Jump to content
Altostrata

How to make a liquid from tablets or capsules

Recommended Posts

scallywag

Room temperature will allow the tablets to dissolve more quickly. Refrigerate after and shake before withdrawing your dose.

Share this post


Link to post
Share on other sites
Hibari

Need help in checking my math:. 

I would like to switch over to a liquid/water suspension of my dosage of Lamictal, which is now 17.50mg.   

 

I have both 25mgs tablets and 5mg tablets. 

 

I have a 10ML syringe and from reading the beginning part of this thread, this is my plan. 

Take the 10ML syringe and fill it twice with water and put it into a small container.   This would equal 20ML of water

Then fill the 10ML syringe 1/2 way with water, which would equal 5ML of water

Total amount of water-25ML

 

Next I would dissolve my 25mg tablet in the 25ML of water.

When it's dissolved:

First draw up10ML of liquid and take that

Then draw up 7.50ML of liquid and take that.

 

Does this seem correct?

 

 

Share this post


Link to post
Share on other sites
artSet3561

Perfect.

 

I personally make up 100ml at a time in a regular kitchen measuring jug. Add two 50mg tabs screw the top on a use for a few days, saves faffing every day. Same difference ?

Share this post


Link to post
Share on other sites
Hibari

Thank you for your confirmation.    With my foggy brain, it has taken me may readings to finally understand what to do. 

Share this post


Link to post
Share on other sites
Hibari

Is anyone doing a hard tablet and liquid suspension combination?

 

If so, how do like it or find it to be helpful. 

 

I feel like I would like to try that to keep enough of the medication in my system as I taper.   Right now I switched completely to a water suspension for accuracy but think I may need more stability as I go lower.

Share this post


Link to post
Share on other sites
ramarko

Hi SA!!

two days ago I prepared 10ml of purified water with 10mg of lexapro and the pill dissolved very fast but it always remains powder on the bottom of the small jar I am using.

I tried shaking, moving, mixing and everything and I sill see the powder on the bottom of the Translucent water.

Any advices?

If I take 1ml of this preparation it will not be at all 1mg. is there any way to have 100% dissolved liquid lexapro home made?

I also tried adding 10ml more resulting of 20ml with a 10mg pill and I got the same result... pill not dissolving 100% still powder there.

 

Maybe I did something wrong?

 

Thanks!

Share this post


Link to post
Share on other sites
ChessieCat

From the very first post in this topic:

 

2. Measure the water (or pharmacy liquid)

  • With an oral syringe: Draw room temperature (not hot, not cold) water into an oral syringe and convey it to the container. A 10mL (10cc) or 20mL (20cc) oral syringe is handy for this purpose.[br][br][br]

    For example, if you wish to make 30mL of a solution, fill the 10mL syringe 3 times with clean water and inject it into your container.
  • With a graduated cylinder: For example, if you wish to make 30mL of a solution, fill the graduated cylinder to the 30mL mark and pour it into the container.
  • With a 100cc (100mL) medicine bottle: Fill carefully to the 100cc or 100mL line. You'll have to bring the bottle up to your eye level to do this. Please note the measurements on these bottles are less exact than the graduated cylinder.

To mix, put the cap on the container, tightly, and shake it gently. You will be able to see particles swirling around in the water (some of the filler used in tablets and capsules is insoluble).
 
Wait until the tablet chunks are dissolved before taking a dose.

Share this post


Link to post
Share on other sites
Altostrata
On 11/7/2017 at 4:04 AM, Drugrage said:

i Am onsdag att really low doser and have a lot of tablets. Buying new liquid lexapro on Sweden costs anout 50 dollars and i domt need the whole bottle.

 

When i solve tablets in water do i get white particles which sinks to the bottom. Is this the coating or the actual active ingredient?

I dont feel comfortable just take a part of the liquid because those particles sink down really fast so if it actually is active ingredients do i have a problem.

 

 

 

 

Please read this topic from the beginning.

Share this post


Link to post
Share on other sites
Jony
On 27/07/2012 at 3:44 AM, Altostrata said:

A liquid preparation of an antidepressant or other psychiatric drug makes controlled tapering much easier. Taking part of your dosage in tablet form and part in liquid form makes the transition from tablet to liquid go smoothly

 

This sentence made me curious...

 

Take 10 mg from a tablet is not the same thing that take 10 mg in liquid form from the pharmacological point of view. At least in a transition phase, since the absorption is different...Over time time it becomes indifferent, of course...

 

But it drives me to other question: taking 5 mg from a tablet and 4 mg from liquid, is not the same thing that taking 9 mg from liquid. I mean, each one has its own  pharmacokinetic.

 

How far is this important during the tapering of low doses?

Share this post


Link to post
Share on other sites
kesh
On Friday, December 29, 2017 at 6:00 PM, Jony said:

 

This sentence made me curious...

 

Take 10 mg from a tablet is not the same thing that take 10 mg in liquid form from the pharmacological point of view. At least in a transition phase, since the absorption is different...Over time time it becomes indifferent, of course...

 

But it drives me to other question: taking 5 mg from a tablet and 4 mg from liquid, is not the same thing that taking 9 mg from liquid. I mean, each one has its own  pharmacokinetic.

 

How far is this important during the tapering of low doses?

It probably depends on a few things.

 

For a long half life drug like prozac or diazepam each dose just tops up what is already in you a fraction, so if that small top up takes place over 15 minutes or 2 hours may not matter.

 

If you take a pill of an easily water-soluble drug on an empty stomach with a warm drink you are probably going to absorb it almost as quickly as a solution. But if you take a pill with a heavy meal and switch to a liquid on an empty stomach it's going to be very different. Or if you dissolve your liquid in a bottle of mineral water and sip it over the course of two hours, you may mimic a pill taken after a large meal.

 

So many variables.

Share this post


Link to post
Share on other sites
JamesF

Hi, could anyone advise how to make a liquid diazepam/valium solution without using alcohol. I can buy all the correct measuring products and do the process, I'm just confused about exactly how to prepare the solution of homogenous valium liquid. 

Some say to use alcohol to dissolve it but I definitely won't do this, since I'm intolerant to it. What can I use instead? 

Thank you

Share this post


Link to post
Share on other sites
Shep
4 hours ago, JamesF said:

Hi, could anyone advise how to make a liquid diazepam/valium solution without using alcohol. I can buy all the correct measuring products and do the process, I'm just confused about exactly how to prepare the solution of homogenous valium liquid. 

Some say to use alcohol to dissolve it but I definitely won't do this, since I'm intolerant to it. What can I use instead? 

Thank you

 

Information about the different benzos and what liquid to use is posted here:

 

Benzo Tapering Nuggets - liquid tapering information

 

I've posted with more information specific to your individual taper here in your benzo thread

 

Share this post


Link to post
Share on other sites
JamesF
On 1/26/2018 at 9:11 AM, Shep said:

 

Information about the different benzos and what liquid to use is posted here:

 

Benzo Tapering Nuggets - liquid tapering information

 

I've posted with more information specific to your individual taper here in your benzo thread

 


Thank you Shep Do you know how much propylene glycol would be required for dissolution per mg of valium? 

Further, I'm wondering if after dissolving in propylene glycol then mixing with water, would it be evenly distributed and stay dissolved?

 

Share this post


Link to post
Share on other sites
JamesF

Just to add to the above. Will a propylene glycol + valium + water mix "keep" in the same state for some days after mixing ? Does it need to be stored in a particular way?

 

Apologies I'm not very good at finding information in my current state

 

Thank you. Jay

 

 

Share this post


Link to post
Share on other sites
Dabhob33

I just picked up prescribed Liquid Valium (Roxane, with non alcohol suspension).  I’m currently holding at 11mg (down from 20mg since Oct 2017) for the past 2 weeks, starting 3 weeks today.  Symptoms are rough - mostly burning body, squeezed head, cog fog, fatigue, ruminating that I’ve permanenrly damage myself with the drugs I’ve taken and ECTs.  

 

Has anyone taken commercial Liquid Valium, even Roxane?   Reactions?   Any feedback is appreciated.   

 

I hope youre doing well. 

 

Dabhob33

 

 

Share this post


Link to post
Share on other sites
Dabhob33
On 1/26/2018 at 4:11 AM, Shep said:

 

Information about the different benzos and what liquid to use is posted here:

 

Benzo Tapering Nuggets - liquid tapering information

 

I've posted with more information specific to your individual taper here in your benzo thread

 

This is a month old, but there is a liquid Valium made by Roxane, owned by West-Ward.  They have one that uses an alcohol suspension and another using a non-alcohol suspension.  Hope this helps.   My Dr prescribed it for me and I will be starting it relatively soon.  

 

http://www.west-ward.com/en//Home/Content/Roxane Landing Page

Share this post


Link to post
Share on other sites
dignan
I have a question regarding the halfway point of a water titration taper. I am looking to see what others have done in my situation and the results they’ve experienced.
 
I am presently tapering mirtazapine via water titration. I am now approaching 15mg, the halfway mark of the taper. 
 
Method Before the Halfway Point
 
I drop a 30mg drug tablet into 60/ml of water to form a drug solution. That means, for every 1mg of drug tablet, there is 2/ml of water. Up to this point, I have removed drug solution with syringes and consumed the remaining solution in the cup, the “dose.” The solution in the syringes is discarded. At present, I remove nearly half the drug solution from the cup; however, soon there will not be enough solution remaining to reliably pull up with a syringe.
 
Method After the Halfway Point
 
Do I now inverse the process? That is, do I now remove the “dose” with the syringes and discard the cup?  I mean, it looks like this is the only way to proceed. However, there are several issues with this.
 
Potential Issues
 
Removing 30/ml of drug solution theoretically removes 15mg of drug. Whether I am actually removing 15mg of drug, who knows. The most important thing thus far has been consistency as opposed to accuracy. But inverting the process causes a major shift in consistency.
 
1a. It seems clear I will be taking the same amount of drug solution. However, am I taking the same amount of drug? Do more or less drug particles get sucked into the syringe? 
 
1b. Is there any experiment to clarify this? I can see lots of white particles (the drug/filler or both) in both the syringes and cup. I am trying to see if I can evaporate the water and measure the particles left behind.
 
2. What about the drug left behind in the syringes? I use four syringes per taper. Even if I rinse the syringes, there will invariably be drug left behind there. This seems like a loss I must accept.
 
3. I am very sensitive to changes and conduct a micro taper (.05mg cuts) so a significant change to the “dose” will definitely be felt. I am concerned that the “dose” may change.
 
What have others done in my situation? What were the results?

Share this post


Link to post
Share on other sites
Altostrata
1 hour ago, dignan said:

Do I now inverse the process? That is, do I now remove the “dose” with the syringes and discard the cup?  I mean, it looks like this is the only way to proceed.

 

You can do this, or you can continue with your current method.

 

By the way, you don't have to discard more than half of your homemade suspension, you can refrigerate it in a sealed container for the next day.

 

As explained at the beginning of this topic, making a suspension with water is not perfect, although many have successfully tapered with this method. We advise shaking or stirring before you take it, to distribute the particles more or less evenly.

 

Making a suspension with a pharmacy liquid such as Ora-Plus may more reliably distribute the particles if you are concerned about that.

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

×

Important Information

By using this site, you agree to our Terms of Use.