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Rave review in Scientific American for Robert Whitaker's Anatomy of an Epidemic

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Altostrata

http://blogs.scientificamerican.com/cross-check/2012/03/05/are-psychiatric-medications-making-us-sicker/

Are Psychiatric Medications Making Us Sicker?

 

By John Horgan Scientific American March 5, 2012

 

Anatomy of an Epidemic: Magic Bullets, Psychiatric Drugs, and the Astonishing Rise of Mental Illness in America (Crown 2010), by the journalist Robert Whitaker, is one of the most disturbing, consequential works of investigative journalism I’ve read in a long time. Perhaps ever. Whitaker has persuaded me that American psychiatry, in collusion with the pharmaceutical industry, may be perpetrating the biggest case of iatrogenesis—harmful medical treatment–in history. I’m even more impressed by Whitaker’s research and reasoning after hearing him speak at my school, Stevens Institute of Technology, on February 29. He is the kind of science journalist who makes me proud to be a science journalist. I’m thus printing here a modified version of an article I wrote about Anatomy last fall for The Chronicle of Higher Education. I also urge you to check out Whitaker’s Psychology Today blog, where he addresses his critics.

 

I first took a close look at treatments for mental illness in the mid-1990s while researching an article for Scientific American. At the time, sales of a new class of antidepressants, selective serotonin reuptake inhibitors, or SSRIs, were booming. The first SSRI, Prozac, had quickly become the most widely prescribed drug in the world. Many psychiatrists, notably Peter Kramer, author of the bestseller Listening to Prozac (Viking 1993), touted SSRIs as a revolutionary advance in the treatment of mental illness. Prozac, Kramer claimed in a phrase that I hope now haunts him (but probably doesn’t), could make patients “better than well.”

 

Clinical trials told a different story. SSRIs are no more effective than two older classes of antidepressants, tricyclics and monoamine oxidase inhibitors. What was even more surprising to me—given the rave reviews Prozac had received from Kramer and others–was that antidepressants as a whole were not more effective than so-called “talking cures,” whether cognitive behavioral therapy or even old-fashioned Freudian psychoanalysis, according to investigators such as the psychologists Seymour Fisher and Roger Greenberg. According to these and other researchers, treatments for depression and other common ailments work—if they do work—by harnessing the placebo effect, the tendency of a patient’s expectation of improvement to become self-fulfilling. I titled my article, published in Scientific American in December 1996, “Why Freud Isn’t Dead.” Far from defending psychoanalysis, my point was that psychiatry has made disturbingly little progress since the heyday of Freudian theory.

 

In retrospect, my critique of modern psychiatry was probably too mild. According to Anatomy of Epidemic by Robert Whitaker, psychiatry has not only failed to progress; it may now be harming many of those it purports to help. Anatomy of an Epidemic has been ignored by most major media. I learned about it only after Marcia Angell, former editor of the New England Journal of Medicine and now a lecturer on public health at Harvard, reviewed Anatomy in The New York Review of Books last year.

 

As recently as the 1950s, Whitaker contends, the four major mental disorders–depression, anxiety disorder, bipolar disorder and schizophrenia–often manifested as episodic and “self-limiting”; that is, most people simply got better over time. Severe, chronic mental illness was viewed as relatively rare. But over the past few decades the proportion of Americans diagnosed with mental illness has skyrocketed. Since 1987, the percentage of the population receiving federal disability payments for mental illness has tripled; among children under the age of 18, the percentage has grown by a factor of 35.

 

This epidemic has coincided, paradoxically, with a surge in prescriptions for psychiatric drugs. Between 1985 and 2008, U.S. sales of antidepressants and antipsychotics multiplied almost fifty-fold, to $24.2 billion. Prescriptions for bipolar disorder and anxiety have also swelled. One in eight Americans, including children and even toddlers, is now taking a psychotropic medication. Whitaker acknowledges that antidepressants and other psychiatric medications often provide short-term relief, which explains why so many physicians and patients believe so fervently in the drugs’ benefits. But over time, Whitaker argues, drugs make many patients sicker than they would have been if they had never been medicated.

 

Whitaker compiles anecdotal and clinical evidence that when patients stop taking SSRIs, they often experience depression more severe than what drove them to seek treatment. A multi-nation report by the World Health Organization in 1998 associated long-term antidepressant usage with a higher rather than lower risk of long-term depression. SSRIs can cause a wide range of side effects, including insomnia, sexual dysfunction, apathy, suicidal impulses and mania–which may then lead patients to be diagnosed with and treated for bipolar disorder.

 

Indeed, Whitaker suspects that antidepressants—as well as Ritalin and other stimulants prescribed for attention deficit disorder—have catalyzed the recent spike in bipolar disorder. Relatively rare just a half century ago, reported rates of bipolar disorder have spiked more than 100-fold to one in 40 adults. Side effects attributed to lithium and other common medications for bipolar disorder include deficits in memory, learning ability and fine-motor skills. Similarly, benzodiazepines such as Valium and Xanax, which are among the drugs prescribed for anxiety, are addictive; withdrawal from these sedatives can cause effects ranging from insomnia to seizures, as well as panic attacks.

 

Whitaker’s analysis of treatments for schizophrenia is especially disturbing. Antipsychotics, from Thorazine to successors like Zyprexa, cause weight gain, physical tremors (called tardive dyskinesia) and, according to some studies, cognitive decline and brain shrinkage. Before the introduction of Thorazine in the 1950s, Whitaker asserts, almost two thirds of the patients hospitalized for an initial episode of schizophrenia were released within a year, and most of this group did not require subsequent hospitalization.

 

Over the past half century, the rate of schizophrenia-related disability has grown by a factor of four, and schizophrenia has come to be seen as a largely chronic, degenerative disease. A decades-long study by the World Health Organization found that schizophrenic patients fared better in poor nations, such as Nigeria and India, where antipsychotics are sparingly prescribed, than in wealthier regions such as the U.S. and Europe.

 

A long-term study by Martin Harrow, a psychologist at the University of Illinois, found an inverse correlation between medication for schizophrenia and positive, long-term outcomes. Beginning in the 1970s, Harrow tracked a group of 64 newly diagnosed schizophrenics. Forty percent of the non-medicated patients recovered—meaning that they could become self-supporting–versus five percent of those who were medicated. Harrow contended that those who were heavily medicated were sicker to begin with, but Whitaker suggests that the medications may be making some patients sicker.

 

A caveat is in order here. Whitaker does NOT claim that medications have no value and that no one should take them. In his talk at my school, as in his book, Whitaker acknowledged that many people benefit from psychopharmacology, especially over the short term. But he does believe that the drugs should be administered far more sparingly.

 

Several possible objections to Whitaker’s case against psychiatry come to mind..... In her review, Marcia Angell called Whitaker’s book “suggestive, if not conclusive.”

 

Anatomy has received other recognition. It won the 2010 Investigative Reporters and Editors Award for Investigative Journalism. A review in New Scientist concluded that Whitaker’s arguments seem “far-fetched” at first but on closer examination “are worryingly sane and consistently based on evidence. They amount to a provocative yet reasonable thesis, one whose astonishing intellectual punch is delivered with the gripping vitality of a novel. Whitaker manages to be damning while remaining stubbornly optimistic in this enthralling and frighteningly persuasive book.” At the very least, Whitaker’s claims warrant further investigation. Check out his book and make up your own mind.

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alexjuice

Wow!

 

This review could be just the gateway I've sought to induce Dr. Caring to give Anatomy a read and fair hearing.

 

Wow, what a reception. I am seriously affected to see an unbiased journalist give serious, overdue attention to the case. Its not just that i want outsiders to believe the MESS in the bigpicture sense, but that MAYBE outsiders will give deserved understanding and consideration to my MESS which, like nearly all present, I endure, at least in part, every single dang day moreorless all alone but for the Internet...

 

Thanks for posting this, Alto.

 

Alex

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Barbarannamated

Agree - In hearing him speak and then briefly talking with Robert myself at ISEPP„ he communicates the overuse of SSRIs and the danger of worsening depression„ but doesn't put them in the category of benzos and antipsychotics regarding dependence and long term dangers aside from worsening the course of depression -

It's very possible that ive missed something in his material „ so please correct me-

I told him that I predict the long term outcomes will show that SSRIs cause more illness due to the many associations being identified - Parkinsons„ diabetes„ frontal lobe dysfunctions/apathy syndrome„ osteoporosis „ etc •

I sensed a strong 'bias' among attendees that antipsychotics are the truly bad drugs based on imaging showing decreased brain mass (but no interpretations of what that translates to) -

SSRIs are still perceived to be safe by many while just the term 'antipsychotic' implies 'serious drug-proceed with caution'

Also„ the withdrawal from SSRIs seems to be downplayed in comparison to benzos - I have not experienced benzo wd and cannot compare but in reading Ashton's manual the wd symptoms appear to be strikingly similar -

I agree that he has done phenomenal work - there was something in the wording of this review about worsening depression that is a can of worms that will open the door to more of 'depression is a lifelong illness needing treatment'-

JMHO after a sleepless nite

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Altostrata

Yes, I think there is an overall perception that antidepressants are less pernicious than the other psychiatric drugs. True, the risk for diabetes and movement disorders is higher with antipsychotics, and benzos are addictive.

 

But -- antidepressants also confer a substantial increase in diabetes risk as well as other health risk, and they have been distributed to far more people.

 

I believe the truth will eventually come out, on a massive scale.

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Barbarannamated

Exactly -

I don't know exact numbers but it seems that SS/NRIs are mentioned as treatment for so many disorders including ones that there is evidence that they cause or worsen - pain syndromes in particular -

I believe it's also important to distinguish between serotonergics and TCAs for starters - I don't trust any of them„ but the profiles are very different and need to be considered as such-

Of course that presents a dilemma because the mechanisms are theoretical -

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bubbles

I'm curious about the differences in "addiction" and "dependence". It seems to be that "they" consider dependence to be physical, and addiction the issue is motivation and desire to take the substance?

 

Bubbles

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Jesse12

Altostrata, thank you for your post. I'm new to this group and a lot of questions about the medications I'm on (and have been on, around 35!) and my "mental illness" have been answered . I never could find answers anywhere else I searched.

 

I remember when Prozac first came out and how the age it was safe to take began increasing. 

 

Just as mentioned, I got sicker than I was before taking that first antidepressant. Worse of all I developed fibromyalgia a few years after starting taking these drugs and I've been the most difficult patient for my doctor to treat. He said all the medications I took could have been the cause for me developing this horrible illness. 

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