopamine-agonist-and-prolactin-inhibitor.3241/ Past AD Experiences : (Fluvoxamine 3 years, D/C'd @ age 15). “Light thinks it travels faster than anything but it is wrong. No matter how fast light travels, it finds the darkness has always got there first, and is waiting for it” ~Terry Pratchett~ WITHDRAWAL REGIMEN/STORY Originally for OCD, the luvox took about 6 months to taper off. Withdrawal supplements; lemon balm, Vitamin B3, black water/fulvic acid, high-protein diet to restore neurotransmitters, aniracetam to counter memory issues, deprenyl for persisting anhedonia. Regimen still maintained til this day. Lemon balm, generally as capsules, however, as I suffer chronic Insomnia, I often use essential oil or as aromatherapy before bed , in combination with magnesium and lysine on bad nights. Link to comment Share on other sites More sharing options...
fema4psychiatrists Posted July 18, 2016 Share Posted July 18, 2016 Take Action Now Fast - everyone do this please Print this http://www.mind.org.uk/information-support/drugs-and-treatments/antidepressants/side-effects-of-antidepressants/#se “Sometimes these side effects persist after you've come off the drug, and might continue indefinitely. If you experience this you might want to report it on a Yellow Card.” And make your doctor fill out a yellow card reporting form on PSSD like the mind website suggests. My psyche claimed he’s not bothered because the reports of indefinite sexual damage on yellow report system are rare compared to reported sexual dysfunction whilst on the drugs. Lets try and change that PS: MIND a trusted UK source by all mental health professionals Cocktail drugged since 9 Genitals went numb Extreme intestinal gas and pain Extreme anxiety cant concentrate All permanent Post-SSRI Sexual Dysfunction (PSSD) http://pssdblog.blogspot.com Link to comment Share on other sites More sharing options...
Theon Posted July 22, 2016 Share Posted July 22, 2016 I ended up getting depressed and anxious because I was very obseesed with pssd.. you feel now asexual because of the pssd? so be it, but better asexual than worrying too much about your pssd and getting anxious or depressed, like it has happened to me. About me ------------------------ College student with a history of anxiety, excessive worrying and health anxiety. April 2014 - May 2015---------- Prozac 20mg On and Off. Second time on it I developed apathy, changes in personality, asexuality. May 2015 - July 2015----------------- Tappering off prozac. Still no feelings,anhedonia, apathy, no libido, asexuality. Current symptoms-------- pssd (asexuality in my case). Anxiety and depression developed some months afer stopping prozac, could have been caused by obsessing and beating myself up too much when I found myself unable to like girls again. The best thing to do with pssd (which in my case is asexuality) is accept it and move on. Link to comment Share on other sites More sharing options...
Moderator Emeritus scallywag Posted July 22, 2016 Moderator Emeritus Share Posted July 22, 2016 Theon, I get what you're saying and that from your perspective, feeling asexual would be welcome. It's doubtful that someone who has enjoyed his/her sexuality and sexual activity likes feeling asexual or would consider it better than feeling any other way. Comparisons are best left to discussing our own symptoms in our own introduction threads. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.1997-1999 Effexor; 2002-2005 Effexor XR 37.5 mg linear taper, dropping same #beads/week with bad results Cymbalta 60 mg 2012 - 2015; 2016: 20 mg to 7 mg exact doses and dates in this post; 2017: 6.3 mg to 0.0 mg Aug. 12; details here scallywag's IntroductionOnline spreadsheet for dose taper calculations and nz11's THE WORKS spreadsheet Link to comment Share on other sites More sharing options...
Area1255 Posted July 23, 2016 Share Posted July 23, 2016 It seems aldosterone plays a role in this condition as well. http://www.ncbi.nlm.nih.gov/pubmed/26527360 http://www.ncbi.nlm.nih.gov/pubmed/9275083 http://www.renalandurologynews.com/erectile-dysfunction-ed/erectile-dysfunction-risk-linked-to-aldosterone/article/453785/ Past AD Experiences : (Fluvoxamine 3 years, D/C'd @ age 15). “Light thinks it travels faster than anything but it is wrong. No matter how fast light travels, it finds the darkness has always got there first, and is waiting for it” ~Terry Pratchett~ WITHDRAWAL REGIMEN/STORY Originally for OCD, the luvox took about 6 months to taper off. Withdrawal supplements; lemon balm, Vitamin B3, black water/fulvic acid, high-protein diet to restore neurotransmitters, aniracetam to counter memory issues, deprenyl for persisting anhedonia. Regimen still maintained til this day. Lemon balm, generally as capsules, however, as I suffer chronic Insomnia, I often use essential oil or as aromatherapy before bed , in combination with magnesium and lysine on bad nights. Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted July 24, 2016 Author Administrator Share Posted July 24, 2016 No doubt, since aldosterone plays a role in everything. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
johnson Posted July 28, 2016 Share Posted July 28, 2016 Just wondering if any men have heard of this treatment? Shockwave therapy. I don't know if it's safe or not. http://www.menshealth.com/health/new-viagra Link to comment Share on other sites More sharing options...
Area1255 Posted August 4, 2016 Share Posted August 4, 2016 Just wondering if any men have heard of this treatment? Shockwave therapy. I don't know if it's safe or not. http://www.menshealth.com/health/new-viagra Mixed results, some say it's worse than ECT/EIT. Some simply get no benefit at all. Past AD Experiences : (Fluvoxamine 3 years, D/C'd @ age 15). “Light thinks it travels faster than anything but it is wrong. No matter how fast light travels, it finds the darkness has always got there first, and is waiting for it” ~Terry Pratchett~ WITHDRAWAL REGIMEN/STORY Originally for OCD, the luvox took about 6 months to taper off. Withdrawal supplements; lemon balm, Vitamin B3, black water/fulvic acid, high-protein diet to restore neurotransmitters, aniracetam to counter memory issues, deprenyl for persisting anhedonia. Regimen still maintained til this day. Lemon balm, generally as capsules, however, as I suffer chronic Insomnia, I often use essential oil or as aromatherapy before bed , in combination with magnesium and lysine on bad nights. Link to comment Share on other sites More sharing options...
Junglechicken Posted August 5, 2016 Share Posted August 5, 2016 Anyone got any tips as to how to get "in the mood" whilst experiencing physical symptoms. If it isn't my TOTM, its asthma, if it isn't that then it was the GERD.....and so on. My face and lips are currently red from eczema. Very difficult to feel remotely sexy with back to back symptoms. Although my hubby is an absolute gem, because of me, we haven't gotten jiggy with it for 8 months. This is tough on any man. I wouldn't blame him at all for getting it from elsewhere, but wish I could restore this part of me which is frankly inert. Really need help in this department. Dose History: 19 Feb 2014 - Escitalopram 10mg daily June 2015 - Started taper, 5mg every other day July 2015 - 5mg every 2 days August 2015 - 5mg every 3 days September 2015 - 5mg every 4 days Sept 14th - Completed tapering, but at 7 weeks "drug free" I suffered serious WD symptoms as a consequence of "incorrect" tapering. Nov 25 2015 - Re-instated Cipralex @ 2.5mg daily. WD symptoms faded. Held at this dose and experienced "windows and waves". 12 Oct 2017 Reduced dose to 1.25mg. 13 Mar 2018 Reduced dose to 0.625mg (approx.). 16 April 2018 0mg. Windows and waves triggered by stress (IBS/reflux, headaches, sinus issues) Aug 2019 Mirena coil fitted 6 Jan 2020 MAJOR Wave hit 19 months following last dose (protracted WD). Symptoms listed below Mar 2020 Mirena coil removal. Therapy: Nov 15th 2016 Re-started therapy Jan 19th 2017 Started CBT Dec 2017 Started listening to Hypnotherapy CD (self-esteem). Nov 2019 Started couples therapy. Supplements: "Bioglan" Biotic Balance Ultimate Flora 10 billion CFU, live Bacteria, Probiotic, suitable for Vegetarians, with Lactobacillus Acidophilus, Lactobacillus Rhamnosus, Bifidobacterium Longum. "Pukka" Vitalise a unique blend of 30 energising botanicals. Diet: 16 April 2018 Detox cleanse / anti-candida for 90 days. Jan 2020 Started "small plate" diet (i.e child size portions). Exercise: Stretching, Yoga, Pilates, Spinning, Elliptical/upper body workout, walking. Medical Test Results: 4 Jan 2017 Homeopathic Treatment starts 24 Feb 2017 Started weight loss program 24 Mar 2017 Naturopathic Treatment + anti-Candida diet started due to suspected Candida Related Complex (CRC). DETOXED for 7 weeks to "re-set" gut. April 2017 "Genova Diagnostics" Comprehensive Stool Analysis NEGATIVE; Full Blood Count (Normal) / Blood Cholesterol: 5.6 (Borderline) / Blood Sugar (Normal) / 28 Jun 2017 FSH 8.2 / 14 Nov 2017 FSH 17.7 Dec 2017 Blood Cholesterol: 3.9 (Normal) / Kidney Function (Normal) / Blood Sugar (Normal). December 2017 "Genova Diagnostics" Food panel allergy (bloodwork) analysis - a few "VERY LOW/VL" allergens; Mar 2018 "Genova Diagnostics" SIBO urine analysis: High Level of Yeast/fungal markers found in small intestine but NO SIBO. April 2018 Thyroid (Normal) / Full Blood Count (Normal) / FSH (Normal). 16 April 2018 Started anti-Candida diet - 3 month protocol. 25 March 2020 All test results "Normal". CRP" 5 mg/L (normal range to 0-5 mg/L). Symptoms: Flu-like symptoms, anxiety, anhedonia, sinus headaches right-side (severe), IBS issues/reflux (severe)**, tinnitus, fatigue, inner tremor, nausea, chills/hot flushes, pounding heart, muscular issues including stiff left hip flexor, intense anger, PSSD (ongoing). **Histhamine intolerance (suspected). Major Life Events: Re-located to UK from Canada: Jan 2016 My father died: 5:05pm, Monday 5 Feb 2018 Last Lexapro dose: 16 April 2018 (its now been over a year since I quit ADs) Moved house: Friday 23rd February 2018 "Divorced" toxic Mother: Monday 26 March 2018 Starting working again: 19 November 2018 Diagnosed with: 5th August 2021 PTSD/C-PTSD Diagnosed with: March 2022 Interstitial Cystitis (IC)/Painful bladder syndrome Link to comment Share on other sites More sharing options...
Junglechicken Posted August 6, 2016 Share Posted August 6, 2016 Thank you Area1255 - will check it out. Dose History: 19 Feb 2014 - Escitalopram 10mg daily June 2015 - Started taper, 5mg every other day July 2015 - 5mg every 2 days August 2015 - 5mg every 3 days September 2015 - 5mg every 4 days Sept 14th - Completed tapering, but at 7 weeks "drug free" I suffered serious WD symptoms as a consequence of "incorrect" tapering. Nov 25 2015 - Re-instated Cipralex @ 2.5mg daily. WD symptoms faded. Held at this dose and experienced "windows and waves". 12 Oct 2017 Reduced dose to 1.25mg. 13 Mar 2018 Reduced dose to 0.625mg (approx.). 16 April 2018 0mg. Windows and waves triggered by stress (IBS/reflux, headaches, sinus issues) Aug 2019 Mirena coil fitted 6 Jan 2020 MAJOR Wave hit 19 months following last dose (protracted WD). Symptoms listed below Mar 2020 Mirena coil removal. Therapy: Nov 15th 2016 Re-started therapy Jan 19th 2017 Started CBT Dec 2017 Started listening to Hypnotherapy CD (self-esteem). Nov 2019 Started couples therapy. Supplements: "Bioglan" Biotic Balance Ultimate Flora 10 billion CFU, live Bacteria, Probiotic, suitable for Vegetarians, with Lactobacillus Acidophilus, Lactobacillus Rhamnosus, Bifidobacterium Longum. "Pukka" Vitalise a unique blend of 30 energising botanicals. Diet: 16 April 2018 Detox cleanse / anti-candida for 90 days. Jan 2020 Started "small plate" diet (i.e child size portions). Exercise: Stretching, Yoga, Pilates, Spinning, Elliptical/upper body workout, walking. Medical Test Results: 4 Jan 2017 Homeopathic Treatment starts 24 Feb 2017 Started weight loss program 24 Mar 2017 Naturopathic Treatment + anti-Candida diet started due to suspected Candida Related Complex (CRC). DETOXED for 7 weeks to "re-set" gut. April 2017 "Genova Diagnostics" Comprehensive Stool Analysis NEGATIVE; Full Blood Count (Normal) / Blood Cholesterol: 5.6 (Borderline) / Blood Sugar (Normal) / 28 Jun 2017 FSH 8.2 / 14 Nov 2017 FSH 17.7 Dec 2017 Blood Cholesterol: 3.9 (Normal) / Kidney Function (Normal) / Blood Sugar (Normal). December 2017 "Genova Diagnostics" Food panel allergy (bloodwork) analysis - a few "VERY LOW/VL" allergens; Mar 2018 "Genova Diagnostics" SIBO urine analysis: High Level of Yeast/fungal markers found in small intestine but NO SIBO. April 2018 Thyroid (Normal) / Full Blood Count (Normal) / FSH (Normal). 16 April 2018 Started anti-Candida diet - 3 month protocol. 25 March 2020 All test results "Normal". CRP" 5 mg/L (normal range to 0-5 mg/L). Symptoms: Flu-like symptoms, anxiety, anhedonia, sinus headaches right-side (severe), IBS issues/reflux (severe)**, tinnitus, fatigue, inner tremor, nausea, chills/hot flushes, pounding heart, muscular issues including stiff left hip flexor, intense anger, PSSD (ongoing). **Histhamine intolerance (suspected). Major Life Events: Re-located to UK from Canada: Jan 2016 My father died: 5:05pm, Monday 5 Feb 2018 Last Lexapro dose: 16 April 2018 (its now been over a year since I quit ADs) Moved house: Friday 23rd February 2018 "Divorced" toxic Mother: Monday 26 March 2018 Starting working again: 19 November 2018 Diagnosed with: 5th August 2021 PTSD/C-PTSD Diagnosed with: March 2022 Interstitial Cystitis (IC)/Painful bladder syndrome Link to comment Share on other sites More sharing options...
Moderator Emeritus JanCarol Posted August 8, 2016 Moderator Emeritus Share Posted August 8, 2016 I understand that the PSSD has definite, chemical, physical factors. Most of those will heal with time. While you are waiting to heal, I suggest you start looking into strategies that balance your sex drive with that of your partner. Emily Nagoski, PhD runs a blog called "The Dirty Normal" and a book called "Come As You Are" which focuses on the fact that nearly all partners have unequal drives. Additionally, she talks about negotiating responsive desire as opposed to spontaneous desire. It is a cultural norm that we all should have spontaneous desire, like in the movies, where you just cannot resist the urge anymore and the two of you go at it on the kitchen table, the park, etc. But it is important to learn your responsive desire - how to tickle out those things which feel good, which lead to you wanting to do more things which feel good, which may lead to sexual desire (and may not - it's a learning process, just like going to "Sex U." Start here, and think about your sex in a new way: http://www.thedirtynormal.com/about/best-of-the-dirty-normal/ Please, chemicals, supplements, substances, devices, they are not going to be strong enough. Especially since 90% of sexy is in the brain. "Easy, easy - just go easy and you'll finish." - Hawaiian Kapuna Holding is hard work, holding is a blessing. Give your brain time to heal before you try again. My suggestions are not medical advice, you are in charge of your own medical choices. A lifetime of being prescribed antidepressants that caused problems (30 years in total). At age 35 flipped to "bipolar," but was not diagnosed for 5 years. Started my journey in Midwest United States. Crossed the Pacific for love and hope; currently living in Australia. CT Seroquel 25 mg some time in 2013. Tapered Reboxetine 4 mg Oct 2013 to Sept 2014 = GONE (3 years on Reboxetine). Tapered Lithium 900 to 475 MG (alternating with the SNRI) Jan 2014 - Nov 2014, tapered Lithium 475 mg Jan 2015 - Feb 2016 = GONE (10 years on Lithium). Many mistakes in dry cutting dosages were made. The tedious thread (my intro): JanCarol ☼ Reboxetine first, then Lithium The happy thread (my success story): JanCarol - Undiagnosed Off all bipolar drugs My own blog: https://shamanexplorations.com/shamans-blog/ I have been psych drug FREE since 1 Feb 2016! Link to comment Share on other sites More sharing options...
Junglechicken Posted August 8, 2016 Share Posted August 8, 2016 Thank you (other) JC, this is really helpful! Have actually been feeling really down because of this for some time now. My hubby is an absolute rock/gem, whom I don't know what I would do without. It sucks that I struggle for lack of libido, because as I said, it just evaporated due to back to back physical symptoms. Dose History: 19 Feb 2014 - Escitalopram 10mg daily June 2015 - Started taper, 5mg every other day July 2015 - 5mg every 2 days August 2015 - 5mg every 3 days September 2015 - 5mg every 4 days Sept 14th - Completed tapering, but at 7 weeks "drug free" I suffered serious WD symptoms as a consequence of "incorrect" tapering. Nov 25 2015 - Re-instated Cipralex @ 2.5mg daily. WD symptoms faded. Held at this dose and experienced "windows and waves". 12 Oct 2017 Reduced dose to 1.25mg. 13 Mar 2018 Reduced dose to 0.625mg (approx.). 16 April 2018 0mg. Windows and waves triggered by stress (IBS/reflux, headaches, sinus issues) Aug 2019 Mirena coil fitted 6 Jan 2020 MAJOR Wave hit 19 months following last dose (protracted WD). Symptoms listed below Mar 2020 Mirena coil removal. Therapy: Nov 15th 2016 Re-started therapy Jan 19th 2017 Started CBT Dec 2017 Started listening to Hypnotherapy CD (self-esteem). Nov 2019 Started couples therapy. Supplements: "Bioglan" Biotic Balance Ultimate Flora 10 billion CFU, live Bacteria, Probiotic, suitable for Vegetarians, with Lactobacillus Acidophilus, Lactobacillus Rhamnosus, Bifidobacterium Longum. "Pukka" Vitalise a unique blend of 30 energising botanicals. Diet: 16 April 2018 Detox cleanse / anti-candida for 90 days. Jan 2020 Started "small plate" diet (i.e child size portions). Exercise: Stretching, Yoga, Pilates, Spinning, Elliptical/upper body workout, walking. Medical Test Results: 4 Jan 2017 Homeopathic Treatment starts 24 Feb 2017 Started weight loss program 24 Mar 2017 Naturopathic Treatment + anti-Candida diet started due to suspected Candida Related Complex (CRC). DETOXED for 7 weeks to "re-set" gut. April 2017 "Genova Diagnostics" Comprehensive Stool Analysis NEGATIVE; Full Blood Count (Normal) / Blood Cholesterol: 5.6 (Borderline) / Blood Sugar (Normal) / 28 Jun 2017 FSH 8.2 / 14 Nov 2017 FSH 17.7 Dec 2017 Blood Cholesterol: 3.9 (Normal) / Kidney Function (Normal) / Blood Sugar (Normal). December 2017 "Genova Diagnostics" Food panel allergy (bloodwork) analysis - a few "VERY LOW/VL" allergens; Mar 2018 "Genova Diagnostics" SIBO urine analysis: High Level of Yeast/fungal markers found in small intestine but NO SIBO. April 2018 Thyroid (Normal) / Full Blood Count (Normal) / FSH (Normal). 16 April 2018 Started anti-Candida diet - 3 month protocol. 25 March 2020 All test results "Normal". CRP" 5 mg/L (normal range to 0-5 mg/L). Symptoms: Flu-like symptoms, anxiety, anhedonia, sinus headaches right-side (severe), IBS issues/reflux (severe)**, tinnitus, fatigue, inner tremor, nausea, chills/hot flushes, pounding heart, muscular issues including stiff left hip flexor, intense anger, PSSD (ongoing). **Histhamine intolerance (suspected). Major Life Events: Re-located to UK from Canada: Jan 2016 My father died: 5:05pm, Monday 5 Feb 2018 Last Lexapro dose: 16 April 2018 (its now been over a year since I quit ADs) Moved house: Friday 23rd February 2018 "Divorced" toxic Mother: Monday 26 March 2018 Starting working again: 19 November 2018 Diagnosed with: 5th August 2021 PTSD/C-PTSD Diagnosed with: March 2022 Interstitial Cystitis (IC)/Painful bladder syndrome Link to comment Share on other sites More sharing options...
Area1255 Posted August 8, 2016 Share Posted August 8, 2016 Thank you (other) JC, this is really helpful! Have actually been feeling really down because of this for some time now. My hubby is an absolute rock/gem, whom I don't know what I would do without. It sucks that I struggle for lack of libido, because as I said, it just evaporated due to back to back physical symptoms. Good to hear JC! Having a committed/supportive partner is always the best magic. Past AD Experiences : (Fluvoxamine 3 years, D/C'd @ age 15). “Light thinks it travels faster than anything but it is wrong. No matter how fast light travels, it finds the darkness has always got there first, and is waiting for it” ~Terry Pratchett~ WITHDRAWAL REGIMEN/STORY Originally for OCD, the luvox took about 6 months to taper off. Withdrawal supplements; lemon balm, Vitamin B3, black water/fulvic acid, high-protein diet to restore neurotransmitters, aniracetam to counter memory issues, deprenyl for persisting anhedonia. Regimen still maintained til this day. Lemon balm, generally as capsules, however, as I suffer chronic Insomnia, I often use essential oil or as aromatherapy before bed , in combination with magnesium and lysine on bad nights. Link to comment Share on other sites More sharing options...
Area1255 Posted August 11, 2016 Share Posted August 11, 2016 Saffron may help. Psychopharmacology (Berl). 2012 Oct;223(4):381-8. Epub 2012 May 3. Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial. Modabbernia A1, Sohrabi H, Nasehi AA, Raisi F, Saroukhani S, Jamshidi A, Tabrizi M, Ashrafi M, Akhondzadeh S. Author information Abstract RATIONALE:Saffron (Crocus sativus L.) has shown aphrodisiac effects in some animal and human studies. OBJECTIVES:To assess the efficacy and tolerability of saffron in fluoxetine-related sexual dysfunction. METHODS:This was a 4-week randomized double-blind placebo-controlled study. Thirty-six married male patients with major depressive disorder whose depressive symptoms had been stabilized on fluoxetine and had subjective complaints of sexual impairment entered the study. The patients were randomly assigned to saffron (15 mg twice per day) or placebo for 4 weeks. International Index of Erectile Function scale was used to assess sexual function at baseline and weeks 2 and 4. RESULTS:Thirty patients finished the study. Baseline characteristics as well as baseline and final depressive symptoms scores were similar between the two groups. Effect of time × treatment interaction on the total score was significant [Greenhouse-Geisser-corrected, F (1.444, 40.434) = 6.154, P = 0.009]. By week 4, saffron resulted in significantly greater improvement in erectile function (P < 0.001) and intercourse satisfaction domains (P = 0.001), and total scores (P < 0.001) than the placebo group. Effect of saffron did not differ significantly from that of placebo in orgasmic function (P = 0.095), overall satisfaction (P = 0.334), and sexual desire (P = 0.517) domains scores. Nine patients (60%) in the saffron group and one patient (7%) in the placebo group achieved normal erectile function (score > 25 on erectile function domain) at the end of the study (P value of Fisher's exact test = 0.005). Frequency of side effects were similar between the two groups. CONCLUSIONS:Saffron is a tolerable and efficacious treatment for fluoxetine-related erectile dysfunction. PMID: 22552758 DOI: 10.1007/s00213-012-2729-6 Past AD Experiences : (Fluvoxamine 3 years, D/C'd @ age 15). “Light thinks it travels faster than anything but it is wrong. No matter how fast light travels, it finds the darkness has always got there first, and is waiting for it” ~Terry Pratchett~ WITHDRAWAL REGIMEN/STORY Originally for OCD, the luvox took about 6 months to taper off. Withdrawal supplements; lemon balm, Vitamin B3, black water/fulvic acid, high-protein diet to restore neurotransmitters, aniracetam to counter memory issues, deprenyl for persisting anhedonia. Regimen still maintained til this day. Lemon balm, generally as capsules, however, as I suffer chronic Insomnia, I often use essential oil or as aromatherapy before bed , in combination with magnesium and lysine on bad nights. Link to comment Share on other sites More sharing options...
Futurerecovery Posted September 13, 2016 Share Posted September 13, 2016 New PSSD research by University of MIlan! https://m.reddit.com/r/PSSD/comments/528pms/pssd_research_by_university_of_milan_italy/ Please complete the questionnaire if you have PSSD. It's also for Post-SSRI PGAD! German fMRI study about PSSD http://survivingantidepressants.org/index.php?/topic/14351-take-part-in-new-pssd-study/ Please also complete this questionnaire in order to possibly promote Italian PSSD research if you have PSSD / Post-SSRI PGAD:http://survivingantidepressants.org/index.php?/topic/4587-persistent-genital-arousal-disorder-pgad/?p=247055 Link to comment Share on other sites More sharing options...
Futurerecovery Posted September 13, 2016 Share Posted September 13, 2016 I have sent Prof. Melcangi a few questions. He told me that "they are not presently working on this matter". He says that the questionnaire was probably translated by a patient (he only made the Italian questionnaire). He also says: "Thus, only to explain you that this is a general questionnaire only to have (in case we may work on it) already some information." German fMRI study about PSSD http://survivingantidepressants.org/index.php?/topic/14351-take-part-in-new-pssd-study/ Please also complete this questionnaire in order to possibly promote Italian PSSD research if you have PSSD / Post-SSRI PGAD:http://survivingantidepressants.org/index.php?/topic/4587-persistent-genital-arousal-disorder-pgad/?p=247055 Link to comment Share on other sites More sharing options...
Area1255 Posted September 13, 2016 Share Posted September 13, 2016 PSSD is absolutely a sophisticated disorder, but it seems to be also the result of decreased bodily sensitivity to sex hormones. Past AD Experiences : (Fluvoxamine 3 years, D/C'd @ age 15). “Light thinks it travels faster than anything but it is wrong. No matter how fast light travels, it finds the darkness has always got there first, and is waiting for it” ~Terry Pratchett~ WITHDRAWAL REGIMEN/STORY Originally for OCD, the luvox took about 6 months to taper off. Withdrawal supplements; lemon balm, Vitamin B3, black water/fulvic acid, high-protein diet to restore neurotransmitters, aniracetam to counter memory issues, deprenyl for persisting anhedonia. Regimen still maintained til this day. Lemon balm, generally as capsules, however, as I suffer chronic Insomnia, I often use essential oil or as aromatherapy before bed , in combination with magnesium and lysine on bad nights. Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted September 14, 2016 Author Administrator Share Posted September 14, 2016 PSSD is absolutely a sophisticated disorder, but it seems to be also the result of decreased bodily sensitivity to sex hormones. Area, this may be your opinion or your guess. It hardly merits an ex cathedra pronouncement. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
Chuck83 Posted September 14, 2016 Share Posted September 14, 2016 For me PSSD It is a set of various factors neurological and endocrinological. Surely there is a desensitization of 5HT1A receptor. There could be a inhibition of pituitary /gonads. Do not forget that SSRIs inhibit the reuptake of serotonin, It decreases the availability of dopamine in the brain, and a certain amount of dopamine is essential for a good sexual function, the pituitary inhibition, with the lowering of dopamine, also generally lead to a raising of prolactin which is another killer libido. Unfortunately, the current medical science has decided not to take an interest in this important issue, then can only make a speculations. 2001, Amisulpride (deniban) - 3 months, I taper in some weeks 2001, Seroquel, 4 weeks - quit cold turkey, 2001. Efexxor, one pill adverse reaction 2002. Amitryptaline (mutabon mite) - 4 months, I taper really faster in some weeks around more 10 years drug free 4 December 2013, 7 drops of citalopram , adverse reaction December 2013, Italian supplement called serenplus with tryptophan, 9 pills adverse reaction, quit cold turkey. After December 2013, Im drug free. Link to comment Share on other sites More sharing options...
Area1255 Posted September 15, 2016 Share Posted September 15, 2016 For me PSSD It is a set of various factors neurological and endocrinological. Surely there is a desensitization of 5HT1A receptor. There could be a inhibition of pituitary /gonads. Do not forget that SSRIs inhibit the reuptake of serotonin, It decreases the availability of dopamine in the brain, and a certain amount of dopamine is essential for a good sexual function, the pituitary inhibition, with the lowering of dopamine, also generally lead to a raising of prolactin which is another killer libido. Unfortunately, the current medical science has decided not to take an interest in this important issue, then can only make a speculations. Yup, desensitization certainly plays a role. However, what we know is that there is a negative feedback loop on gonadotropins, and that gonadotropins themselves attempt to inhibit themselves through CRH and thus, cortisol being a HPTA inhibitor. The study below is useful for determining what contributes to these SSRI-induced hypogonadism cases. http://www.ncbi.nlm.nih.gov/pubmed/1312425 Endocrinology. 1992 Apr;130(4):1780-8. Regulation of corticotropin-releasing factor secretion from Leydig cells by serotonin. Tinajero JC1, Fabbri A, Dufau ML. Author information AbstractCRF is produced in the Leydig cells and acts as a negative autocrine regulator of Leydig cell function. To clarify the hormonal control of CRF secretion by Leydig cells, we evaluated the participation of serotonin (5HT) and serotonin agonists in the release of CRF from Leydig cells and their effects on hCG-induced cAMP generation and steroidogenesis. Serotonin stimulated CRF secretion up to 4-fold above basal levels and inhibited basal and hCG-stimulated cAMP generation and testosterone production (ID50, 1 nM). The inhibitory action of 5HT was prevented by a CRF antibody and the alpha-helical CRF-(9-41) antagonist. The selective 5HT2 receptor agonist (+-)1-[2,5-dimethoxy-4-iodophyryl]2-amino propane hydrochloride (DOI) also stimulated CRF secretion and inhibited hCG-stimulated cAMP generation and testosterone production to control levels (ID50, 7 microM). Serotonergic 5HT1A, 5HT1B/1C, 5HT1D, and 5HT3/5HT2 agonists were less effective inhibitors of hCG-stimulated cAMP and testosterone production, while agonists for the 5HT3 receptor had no effect. [125I]DOI binding studies in Leydig cells demonstrated two sets of receptors with Kd values in the nanomolar and micromolar range, with low and high capacities, respectively. The low affinity site differed from that of brain receptors (Kd, 4.2 nM) and displayed higher binding capacity (50-fold). The selective 5HT2 receptor antagonist ketanserin prevented CRF stimulation and blocked the inhibitory actions of 5HT and DOI, while the alpha 1-adrenergic antagonist prazosin had no effect. Also, treatment of cells with ketanserin increased sensitivity to hCG and raised maximal cAMP and testosterone production. 5HT was a more effective stimulus than hCG in stimulating CRF secretion, and gonadotropin-induced CRF release was inhibited by ketanserin. Inhibitory effects of exogenous CRF were demonstrable after blockade of 5HT action by ketanserin. The inhibitory actions of 5HT were unaffected by pertussis and cholera toxins and were reversed by the addition of 8-bromo-cAMP. These results demonstrate that 5HT acts on 5HT2 receptors in Leydig cells that are distinct from those in the brain to stimulate CRF secretion through a pertussis toxin-insensitive G-protein. This action of 5HT is predominantly mediated by the low affinity 5HT2-binding site and requires full occupancy for maximal CRF stimulation, indicating the absence of spare receptors. 5HT-stimulated CRF inhibits basal and hCG-induced cAMP generation and steroidogenesis. Furthermore, 5HT mediates the stimulatory action of LH/hCG on CRF secretion from Leydig cells and, thus, participates in a negative autoregulatory loop to limit the testosterone response to the gonadotropic stimulus. PMID: 1312425 DOI: 10.1210/endo.130.4.1312425 [PubMed - indexed for MEDLINE] Past AD Experiences : (Fluvoxamine 3 years, D/C'd @ age 15). “Light thinks it travels faster than anything but it is wrong. No matter how fast light travels, it finds the darkness has always got there first, and is waiting for it” ~Terry Pratchett~ WITHDRAWAL REGIMEN/STORY Originally for OCD, the luvox took about 6 months to taper off. Withdrawal supplements; lemon balm, Vitamin B3, black water/fulvic acid, high-protein diet to restore neurotransmitters, aniracetam to counter memory issues, deprenyl for persisting anhedonia. Regimen still maintained til this day. Lemon balm, generally as capsules, however, as I suffer chronic Insomnia, I often use essential oil or as aromatherapy before bed , in combination with magnesium and lysine on bad nights. Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted September 16, 2016 Author Administrator Share Posted September 16, 2016 Please note that anything Area posts is his theory or guess and is not endorsed by this Web site. Area, you may offer information you think is relevant but please stop presenting it as an expert opinion. No one, including you, knows exactly what causes PSSD. Please consider this a verbal warning. The next step will be a system warning. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
Chuck83 Posted September 16, 2016 Share Posted September 16, 2016 Last year my endo put on me for one month on dostinex for lowering prolactine i had little high, and pregnyl(HCG inejection) to try to fix PSSD, and raise my testo, I have some benefits but I have not completely solved, however, remember that at that time I was very strong in the gym( I really love training with heavy weights), I had a lot of energy, High Libido, the mood was better, and I had great shape. Now I have a little bit afraid because I have symptoms of ulcerative colitis, is three months that I can not go to the gym because of rectal bleeding,and I lost lot of weight, I made a virtual colonoscopy, Endo anal ultrasound, and is all normal, and I felt that autoimmune diseases may also be due to low testosterone, I believe that in addition to gastrointerologist I return also from my endo. 2001, Amisulpride (deniban) - 3 months, I taper in some weeks 2001, Seroquel, 4 weeks - quit cold turkey, 2001. Efexxor, one pill adverse reaction 2002. Amitryptaline (mutabon mite) - 4 months, I taper really faster in some weeks around more 10 years drug free 4 December 2013, 7 drops of citalopram , adverse reaction December 2013, Italian supplement called serenplus with tryptophan, 9 pills adverse reaction, quit cold turkey. After December 2013, Im drug free. Link to comment Share on other sites More sharing options...
Chuck83 Posted September 17, 2016 Share Posted September 17, 2016 A historical find, the first discussion of PSSD appearance online from 1995: http://www.dr-bob.org/tips/split/SSRI-sexual-dysfunction.html 2001, Amisulpride (deniban) - 3 months, I taper in some weeks 2001, Seroquel, 4 weeks - quit cold turkey, 2001. Efexxor, one pill adverse reaction 2002. Amitryptaline (mutabon mite) - 4 months, I taper really faster in some weeks around more 10 years drug free 4 December 2013, 7 drops of citalopram , adverse reaction December 2013, Italian supplement called serenplus with tryptophan, 9 pills adverse reaction, quit cold turkey. After December 2013, Im drug free. Link to comment Share on other sites More sharing options...
Futurerecovery Posted September 17, 2016 Share Posted September 17, 2016 A historical find, the first discussion of PSSD appearance online from 1995: http://www.dr-bob.org/tips/split/SSRI-sexual-dysfunction.html Is related to SSRI-induced sexual dysfunction, not PSSD. German fMRI study about PSSD http://survivingantidepressants.org/index.php?/topic/14351-take-part-in-new-pssd-study/ Please also complete this questionnaire in order to possibly promote Italian PSSD research if you have PSSD / Post-SSRI PGAD:http://survivingantidepressants.org/index.php?/topic/4587-persistent-genital-arousal-disorder-pgad/?p=247055 Link to comment Share on other sites More sharing options...
ravijaua Posted September 30, 2016 Share Posted September 30, 2016 Weightlifting and yoga, especially weightlifting helps a lot with sexual dysfunction. I feel sexually arouse for a like an hour or two after weightlifting. Update 8122017 Zoloft 2004. Effexor 2004-2006. Paxil 20 mg for 2006-2010. Ct 2010, bad effects back on, stable by 2011. Poopout June 2015. Zoloft with paxil for a while, stopped Zoloft. Sep 2016 paxil 16.2 mg alone(295 mg pill weight). Started tapering 11/14/2016. Took off 1 mg pill weight(total pill weight of 20 mg = 365 mg and 16 mg is 295 mg). Went down 1 mg per week of pill weight so down to 291 mg by end of November. Starting getting anxiety issues starting since 12/10/2016. Hoping that a faster taper will help. 12/14/2016 - 15.95 mg (291 mg pill weight) 12/16/2016 - 15.83 mg (289 mg pill weight) 12/23/2016 - 15.67 (286 mg pill weight) 8/12/2017 - 15.34 (280 mg pill weight) Link to comment Share on other sites More sharing options...
Zero Posted October 8, 2016 Share Posted October 8, 2016 Hormone replacement with 17β-estradiol plus dihydrotestosterone restores male sexual behavior in rats treated neonatally with clomipramine. https://www.ncbi.nlm.nih.gov/pubmed/25449595 Male sexual behavior (MSB) in rodents, in both its consummatory and motivational components, is regulated by hormones such as testosterone, 17β-estradiol and 5-α-dihydrotestosterone. In experiments, neonatal treatment with clomipramine (CMI; a serotonin reuptake inhibitor) reproduces some of the signs of depression in adult age, including reduced sexual behavior manifested in a lower percentage of subjects that mount, intromit and ejaculate, although their testosterone levels were not altered. However, the effect of this treatment on estrogen levels and the consequences of hormone substitution using 17β-estradiol and 5-α-dihydrotestosterone on the expression of male sexual behavior are still unknown. Therefore, the objective of the present study was to analyze the effect of neonatal treatment with CMI on plasma testosterone and 17β-estradiol levels, and the role of testosterone, 17β-estradiol and 5-α-dihydrotestosterone in altering the consummatory and motivational components of sexual behavior in male rats. To this end, it analyzed the copulatory parameters and sexual incentive motivation (SIM) of rats treated with CMI under two conditions: basal and post-hormone replacements. Neonatal treatment with CMI did not affect plasma testosterone or 17β-estradiol concentrations, but did decrease both the consummatory component and sexual motivation according to the results of the SIM test. These aspects were recovered after administering 17β-estradiol +5-α-dihydrotestosterone, but not testosterone. Link to comment Share on other sites More sharing options...
sjv16477 Posted November 26, 2016 Share Posted November 26, 2016 (edited) Hi people! I'm a pssd sufferer. I invite you to think about what is the main problem of PSSD: that doctors, researchers, pharmacologists, journalist media and people don't know the existence of PSSD. No one (maybe also a lot of people who suffer of it) knows that SSRI cause a so severe damage. No one exept us. In my opinion stay sitted down on a sofa posting messages on a forum and hoping that someone will find a solution for us will not lead us to anywhere. In my opinion we ahve to do something of actually concrete to change our situation. For this reason, for example, I contacted every single TV broadcast and inquiry tv programs, journal and tv journal in my country telling him about the problem and asking him to talk about it. I contacted magazines and experts and opinionist on antidepressant and psychiatric.At least I found a scientist that is very interested to study our condition (I don't write his name because his study is not officially approved yet) for first on human looking for any hormone imbalance in the brain and then doing a study on mice looking for any alteration in the brain, but he needs money (50000 euros) than we are looking for to do a foundraising campaigne to raise money, maybe by crowdfunding: this is in my opinion doing something actually usefull for us. Then I'm doing a website on pssd with reliable and clear information about our syndrome. You can find it at [link deleted] ("foundation", until now, is only an evocative name that mean there's a pool of people that is collaborating togheter for a purpose but in the future we want to do a legally recognized foundation).On this website I want to launch a foundraising campaign in order to found the research above when it will be approved.I'm looking for people that want to help me to tranlsate my website in most language as possible in order to offer reliable information about PSSD to physician and people from all over the world. Is there anyone that want to help me doing translation from english to another language? Edited November 26, 2016 by scallywag delete link - pssdfoundation dot jimdo dot com Link to comment Share on other sites More sharing options...
Djderek Posted November 26, 2016 Share Posted November 26, 2016 Just relax man. It's not permanent. . When I had it, everyone had the same tone as you, everyone told me I was screwed for life and it went away. I almost killed myself because of those people. Do you sleep? Enjoy anything? Exercise? Work? Have fun? Can you relax? Feel calm and rested? These are all problems that your most likely suffering from. Right? Learn how to take a deep breath, sit back and smell the roses Link to comment Share on other sites More sharing options...
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