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Apple123

Low-dose naltrexone -- LDN anyone ?

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Apple123

This is my first posting here and I apologize in advance if the topic of LDN is well known. LDN is the acronymn for Low Dose Naltrexone. Naltrexone has been used for many years to help treat opiate and alcohol addictions. I was put on Cymbalta in 2010 after the death of my 21 year old son in a car crash. I was in shock (still am) but I also felt like my body weighed 3000 lbs. The Cymbalta DID help relieve me of that unbearable heaviness. I did eventually reach the max dose of 120mg.

 

I had run out of my prescription a couple of times, due to forgetting to pick it up etc. I do recall becoming tearful and the "zaps" in the head. The last couple of years are much a blur anyway. My most recent incident occurred during a trip out of state to see my brother. I ended up staying an additional week to help him with a number of things but had only packed my "pillbox" for a 5 day stay. Needless to say I started to feel terrible pretty quickly. I remembering saying to my brother that I could relate to the heroin addicts that always feel sick until their next fix. I at first thought that I could tuff it out. No I could not! By day 3 I called my PCP for a script to be faxed over to an out of state pharmacy. That was in October 2013.

 

I did discuss this event with the psychiatrist that prescribes my Cymbalta and it seems to be a rare occurrence according to him ? Well I did go from 120mg down to 90mg after that appt without a problem.

 

Fast forward to January 2014, I am doing some research on autoimmune disease as my siblings and I have developed a few. I came across the use of LDN ( low dose naltrexone) in a number of auto immune disorders and requested a prescription from my PCP 2 weeks ago. I read as much as I could find and it made sense to me to try to further reduce my heroin like addiction to Cymbalta to see if the LDN may reduce the awful withdrawal symptoms.

 

I am currently taking LDN 4.5mg at bedtime along with only 30mg of Cymbalta! And I am happy to say not only do I feel a little better from the LDN I have not experienced a single uncomfortable symptom from the reduction in Cymbalta. I am a bit nervous about going from 30 to 0, I may wait a couple weeks. I did want to put this info out here tho. LDN is not very well known, it's cheap, off patent etc. Just google LDN and educate yourself. It may not work for everyone. BTW, my auto immune disorder was/is Transverse Myelitis. My withdrawal symptoms had NOTHING to do with the TM. I had TM in 1977 with a 90% recovery.

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Barbarannamated

I look forward to more info on this topic. Thank you.

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GiaK

I'm glad it's helping you...it's like anything else...might help some...

 

it was one of the (now many) things that I had a very severe reaction to and it set me back...big time

 

I was taking less than .5 to start...

 

if anyone else wants to try it be careful...there are hard-core fanatics out there who swear it fixes everything...that's because when it works it is, indeed, sometimes miraculous...I have a friend whose MS completely disappeared once she got on it...

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compsports

It is always amazing how varied people are in their responses to treatment.  My guess is based on my reactions to meds and supplements, I would have a similar outcome to you GiaK.

 

Apple123, I hope it continues to work for you.

 

CS

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Altostrata
I did discuss this event with the psychiatrist that prescribes my Cymbalta and it seems to be a rare occurrence according to him ?

 

 

Withdrawal symptoms from Cymbalta are well-known. This remark suggests you need a new psychiatrist.

 

There are reports that LDN can help with many mysterious pain conditions. I haven't seen any evidence that it can assist psychiatric drug withdrawal -- but who knows?

 

It may be that 30mg Cymbalta are enough to forestall withdrawal symptoms for you. Please consider a much more gradual taper if you decide to reduce it further, see http://survivingantidepressants.org/index.php?/topic/283-tips-for-tapering-off-cymbalta-duloxetine/

 

You are fortunate that you have reduced Cymbalta this far and done so well.

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Ks1994

Can ldn help with adrenal/endocrine problems in benzo withdrawal?

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eva

I have been taking ldn for a while now, since I've stopped taking Prozac after 20 years of use. I am not sure if it's the ldn, because i also take magnesium, taurine, and ashwaganda, but I do feel more relaxed and more positive. And i dp have a feeling that ldn is contributing to that.

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btdt

There was once a very long extensive thread about this at topix effexor withdrawal forum... it was put there years ago.  So there is some information some place about LDN as a treatment for antidepressant withdrawal as I found it before it was there once.  I will take a look around as see if I can find it.  To my memory it was a least three years ago.  

 

This may be of some use to you Barb.

http://hopefulgeranium.blogspot.ca/2013/03/our-first-song-for-today-is.html

 

I cannot find the exact old references but this is sure interesting

 

  • What is Low-Dose Naltrexone? | Dr. Julian Whitaker
    www.drwhitaker.com › View Health A-Z  › Clinical Therapies ‎
    •  
     

    Feb 14, 2014 - Discover the benefits of safe, inexpensive low-dose naltrexone in people with autism, Crohn's disease, Alzheimers, Lupus and many other autoimmune conditions. ... What Does Treatment With LDN Involve? LDN requires a ...

     

    Have read it helps with fibro... and circadian rhythm sounds like a wonder drug have not looked up side effects or withdrawal and have not tried it.

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Nadia

I've been very curious about LDN for a long, long time. I know someone who takes it for Ulcerative Colitis (an autoimmune disorder) and does very well. I had thought to try it for withdrawal since I saw there was a doctor experimenting with it. Also, because some people find relief for chronic fatigue syndrome, and I've always wondered if I am perhaps affected by that (I had chronic mononucleosis for years and never recovered my energy levels from before I had it).

In the end, though, I've become very wary of trying anything, and have realized my best healing has happened when I wasn't even taking any supplements! But I'm still curious about LDN for sure.

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btdt

This is my first posting here and I apologize in advance if the topic of LDN is well known. LDN is the acronymn for Low Dose Naltrexone. Naltrexone has been used for many years to help treat opiate and alcohol addictions. I was put on Cymbalta in 2010 after the death of my 21 year old son in a car crash. I was in shock (still am) but I also felt like my body weighed 3000 lbs. The Cymbalta DID help relieve me of that unbearable heaviness. I did eventually reach the max dose of 120mg.

I had run out of my prescription a couple of times, due to forgetting to pick it up etc. I do recall becoming tearful and the "zaps" in the head. The last couple of years are much a blur anyway. My most recent incident occurred during a trip out of state to see my brother. I ended up staying an additional week to help him with a number of things but had only packed my "pillbox" for a 5 day stay. Needless to say I started to feel terrible pretty quickly. I remembering saying to my brother that I could relate to the heroin addicts that always feel sick until their next fix. I at first thought that I could tuff it out. No I could not! By day 3 I called my PCP for a script to be faxed over to an out of state pharmacy. That was in October 2013.

I did discuss this event with the psychiatrist that prescribes my Cymbalta and it seems to be a rare occurrence according to him ? Well I did go from 120mg down to 90mg after that appt without a problem.

Fast forward to January 2014, I am doing some research on autoimmune disease as my siblings and I have developed a few. I came across the use of LDN ( low dose naltrexone) in a number of auto immune disorders and requested a prescription from my PCP 2 weeks ago. I read as much as I could find and it made sense to me to try to further reduce my heroin like addiction to Cymbalta to see if the LDN may reduce the awful withdrawal symptoms.

I am currently taking LDN 4.5mg at bedtime along with only 30mg of Cymbalta! And I am happy to say not only do I feel a little better from the LDN I have not experienced a single uncomfortable symptom from the reduction in Cymbalta. I am a bit nervous about going from 30 to 0, I may wait a couple weeks. I did want to put this info out here tho. LDN is not very well known, it's cheap, off patent etc. Just google LDN and educate yourself. It may not work for everyone. BTW, my auto immune disorder was/is Transverse Myelitis. My withdrawal symptoms had NOTHING to do with the TM. I had TM in 1977 with a 90% recovery.

I would love to have an update Apple 123. 

How did the LDN work out?

 

I looked it up here as a link about LDN came my way today I find it interesting. 

http://www.lowdosenaltrexone.org/index.htm#What_is_low_dose_naltrexone

 

Apparently it is used to treat all sorts of auto immune disorders and heals the circadian rythm is it just too good to be true I can't decide I am too tires but the link is there if you want to look. 

peace all

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JayPea

I am quite a few meds to address the symptoms of MS, baclofen for spasticity, oxybutin for bladder control, and LDN for quality of life with MS. In addition to dilantin for lifelong seizure disorder.  The LDN does help the MS and I hope too it will help with the stepping down of the Celexa,

 

check it out.

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alwayslookup

Bumping this

 

Anyone tried this ???

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Lexy

Is anyone on this? My doctor recommended low dose naltrexone .5mg to start for chronic fatigue and body aches. I'm so wary of trying anything new. He says low dose is anywhere from .5mg to 4.5mg, I would be starting at the bare minimum, however I'm so sensitized with effexor withdrawals. Please anyone...?

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westcoast

How interesting. I searched the net in several ways, including looking for Apple123. Can't find anything. On RxIsk, Dr Healy lists it as something they've heard of, but that he knows of no research.

 

One clue. On Naltrexons'e wikipedia page, it says that it's used for the psychiatric side effects of interferon alpha therapy for Hep C, but there's no reference listed. It's interesting, though, because treatment with interferon alpha is associated with:

 

depressive symptoms,

cognitive disturbances,

chronic fatigue syndrome,

dysphoria,

anxiety symptoms,

anorexia,

mania and

psychotic states.

akathisia

http://www.ncbi.nlm.nih.gov/pubmed/17068950

http://www.ncbi.nlm.nih.gov/pubmed/15697325

 

I'd have tried it if I had been able to leave my attic and go to a doctor during withdrawal...

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Lexy

I just started low dose naltrexone .5mg two days ago. First day I didn't feel anything apart from the same wds as always. Second day- I felt drunk-like, and a heaviness on my entire body. I'll report back if I decide to continue.

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westcoast

I wish you luck, Lexy.

 

Is it good/relaxed heavy or fatigued/achey heavy? Or I guess I mean--did you feel your usual WD on Day 2?

 

Naltrexone is said not to cause dependency, I saw on a medical site. Please be true, right?

 

While searching for that information, I found a thread on a poly-drug forum where the OP was quite thrilled about the drug, but s/he wasn't using it for AD WD. She has a grand theory that it backs your brain out of addiction mode. Might be interesting but I have to run off, and will read the rest later. I pasted it into:

http://survivingantidepressants.org/index.php?/topic/8688-interesting-threads-on-other-psych-drug-boards/#entry157668 (In the [social] Media)

 

W

 

PS

I will read that page, B. I was fascinated by everything to do with pineal gland during row 6 of my sig file (2012). Thanks for posting it. The defunct Topix is like an alternate universe. I just remembered there are layers of defunct net eras...I was on text-only message boards in the 1980s and as far as I know they're still archived--the original alt.net for example. It was taboo to sell anything or run an ad back then.

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bluebalu86

I am interested in this. Will research it.

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btdt

 

 At night, a brain chemical called

norepinephrine, which transmits information through nerve cell networks, is released in the pineal gland. Norepinephrine, in turn, stimulates the production of another compound within the cells of the pineal gland, known as cyclic adenosine monophosphate (cyclic AMP). Cyclic AMP causes the pineal gland to produce melatonin.

 

The researchers noted that the daily changes in gene activity observed in the study were controlled by the release of norepinephrine and the increase of cyclic AMP.

"This is surprising, because we did not anticipate that the release of one

molecule - norepinephrine - would be found to control the activity of

hundreds of genes," Dr. Klein said. "It appears that this one signal

triggers a highly complex response that is necessary for normal rhythmic function of the pineal gland."

 

Dr. Klein added that he and his colleagues are planning future studies to discern both how the cells of the pineal gland are controlled and how they influence the genes controlling other cellular functions.

 

"We have a long way to go before we can fully understand the role of the pineal gland and what makes it tick," Dr. Klein said. "I suspect that the pineal gland plays a much broader role in human health than anyone has ever imagined."

 

Makes me wonder the effects of drugs that are norepinephrine reuptake inhibitors cymbalta and effexor... and the new pain drug called nycenta.. there may be a u in that name.. it is demeral and norepinephrine that is what a doc told me.... not sure it is completely true. 

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Amygdala

I take Cymbalta for Fibromyalgia and it worked well for that but I still wish I had never started. Cymbalta will be my next taper.

 

Anway, I recently saw a chart with the top 20 drugs for fibromyalgia, Cymbalta was rated the lowest and LDN was rated the highest, sorry I did not bookmark the page.

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btdt

How interesting. I searched the net in several ways, including looking for Apple123. Can't find anything. On RxIsk, Dr Healy lists it as something they've heard of, but that he knows of no research.

 

One clue. On Naltrexons'e wikipedia page, it says that it's used for the psychiatric side effects of interferon alpha therapy for Hep C, but there's no reference listed. It's interesting, though, because treatment with interferon alpha is associated with:

 

depressive symptoms,

cognitive disturbances,

chronic fatigue syndrome,

dysphoria,

anxiety symptoms,

anorexia,

mania and

psychotic states.

akathisia

http://www.ncbi.nlm.nih.gov/pubmed/17068950

http://www.ncbi.nlm.nih.gov/pubmed/15697325

 

I'd have tried it if I had been able to leave my attic and go to a doctor during withdrawal...

I did not see Naltrexone in the second link is it a mistake do you have a different link in mind ... never mind I get it now bit slow today .. it is starting to look better. 

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Lexy

Started LDN in Monday. Last night I took .5 twice a day. It made me feel like I had had two/three shots of alcohol, dizziness, slurred speech, feeling stuck to the couch.

I will take it right before bedtime today.

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Lexy

Last night I took Ldn twice, I slept very little.

I have been micro tapering effexor and this is the first bad night I've had.

I am too afraid to take it again. Sleep had been the only good thing that had remained.

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Lexy

Last night I did not take the pm dose of LDN. My sleep was normal. Everything else (pain, fatigue, mood swings, etc) are the same.

I still felt the drunken stupor as the previous day's.

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btdt

In the articles I have read they are giving one dose at night from .5 - 4 mg... what dose are you taking and why do you take it twice a day?

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Lexy

Btdt

Thank you, I've read all your links. Previously I couldn't get into topix as they closed it down. I imagine paxilprogress also might have had info.

My doctor acknowledges how sensitized I am, that's probably why he had the dose broken in two doses starting at .5mgs.

I've only taken one am dose today and feeling nauseous, drunklike, dizzy and faint. Not that I haven't had these symptoms before except for the drunkeness.

Somewhere I read if sleep disturbances occur, take the dose in the morning. Also that these startup effects last couple weeks before patients start to feel better.

I hope that's the case with me, however I don't know whether I should keep struggling with Ldn and effexor wds.:/

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btdt

This is the topix link found on waybackmachine  it is part of it at least I am not sure how to get the rest of it.  I found it just the other day the idea of one late night dose to to take it at the time your body would be doing what it stimulates ... I think between 9 pm and 3am ... taking it in the day time would confuse your body into thinking it was that time of night is my guess....further to that 2 doses in 24 hours when the body only normally makes it at one time in 24 hours may be confusing to the brain body too.  That is if this information is correct. 

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Lexy

Thanks btdt...you do a lot for many people here. I've also read your other posts on other sites. You are always trying to spread the word. We need more people like you and Alto.

 

I couldn't hang with the LDN, I stopped it 4 days ago and have been having lingering nausea and queasiness. I didn't feel any benefit at all. Or for that matter only a slight decrease on the side effects. I told my doctor about the side effects however he said to continue taking it as it has wds...,..?! I feel I dug my hole deeper. When I asked him specifically if any wds on Ldn when he prescribed he said no this is a very simple med. I shouldn't have a problem! What the....! I should have listened to Giak who said she had tried it and set her back. I took it for two weeks I wonder how long it will take to get it out if my system.

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Lexy

I'm not sure if it's still naltrexone but I have been feeling very faint and dizzy.

From now on I will not be taking anymore drugs to combat my wds.

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Celeste

Hi all. Anyone with protracted withdrawal syndrome try this?? I am four years into withdrawal and have been struggling with CFS and fibromyalgia symptoms that have progressed this past year. I am also pretty sensitized..not sure if that's gotten any better or not. I tried reinstating Celexa 6 months after I was done with withdrawal and that was pretty detrimental but Klonopin helps me when I used it sparingly. I'm curious about this drug and really need some symptom relief as I had to leave work. Anyone have experience?

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Altostrata

There are several low dose naltrexone groups on Facebook that would be able to give you more information.

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Lexy

If you read a couple of my posts in this thread you can see it made me worse. Also Giak took in the midst of wds that set her back. If you do try I recommend taking very little and titrating up very slowly.

After the fact my doctor said he shoukd have given me half or .25mg of LDN. It took several weeks to get back to pre LDN. I also was hoping it would help fatigue and fibromyalgia.

What im doing now is looking for natural alternatives. Example my Mom suggested a salt cave treatment. The cave has Homalayan salt rocks, I say down on a lounge chair. They turned on a fan and microscopic salt woukd blow in air.

Idk if it was a placebo effect but body aches where much lower. And that was after a long day of exerting myself on vacation. I'm going to look up to find one closer to home.

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Celeste

Thanks Lexy and Altostrata. I did read all of the posts in this thread and was not sure if those situations applied to me. GiaK's injury from psych drugs is much worse than mine and like you mentioned with your situation, I was wondering if your doctor prescribed you too much to begin with. 

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Celeste

I am also looking into more holistic treatments starting with diet. I want to try gluten free and possibly talk to my doctor about anti-candida treatment. I have a lot of signs of candida overgrowth...gained 20 lbs in 3 years but my diet got much better, bloating, pain and fatigue, vaginal infection-either yeast or bacterial vaginosis (sorry for the details) since July, 2014 that has been treated around 10 times that still hasn't gone away. There is something obviously going on with bacteria in my gut that needs addressed. that salt rock cave treatment sounds interesting. I'd interested to hear if that works for you, Lexy.

 

My symptoms were pretty bad yesterday and I was craving chocolate just for comfort I guess. My husband got me an organic, dark chocolate bar and I ate about 4 squares out of the 10 and my symptoms went away. I did some research and found that chocolate can help to stimulate endorphins which is what the LDN is supposed to help do. I'm not sure if I'm going to try it...I'm still nervous because of my sensitivities but if I do I'm going to start low, like .25 mg. I will update this thread with my experiences if I try it for sure.

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Altostrata

I would take it with a grain of salt that chocolate has any significant effect on endorphins. It does contain potassium, though. You may be hypokalemic.

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