Administrator Altostrata Posted May 20, 2018 Administrator Share Posted May 20, 2018 (edited) Int J Risk Saf Med. 2018 May 9. doi: 10.3233/JRS-180018. [Epub ahead of print] SSRI and SNRI withdrawal symptoms reported on an internet forum. Stockmann T1, Odegbaro D2, Timimi S3, Moncrieff J4. Abstract at https://www.ncbi.nlm.nih.gov/pubmed/29758951 Full text here (pdf) BACKGROUND: Antidepressant withdrawal symptoms are well-recognised, but their potential duration remains uncertain. OBJECTIVE: We aimed to describe the characteristics of withdrawal associated with two popular classes of antidepressants, including duration. METHODS: We analysed the content of a sample of posts on an antidepressant withdrawal website. We compared the characteristics of withdrawal associated with SSRIs and SNRIs, including time of onset, duration and nature of symptoms. RESULTS: 110 posts about SSRI withdrawal, and 63 concerning SNRI withdrawal, were analysed. The mean duration of withdrawal symptoms was significantly longer with SSRIs than SNRIs: 90.5 weeks (standard deviation, SD, 150.0) and 50.8 weeks (SD 76.0) respectively; p = 0.043). Neurological symptoms, such as 'brain zaps,' were more common among SNRI users (p = 0.023). Psychosexual/genitourinary symptoms may be more common among SSRI users (p = 0.054). LIMITATIONS: The website aims to help people with antidepressant withdrawal, and is therefore likely to attract people who have difficulties. Length of prior use of antidepressants was long, with a mean of 252.2 weeks (SD 250.8). CONCLUSIONS: People accessing antidepressant withdrawal websites report experiencing protracted withdrawal symptoms. There are some differences in the characteristics of withdrawal associated with different classes of antidepressants. KEYWORDS: Antidepressant; SNRI; SSRI; antidepressant withdrawal; online report Edited January 30, 2019 by ChessieCat added link to pdf This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
peng Posted May 21, 2018 Share Posted May 21, 2018 Look forward to reading that. Well done and thanks, Alto. Born 1945. 1999 - First Effexor/Venlafaxine. 2016 Withdrawal research. Effexor. 13Jul - 212.5mg; 6Aug - 200.0mg; 24Aug - 187.5mg; 13Sep - 175.0mg; 3Oct - 162.5mg; 26Oct - 150mg 2017 9Jan - 150.00mg; 23Mar - 137.50mg; 24Apr - 125.00mg; 31May - 112.50mg holding; 3Sep - 100.00mg; 20Sep - 93.75mg; 20Oct - 87.5mg; 12Nov - 81.25mg; 13 Dec - 75.00mg 2018 18Jan - 69.1mg; 16Feb - 62.5mg; 16March - 57.5mg (-8%); 22Apr - 56.3mg(-2%); CRASHED - Updose 29May - 62.5mg; Updose - 1Jul - 75.0mg. Updose - 2Aug - 87.5mg. Updose - 27Aug - 100.0mg. Updose - 11Oct 112.5mg. Updose - 6Nov 125.00mg. 2019 Updoses 19 Jan - 150.0mg. 1April - 162.5mg. 24 April - Feeling better - doing tasks, getting outside. 7 May - usual depression questionnaire gives "probably no depression" result. Supps/Vits Omega 3; Chelated Magnesium; Prebiotics/Probiotics, Vit D3. Link to comment Share on other sites More sharing options...
Barbarannamated Posted May 21, 2018 Share Posted May 21, 2018 I strongly believe that some *withdrawal symptoms* should be categorized as tardive effects like those that are known to occur with neuroleptics / antipsychotics. Tardive effects appear after the drug is STOPPED and are generally considered permanent. Pristiq tapered over 8 months ending Spring 2011 after 18 years of polydrugging that began w/Zoloft for fatigue/general malaise (not mood). CURRENT: 1mg Klonopin qhs (SSRI bruxism), 75mg trazodone qhs, various hormonesLitigation for 11 years for Work-related injury, settled 2004. Involuntary medical retirement in 2001 (age 39). 2012 - brain MRI showing diffuse, chronic cerebrovascular damage/demyelination possibly vasculitis/cerebritis. Dx w/autoimmune polyendocrine failure.<p>2013 - Dx w/CNS Sjogren's Lupus (FANA antibodies first appeared in 1997 but missed by doc). Link to comment Share on other sites More sharing options...
bubbles Posted May 22, 2018 Share Posted May 22, 2018 I'd love to read that article. Was this the forum they mentioned? The abstract doesn't seem to mention mood issues as withdrawal effects. Also I wonder how they address "psychosexual" issues. That is an intensely personal issue and even on a forum like this one, where we are able to hide our names, people may prefer not to mention it. This means that the frequency with which this issue occurs may not be accurately assessed. The abstract says "the website aims to help people with antidepressant withdrawal, and is therefore likely to attract people who have difficulties". While that is true enough, it isn't possible to draw any conclusions as to the proportion of people having difficulties. It is only possible to assess that, of those people who post, this is what was noticed. A forum such as this one does indeed attract people who are having difficulties withdrawing, but of the people having difficulties, only those who don't believe that symptoms are the return of their original illness. People who try to withdraw, become unwell and interpret that unwellness as meaning that "the drug was keeping me well", are not on this forum. So my interpretation of that line in the abstract is "yes, but...". 2005 St John's Wort / 2006-2012 Lexapro 20mg, 2 failed attempts to stop, tapered over 4.5 months in early 2012 January 2013 started Sertraline, over time worked up to 100mg July 2014 Sertraline dropped from 100mg to 75mg, held for six months, slower tapering until 2019 22 Dec 3.2mg 2020 Sertraline 19 Jan 3.1mg, 26 Jan 3.0mg; 1 Mar 2.9, 7 Mar 2.8, May (some drops here) 24 May 2.5, May 29 2.4, June 21 2.3, June 28 2.2mg, July 4 2.1mg, July 24 (or maybe a bit before) 2mg, early Nov switched to home made suspension; 29 Nov 1.8mg; approx 25 Dec 1.6mg) 2021 Some time in about Jan/Feb realised probably on more like 1.8mg and poss mixing error in making suspension; doses after 10 Feb accurate; 10 Feb 1.6mg; 7 Mar 1.4, continued monthly 10% drops until 1mg, then dropped 0.1mg monthly. May 2022,0.1mg, now dropping 0.01mg per week 29 August 2022 - first day of zero! My thread here at SA: https://www.survivingantidepressants.org/topic/1775-bubbles/page/21/ Current: Armour Thyroid Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted May 22, 2018 Author Administrator Share Posted May 22, 2018 I don't know. I've requested the article. If anyone can retrieve it, please let me know. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
bubbles Posted June 19, 2018 Share Posted June 19, 2018 Full text link here: https://joannamoncrieff.files.wordpress.com/2018/06/antidepressant_withdrawal.pdf (Yes, it was SA!) 2005 St John's Wort / 2006-2012 Lexapro 20mg, 2 failed attempts to stop, tapered over 4.5 months in early 2012 January 2013 started Sertraline, over time worked up to 100mg July 2014 Sertraline dropped from 100mg to 75mg, held for six months, slower tapering until 2019 22 Dec 3.2mg 2020 Sertraline 19 Jan 3.1mg, 26 Jan 3.0mg; 1 Mar 2.9, 7 Mar 2.8, May (some drops here) 24 May 2.5, May 29 2.4, June 21 2.3, June 28 2.2mg, July 4 2.1mg, July 24 (or maybe a bit before) 2mg, early Nov switched to home made suspension; 29 Nov 1.8mg; approx 25 Dec 1.6mg) 2021 Some time in about Jan/Feb realised probably on more like 1.8mg and poss mixing error in making suspension; doses after 10 Feb accurate; 10 Feb 1.6mg; 7 Mar 1.4, continued monthly 10% drops until 1mg, then dropped 0.1mg monthly. May 2022,0.1mg, now dropping 0.01mg per week 29 August 2022 - first day of zero! My thread here at SA: https://www.survivingantidepressants.org/topic/1775-bubbles/page/21/ Current: Armour Thyroid Link to comment Share on other sites More sharing options...
bubbles Posted June 19, 2018 Share Posted June 19, 2018 "Reported time before onset of withdrawal symptoms was also longer than previously documented for people withdrawing from SSRIs/SNRIs. For 50% ofSSRI users this was almost 9 days or more, and for 25% of users it exceeded 6 weeks. For those taking SNRIs it was closer to the duration previously reported, which likely reflects the short action of venlafaxine, the most commonly used agent in this group." (p. 177) 2005 St John's Wort / 2006-2012 Lexapro 20mg, 2 failed attempts to stop, tapered over 4.5 months in early 2012 January 2013 started Sertraline, over time worked up to 100mg July 2014 Sertraline dropped from 100mg to 75mg, held for six months, slower tapering until 2019 22 Dec 3.2mg 2020 Sertraline 19 Jan 3.1mg, 26 Jan 3.0mg; 1 Mar 2.9, 7 Mar 2.8, May (some drops here) 24 May 2.5, May 29 2.4, June 21 2.3, June 28 2.2mg, July 4 2.1mg, July 24 (or maybe a bit before) 2mg, early Nov switched to home made suspension; 29 Nov 1.8mg; approx 25 Dec 1.6mg) 2021 Some time in about Jan/Feb realised probably on more like 1.8mg and poss mixing error in making suspension; doses after 10 Feb accurate; 10 Feb 1.6mg; 7 Mar 1.4, continued monthly 10% drops until 1mg, then dropped 0.1mg monthly. May 2022,0.1mg, now dropping 0.01mg per week 29 August 2022 - first day of zero! My thread here at SA: https://www.survivingantidepressants.org/topic/1775-bubbles/page/21/ Current: Armour Thyroid Link to comment Share on other sites More sharing options...
Barbarannamated Posted June 22, 2018 Share Posted June 22, 2018 This is groundbreaking in the context of being mocked, dismissed (and worse) for going to the internet for help in the absence of knowledge or help from medical professionals. Kudos, Alto! Pristiq tapered over 8 months ending Spring 2011 after 18 years of polydrugging that began w/Zoloft for fatigue/general malaise (not mood). CURRENT: 1mg Klonopin qhs (SSRI bruxism), 75mg trazodone qhs, various hormonesLitigation for 11 years for Work-related injury, settled 2004. Involuntary medical retirement in 2001 (age 39). 2012 - brain MRI showing diffuse, chronic cerebrovascular damage/demyelination possibly vasculitis/cerebritis. Dx w/autoimmune polyendocrine failure.<p>2013 - Dx w/CNS Sjogren's Lupus (FANA antibodies first appeared in 1997 but missed by doc). Link to comment Share on other sites More sharing options...
bubbles Posted June 22, 2018 Share Posted June 22, 2018 Yes, it is. So glad for these people doing this work. 2005 St John's Wort / 2006-2012 Lexapro 20mg, 2 failed attempts to stop, tapered over 4.5 months in early 2012 January 2013 started Sertraline, over time worked up to 100mg July 2014 Sertraline dropped from 100mg to 75mg, held for six months, slower tapering until 2019 22 Dec 3.2mg 2020 Sertraline 19 Jan 3.1mg, 26 Jan 3.0mg; 1 Mar 2.9, 7 Mar 2.8, May (some drops here) 24 May 2.5, May 29 2.4, June 21 2.3, June 28 2.2mg, July 4 2.1mg, July 24 (or maybe a bit before) 2mg, early Nov switched to home made suspension; 29 Nov 1.8mg; approx 25 Dec 1.6mg) 2021 Some time in about Jan/Feb realised probably on more like 1.8mg and poss mixing error in making suspension; doses after 10 Feb accurate; 10 Feb 1.6mg; 7 Mar 1.4, continued monthly 10% drops until 1mg, then dropped 0.1mg monthly. May 2022,0.1mg, now dropping 0.01mg per week 29 August 2022 - first day of zero! My thread here at SA: https://www.survivingantidepressants.org/topic/1775-bubbles/page/21/ Current: Armour Thyroid Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted June 27, 2018 Author Administrator Share Posted June 27, 2018 Thank you so much, bubbles. This paper is a very intelligent assessment of the evidence presented in the Introductions topics. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
RealMe Posted June 29, 2018 Share Posted June 29, 2018 On 6/27/2018 at 2:40 PM, Altostrata said: Thank you so much, bubbles. This paper is a very intelligent assessment of the evidence presented in the Introductions topics. Hi Altostrata, I just read the assessment paper. Can you explain the following comment? "The positive correlation between duration of symptoms and length of taper is likely to indicate that people experiencing difficult and protracted withdrawal symptoms reduce their antidepressants more slowly." Does it mean that people experiencing ...withdrawal symptoms (should?) reduce their antidepressants more slowly." Thanks, RM Alcohol periodic excessive 1963-1976, Valium sporadic 1964-1973, Imipramine off & on 1982-1985, Fluoxetine 10mg-80 mg. Oct., 1995-Jan., 2014; Cymbalta, other ADs 1/2014-3/2014; Abilify 5 mg. 3/2014 - 8/8/17; Trintellix 20 mg. 3/2014 - 9/2017; Propranolol 60-80 mg. sporadically Sept-Oct, 2017; Seroquel few days Sept 2017 (c/t); Wellbutrin 150 mg. Sept, 2017 updosed to 300 mg. few days till c/t Oct 8, 2017, fish oil, vitD, vitE Oct 16, 2017-pres. Lipoflavonoid 4/2017-pres. Fluoxetine 10 mg. Sept-Oct 8, 2017, 20 mg. 10/9- 10/15; 10 mg. 10/16 - 12/29; 9 mg. 12/30 - 2/9; 2 mL liquid (8.1mg) 2/10 - 3/7; 1.8 mL (7.29 mg) 3/8 -3/20; 1.6 mL (6.561mg) 3/20-4/2; 1.4 mL (5.9 mg) 4/3-4/14; 1mL (4 mg.) 4/15-4/22; .9mL (3.6mg) 4/23-5/1; .81mL (3.24 mg) 5/2-5/24; .73mL (2.916mg.) 5/25-6/8; .65mL 6/9-6/23; .6mL 6/24-7/17; .58mL 7/18-7/28; .525mL 7/29-8/13; .5 mL 8/14-21; .45mL 8/22-31; .4mL 9/2-21; .35mL 9/22-10/4; .3mL 10/5-28; .25mL 10/28-11/10; .2mL 11/11-11/24; .18mL 11/25-12/3; .1mL 12/4-12/18. Zero-12/19/18-present. Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted June 29, 2018 Author Administrator Share Posted June 29, 2018 I think that's infelicitously phrased, what they mean is people who have trouble tapering should taper more slowly, which they state in conclusion. I have written to the authors for clarification. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
bubbles Posted June 30, 2018 Share Posted June 30, 2018 I took it to mean that difficulties incurred along the way force the person to go more slowly. So if you have no problems, you just go off more quickly; if you have issues with that speed you go more slowly (perhaps if you end up here and get advice to do that). (Of course, many people probably have troubles and when doctor tells them it means they need to stay on longer, they do that and never come to a site like this one so it only refers to people who've actually ended up here.) Alto, I'll be interested to hear what the authors say. 2005 St John's Wort / 2006-2012 Lexapro 20mg, 2 failed attempts to stop, tapered over 4.5 months in early 2012 January 2013 started Sertraline, over time worked up to 100mg July 2014 Sertraline dropped from 100mg to 75mg, held for six months, slower tapering until 2019 22 Dec 3.2mg 2020 Sertraline 19 Jan 3.1mg, 26 Jan 3.0mg; 1 Mar 2.9, 7 Mar 2.8, May (some drops here) 24 May 2.5, May 29 2.4, June 21 2.3, June 28 2.2mg, July 4 2.1mg, July 24 (or maybe a bit before) 2mg, early Nov switched to home made suspension; 29 Nov 1.8mg; approx 25 Dec 1.6mg) 2021 Some time in about Jan/Feb realised probably on more like 1.8mg and poss mixing error in making suspension; doses after 10 Feb accurate; 10 Feb 1.6mg; 7 Mar 1.4, continued monthly 10% drops until 1mg, then dropped 0.1mg monthly. May 2022,0.1mg, now dropping 0.01mg per week 29 August 2022 - first day of zero! My thread here at SA: https://www.survivingantidepressants.org/topic/1775-bubbles/page/21/ Current: Armour Thyroid Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted September 8, 2018 Author Administrator Share Posted September 8, 2018 I verified in correspondence: They mean people who have trouble tapering should taper more slowly. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
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