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Tips for tapering off Wellbutrin, SR, XR, XL (buproprion)

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brassmonkey

The half life of Wellbutrin is 37 hours.  The hour by hour fluctuation of this med is negligible, so hour by hour dosing would be of little to no value.  All it would do is add to anxiety and the probability of not getting your dose correct for the day.  Splitting the dose morning and evening might have some benefit, but more than likely not.  I'm glad that splitting your  dose worked for you HikingAlong, but I don't think hourly dosing of this medication is warranted.

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felin

Very interesting Hiking. I am going to look into this!!

 

Can't wait for the day that my brain is working on it's own again!!

 

Thank you so much for taking the time to give me your input!!

 

Brass, hmmm....what do you suggest though if I've tried the dreaded purple pill and it made me so sick?? Thx

 

Also, when you say that the half life of Wellbutrin is 37 hours are you referring to IR, SR, XR, XL or all?

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ChessieCat
27 minutes ago, felin said:

Also, when you say that the half life of Wellbutrin is 37 hours are you referring to IR, SR, XR, XL or all?

 

From:  https://en.wikipedia.org/wiki/Bupropion

 

See under the heading:  Pharmacodynamics for the following table:

 

Human pharmacology

 

  Bupropion R,R- S,S- Threo- Erythro-
  Hydroxy Hydroxy hydro hydro
  bupropion bupropion bupropion bupropion
Exposure (concentration over time; bupropion exposure = 100%) and half-life
Exposure 100% 800% 160% 310% 90%
Half-life 10 h (IR) 21 h 25 h 26 h 26 h
17 h (SR)

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HikingAlong

That looks like the half life of IR is 10 Hours. I don't understand why it needs an ER version if that's really how it works in a human system.

 

I only know my own experience, which was that it worked for me to have 3-4 doses through the day.

 

Hiking

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Altostrata

10 hours is a short half-life. You may metabolize it even faster. If several doses throughout the day works for you, that makes sense. Strongly recommend taking the doses on a regular schedule and keep notes of how much you're taking -- this will be important while tapering.

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firepink

So I only have Bupropion SR - right now dividing each 150mg pill into eighths is fine (I'm at 15/16 total dose right now), but in the future if I need to start a liquid taper is that at all possible to do with an SR pill? I was unclear as to whether the instruction to only liquid taper with IR pills is due to some chemical or physical limitation of the SR pill or if it's just that turning an SR pill into a liquid turns it into an IR liquid. Could anyone clarify, please?

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Altostrata

You can only make a liquid from immediate-release buproprion. The other types contain binders that will not dissolve well.

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    Hoonie

    I am in my 3rd month of taking bupropion, which was prescribed for suicidal depression. I initially started on 150mg daily and this was increased to 300mg daily (in an attempt to stop my headaches). I think I want to come off them, and not to be started on any other psychiatric medication.

    The preparation of bupropion I am currently taking is a "modified release" form (Elontril®). I have searched the 4 pages of this thread for the words "modified" and "Elontril", and there were no hits. Does anyone know which preparation from the list "IR, SR, XR, XL" this refers to? My medication seems to have been manufactured in Spain by GlaxoSmithKline, "liberacíon modificada" translating to "modified release".

     

    Cheers

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    Altostrata

    Hello, Hoonie. Please start a topic for yourself in the Introductions forum, where we can answer questions about your particular situation.

     

    Please ask a pharmacist to identify what kind of bupropion you have. We can't keep up with all the brands.

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    emergingfromhell
    19 hours ago, Hoonie said:

    I am in my 3rd month of taking bupropion, which was prescribed for suicidal depression. I initially started on 150mg daily and this was increased to 300mg daily (in an attempt to stop my headaches). I think I want to come off them, and not to be started on any other psychiatric medication.

    The preparation of bupropion I am currently taking is a "modified release" form (Elontril®). I have searched the 4 pages of this thread for the words "modified" and "Elontril", and there were no hits. Does anyone know which preparation from the list "IR, SR, XR, XL" this refers to? My medication seems to have been manufactured in Spain by GlaxoSmithKline, "liberacíon modificada" translating to "modified release".

     

    Cheers

     

    If you take it once a day, it’s likely extended release (XL which is the same is XR). It releases over time or you’d have to take more than one a day. X

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    Altostrata

    Different countries have different brands and forms of this drug.

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    felin

    I am going to Primary Care next week to discuss a plan of action. Not looking forward to going to IR but see no other option.

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