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Hypersensitivity and Kindling


Shep

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Oh and muscle twitches all over my body have ramped up like crazy. Yeah I have had on and off the off balance feeling. 

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I always have balance issues. It feels like I’m on a boat or drunk. My legs go heavy like I’ve done leg day too. 

Citalopram 10mg sep14-nov14,

cit 20mg nov14-jan15,

cit 40mg jan15 -jan22,

tapered cit 40mg-0mg in 10 days.

mirtazapine 15mg then 30mg jan22-Mar22,

tapered in 1 week.

citalopram 20mg apr22- may22( had a reaction this time, hives everywhere),

no taper cold turkey 

sertraline 50mg then 100mg may22-nov22, tapered in 2 weeks.

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I reinstated a couple of weeks ago, started at .1ml for a week then went up to .2ml for a week, then went up to .3ml. I have had 3 bad nights/days... is it possible that I kindled from that small amount or is it probably just a bad wave?

Cymbalta - 2005-2008 - quit CT with no issues 

2008-2013 - on and off Fluoxetine with no issues

Fluoxetine - January 2013 - October 2016

Switched to Cymbalta - October 2016

Quit Cymbalta CT - January 26, 2017 -9 1/2 months of WD

Fluoxetine & Gabapentin - February 2017

Slow taper of Gabapentin - May 2017

Taper Fluoxetine 20mg to 5mg - September 2023 - January 2024 (now I know too fast)

Last 5mg dose of Fluoxetine - January 31, 2024 (now I know considered CT)

WD started February 7, 2024

*Reinstated .1ml Fluoxetine 6/11/24, .2ml 6/18, .3ml 6/25, .4ml 7/8, .5ml 7/15 - symptoms increased went back down to .4ml 7/20 - holding

WD symptoms: nausea and insomnia are the worst, bouts of anxiety, depression, fear/dread, emotional and lots of crying, loss of appetite, lost a lot of weight, constipation, sensitive teeth, hair falling out, sensitive to noise, body aches and pains/sciatica, dry mouth, Vagus nerve dysfunction, blurred vision, weird feeling like my shirt is choking me even though it's nowhere near my throat, acid reflux, chemical/metallic taste in my mouth, lump in my throat feeling, pins and needles sensations, tingling in my back, air hunger, akathisia, yawning and the tinny feeling doesn't go away

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  • 2 weeks later...

For SSRIs such as Zoloft, how much time should be given before attempting a taper after recovering from rather severe withdrawals? In order to lessen this supposed hypersensitivity 

08/2023 - Started 50MG Zoloft

10/2023 - Started 40MG Straterra

03/2024 - Upped to 75MG Zoloft

04/2024 - Upped to 100MG Zoloft

04/2024 - Started 5MG Trintellix

05/2024 - Tried cold turkey Sertraline (failed and went back on)

07/2024 - Currently still on 50mg Zoloft, 5mg Trintellix, and 40mg Strattera

 

 

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On 10/12/2022 at 1:25 PM, Sottana said:

I’d say they’re both incredibly severe but wd might be more severe. So hard to know what to do. I feel so hopeless. Thanks for your reply. 

Can I ask what you did?

Escitalopram  approximately 2012 to March 31st 2023 20mg cold turkey.

Back on to escitalopram 10 mg approximately 3weeks later.

Switch to Fluoxetine approximately 3 weeks after that.

Come off Fluoxetine 20 mg 22nd of June cold turkey.

 

2018 Saphris 5mg, 2022 Nov upped to 15mg, March 2024 decreased to 10mg, in April started to drop by 2.5mg a month. Got to 2.5mg and went back up to 7.5mg due to possibly dopamine sensitivety or withdrawal but can be sure. Not sure if kindled or withdrawal of symptoms I'm getting.

 

Been on antipsychotics such as Serrequal, Abilify, Zyprexa, but can't remember dates.

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On 10/12/2022 at 1:25 PM, Sottana said:

 

@ShepCan I ask can you become hypersensitive if you decrease and get what i think is dopamine sensitivety so you increase?

 

Also can epilepsy medication be kindled/hypersensitive?

 

How do you know if you've kindled on a antipsychotic?

Escitalopram  approximately 2012 to March 31st 2023 20mg cold turkey.

Back on to escitalopram 10 mg approximately 3weeks later.

Switch to Fluoxetine approximately 3 weeks after that.

Come off Fluoxetine 20 mg 22nd of June cold turkey.

 

2018 Saphris 5mg, 2022 Nov upped to 15mg, March 2024 decreased to 10mg, in April started to drop by 2.5mg a month. Got to 2.5mg and went back up to 7.5mg due to possibly dopamine sensitivety or withdrawal but can be sure. Not sure if kindled or withdrawal of symptoms I'm getting.

 

Been on antipsychotics such as Serrequal, Abilify, Zyprexa, but can't remember dates.

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On 10/12/2022 at 1:25 PM, Sottana said:

I’d say they’re both incredibly severe but wd might be more severe. So hard to know what to do. I feel so hopeless. Thanks for your reply. 

Can I ask what did you do?

Escitalopram  approximately 2012 to March 31st 2023 20mg cold turkey.

Back on to escitalopram 10 mg approximately 3weeks later.

Switch to Fluoxetine approximately 3 weeks after that.

Come off Fluoxetine 20 mg 22nd of June cold turkey.

 

2018 Saphris 5mg, 2022 Nov upped to 15mg, March 2024 decreased to 10mg, in April started to drop by 2.5mg a month. Got to 2.5mg and went back up to 7.5mg due to possibly dopamine sensitivety or withdrawal but can be sure. Not sure if kindled or withdrawal of symptoms I'm getting.

 

Been on antipsychotics such as Serrequal, Abilify, Zyprexa, but can't remember dates.

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@Shep

Can paradoxical reactions go away? Well im not sure if its that or withdrawal. I was tapering off a antipsychotic and got dopamine sensitivety psycosis and insomnia so i up dosed and slept for 3 nights and then had insomnia for 2 nights. Im at ends and dont know what to do as i cant come off medication because it is Saphris.

Escitalopram  approximately 2012 to March 31st 2023 20mg cold turkey.

Back on to escitalopram 10 mg approximately 3weeks later.

Switch to Fluoxetine approximately 3 weeks after that.

Come off Fluoxetine 20 mg 22nd of June cold turkey.

 

2018 Saphris 5mg, 2022 Nov upped to 15mg, March 2024 decreased to 10mg, in April started to drop by 2.5mg a month. Got to 2.5mg and went back up to 7.5mg due to possibly dopamine sensitivety or withdrawal but can be sure. Not sure if kindled or withdrawal of symptoms I'm getting.

 

Been on antipsychotics such as Serrequal, Abilify, Zyprexa, but can't remember dates.

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Hi all.. so I’m know I’m hypersensitive and am starting to think I might be feeling a kindling affect. Do I still hold my dose if I’m kindling?

Started Effexor xr in 2006 went off cold Turkey in 2010 after a year I got hit with horrible panic attacks and was put on benzos and Zoloft . In 2015 I was switched from 25 mg Zoloft to 10 mg celexa

in 2016 I started my benzo taper 

min 2020 I finished my benzo taper 

and now in 2021 I want to try and taper off the 10 mg celexa

have been on 10 mg celexa since 2015  

switched over to liquid celexa and tapered down to 4mg celexa over the span of 6 years 2023

in March of 2024 I hit a wall and started updosed back up to 8mg, took me few months to stabilize 

june 11 2024 I cross tapered from 8 mg of celexa to 4mg lexapro in 3 weeks. 
June  23 2024 felt awful on lexapro jumped back on to 8mg celexa 

now I feel even worse than ever 

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  • 1 month later...
On 2/10/2024 at 11:14 AM, Moe96 said:

Thank you, @PortugueseSea. :) 
 

I was afraid i was getting re-kindled every time i’m exposed to it, and that i would never recover due to this sensitivity because it’s extremely difficult to completely get rid of second handsmoke when you live with smokers, and in the city. But hopefully as you said it will calm down as my body heals. 
 

Sometimes spices give the same reaction too. One time i had a meal that contained  turmeric, cinnamon, ginger, saffron, oregano, and black pepper all at once…the reaction was a DISASTER !! I went into a deep (indescribable) dpdr state  with intense depression and SI that lasted like for 16 hours . As a result, i’m terrified of food now 😣

 

i just can’t wait until this adverse reaction crap resolves because it’s been extremely traumatic for the last 7-8 months…

I added saffron to dinner the other night. I wonder ifbthat is what has causes me to feel this way this weekend. 

Sertaline- tried 50 mg beginning of June 2023. Caused hyperreflexia.  So stopped after one dose. Tried several smaller doses that month.  Had burning and twitching so just stopped. 

Lexapro

June of 2023' 2.5 mg for two weeks 

July of 2023 5 mg for two weeks

July of 2023 7.5 mg for 2 weeks

August to mid September 10 mg

Mid September reduced to 7.5

October to October 15 reduced to 5

October 15 to October 30 reduced to 2.5 

October 30-off

 

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I've been in this wave for a month now.  I go to bed and I sleep until 1130-midnight. Then I'm awake. When 230 3 am comes around my body feels like it's being electrocuted and the nausea kicks in. If I fall asleep I'm jolted awake and feel 20 times worse. I'm forced to get out of bed at 5am. The rest of the day is fighting pure exhaustion. Doing the simplest tasks is hard as hell. I survive a day to get to another night of torture. I have no idea how long this will last, how much I can take. My poor husband has to do so much because I'm bearly functioning. I need this to release. I'm a year off of valafexine and this is the worst wave yet. 

2012 july started prozac (i cant remember dosage)

2013 october tappered off prozac so i could switch to valafexine.

Nov 2013 started valafexine 37.5 day

Dec 2013 went up to 150 mg a day of valafexine (2-75s)

2020-started trazadone 1 50 mg

March 2022 - started tapper valafexine. I would take a 75 mg and cut 1/4 off of the second 75 mg tablet.

July 2023- completely off valafexine 

Oct 5th 2023 started 2 25s a day of valafexine Oct 9th went up to 100mg of valafexine a day

Oct 14 went down to 37.5 of valafexine.

Oct 21 started mirtazapine 15 mg and 2- 5 mg buspar

Oct 23 stopped valafexine

Oct 28 stopped buspar

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On 3/18/2024 at 7:20 AM, jon1 said:

+1 for horrible depression from magnesium. I’ve tried all types, at all dosages, but it always makes me feel absolutely awful. So I just eat foods with a healthy amount of natural magnesium in.

 

If it’s one thing I’ve learned, my body loves naturally nutritious foods, and hates man-made synthetic supplements- even fortified foods are out.

 

It’s not a problem though, the vast majority of people don’t need any supplements at all, they’re a complete waste of money. Much like the pharma industry has convinced the world anxiety and depression needs ‘fixing’ with a pill, the supplement industry has told everybody they’ll only ever be at their best if they take their products. It’s all marketing nonsense.

 

 

It’s worth mentioning that even a completely healthy person (not in withdrawal) would probably have an unusually strong reaction to caffeine after 8 months off. By the point, the nervous system has adjusted, the brain has healed, and no longer ‘needs’ caffeine to function. So essentially it’s like using a powerful drug for the first time again.

 

Caffeine doubles the amount of stress hormones in the blood, especially adrenaline and cortisol, for several hours (for some people up to 24 hours) after ingestion.

 

Meanwhile the dopamine spike - which causes the warm ‘feel good’ sensations, and is responsible for the cravings and addiction to caffeine - only lasts about 30 minutes!

 

It’s a pretty bad trade off really.

10mg of caffeine csn cause 50% increase in glutamate i just read that in a study

Valium used very sporadically for anxiety (no tolerance or dependency)

Progesterone 100mg for 10 days 

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On 4/15/2024 at 8:17 AM, Tigz91 said:

Yes I’m 19 months out and my diet is very restricted. I worry this has given me mcas because it seems like my body just can’t tolerate much at all, even this far out.

If you have histamine symptoms it could be leaky gut which could be confirmed via GI Map + Zonulin test.

Valium used very sporadically for anxiety (no tolerance or dependency)

Progesterone 100mg for 10 days 

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On 9/3/2024 at 2:08 AM, Farm24 said:

I added saffron to dinner the other night. I wonder ifbthat is what has causes me to feel this way this weekend. 

Saffron can be used as an alternative anti depressant so possibly 

Valium used very sporadically for anxiety (no tolerance or dependency)

Progesterone 100mg for 10 days 

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On 9/3/2024 at 4:08 AM, Farm24 said:

I added saffron to dinner the other night. I wonder ifbthat is what has causes me to feel this way this weekend. 

I think it’s calmed down a little for me. I don’t get as intense reactions as then but still quite annoying. How long have you been dealing with this? It’s been 14 months for me. 

08/2016-05/2018 Effexor 250mg

05/2018-04/2019 Paxil 40mg
05/2019-08/2020 Effexor 150mg

05/2019 (risperidone for 4 days)
12/2020-12/2021 Effexor 150mg
12/2021-04/2022 Prozac 40mg (cross tappered for 10 days)
02/2022 Abilify 10mg (2 weeks)
04/2022-05/2022 Anafranil 50mg (one month)
05/2022-06/2022 Strattera 40mg (one month), 07/2022 Bupropion 150mg (2 weeks)
07/2022-11/2022 Duloxetine 90mg (with Concerta 54mg and Ritalin 10-20mg)

10/2022 - 11/2022 Quetiapine 25 mg for sleep
02/2023 prozac 20 mg  (3weeks),05/2023 Anfranil 25mg (2 days), 06/2023 Effexor (1 week 37,5mg, 4 days 75mg)

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2 hours ago, Moe96 said:

I think it’s calmed down a little for me. I don’t get as intense reactions as then but still quite annoying. How long have you been dealing with this? It’s been 14 months for me. 

10. Not too far behind you

Sertaline- tried 50 mg beginning of June 2023. Caused hyperreflexia.  So stopped after one dose. Tried several smaller doses that month.  Had burning and twitching so just stopped. 

Lexapro

June of 2023' 2.5 mg for two weeks 

July of 2023 5 mg for two weeks

July of 2023 7.5 mg for 2 weeks

August to mid September 10 mg

Mid September reduced to 7.5

October to October 15 reduced to 5

October 15 to October 30 reduced to 2.5 

October 30-off

 

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Does anyone get dermagraphia? 

Citalopram 10mg sep14-nov14,

cit 20mg nov14-jan15,

cit 40mg jan15 -jan22,

tapered cit 40mg-0mg in 10 days.

mirtazapine 15mg then 30mg jan22-Mar22,

tapered in 1 week.

citalopram 20mg apr22- may22( had a reaction this time, hives everywhere),

no taper cold turkey 

sertraline 50mg then 100mg may22-nov22, tapered in 2 weeks.

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20 hours ago, Tigz91 said:

Does anyone get dermagraphia? 

i had it first year i quit lexapro but gone

2015 20mg lexapro 

2016 20mg attempt get off one month taper(doctor advice) xtreme terror and anxiety 

2016 again  20mg attempt get off extreme ocd and social fear as withdraws

2018 reduce to 10mg ocd visual snow fatigue couldn't learn

2022 10mg get off again one month taper(doctor advice) had reactions on it and inflammation markers... xtreme protracted  withdraws symptoms 

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17 minutes ago, margaretLO said:

i had it first year i quit lexapro but gone

Good to hear it’s improved for you. I had it first year on citalopram and now I’ve had it for 22 months since I’ve been off 

Citalopram 10mg sep14-nov14,

cit 20mg nov14-jan15,

cit 40mg jan15 -jan22,

tapered cit 40mg-0mg in 10 days.

mirtazapine 15mg then 30mg jan22-Mar22,

tapered in 1 week.

citalopram 20mg apr22- may22( had a reaction this time, hives everywhere),

no taper cold turkey 

sertraline 50mg then 100mg may22-nov22, tapered in 2 weeks.

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  • 2 weeks later...

Please help! I went off sertraline too quickly (2 month taper) and experienced severe withdrawal symptoms (brain zaps, dizziness, rage episodes, suicidality) . However when I tried to reinstate with a low dose I experienced severe kindling symptoms (back pain, fever, headache, muscle pain). Am I supposed to keep taking the antidepressants or go off of them again? It seems like either option is bad, the withdrawal was intolerable but the kindling is also intolerable. Do I try a smaller dose, or keep taking the same dose to see if I stabilize? I can't find the answer to this issue anywhere. There's a 6 month wait for a psychiatrist and I need help now! 

Started Citalopram 20 mg in 2017 

One unsuccessful attempt to stop in early 2022 (2 month taper, resumed taking it after 2 weeks at zero)

May 2022: started taking Vyvanse 10 mg (still at the same dose today)

Switched to Sertraline 75 mg in early June 2024 after a 2 week cross taper

Started Sertraline taper mid July

July 17: 50 mgJuly 31: 25 mgAugust 14: 12.5 mgAugust 23: 6.25 mgAugust 30: 0 mg

Week 1 of withdrawals: brain zaps, dizziness, fatigue, low mood, digestive issues

Week 2 of withdrawals: intense rage episodes, paranoia, suicidal thoughts, anxiety, depression, hypomania 

September 15: Reinstated 12.5 mg, September 17: 6.25 mg, September 19: 3.5 mg

(Rapidly reduced dose after reinstating due to adverse reaction)

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41 minutes ago, AugustC said:

Please help! I went off sertraline too quickly (2 month taper) and experienced severe withdrawal symptoms (brain zaps, dizziness, rage episodes, suicidality) . However when I tried to reinstate with a low dose I experienced severe kindling symptoms (back pain, fever, headache, muscle pain). Am I supposed to keep taking the antidepressants or go off of them again? It seems like either option is bad, the withdrawal was intolerable but the kindling is also intolerable. Do I try a smaller dose, or keep taking the same dose to see if I stabilize? I can't find the answer to this issue anywhere. There's a 6 month wait for a psychiatrist and I need help now! 

Hi 👋 @AugustC To get a response from a moderator you need to post in the @introductions and updates section. If you to the top of the page on the right side there is a “plus” sign (+). Click on that to redo your post.

1991-2016 Zoloft, Klonopine, Wellbutrin added in 2000 2016 Lexapro, Klonopin, Wellbutrin 2016-2017 Effexor, Lamotrigine, Nortriptyline, Abilify, Cymbalta, Klonopin, Seroquel, Lexapro- slow taper 2016 2018-2021 Cymbalta 60 mg, Lexapro liquid 5ml/5mg (Apr 1, .26 ml/.26 mg) Klonopin 0.5 mg, Seroquel 20 mg. 4/1/21 added Magnesium and omega 3 oil. 9/21 Lexapro 0.15 mg.  8/9/22 Lex 0.15 ml/0.15 mg drop to 0.13 ml/0.13 mg; Klon 0.5 mg; Seroq 12.5 mg; Dulox 60 mg; Magnesium Chlor 1000 mg; Multi Vit; Omega Oil; probiotic. 10/2/22 Jumped off Lex at .018 mgs. 8/28/24 Seroq 3.2 mgs, Cym 60 mgs, klon .5 mg.

 

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2 hours ago, AugustC said:

Please help! I went off sertraline too quickly (2 month taper) and experienced severe withdrawal symptoms (brain zaps, dizziness, rage episodes, suicidality) . However when I tried to reinstate with a low dose I experienced severe kindling symptoms (back pain, fever, headache, muscle pain). Am I supposed to keep taking the antidepressants or go off of them again? It seems like either option is bad, the withdrawal was intolerable but the kindling is also intolerable. Do I try a smaller dose, or keep taking the same dose to see if I stabilize? I can't find the answer to this issue anywhere. There's a 6 month wait for a psychiatrist and I need help now! 

Some of the best advice on this is from the founder of this site. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7970174/ This is all about how the withdrawal is affecting you so you need to gradually identify what helps and what hurts your condition with a little trial and error. Adele describes how keeping a diary of your symptoms will help you with this as it's not just about the tapering but also about eliminating foods which aggravate the withdrawal. I experienced what you describe, resulting from both benzodiazepine and sertraline withdrawal, so know what you're going through as do many others here.

Prior medications;

sertraline 50mg April

sertraline 100mg May to July 2014 (ceased medication immediately upon occurrence of first thunderclap headache)

lorazepam April 2014 and November 2014 to January 2015 (each time suppressing symptoms of illness until two weeks after cessation of medication)

seroquel November 2014 to January 2015 50mg prior to being raised to 100mg for one day (medication ceased immediately upon occurrence of convulsive seizure)

warfarin 1990 to June 2023

Was instructed to 'cease doing anything healthy' by treating psychiatrist in June 2014 (the psychiatrist stating that belief in disease is the cause of disease and that dietary supplementation encourages people to think there's something wrong with us) so only commenced taking supplements again in June 2023 upon contrary instructions from GP.

 

Current medications;

eliquis since June 2023

Supplements; multivitamin/mineral, zinc, magnesium, calcium/magnesium, vitamin c, vitamin d, spirulina, resveratrol, iron.

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Does anyone know if kindling can cause swollen lymph nodes? I’m now starting to wonder if I actually have an infection that just so happened to line up with when I started taking Sertraline 4 days ago…

Started Citalopram 20 mg in 2017 

One unsuccessful attempt to stop in early 2022 (2 month taper, resumed taking it after 2 weeks at zero)

May 2022: started taking Vyvanse 10 mg (still at the same dose today)

Switched to Sertraline 75 mg in early June 2024 after a 2 week cross taper

Started Sertraline taper mid July

July 17: 50 mgJuly 31: 25 mgAugust 14: 12.5 mgAugust 23: 6.25 mgAugust 30: 0 mg

Week 1 of withdrawals: brain zaps, dizziness, fatigue, low mood, digestive issues

Week 2 of withdrawals: intense rage episodes, paranoia, suicidal thoughts, anxiety, depression, hypomania 

September 15: Reinstated 12.5 mg, September 17: 6.25 mg, September 19: 3.5 mg

(Rapidly reduced dose after reinstating due to adverse reaction)

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